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8. Ki-67 cytological index can distinguish well-differentiated from poorly differentiated pancreatic neuroendocrine tumors: a comparative cytohistological study of 53 cases

Author

Carlinfante, Gabriele, Baccarini, Paola, Berretti, Debora, Cassetti, Tiziana, Cavina, Maurizio, Conigliaro, Rita, De Pellegrin, Alessandro, Di Tommaso, Luca, Fabbri, Carlo, Fornelli, Adele, Frasoldati, Andrea, Gardini, Giorgio, Losi, Luisa, Maccio, Livia, Manta, Raffaele, Pagano, Nico, Sassatelli, Romano, Serra, Silvia, and Camellini, Lorenzo

Published
2014
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14. Thymoma

Author

Cancellieri, Alessandra, primary, Cavazza, Alberto, additional, Gardini, Giorgio, additional, Boaron, Maurizio, additional, Santelmo, Nicola, additional, and Baruzzi, Giuseppe, additional

Published
1997
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16. Gastric carcinoids and their precursor lesions: a histologic and immunohistochemical study of 23 cases

Author

Bordi, Cesare, Yu, Ji-Yao, Baggi, Maria Teresa, Davoli, Carla, Pilato, Francesco P., Baruzzi, Giuseppi, Gardini, Giorgio, Zamboni, Giuseppe, Franzin, Giuseppe, Papotti, Mauro, and Bussolati, Gianni

Subjects
Carcinoid -- Development and progression, Gastrointestinal tumors -- Development and progression, Stomach cancer -- Risk factors, Gastritis -- Complications, Health
Abstract

Carcinoids are tumors usually associated with the gastrointestinal tract, although similar lesions may occur in the bronchial tubes of the lungs as well. Carcinoids were given their name at a time when it was believed that they could not metastasize, but now it is recognized that these tumors are, in some cases, capable of metastatic spread. Older pathology books state that carcinoids of the stomach comprise no more than five percent of all carcinoids of the gastrointestinal tract. However, the widespread use of endoscopy has led to the recognition that gastric carcinoids are, in fact, far more common than previously suspected and may actually comprise one-third of all gastrointestinal carcinoids. Several conditions confer high risk for the development of gastric carcinoids. Among these is pernicious anemia; up to nine percent of all pernicious anemia patients may have gastric carcinoids. These tumors are also likely in patients taking inhibitors of gastric secretion for Zollinger-Ellison syndrome, which is associated with secreting pancreatic tumors. Hypergastrinemic chronic atrophic gastritis type A is also associated with the development of gastric carcinoids. There is evidence that in all these conditions, the trophic effect of excess gastrin contributes to the development and growth of the carcinoid. In such cases, surgical removal of the antrum of the stomach, where the gastrin-secreting cells are located, may result in the regression of the carcinoids, and be preferable to removal of most, or all, of the stomach. A histopathological study of 23 gastric carcinoids was conducted, and it was found that in 19 cases the syndrome was associated with hypergastrinemic chronic atrophic gastritis type A. Such patients would be good candidates for the less aggressive surgical approach of antral resection. The remaining four carcinoids, however, showed histological signs of being more aggressive, and signs of hypertrophy of gastrin-secreting cells were not found in these specimens. These four carcinoids, therefore, would not have been expected to respond to antrectomy, and aggressive surgical treatment would be advisable. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

17. Impact of 2013 ASCO/CAP guidelines on HER2 determination of invasive breast cancer: A single institution experience using frontline dual-color FISH.

Author

Gasparini, Elisa, primary, Ragazzi, Moira, additional, Bisagni, Alessandra, additional, Kuhn, Elisabetta, additional, Bassano, Cristina, additional, Tamagnini, Ione, additional, Foroni, Moira, additional, Falco, Giuseppe, additional, Ferrari, Guglielmo, additional, Braglia, Luca, additional, Savoldi, Luisa, additional, Bologna, Alessandra, additional, di Cicilia, Roberto, additional, Gardini, Giorgio, additional, and Bisagni, Giancarlo, additional

Published
2017
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18. HER2-amplification level and tumor-infiltrating lymphocytes in breast cancer patients treated with neoadjuvant trastuzumab.

Author

Masini, Cristina, primary, Bisagni, Giancarlo, additional, Ragazzi, Moira, additional, Bisagni, Alessandra, additional, Dallaglio, Katiuscia, additional, Falco, Giuseppe, additional, Bassano, Cristina, additional, Ferrari, Guglielmo, additional, Gardini, Giorgio, additional, Bologna, Alessandra, additional, Moretti, Gabriella, additional, Boni, Corrado, additional, and Pinto, Carmine, additional

Published
2016
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19. Pedunculated Angiomyofibroblastoma of the Vulva: Case Report and Review of the Literature

Author

Giannella, Luca, Costantini, Matteo, Mfuta, Kabala, Cavazza, Alberto, Cerami, Lillo Bruno, Gardini, Giorgio, and Boselli, Fausto

Subjects
Article Subject
Abstract

Angiomyofibroblastoma (AMFB) is a rare benign mesenchymal tumour that occurs almost exclusively in the vulvovaginal region of women but can also occur occasionally in the inguinoscrotal region of men. It is a well-circumscribed lesion that clinically is often thought to represent a Bartholin's gland cyst and usually does not form a pedunculated mass. To our knowledge, only five cases of vulvar AMFB with pedunculated mass have been reported in the English literature and all cases involving the labia majora and middle-aged women. We report the first case of pedunculated AMFB of the vulva occurring in a young woman of 21 years old and involving the left labia minora. After excluding the most common diseases, pedunculated AMFB should be part of differential diagnosis in the workup of any pedunculated vulvar mass even in young women with a lesion involving the labia minora. We reviewed the literature and summarized all reported cases.

Published
2011
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20. Strong Notch activation hinders bevacizumab efficacy in advanced colorectal cancer

Author

Negri, Francesca V, primary, Crafa, Pellegrino, additional, Pedrazzi, Giuseppe, additional, Bozzetti, Cecilia, additional, Lagrasta, Costanza, additional, Gardini, Giorgio, additional, Tamagnini, Ione, additional, Bisagni, Alessandra, additional, Azzoni, Cinzia, additional, Bottarelli, Lorena, additional, Graiani, Gallia, additional, Romano, Ida, additional, Porzio, Rosa, additional, Bacchini, Gian P, additional, Paties, Carlo, additional, Tomasello, Gianluca, additional, Marchetti, Giovanni, additional, Fanello, Silvia, additional, Pinto, Carmine, additional, Sala, Roberto, additional, and Ardizzoni, Andrea, additional

Published
2015
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21. Diamond: immunohistochemistry versus sequencing in EGFR analysis of lung adenocarcinomas

Author

Ragazzi, Moira, primary, Tamagnini, Ione, additional, Bisagni, Alessandra, additional, Cavazza, Alberto, additional, Pagano, Maria, additional, Baldi, Licia, additional, Boni, Corrado, additional, Cantile, Flavia, additional, Barbieri, Fausto, additional, Nicoli, Davide, additional, Sartori, Giuliana, additional, de Biase, Dario, additional, Gardini, Giorgio, additional, and Rossi, Giulio, additional

Published
2015
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22. Relationship between levels of HER-2 amplification and pathologic complete response to trastuzumab-based neoadjuvant treatment.

Author

Masini, Cristina, primary, Bisagni, Alessandra, additional, Falco, Giuseppe, additional, Bassano, Cristina, additional, Baldi, Licia, additional, Bisagni, Giancarlo, additional, Moretti, Gabriella, additional, Albini, Adriana, additional, Ferrari, Guglielmo, additional, Boni, Corrado, additional, and Gardini, Giorgio, additional

Published
2015
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24. Notch expression and bevacizumab efficacy in colorectal cancer patients.

Author

Negri, Francesca, primary, Sala, Roberto, additional, Bozzetti, Cecilia, additional, Crafa, Pellegrino, additional, Lagrasta, Costanza, additional, Pedrazzi, Giuseppe, additional, Gardini, Giorgio, additional, Tamagnini, Ione, additional, Bisagni, Alessandra, additional, Azzoni, Cinzia, additional, Bottarelli, Lorena, additional, Romano, Ida, additional, Porzio, Rosa, additional, Bacchini, Gian Paolo, additional, Paties, Carlo, additional, Tomasello, Gianluca, additional, Leonardi, Francesco, additional, Ardizzoni, Andrea, additional, and Pinto, Carmine, additional

Published
2015
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25. Pattern of care and effectiveness of treatment for glioblastoma patients in the real world: Results from a prospective population-based registry. Could survival differ in a high-volume center?

Author

Brandes, Alba A., primary, Franceschi, Enrico, additional, Ermani, Mario, additional, Tosoni, Alicia, additional, Albani, Fiorenzo, additional, Depenni, Roberta, additional, Faedi, Marina, additional, Pisanello, Anna, additional, Crisi, Girolamo, additional, Urbini, Benedetta, additional, Dazzi, Claudio, additional, Cavanna, Luigi, additional, Mucciarini, Claudia, additional, Pasini, Giuseppe, additional, Bartolini, Stefania, additional, Marucci, Gianluca, additional, Morandi, Luca, additional, Zunarelli, Elena, additional, Cerasoli, Serenella, additional, Gardini, Giorgio, additional, Lanza, Giovanni, additional, Silini, Enrico Maria, additional, Cavuto, Silvio, additional, Baruzzi, Agostino, additional, Baruzzi, A., additional, Albani, F., additional, Calbucci, F., additional, D'Alessandro, R., additional, Michelucci, R., additional, Brandes, A., additional, Eusebi, V., additional, Ceruti, S., additional, Fainardi, E., additional, Tamarozzi, R., additional, Emiliani, E., additional, Cavallo, M., additional, Franceschi, E., additional, Tosoni, A., additional, Fiorica, F., additional, Valentini, A., additional, Depenni, R., additional, Mucciarini, C., additional, Crisi, G., additional, Sasso, E., additional, Biasini, C., additional, Cavanna, L., additional, Guidetti, D., additional, Marcello, N., additional, Pisanello, A., additional, Cremonini, A.M., additional, Guiducci, G., additional, de Pasqua, S., additional, Testoni, S., additional, Agati, R., additional, Ambrosetto, G., additional, Bacci, A., additional, Baldin, E., additional, Baldrati, A., additional, Barbieri, E., additional, Bartolini, S., additional, Bellavista, E., additional, Bisulli, F., additional, Bonora, E., additional, Bunkheila, F., additional, Carelli, V., additional, Crisci, M., additional, Dall'Occa, P., additional, de Biase, D., additional, Ferro, S., additional, Franceschi, C., additional, Frezza, G., additional, Grasso, V., additional, Leonardi, M., additional, Marucci, G., additional, Mazzocchi, V., additional, Morandi, L., additional, Mostacci, B., additional, Palandri, G., additional, Pasini, E., additional, Pastore Trossello, M., additional, Pession, A., additional, Ragazzi, M., additional, Riguzzi, P., additional, Rinaldi, R., additional, Rizzi, S., additional, Romeo, G., additional, Spagnolli, F., additional, Tinuper, P., additional, Trocino, C., additional, Cerasoli, S., additional, Dall'Agata, M., additional, Faedi, M., additional, Frattarelli, M., additional, Gentili, G., additional, Giovannini, A., additional, Iorio, P., additional, Pasquini, U., additional, Galletti, G., additional, Guidi, C., additional, Neri, W., additional, Patuelli, A., additional, Strumia, S., additional, Casmiro, M., additional, Gamboni, A., additional, Rasi, F., additional, Cruciani, G., additional, Cenni, P., additional, Dazzi, C., additional, Guidi, AR., additional, Zumaglini, F., additional, Amadori, A., additional, Pasini, G., additional, Pasquinelli, M., additional, Pasquini, E., additional, Polselli, A., additional, Ravasio, A., additional, Viti, B., additional, Sintini, M., additional, Ariatti, A., additional, Bertolini, F., additional, Bigliardi, G., additional, Carpeggiani, P., additional, Cavalleri, F., additional, Meletti, S., additional, Nichelli, P., additional, Pettorelli, E., additional, Pinna, G., additional, Zunarelli, E., additional, Artioli, F., additional, Bernardini, I., additional, Costa, M., additional, Greco, G., additional, Guerzoni, R., additional, Stucchi, C., additional, Iaccarino, C., additional, Rizzi, R., additional, Zuccoli, G., additional, Api, P., additional, Cartei, F., additional, Fallica, E., additional, Granieri, E., additional, Latini, F., additional, Lelli, G., additional, Monetti, C., additional, Ramponi, V., additional, Saletti, A., additional, Schivalocchi, R., additional, Seraceni, S., additional, Tola, M.R., additional, Urbini, B., additional, Giorgi, C., additional, Montanari, E., additional, Cerasti, D., additional, Crafa, P., additional, Dascola, I., additional, Florindo, I., additional, Mazza, S., additional, Servadei, F., additional, Silini, EM., additional, Torelli, P., additional, Immovilli, P., additional, Morelli, N., additional, and Vanzo, C., additional

Published
2014
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26. Diamond project: Immunohistochemical screening using EGFR mutation-specific antibodies in lung adenocarcinomas.

Author

Boni, Corrado, primary, Pagano, Maria, additional, Tamagnini, Ione, additional, Bisagni, Alessandra, additional, Baldi, Licia, additional, Ragazzi, Moira, additional, Gardini, Giorgio, additional, Barbieri, Fausto, additional, Cantile, Flavia, additional, Zanelli, Francesca, additional, Nicoli, Davide, additional, and Giulio, Rossi, additional

Published
2014
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27. Mo1478 KI-67 Cytological Index Can Distinguish Low Grade From High Grade Pancreatic Neuroendocrine Tumors: a Comparative Cyto-Histological Study of 53 Cases

Author

Carlinfante, Gabriele, primary, Baccarini, Paola, additional, Cecinato, Paolo, additional, Berretti, Debora, additional, Cassetti, Tiziana, additional, Cavina, Maurizio, additional, Cavuto, Silvio, additional, Conigliaro, Rita, additional, De Pellegrin, Alessandro, additional, Di Tommaso, Luca, additional, Fabbri, Carlo, additional, Fornelli, Adele, additional, Frasoldati, Andrea, additional, Gardini, Giorgio, additional, Losi, Luisa, additional, Maccio, Livia, additional, Manta, Raffaele, additional, Pagano, Nico, additional, Sassatelli, Romano, additional, Serra, Silvia, additional, and Camellini, Lorenzo, additional

Published
2014
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28. A large prospective Italian population study (Project of Emilia-Romagna Region in Neuro-Oncology; PERNO) in newly diagnosed GBM patients (pts): Outcome analysis and correlations with MGMT methylation status in the elderly population.

Author

Franceschi, Enrico, primary, Tosoni, Alicia, additional, Morandi, Luca, additional, Cerasoli, Serenella, additional, Lanza, Giovanni, additional, Depenni, Roberta, additional, Gamboni, Alessandro, additional, Dazzi, Claudio, additional, Marucci, Gianluca, additional, Gardini, Giorgio, additional, Pozzati, Eugenio, additional, Urbini, Benedetta, additional, Dascola, Isabella, additional, Bartolini, Stefania, additional, Biasini, Claudia, additional, Carpeggiani, Paolo, additional, Zunarelli, Elena, additional, Silini, Enrico Maria, additional, Ermani, Mario, additional, and Brandes, Alba Ariela, additional

Published
2013
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29. Abstract 4646: Notch and DLL4 expression in bevacizumab-treated colon cancer patients.

Author

Negri, Francesca, primary, Bozzetti, Cecilia, additional, Crafa, Pellegrino, additional, Lagrasta, Costanza, additional, Cavalli, Stefano, additional, Pedrazzi, Giuseppe, additional, Gardini, Giorgio, additional, Tamagnini, Ione, additional, Porzio, Rosa, additional, Cavanna, Luigi, additional, Paties, Carlo, additional, Romano, Ida, additional, Musolino, Antonino, additional, Tomasello, Gianluca, additional, Petronini, Pier Giorgio, additional, and Ardizzoni, Andrea, additional

Published
2013
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31. In Reply

Author

Piana, Simonetta, primary, Frasoldati, Andrea, additional, Gardini, Giorgio, additional, Tallini, Giovanni, additional, and Rosai, Juan, additional

Published
2011
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32. In Response

Author

Piana, Simonetta, primary, Frasoldati, Andrea, additional, Di Felice, Enza, additional, Gardini, Giorgio, additional, Tallini, Giovanni, additional, and Rosai, Juan, additional

Published
2010
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38. Combined Conn's Syndrome and Subclinical Hypercortisolism From an Adrenal Adenoma Associated With Homolateral Renal Carcinoma.

Author

Rossi, Ermanno, Foroni, Moira, Regolisti, Giuseppe, Perazzoli, Franco, Negro, Aurelio, Santi, Rosaria, Grasselli, Chiara, Galli, Paola, and Gardini, Giorgio

Subjects
HYPERTENSION, HYPOKALEMIA, ADRENOCORTICOTROPIC hormone, CARDIOVASCULAR agents, RENAL cancer, CLINICAL pathology, QUALITATIVE research
Abstract

The article presents a case study of a 62-year-old man who was diagnosed with hypertension and hypokalemia. He had been treated with various drugs such as spironolactone, amlodipine and ramipril. Laboratory diagnosis revealed a combination of primary aldosteronism (PA) and adrenocorticotropic hormone (ACTH)-independent hypercortisolism. The prevalence of subclinic hypercortisolism in patients with PA is claimed underestimated.

Published
2008
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39. Metastasizing Meningeal Melanocytoma

Author

Ferracini, Romano, Gardini, Giorgio, Brisigotti, Massimo, Lanzanova, Giuseppe, Manetto, Valeria, and Lorenzini, Paolo

Abstract

The first case in the literature of a metastasizing meningeal melanocytoma is described. The tumor, which arose at the D9-D11spinal cord level of a 46-year-old woman, metastasized 7 years later to the latero-suprasellar region.

Published
1980
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42. Diamond: Immunohistochemistry versus sequencing in EGFR analysis of lung adenocarcinomas

Author

Ione Tamagnini, Dario de Biase, Corrado Boni, Moira Ragazzi, Davide Nicoli, Alessandra Bisagni, Flavia Cantile, Giulio Rossi, Fausto Barbieri, Giuliana Sartori, Maria Pagano, Alberto Cavazza, Giorgio Gardini, Licia Baldi, Ragazzi, Moira, Tamagnini, Ione, Bisagni, Alessandra, Cavazza, Alberto, Pagano, Maria, Baldi, Licia, Boni, Corrado, Cantile, Flavia, Barbieri, Fausto, Nicoli, Davide, Sartori, Giuliana, DE BIASE, Dario, Gardini, Giorgio, and Rossi, Giulio

Subjects
0301 basic medicine, Male, Pathology, medicine.medical_specialty, Lung Neoplasms, EGFR, DNA Mutational Analysis, Clone (cell biology), Exon, Adenocarcinoma, Sensitivity and Specificity, Pathology and Forensic Medicine, DNA Mutational Analysi, 03 medical and health sciences, 0302 clinical medicine, Cytology, Biopsy, medicine, Humans, IMMUNOHISTOCHEMISTRY, LUNG, LUNG CANCER, Exons, Female, Mutation, Receptor, Epidermal Growth Factor, High-Throughput Nucleotide Sequencing, Immunohistochemistry, 2734, Medicine (all), Epidermal growth factor receptor, Lung cancer, medicine.diagnostic_test, biology, General Medicine, medicine.disease, ErbB Receptors, Lung Neoplasm, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Receptor, Epidermal Growth Factor, Antibody, Human
Abstract

AimsIdentification of epidermal growth factor receptor (EGFR) mutations in lung adenocarcinomas is the single most important predictor of clinical response and outcome using EGFR tyrosine kinase inhibitors (TKIs). EGFR E746-A750del and L858R mutations are the most common gene alterations, also predicting the best clinical response to TKIs. We evaluated the accuracy of EGFR mutation-specific antibodies in a large cohort of lung adenocarcinomas, with different molecular settings and types of tissue samples.Methods300 lung adenocarcinomas diagnosed on cytology (48 cell blocks), biopsy (157 cases) and surgical resections (95 cases) were selected. All cases were investigated for EGFR by sequencing and two mutation-specific antibodies (clone 6B6 for E746-A750del; clone 43B2 for L858R) were tested using an automated immunostainer. Discordant results were investigated by next-generation sequencing (NGS).ResultsOverall sensitivity and specificity of mutant-specific antibodies were 58.6% and 98.0%, respectively, and they increased up to 84% and 100% if only tumours harbouring E746-A750del were considered. In 13 discordant cases, NGS confirmed immunohistochemistry results in eight samples.ConclusionsThe EGFR mutation-specific antibodies have a fair/good sensitivity and good/high specificity in identifying classic mutations, but they cannot replace molecular tests. The antibodies work equally well on biopsies and cell blocks, possibly permitting a rapid screening in cases with poor material.

Published
2016

43. Strong Notch activation hinders bevacizumab efficacy in advanced colorectal cancer

Author

Gianluca Tomasello, Cinzia Azzoni, Alessandra Bisagni, Silvia Fanello, Giovanni Marchetti, Costanza Lagrasta, Gallia Graiani, Giorgio Gardini, Cecilia Bozzetti, Ida Romano, Rosa Porzio, Lorena Bottarelli, Carlo Terenzio Paties, Ione Tamagnini, Roberto Sala, Andrea Ardizzoni, Giuseppe Pedrazzi, Gian Paolo Bacchini, Pellegrino Crafa, Carmine Pinto, Francesca Negri, Negri, Francesca V, Crafa, Pellegrino, Pedrazzi, Giuseppe, Bozzetti, Cecilia, Lagrasta, Costanza, Gardini, Giorgio, Tamagnini, Ione, Bisagni, Alessandra, Azzoni, Cinzia, Bottarelli, Lorena, Graiani, Gallia, Romano, Ida, Porzio, Rosa, Bacchini, Gian P, Paties, Carlo, Tomasello, Gianluca, Marchetti, Giovanni, Fanello, Silvia, Pinto, Carmine, Sala, Roberto, and Ardizzoni, Andrea

Subjects
Oncology, Male, Pathology, Cancer Research, Colorectal cancer, medicine.medical_treatment, Colorectal Neoplasm, law.invention, Randomized controlled trial, law, Antineoplastic Combined Chemotherapy Protocols, Intercellular Signaling Peptides and Protein, Neoplasm Metastasis, Aged, 80 and over, Receptors, Notch, Notch activation, General Medicine, Middle Aged, Neoplasm Metastasi, Bevacizumab, Treatment Outcome, Retreatment, Immunohistochemistry, Intercellular Signaling Peptides and Proteins, Female, Case-Control Studie, Colorectal Neoplasms, medicine.drug, Human, Adult, medicine.medical_specialty, colorectal cancer, DLL4, Advanced colorectal cancer, Negatively associated, Internal medicine, medicine, Humans, Adaptor Proteins, Signal Transducing, Aged, Neoplasm Staging, Chemotherapy, Antineoplastic Combined Chemotherapy Protocol, business.industry, Calcium-Binding Proteins, Case-control study, Biomarker, medicine.disease, Case-Control Studies, business, Biomarkers
Abstract

Aim: To assess the role of Notch activation in predicting bevacizumab efficacy in colorectal cancer (CRC). Materials & methods: Notch activation was evaluated by immunohistochemistry (IHC) on 65 CRC enrolled within randomized clinical trials assessing first-line bevacizumab-based chemotherapy and on 21 CRC treated with chemotherapy alone. Results: Strong Notch (IHC 3+) activation was negatively associated with response (18 vs 62% in low Notch cases [IHC 0, 1, 2+]; p = 0.016), progression-free survival (4.9 vs 12.1 months; p = 0.002) and overall survival (19.3 vs 30.4 months; p = 0.039). No correlation was found between Notch activation and clinical outcome in CRC treated with chemotherapy alone. Conclusion: A potential role of Notch activation in the antitumor activity of bevacizumab could be hypothesized.

Published
2015

44. Pattern of care and effectiveness of treatment for glioblastoma patients in the real world: Results from a prospective population-based registry. Could survival differ in a high-volume center?

Author

Alba A. Brandes, Enrico Franceschi, Mario Ermani, Alicia Tosoni, Fiorenzo Albani, Roberta Depenni, Marina Faedi, Anna Pisanello, Girolamo Crisi, Benedetta Urbini, Claudio Dazzi, Luigi Cavanna, Claudia Mucciarini, Giuseppe Pasini, Stefania Bartolini, Gianluca Marucci, Luca Morandi, Elena Zunarelli, Serenella Cerasoli, Giorgio Gardini, Giovanni Lanza, Enrico Maria Silini, Silvio Cavuto, Agostino Baruzzi, A. Baruzzi, F. Albani, F. Calbucci, R. D'Alessandro, R. Michelucci, A. Brandes, V. Eusebi, S. Ceruti, E. Fainardi, R. Tamarozzi, E. Emiliani, M. Cavallo, E. Franceschi, A. Tosoni, F. Fiorica, A. Valentini, R. Depenni, C. Mucciarini, G. Crisi, E. Sasso, C. Biasini, L. Cavanna, D. Guidetti, N. Marcello, A. Pisanello, A.M. Cremonini, G. Guiducci, S. de Pasqua, S. Testoni, R. Agati, G. Ambrosetto, A. Bacci, E. Baldin, A. Baldrati, E. Barbieri, S. Bartolini, E. Bellavista, F. Bisulli, E. Bonora, F. Bunkheila, V. Carelli, M. Crisci, P. Dall'Occa, D. de Biase, S. Ferro, C. Franceschi, G. Frezza, V. Grasso, M. Leonardi, G. Marucci, V. Mazzocchi, L. Morandi, B. Mostacci, G. Palandri, E. Pasini, M. Pastore Trossello, A. Pession, M. Ragazzi, P. Riguzzi, R. Rinaldi, S. Rizzi, G. Romeo, F. Spagnolli, P. Tinuper, C. Trocino, S. Cerasoli, M. Dall'Agata, M. Faedi, M. Frattarelli, G. Gentili, A. Giovannini, P. Iorio, U. Pasquini, G. Galletti, C. Guidi, W. Neri, A. Patuelli, S. Strumia, M. Casmiro, A. Gamboni, F. Rasi, G. Cruciani, P. Cenni, C. Dazzi, AR. Guidi, F. Zumaglini, A. Amadori, G. Pasini, M. Pasquinelli, E. Pasquini, A. Polselli, A. Ravasio, B. Viti, M. Sintini, A. Ariatti, F. Bertolini, G. Bigliardi, P. Carpeggiani, F. Cavalleri, S. Meletti, P. Nichelli, E. Pettorelli, G. Pinna, E. Zunarelli, F. Artioli, I. Bernardini, M. Costa, G. Greco, R. Guerzoni, C. Stucchi, C. Iaccarino, R. Rizzi, G. Zuccoli, P. Api, F. Cartei, E. Fallica, E. Granieri, F. Latini, G. Lelli, C. Monetti, V. Ramponi, A. Saletti, R. Schivalocchi, S. Seraceni, M.R. Tola, B. Urbini, C. Giorgi, E. Montanari, D. Cerasti, P. Crafa, I. Dascola, I. Florindo, S. Mazza, F. Servadei, EM. Silini, P. Torelli, P. Immovilli, N. Morelli, C. Vanzo, Brandes, Alba A, Franceschi, Enrico, Ermani, Mario, Tosoni, Alicia, Albani, Fiorenzo, Depenni, Roberta, Faedi, Marina, Pisanello, Anna, Crisi, Girolamo, Urbini, Benedetta, Dazzi, Claudio, Cavanna, Luigi, Mucciarini, Claudia, Pasini, Giuseppe, Bartolini, Stefania, Marucci, Gianluca, Morandi, Luca, Zunarelli, Elena, Cerasoli, Serenella, Gardini, Giorgio, Lanza, Giovanni, Silini, Enrico Maria, Cavuto, Silvio, Baruzzi, Agostino, Calbucci, F, D'Alessandro, R, Michelucci, R, Eusebi, V, Ceruti, S, Fainardi, E, Tamarozzi, R, Emiliani, E, Cavallo, M, Fiorica, F, Valentini, A, Depenni, R, Mucciarini, C, Crisi, G, Sasso, E, Biasini, C, Cavanna, L, Guidetti, D, Marcello, N, Pisanello, A, Cremonini, A M, Guiducci, G, de Pasqua, S, Testoni, S, Agati, R, Ambrosetto, G, Bacci, A, Baldin, E, Baldrati, A, Barbieri, E, Bartolini, S, Bellavista, E, Bisulli, F, Bonora, E, Bunkheila, F, Carelli, V, Crisci, M, Dall'Occa, P, de Biase, D, Ferro, S, Franceschi, C, Frezza, G, Grasso, V, Leonardi, M, Marucci, G, Mazzocchi, V, Morandi, L, Mostacci, B, Palandri, G, Pasini, E, Pastore Trossello, M, Pession, A, Ragazzi, M, Riguzzi, P, Rinaldi, R, Rizzi, S, Romeo, G, Spagnolli, F, Tinuper, P, Trocino, C, Cerasoli, S, Dall'Agata, M, Faedi, M, Frattarelli, M, Gentili, G, Giovannini, A, Iorio, P, Pasquini, U, Galletti, G, Guidi, C, Neri, W, Patuelli, A, Strumia, S, Casmiro, M, Gamboni, A, Rasi, F, Cruciani, G, Cenni, P, Dazzi, C, Guidi, Ar, Zumaglini, F, Amadori, A, Pasini, G, Pasquinelli, M, Pasquini, E, Polselli, A, Ravasio, A, Viti, B, Sintini, M, Ariatti, A, Bertolini, F, Bigliardi, G, Carpeggiani, P, Cavalleri, F, Meletti, S, Nichelli, P, Pettorelli, E, Pinna, G, Zunarelli, E, Artioli, F, Bernardini, I, Costa, M, Greco, G, Guerzoni, R, Stucchi, C, Iaccarino, C, Rizzi, R, Zuccoli, G, Api, P, Cartei, F, Fallica, E, Granieri, E, Latini, F, Lelli, G, Monetti, C, Ramponi, V, Saletti, A, Schivalocchi, R, Seraceni, S, Tola, M R, Urbini, B, Giorgi, C, Montanari, E, Cerasti, D, Crafa, P, Dascola, I, Florindo, I, Mazza, S, Servadei, F, Silini, Em, Torelli, P, Immovilli, P, Morelli, N, and Vanzo, C

Subjects
Oncology, medicine.medical_specialty, medicine.medical_treatment, Population, Medicine (miscellaneous), temozolomide, NO, surgery, center volume, glioblastoma, radiotherapy, Internal medicine, Glioma, medicine, education, Prospective cohort study, education.field_of_study, Temozolomide, Neurologic Oncology, business.industry, Incidence (epidemiology), Articles, medicine.disease, nervous system diseases, Clinical trial, Radiation therapy, business, medicine.drug
Abstract

Background As yet, no population-based prospective studies have been conducted to investigate the incidence and clinical outcome of glioblastoma (GBM) or the diffusion and impact of the current standard therapeutic approach in newly diagnosed patients younger than aged 70 years. Methods Data on all new cases of primary brain tumors observed from January 1, 2009, to December 31, 2010, in adults residing within the Emilia-Romagna region were recorded in a prospective registry in the Project of Emilia Romagna on Neuro-Oncology (PERNO). Based on the data from this registry, a prospective evaluation was made of the treatment efficacy and outcome in GBM patients. Results Two hundred sixty-seven GBM patients (median age, 64 y; range, 29–84 y) were enrolled. The median overall survival (OS) was 10.7 months (95% CI, 9.2–12.4). The 139 patients ≤aged 70 years who were given standard temozolomide treatment concomitant with and adjuvant to radiotherapy had a median OS of 16.4 months (95% CI, 14.0–18.5). With multivariate analysis, OS correlated significantly with KPS (HR = 0.458; 95% CI, 0.248–0.847; P = .0127), MGMT methylation status (HR = 0.612; 95% CI, 0.388–0.966; P = .0350), and treatment received in a high versus low-volume center (HR = 0.56; 95% CI, 0.328–0.986; P = .0446). Conclusions The median OS following standard temozolomide treatment concurrent with and adjuvant to radiotherapy given to (72.8% of) patients aged ≤70 years is consistent with findings reported from randomized phase III trials. The volume and expertise of the treatment center should be further investigated as a prognostic factor.

Published
2014

45. Combined small cell carcinoma and clear cell carcinoma of the gallbladder: report of a case and review of the literature.

Author

Piana S, Cavazza A, Corrado S, Putrino I, and Gardini G

Subjects
Adenocarcinoma, Clear Cell metabolism, Aged, Carcinoma, Small Cell metabolism, Cholecystectomy, Cholelithiasis complications, Cholelithiasis surgery, Fatal Outcome, Female, Gallbladder Neoplasms complications, Gallbladder Neoplasms metabolism, Gallbladder Neoplasms surgery, Humans, Immunohistochemistry, Mixed Tumor, Malignant metabolism, Neoplasms, Multiple Primary metabolism, Neoplasms, Multiple Primary surgery, Adenocarcinoma, Clear Cell pathology, Carcinoma, Small Cell pathology, Gallbladder Neoplasms pathology, Mixed Tumor, Malignant pathology, Neoplasms, Multiple Primary pathology
Abstract

We report a case of an incidental combined carcinoma of the gallbladder in a 66-year-old woman who underwent cholecistectomy for gallstones. The neoplasm was mainly constituted by a clear cell component and a small cell, chromogranin-positive one; it also showed some areas of conventional adenocarcinoma and foci of vascular invasion. The patient died after 3 years following treatment with combination chemotherapy. The histologic and immunohistochemical profile of the lesion is described, together with a brief review of the pertinent bibliography.

Published
2002
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