132 results on '"Gardiner HM"'
Search Results
2. Fetal hemodynamic response to aortic valvuloplasty and postnatal outcome:a European multicenter study
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Kovacevic, A, Öhman, A, Tulzer, G, Herberg, U, Dangel, J, Carvalho, J, Fesslova, V, Jicinska, H, Sarkola, T, Pedroza, C, Averiss, I, Mellander, M, and Gardiner, HM
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fetus ,fetal therapy ,aortic stenosis ,Norwood procedure - Abstract
Objective: Fetal aortic stenosis may progress to hypoplastic left heart syndrome. Fetal valvuloplasty (FV) has been proposed to improve left heart hemodynamics and maintain biventricular (BV) circulation. The aim of this study was to assess FV efficacy by comparing survival and postnatal circulation between fetuses that underwent FV and those that did not. Methods: This was a retrospective multicenter study of fetuses with aortic stenosis that underwent FV between 2005 and 2012, compared with contemporaneously enrolled natural history (NH) cases sharing similar characteristics at presentation but not undergoing FV. Main outcome measures were overall survival, BV-circulation survival and survival after birth. Secondary outcomes were hemodynamic change and left heart growth. A propensity score model was created including 54/67 FV and 60/147 NH fetuses. Analyses were performed using logistic, Cox or linear regression models with inverse probability of treatment weighting (IPTW) restricted to fetuses with a propensity score of 0.14–0.9, to create a final cohort for analysis of 42 FV and 29 NH cases. Results: FV was technically successful in 59/67 fetuses at a median age of 26 (21–34) weeks. There were 7/72 (10%) procedure-related losses, and 22/53 (42%) FV babies were delivered at < 37 weeks. IPTW demonstrated improved survival of liveborn infants following FV (hazard ratio, 0.38; 95% CI, 0.23–0.64; P = 0.0001), after adjusting for circulation and postnatal surgical center. Similar proportions had BV circulation (36% for the FV cohort and 38% for the NH cohort) and survival was similar between final circulations. Successful FV cases showed improved hemodynamic response and less deterioration of left heart growth compared with NH cases (P ≤ 0.01). Conclusions: We report improvements in fetal hemodynamics and preservation of left heart growth following successful FV compared with NH. While the proportion of those achieving a BV circulation outcome was similar in both cohorts, FV survivors showed improved survival independent of final circulation to 10 years' follow-up. However, FV is associated with a 10% procedure-related loss and increased prematurity compared with the NH cohort, and therefore the risk-to-benefit ratio remains uncertain. We recommend a carefully designed trial incorporating appropriate and integrated fetal and postnatal management strategies to account for center-specific practices, so that the benefits achieved by fetal therapy vs surgical strategy can be demonstrated clearly.
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- 2018
3. GROWTH RETARDED FETUSES SHOW DIFFERENT BIOPHYSICAL PROPERTIES OF THE AORTA: SUPPORTIVE EVIDENCE FOR FETAL PROGRAMMING?
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Gardiner, HM, Kopecka, J, Stale, H, and Marsal, K
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- 1997
4. INCIDENCE AND DETERMINANTS OF ARRHYTHMIA FOLLOWING TOTAL CAVOPULMONARY CONNECTION: A PROSPECTIVE STUDY OF 119 CASES
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Gardiner, HM, Dhillon, Bull, C, de Leval, and Deanfield, JE
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- 1996
5. Access to perinatal cardiology in the United Kingdom
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Gardiner Hm
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Heart Defects, Congenital ,medicine.medical_specialty ,Pediatrics ,Heart disease ,Heart malformation ,Cost-Benefit Analysis ,Reproductive medicine ,Coronary Disease ,Prenatal diagnosis ,Disease ,Prenatal care ,Health Services Accessibility ,Ultrasonography, Prenatal ,Coronary artery disease ,Pregnancy ,Risk Factors ,Prenatal Diagnosis ,Internal medicine ,Epidemiology ,medicine ,Humans ,Child ,business.industry ,Prenatal Care ,General Medicine ,medicine.disease ,United Kingdom ,Perinatal Care ,Editorial ,Echocardiography ,Cardiology ,Female ,business - Abstract
Social inequality augmented by decreased access to appropriate health care has been shown to influence both the predisposition to coronary artery disease and its outcome in the adult population.1 2 Does the access of pregnant women to obstetric screening programmes influence the outcome of an individual with congenital heart disease? The United Kingdom audit of important cardiac diagnoses made antenatally suggests that postcode inequality may exist.3The more affluent areas of the United Kingdom achieved higher rates of antenatal detection, mirroring the regional differences in prevalence of adult cardiovascular disease. Does this suggest inequality of access to perinatal cardiology, or are there other explanations? Looking at the figures closely, two facts emerge. First, those areas with the lowest antenatal yield of congenital heart disease are similar to those with the highest incidence of adult coronary artery disease. Second, those areas with the highest detection rate of congenital heart disease before birth (up to 75% of cases detected) lie close to those teaching hospitals that have shown a special interest in the prenatal diagnosis of heart malformations during the years preceding the audit. One of the prerequisites of screening is that the test applied is both highly sensitive and specific for the condition. Ultrasound screening at 18–20 weeks of gestation detects at least 85% of spinal and renal abnormalities in the fetus, and yet overall only 23% of structural cardiac abnormalities were detected in the United Kingdom survey.3 4 If the public were aware of this low sensitivity compared with screening for other conditions, would the rate of cardiac diagnosis be deemed acceptable? I doubt it. Screening is applied to populations to delineate a high risk group that may be offered a diagnostic procedure. However, it is not clear which pregnancies are …
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- 2001
6. The persistently patent arterial duct in the premature infant
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Karatza, AA, Azzopardi, DV, and Gardiner, HM
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Invited Article ,Pediatric cardiology ,Echocardiography ,Ductus arteriosus ,Echocardiography -- In infancy and childhood ,Indomethacin ,Prostaglandins ,Infant ,Patent ,transthoracic ,Prostaglandin antagonists ,Ductus Arteriosus ,Premature - Abstract
The presence of a persistently patent arterial duct is common in premature neonates and may be associated with high morbidity. Early accurate diagnosis, assessment of the significance of the left to right shunt and prompt treatment are required to improve the outcome in this infant population., peer-reviewed
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- 2001
7. 3D volume reconstruction of the fetal brain in twin-twin transfusion syndrome: brain volumes are concordant in ex-recipients and ex-donors
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Taylor-Clarke, M, primary, Kyriakopoulou, V, additional, Allsop, J, additional, Wimalasundera, RC, additional, Gardiner, HM, additional, and Rutherford, MA, additional
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- 2012
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8. The role of fetal magnetic resonance imaging in high risk monochorionic diamniotic pregnancy
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Taylor-Clarke, M, primary, Allsop, J, additional, McGuinness, A, additional, Gardiner, HM, additional, Wimalasundera, RC, additional, and Rutherford, MA, additional
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- 2012
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9. Reduced left ventricular strain in the recipient heart is an early sign of twin-twin transfusion syndrome
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Taylor-Clarke, M, primary, Matsui, H, additional, Wimalasundera, RC, additional, and Gardiner, HM, additional
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- 2012
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10. Noninvasive fetal electrocardiography following intermittent umbilical cord occlusion in the preterm ovine fetus
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Cleal, JK, primary, Thomas, M, additional, Hanson, MA, additional, Paterson-Brown, S, additional, Gardiner, HM, additional, and Green, LR, additional
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- 2010
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11. Isolated atrioventricular block in the fetus: a retrospective, multinational, multicenter study of 175 patients.
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Eliasson H, Sonesson SE, Sharland G, Granath F, Simpson JM, Carvalho JS, Jicinska H, Tomek V, Dangel J, Zielinsky P, Respondek-Liberska M, Freund MW, Mellander M, Bartrons J, Gardiner HM, and Fetal Working Group of the European Association of Pediatric Cardiology
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- 2011
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12. Morphological and physiological predictors of fetal aortic coarctation.
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Matsui H, Mellander M, Roughton M, Jicinska H, Gardiner HM, Matsui, Hikoro, Mellander, Mats, Roughton, Michael, Jicinska, Hana, and Gardiner, Helena M
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- 2008
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13. Examination of the fetal heart: making a diagnosis and avoiding pitfalls.
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Matsui H and Gardiner HM
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- 2007
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14. Antenatal detection of heart defects is important and achievable.
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Gardiner HM
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- 2005
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15. Successes and shortcomings of fetal echocardiography.
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Gardiner HM
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- 2001
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16. Aminopeptidase A, pregnancy and hypertension.
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Gardiner HM and Gardiner, Helena M
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- 2002
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17. Folic acid fortification and congenital heart disease.
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Gardiner HM and Fouron JC
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- 2009
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18. Fetal echocardiography: 20 years of progress.
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Gardiner HM
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- 2001
19. Fetal pulmonary valvuloplasty for critical pulmonary stenosis or atresia with intact septum.
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Tulzer G, Arzt W, Franklin RCG, Loughna PV, Mair R, and Gardiner HM
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- 2002
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20. Developing online communication training to request donation for vascularized composite allotransplantation (VCA): improving performance to match new US organ donation targets.
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Siminoff LA, Alolod GP, McGregor H, Hasz RD, Mulvania PA, Barker LK, and Gardiner HM
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- Humans, Communication, Benchmarking, Vascularized Composite Allotransplantation, Tissue and Organ Procurement, Education, Medical
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Background: Approaching families of dying or newly deceased patients to donate organs requires specialized knowledge and a mastery of relational communication. As the transplantation field has progressed, Donation Professionals (DPs) are also leading conversations with family decision makers (FDMs) about the donation of uncommon anatomical gifts, such as face, hands, genitalia, referred to as Vascularized Composite Allotransplants (VCA) without much training or experience. To address the need for training, we adapted and beta tested an evidenced-based communication training program for donation discussions to VCA requests. The overarching goal of Communicating Effectively about Donation for Vascularized Composite Allotransplantation (CEaD-VCA) is to increase the number of VCA authorizations and to improve the socioemotional outcomes of FDMs., Methods: We developed CEaD-VCA, an online, on-demand training program based on the previously tested, evidenced-based communication skills training program designed to train DPs to have conversations about solid organ donation. The training was modified utilizing data from a national telephone survey with DPs and results of 6 focus groups conducted with members of the general public. The survey and focus groups assessed knowledge, attitudes, and barriers to VCA donation. The training was shaped by a partnership with a leading industry partner, the Gift of Life Institute.™ RESULTS: Using the results as a guide, the existing CEaD training program, consisting of interactive eLearning modules, was adapted to include technical information about VCA, foundational communication skills, and two interactive example VCA donation request scenarios to facilitate active learning. Forty-two DPs from two partner Organ Procurement Organizations (OPOs) participated in the beta test of CEaD-VCA. Pre- and post-test surveys assessed the impact of the training., Conclusions: The training was scored highly by DPs in effectiveness and ease of use. This project created a standardized, accessible, and comprehensive training for DPs to communicate about VCA donation. CEaD-VCA is an example of how to develop a communication skills training for difficult conversations utilizing input from stakeholders, guided by communication theory. It also demonstrates how gaps in communication skills during medical education can be filled utilizing advanced online Learning Management Systems. The training specifically addresses new CMS rules concerning OPO performance metrics., (© 2024. The Author(s).)
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- 2024
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21. Organ Donation Willingness Among Asian Americans: Results from a National Study.
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Alolod GP, Gardiner HM, Blunt R, Yucel RM, and Siminoff LA
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- Humans, Family, Health Knowledge, Attitudes, Practice, Surveys and Questionnaires, Tissue Donors, Asian psychology, Asian statistics & numerical data, Tissue and Organ Procurement statistics & numerical data
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Asian Americans are the fastest growing racial group in the USA, but their health disparities are often overlooked. Although their needs for transplantable organs are substantial, they have the lowest rates of organ donation per million compared to other Americans by race. To better understand Asian Americans' disposition toward organ donation, a self-administered survey was developed based on formative data collection and guidance from a Community Advisory Board composed of Asian American stakeholders. The instrument was deployed online, and quota sampling based on the 2017 American Community Survey was used to achieve a sample representative (N = 899) of the Asian American population. Bivariate tests using logistic regression and the chi-square test of independence were performed. Over half (58.1%) of respondents were willing to be organ donors. A majority (81.8%) expressed a willingness to donate a family member's organs, but enthusiasm depended on the family member's donor wishes. Only 9.5% of respondents indicated that the decision to donate their organs was theirs alone to make; the remainder would involve at least one other family member. Other key sociodemographic associations were found. This study demonstrates both the diversity of Asian Americans but also the centrality of the family's role in making decisions about organ donation. Practice and research considerations for the field are also presented., (© 2022. W. Montague Cobb-NMA Health Institute.)
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- 2023
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22. A Nominal Group Technique Study of Patients Who Identify as Black or African American and Access to Renal Transplantation.
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Nonterah CW, Utsey SO, Gupta G, Wilkins S, and Gardiner HM
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- Humans, Black or African American, Focus Groups, Kidney, United States, Health Equity, Kidney Failure, Chronic surgery, Kidney Transplantation
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Introduction: Completion of the renal transplant evaluation has been associated with several barriers for patients who identify as Black or African American. This study sought to prioritize barriers to and motivators of completing the renal transplant evaluation. Methods/Approach: Semi-structured interviews and focus groups with a nominal group technique were used to generate priority scores. Transplant professionals (N = 23) were recruited from 9 transplant centers in the Mid-Atlantic, Mid-Western, and Southeastern parts of the United States. Black or African American identifying renal patients (N = 30) diagnosed with end-stage kidney disease were recruited from 1 transplant center in the Mid-Atlantic region. Findings: Priority scores were created to assess the quantitative data of participant rankings of top barriers and motivators. The most significant barriers identified by both patients and transplant professionals comprised financial constraints, insurance issues, difficulty navigating the healthcare system, transportation difficulties, and multiple health problems. Facilitators consisted of family/social support, transplant education, patient navigators, comprehensive insurance, and physician repertoire and investment. A qualitative description of the ranked factors resulted in themes classified as intrapersonal, health, socioeconomic, transplant-specific healthcare, and general healthcare. Conclusion: These findings provided vital information to transplant centers nationwide about assessing the influences of renal transplant evaluation completion. Achieving equity in access to transplantation for Black or African American renal patients requires multilayered approaches.
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- 2023
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23. Dialysis Patients' Social Networks and Living Donation Offers.
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Gillespie A, Daw J, Brown R, Cappiello J, Lee BE, Fink EL, Gardiner HM, Reese PP, Gadegbeku CA, and Obradovic Z
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Rationale & Objective: Most living kidney donors are members of a hemodialysis patient's social network. Network members are divided into core members, those strongly connected to the patient and other members; and peripheral members, those weakly connected to the patient and other members. We identify how many hemodialysis patients' network members offered to become kidney donors, whether these offers were from core or peripheral network members, and whose offers the patients accepted., Study Design: A cross-sectional interviewer-administered hemodialysis patient social network survey., Setting & Participants: Prevalent hemodialysis patients in 2 facilities., Predictors: Network size and constraint, a donation from a peripheral network member., Outcomes: Number of living donor offers, accepting an offer., Analytical Approach: We performed egocentric network analyses for all participants. Poisson regression models evaluated associations between network measures and number of offers. Logistic regression models determined the associations between network factors and accepting a donation offer., Results: The mean age of the 106 participants was 60 years. Forty-five percent were female, and 75% self-identified as Black. Fifty-two percent of participants received at least one living donor offer (range 1-6); 42% of the offers were from peripheral members. Participants with larger networks received more offers (incident rate ratio [IRR], 1.26; 95% CI, 1.12-1.42; P = 0.001), including networks with more peripheral members (constraint, IRR, 0.97; 95% CI, 0.96-0.98; P < 0.001). Participants who received a peripheral member offer had 3.6 times greater odds of accepting an offer (OR, 3.56; 95% CI, 1.15-10.8; P = 0.02) than those who did not receive a peripheral member offer., Limitations: A small sample of only hemodialysis patients., Conclusions: Most participants received at least one living donor offer, often from peripheral network members. Future living donor interventions should focus on both core and peripheral network members., (© 2023 The Authors.)
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- 2023
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24. A mixed-methods examination of public attitudes toward vascularized composite allograft donation and transplantation.
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Gardiner HM, Davis EE, Alolod GP, Sarwer DB, and Siminoff LA
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Background: This mixed-methods study examined the general public's knowledge and attitudes about vascularized composite allografts. The availability of these anatomical gifts to treat individuals with severe disfiguring injuries relies largely on decisions made by family members. If vascularized composite allograft transplantation is to become more readily available, the knowledge and beliefs of the general public must be explored to ensure vascularized composite allograft donation approaches adequately support the donation decision-making process., Methods: We conducted six focus groups with 53 members of the general public, which were audio-recorded for accuracy and transcribed. Before each session, participants completed a brief survey assessing donation-related knowledge, attitudes, and beliefs. Analysis of qualitative data entailed the constant comparison method in the development and application of a schema for thematic coding. Descriptive statistics and Spearman's rank coefficient were used in the analysis of the quantitative data., Results: Respondents were most knowledgeable about solid organ donation and least knowledgeable about vascularized composite allograft donation. Six major themes emerged: (1) strong initial reactions toward vascularized composite allografts, (2) limited knowledge of and reservations about vascularized composite allografts, (3) risk versus reward in receiving a vascularized composite allograft, (4) information needed to authorize vascularized composite allograft donation, (5) attitudes toward donation, and (6) mistrust of the organ donation system., Conclusion: The general public has low levels of knowledge and high levels of hesitation about vascularized composite allograft donation and transplantation. Education campaigns to familiarize the general public with vascularized composite allografts and specialized training for donation professionals to support informed family decision-making about vascularized composite allograft donation may address these issues., Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2022.)
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- 2022
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25. Evaluation of an eLearning System to Train Health Professionals to Communicate about Vascularized Composite Allotransplantation with Donor Families.
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Siminoff LA, Alolod GP, Davis EE, McGregor HR, Litsas DC, Sarwer DB, Mulvania PA, Hasz RD, and Gardiner HM
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- Health Personnel, Humans, Tissue Donors, Computer-Assisted Instruction, Tissue and Organ Procurement, Vascularized Composite Allotransplantation
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Introduction: Vascularized composite allotransplantation (VCA) donation relies on obtaining surrogate authorization. Yet, many donor professionals have limited experience discussing composite allograft donation. Using virtual and interactive elements, the eLearning program, Communicating Effectively about Donation for Vascularized Composite Allotransplantation (CEaD-VCA), was developed to enhance the quality of donor professionals' communication approach. Research Questions: We tested the effectiveness of the eLearning program in improving donor professionals' knowledge, preparedness, and confidence leading discussions with families. Design: Donor professionals who primarily obtain family authorization for solid organ and tissue donation were recruited from 2 regional Organ Procurement Organizations. The training was evaluated using a nonrandomized pre-post design. Participants completed an online survey with items assessing their knowledge, preparedness, and confidence for donation discussions. Pre- and post-training responses were compared using paired sample t-tests. Results: The sample included 42 donor professionals. The majority (71.4%) had at least 3 years of work experience, and over half (52.4%) had no experience discussing VCA donation with families. Post-training, significant increases in mean knowledge scores (6.4 pre to 7.0 post, P < 0.01) and mean self-reported preparation (6.6 pre to 7.9 post, P < 0.0001) were observed. There were significant increases in mean confidence scores for discussing face (6.2 pre to 7.9 post, P < 0.0001) and hand (6.2 pre to 8.0 post, P < 0.0001) transplants. Conclusion: The CEaD-VCA program was effective in increasing donor professionals' knowledge, preparation, and confidence when discussing donation, and holds potential for improving donor professional communication during donation discussions.
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- 2022
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26. The psychosocial burden of visible disfigurement following traumatic injury.
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Sarwer DB, Siminoff LA, Gardiner HM, and Spitzer JC
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Hundreds of thousands of individuals experience traumatic injuries each year. Some are mild to moderate in nature and patients experience full functional recovery and little change to their physical appearance. Others result in enduring, if not permanent, changes in physical functioning and appearance. Reconstructive plastic surgical procedures are viable treatments options for many patients who have experienced the spectrum of traumatic injuries. The goal of these procedures is to restore physical functioning and reduce the psychosocial burden of living with an appearance that may be viewed negatively by the patient or by others. Even after receipt of reconstructive procedures, many patients are left with residual disfigurement. In some, disability and disfigurement may be so profound that individuals are candidates for vascularized composite allotransplantation (VCA) procedures, i.e., the transplantation of a vascularized human body part containing multiple tissue types (skin, muscle, bone, nerves, and blood vessels) as an anatomical and/or structural unit. This narrative review paper summarizes the literature on the psychosocial burden experienced by those who have visible disfigurement. While many of these individuals experience stigma and discrimination, relatively few studies have employed a stigma framework to understand the psychosocial sequelea. This paper briefly addresses this framework. Last, particular focus is given to the psychosocial issues of individuals with particularly severe injuries who are potential candidates for VCA procedures., Competing Interests: DS currently has grant funding from the National Institute of Dental and Craniofacial Research (R01 DE026603) and Department of Defense. He has consulting relationships with Ethicon and Novo Nordisk. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Sarwer, Siminoff, Gardiner and Spitzer.)
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- 2022
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27. Culturally Tailored and Community-Based Social Media Intervention to Promote Organ Donation Awareness among Asian Americans: "Heart of Gold".
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Siminoff LA, Chansiri K, Alolod G, and Gardiner HM
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- Female, Humans, Asian, Tissue Donors, United States, Social Media, Tissue and Organ Procurement
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Organ donation disparities among ethnic minorities have persisted for decades, especially among Asian Americans (AAs). AAs represent a substantial proportion of the national transplant waitlist but have historically had the lowest organ donation rate in the United States. Community based and culturally tailored (CBCT) interventions are needed to increase donor designation within AA communities. In collaboration with local AA organizations and representatives and national partners, we developed a culturally and linguistically tailored video using a family appeal to promote donor designation among AAs. The video was distributed on social media platforms in two stages from February 17 to September 17, 2021 and tracked Reaches, Impressions, Views, and Engagements as part of a larger evaluation. The results revealed higher social media activities and engagements on Facebook than on Instagram with and without paid advertisements, although the paid approach yielded 5 to 16 times higher viewer engagement. Over six months, the video reached 36,845 AAs and gained 53,308 Impressions, 20,139 Views, 2,455 Engagements, and 232 visits to the organ donation registration page. The findings indicated Facebook and CBCT approaches as effective communication strategies to potentially raise AAs' organ donation awareness, especially among AA females over 45 years of age. Implications and limitations are discussed.
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- 2022
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28. Twin-twin transfusion syndrome: don't rely on fluids and bladders to catch it early.
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Wohlmuth C and Gardiner HM
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- Female, Fetal Heart physiopathology, Fetofetal Transfusion physiopathology, Fetofetal Transfusion therapy, Fetoscopy, Humans, Pregnancy, Fetal Heart diagnostic imaging, Fetofetal Transfusion diagnostic imaging, Prenatal Diagnosis methods
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- 2022
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29. Making a family decision to donate the brain for genomic research: lessons from the genotype-tissue expression project (GTEx).
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Siminoff LA, Mash D, Wilson-Genderson M, Gardiner HM, Mosavel M, and Barker L
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- Brain, Decision Making, Genomics, Genotype, Health Knowledge, Attitudes, Practice, Humans, Tissue Donors, Family, Tissue and Organ Procurement
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This study sheds light on the attitudes and circumstances that influence decisions by families to donate the brain of a deceased family member for research. This study, a part of the Genotype-Tissue Expression (GTEx) project, interviewed families of patients who had authorized organ and/or tissue donation for transplantation. A total of 384 family decision makers (FDMs) who decided to donate organs and/or tissues for transplantation were also asked to donate to GTEx. Of these, 297 families were asked to donate their loved one's whole brain and 87 families responded to a hypothetical request for brain donation. The decision to donate the brain to GTEx, actually or hypothetically, was the major outcome measure. The majority of the FDMs would choose to donate the brain, 78%. Unwillingness to donate the brain was associated with four attitudes: (1) the FDM unwillingness to donate their own tissues for research (OR 1.91, 95% CI .67 to 2.96; p = .05), (2) concern with potential for-profit use of tissues (OR 2.12, 95% CI 1.2 to 3.7; p = .008), (3) reported squeamishness about tissue donation (OR 1.34, 95% CI 1.1 to 1.7; p = .006), and (4) belief that FDMs should have a say in how the donated tissues are used (OR 1.36, 95% CI 1.13 to 1.5; p = .01). Organ and tissue donors may present a plenteous source of brains for research. Family concerns about tissue use and collection should be addressed by requesters., (© 2021. The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.)
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- 2021
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30. A Comparison of the Content and Quality of Organ Donation Discussions with African American Families Who Authorize and Refuse Donation.
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Siminoff LA, Alolod GP, Gardiner HM, Hasz RD, Mulvania PA, and Wilson-Genderson M
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- Adult, Black or African American statistics & numerical data, Female, Humans, Male, Middle Aged, Black or African American psychology, Communication, Family ethnology, Family psychology, Tissue and Organ Procurement statistics & numerical data
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Background: This study compares the experiences of African American (AA) families who authorized organ donation with those who refused., Methods: Large administrative datasets were obtained from 9 partnering Organ Procurement Organizations (OPO). Initial analyses used these data to assess authorization among African American families (n = 1651). Subsequent analyses were performed using a subsample of interview data of AA family decision makers (n = 276). Initial bivariate analyses tested differences in study variables by authorization status (donor/nondonor). Two separate multilevel logistic regressions examined associations between independent variables and family authorization., Results: Analyses of the administrative datasets found that refusal was more likely when the patient was older, female, a DCD case, and not referred in a timely manner; refusal was less likely when families initiated donation conversations. Interview data revealed that families who refused donation were less likely to respond favorably to initial donation requests and reported less satisfaction with the overall approach, amount of time with OPO staff, and how questions were handled. Refusing families were also more likely to feel pressured, had less comprehensive donation discussions, and rated the OPO requesters' communication skills lower. No significant differences in organ donation attitudes were found between families who authorized donation and those refusing to donate., Conclusions: The study suggests that AA families making decisions about organ donation would benefit from culturally appropriate discussions., Trial Registration: Clinical Trial Notation: NCT02138227.
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- 2021
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31. Does Whom Patients Sit Next to during Hemodialysis Affect Whether They Request a Living Donation?
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Gillespie A, Fink EL, Gardiner HM, Gadegbeku CA, Reese PP, and Obradovic Z
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- Humans, Living Donors, Prospective Studies, Renal Dialysis, Surveys and Questionnaires, Kidney Transplantation
- Abstract
Background: The seating arrangement of in-center hemodialysis is conducive to patients forming a relationship and a social network. We examined how seating in the in-center hemodialysis clinic affected patients forming relationships, whether patients formed relationships with others who have similar transplant behaviors (homophily), and whether these relationships influenced patients (social contagion) to request a living donation from family and friends outside of the clinic., Methods: In this 30-month, prospective cohort study, we observed the relationships of 46 patients on hemodialysis in a hemodialysis clinic. Repeated participant surveys assessed in-center transplant discussions and living-donor requests. A separable temporal exponential random graph model estimated how seating, demographics, in-center transplant discussions, and living-donor requests affected relationship formation via sociality and homophily. We examined whether donation requests spread via social contagion using a susceptibility-infected model., Results: For every seat apart, the odds of participants forming a relationship decreased (OR, 0.74; 95% CI, 0.61 to 0.90; P =0.002). Those who requested a living donation tended to form relationships more than those who did not (sociality, OR, 1.6; 95% CI, 1.02 to 2.6; P =0.04). Participants who discussed transplantation in the center were more likely to form a relationship with another participant who discussed transplantation than with someone who did not discuss transplantation (homophily, OR, 1.9; 95% CI, 1.03 to 3.5; P =0.04). Five of the 36 susceptible participants made a request after forming a relationship with another patient., Conclusions: Participants formed relationships with those they sat next to and had similar transplant behaviors. The observed increase in in-center transplant discussions and living-donation requests by the members of the hemodialysis-clinic social network was not because of social contagion. Instead, participants who requested a living donation were more social, formed more relationships within the clinic, and discussed transplantation with each other as a function of health-behavior homophily., Competing Interests: C.A. Gadegbeku reports receiving research funding from Akebia and Vertex; being a scientific advisor or member of the American Society of Nephrology Council; and having consultancy agreements with Fresenius Kidney Care as medical director. H.M. Gardiner reports receiving honoraria from National Institutes of Health (NIH) and Public Health Management Corporation; and being a governing councilor for the Public Health Education and Health Promotion Section of the American Public Health Association. P.P. Reese reports having ownership interest in various equities, but none which are health related or related to his research; being a coprincipal investigator for investigator-initiated demonstration trials, funded by AbbVie and Merck, which involve transplantation of hepatitis C virus (HCV)–infected organs into recipients who are negative for HCV, followed by HCV treatment; being an associate editor for American Journal of Kidney Diseases; receiving honoraria for talks at academic centers or academic consortia, including Brigham and Women’s Hospital, Brown University, Cedars-Sinai, Health and Human Services, Massachusetts General Hospital, National Kidney Foundation, Northwestern University, and University of Pittsburgh; being a coprincipal investigator for studies of medication adherence (to any statin) funded by CVS Caremark and the NIH; providing volunteer ethics consultation to eGenesis, related to patient selection and education; being a volunteer for United Network for Organ Sharing, including in the role of past chair and current member of the ethics committee; having consultancy agreements with VAL Health – identification of patients with CKD and behavior change strategies; and providing legal consultation for an individual and not a company or institution. All remaining authors have nothing to disclose., (Copyright © 2021 by the American Society of Nephrology.)
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- 2021
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32. Does Sex, Race, and the Size of a Kidney Transplant Candidate's Social Network Affect the Number of Living Donor Requests? A Multicenter Social Network Analysis of Patients on the Kidney Transplant Waitlist.
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Gillespie A, Gardiner HM, Fink EL, Reese PP, Gadegbeku CA, and Obradovic Z
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- Adult, Family, Female, Friends, Humans, Interpersonal Relations, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic psychology, Male, Middle Aged, Race Factors, Retrospective Studies, Sex Factors, Kidney Failure, Chronic surgery, Kidney Transplantation, Living Donors supply & distribution, Social Networking, Social Support, Waiting Lists
- Abstract
Background: A kidney transplant candidate's social network serves as a pool of potential living donors. Sex and racial differences in network size, network strength, and living donor requests may contribute to disparities in living donor kidney transplantation., Methods: In this multicenter cross-sectional study, we performed an egocentric network analysis via a telephone survey of 132 waitlisted candidates (53% female and 69% Black) to identify demographic and network factors associated with requesting living kidney donations., Results: Female participants made requests to more network members than male participants: incidence rate ratio (IRR) 1.95, 95% confidence interval (CI) [1.24-3.06], P < 0.01. Black participants tended to make more requests than whites (IRR 1.65, 95% CI [0.99-2.73], P = 0.05). The number of requests increased with the size of the network (IRR 1.09, 95% CI [1.02-1.16], P = 0.01); however, network size did not differ by sex or race. Network members who provided greater instrumental support to the candidates were most likely to receive a request: odds ratio 1.39, 95% CI [1.08-1.78], P = 0.01., Conclusions: Transplant candidates' networks vary in size and in the number of requests made to the members. Previously observed racial and sex disparities in living donor kidney transplantation do not appear to be related to network size or to living donation requests, but rather to the network members themselves. Future living donor interventions should focus on the network members and be tailored to their relationship with the candidate.
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- 2020
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33. Fetal ventricular strain in uncomplicated and selective growth-restricted monochorionic diamniotic twin pregnancies and cardiovascular response in pre-twin-twin transfusion syndrome.
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Wohlmuth C, Agarwal A, Stevens B, Johnson A, Moise KJ Jr, Papanna R, Donepudi R, Bell CS, Averiss IE, and Gardiner HM
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- Adult, Female, Fetal Growth Retardation physiopathology, Fetal Heart embryology, Fetal Weight, Fetofetal Transfusion physiopathology, Gestational Age, Heart Ventricles embryology, Humans, Multilevel Analysis, Placental Circulation, Pregnancy, Prospective Studies, Regression Analysis, Reproducibility of Results, Single-Blind Method, Ultrasonography, Prenatal, Fetal Heart physiopathology, Fetus blood supply, Heart Ventricles physiopathology, Pregnancy, Twin, Twins statistics & numerical data
- Abstract
Objectives: Our primary aim was to confirm whether intertwin discordance in ventricular strain and ductus venosus (DV) time intervals predicts twin-twin transfusion syndrome (TTTS). Secondary aims were to create gestational-age ranges for ventricular strain in uncomplicated monochorionic diamniotic (MCDA) twin pregnancies without selective intrauterine growth restriction (sIUGR) and to characterize the relationship of ventricular strain with gestational age in MCDA twin pregnancies with sIUGR that did not develop TTTS., Methods: In the period 2015-2018, we enrolled 150 MCDA twin pregnancies consecutively into this prospective, blinded study of global longitudinal left and right ventricular strain. With the observer blinded to twin pairing and pregnancy outcome, videoclips of the four-chamber view, which had been recorded during ultrasound surveillance in the usual window for development of TTTS (16-26 completed gestational weeks), underwent offline measurement of strain. Uncomplicated MCDA twin pregnancies, without sIUGR, were used to test the association between strain, gestational age and estimated fetal weight using mixed-effects multilevel regression. Inter-rater reliability was tested in 208 strain measurements in 31 fetuses from pregnancies which did not develop TTTS and within-fetus variation was assessed in 16 such fetuses, in which multiple four-chamber views were taken on the same day. The effect of sIUGR on strain in otherwise uncomplicated MCDA twin pregnancy was analyzed. MCDA twin pregnancies were defined as 'pre-TTTS' when, having been referred for TTTS evaluation, they did not satisfy Quintero staging criteria, but subsequently developed TTTS requiring laser treatment. MCDA pregnancies which did not develop TTTS comprised the 'non-TTTS' group. Cardiovascular parameters measured in these cases included tissue Doppler parameters and DV early filling time as a percentage of the cardiac cycle (DVeT%). Intertwin strain and DVeT% discordance was compared between non-TTTS and pre-TTTS cases, matched for gestational age., Results: Paired strain data were available for intertwin comparison in 127/150 MCDA twin pregnancies, comprising 14 pre-TTTS and 113 non-TTTS pregnancies, after exclusions. Scans were collected at a median frame rate of 97 (range, 28-220) Hz. Laser therapy was performed at a median gestational age of 20.6 (range, 17.2-26.6) weeks. There were no group differences in right (RV) or left (LV) ventricular strain discordance between 68/113 non-TTTS and 13/14 pre-TTTS MCDA twin pregnancies < 20 completed gestational weeks (RV, P = 0.338; LV, P = 0.932). DVeT% discordance > 3.6% was found in eight of 13 pre-TTTS pregnancies. In non-TTTS pregnancies, the estimated variability in ventricular strain within each twin during the day was high (RV, 19.7; LV, 12.9). However, within each pair (intertwin variation), variability was low (RV, 5.5; LV, 2.9). Interclass correlation reflecting the proportion of total variability represented by the variability between twin pairs was low (RV, 0.22; LV, 0.18). Both RV (P < 0.001) and LV (P = 0.025) strain showed a negative association with gestational age. Among non-TTTS MCDA twin pregnancies, LV strain was, on average, higher by 1.83 in sIUGR compared with normally grown fetuses (P = 0.023), with no statistically significant difference in RV strain (P = 0.271)., Conclusions: Although ventricular strain has been reported previously as a possible predictor of developing TTTS, in this blinded, prospective study, we found no significant intergroup differences in ventricular strain in pre-TTTS compared with age-matched non-TTTS MCDA twin pregnancies. We recommend using DVeT% discordance as a more practical screening tool in MCDA twin pregnancies. This study also provides new information on the changes with gestational age, and the biological and technical variation, of global longitudinal ventricular strain in uncomplicated MCDA twin pregnancies and those with isolated sIUGR. © 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology., (© 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.)
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- 2020
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34. Vascularized composite allotransplantation: Knowledge and attitudes of a national sample of organ procurement organization professionals.
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Siminoff LA, Alolod GP, Davis EE, Sarwer DB, and Gardiner HM
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- Attitude, Humans, Tissue Donors, Composite Tissue Allografts, Tissue and Organ Procurement, Vascularized Composite Allotransplantation
- Abstract
With the emergence of vascularized composite allografts (VCAs) for transplantation, donation professionals' ability to obtain authorization for these anatomical gifts has become paramount for its continued practice. Our national study examines the experience of organ procurement organization (OPO) professionals responsible for presenting the opportunity to donate VCAs to families of deceased donor-eligible patients. Semi-structured telephone interviews conducted with 157 OPO staff assessed experience with VCA discussions, VCA knowledge, and comfort, confidence, and feeling prepared with discussions about different VCA types. Standard procedures were used to code and analyze the qualitative data and summarize the quantitative data. Most respondents (70.1%) never held a VCA donation discussion, but those with experience reported overall low levels of knowledge, comfort, and confidence talking with families about VCA. Although 44.4% of the sample had VCA-related training, many felt unprepared, with most (75.0%) stating the training was insufficient. Participants without experience indicated even lower ratings of the aforementioned constructs. Findings support extant work demonstrating that no standardized procedures exist for VCA donation discussions; however, donation professionals are willing to adopt new VCA-related skills. This report concludes that sustained and content-specific training will elevate donation professionals' ability to augment the supply of VCAs available for transplantation., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2020
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35. Using Online Communication Skills Training to Increase Organ Donation Authorization.
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Siminoff LA, Gardiner HM, Alolod GP, and Wilson-Genderson M
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- Adult, Decision Making, Female, Humans, Male, Middle Aged, United States, Communication, Online Social Networking, Tissue and Organ Procurement methods, Tissue and Organ Procurement organization & administration
- Abstract
Introduction: Family denial of organ donation from deceased donor-eligible patients is a major contributor to the deficit of transplantable organs in the United States., Research Question: Does an evidence-based communication intervention improve deceased organ donor authorization rates from family decision-makers?, Design: This implementation and dissemination study used Communicating Effectively about Donation on Organ Procurement Organization professionals responsible for discussing donation and obtaining authorization from family decision-makers. A 14-month, nationwide social marketing campaign generated a sample of 682 requesters, yielding a final analyzable sample of 253 participants. Serving as their own controls, participants spent the first 3 months in a preintervention period, completed the web-based intervention, and progressed to a 3-month postintervention period. Participants completed brief online weekly surveys to assess the intervention's impact on their communication skills., Results: Authorization rates did not improve overall between the pre- and postintervention periods. A differential effect of the intervention on 3 distinct groups of requesters was found: one group exhibited high and stable authorization rates pre-post (78%-74%); a second group had low initial authorization rates that increased after exposure to the intervention (46%-73%); the third had low and variable rates of authorization that failed to improve after the intervention (45%-36%)., Conclusion: This study underscores the value of evidence-based communication training. Training targeted to requesters' skill levels is needed to realize overall improvements in individual performance, the quality of donation discussions, and rates of family decision-maker authorization to solid organ donation.
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- 2020
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36. Attitudes of intensive care and emergency physicians in Australia with regard to the organ donation process: A qualitative analysis.
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Macvean E, Yuen EY, Tooley G, Gardiner HM, and Knight T
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- Australia, Critical Care, Humans, Physicians, Terminal Care, Tissue and Organ Procurement
- Abstract
Specialized hospital physicians have direct capacity to impact Australia's sub-optimal organ donation rates because of their responsibility to identify and facilitate donation opportunities. Australian physicians' attitudes toward this responsibility are examined. A total of 12 intensive care unit and three emergency department physicians were interviewed using a constructionist grounded theory and situational analysis approach. A major theme emerged, related to physicians' conflicts of interest in maintaining patients'/next-of-kin's best interests and a sense of duty-of-care in this context. Two sub-themes related to this main theme were identified as follows: (1) discussions about organ donation and who is best to carry these out and (2) determining whether organ donation is part of end-of-life care; including the avoidance of non-therapeutic ventilation; and some reluctance to follow clinical triggers in the emergency department. Overall, participants indicated strong support for organ donation but would not consider it part of end-of-life care, representing a major obstacle to the support of potential donation opportunities. Findings have implications for physician education and training. Continued efforts are needed to integrate the potential for organ donation into end-of-life care within intensive care units and emergency departments.
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- 2020
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37. Pre-transplant evaluation completion for Black/African American renal patients: Two theoretical frameworks.
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Nonterah CW and Gardiner HM
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- Black or African American, Black People, Female, Focus Groups, Humans, Interviews as Topic, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic ethnology, Male, Qualitative Research, Renal Dialysis, Socioeconomic Factors, Trust, Health Knowledge, Attitudes, Practice ethnology, Health Services Accessibility, Healthcare Disparities ethnology, Kidney Failure, Chronic psychology, Kidney Failure, Chronic surgery, Kidney Transplantation psychology
- Abstract
Objective: Black/African Americans (B/AA) are less likely to complete the pre-transplant evaluation for kidney transplantation despite higher prevalence rates of end-stage renal disease (ESRD). To better understand the barriers and motivators to completing the evaluation process, two qualitative studies were conducted to categorize and elucidate the relationships between these factors., Methods: In Phase I, semi-structured interviews were conducted with a stratified purposeful sample of transplant professionals (N = 23). Focus groups were conducted during Phase II with a purposeful sample of B/AA patients (N = 30)., Results: Thematic analyses assessed using grounded theory revealed a multitude of factors at individual and systemic levels, including health and informational/educational-related factors. Two comprehensive theoretical frameworks, a socio-ecological model of barriers and a model of motivators are presented. Medical mistrust is an example of a community factor identified as impeding completion rates. Systemic motivators included compressed time for testing and fewer intervals between doctor's appointments., Conclusions: This study offers a structure for understanding impediments to and facilitators of pre-transplant evaluation completion as seen through the eyes of both B/AA ESRD patients seeking transplant and the providers who work with them., Practice Implications: Recommendations for intervention and systemic changes to narrow health disparities are discussed., Competing Interests: Declaration of Competing Interest The authors of this publication do not have conflicts of interest to disclose as delineated by Patient Education and Counseling., (Copyright © 2019 Elsevier B.V. All rights reserved.)
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- 2020
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38. Family First: Asian Americans' Attitudes and Behaviors Toward Deceased Organ Donation.
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Siminoff LA, Bolt S, Gardiner HM, and Alolod GP
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- Adolescent, Adult, Aged, Female, Focus Groups, Humans, Male, Middle Aged, Philadelphia, Qualitative Research, Young Adult, Asian psychology, Asian statistics & numerical data, Culture, Health Knowledge, Attitudes, Practice, Tissue and Organ Procurement statistics & numerical data
- Abstract
Asian Americans have substantial transplantation needs but have the lowest rates of organ donation in the USA. As the shortage of transplantable organs persists, the rate of deceased donation by Asian Americans has not kept pace with that of the general population. This report is a qualitative study of organ donation-related attitudes and beliefs of three Asian ethnic groups located in the greater Philadelphia metropolitan area: Chinese, Filipino, and Vietnamese Americans. Guided by a Community Advisory Board representing these groups, we conducted 9 focus groups with a total of 64 participants and subsequent thematic analyses. Six major themes emerged: (1) positive views about organ donation, (2) previous exposure to organ donation, (3) primacy of the family in decision making, (4) mistrust of the healthcare and donation systems, (5) religious and cultural beliefs concerning the body, and (6) isolation from mainstream American society. Although participants expressed commonalities and beliefs in line with other American racial and ethnic groups, we also identified unique beliefs, such as familial influence, religious and cultural concerns regarding body wholeness and the dead, and underlying reasons for medical mistrust, such as a belief in a black market. The study's findings challenge the dominant educational and awareness campaigns about organ donation decision making that focus on individual autonomy and overlook the need for incorporating the specific content and message delivery needs of Asian Americans. This study is the first to explore attitudes and knowledge about posthumous organ donation among US Asian American populations in at least a decade.
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- 2020
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39. Responsiveness and adaptability in community engaged biobanking research: experiences from a Hispanic community.
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Mosavel M, Barker KL, Gardiner HM, and Siminoff LA
- Abstract
The success of biobanking research relies on the willingness of the public to provide biological and sociological information, donate tissue samples, and complete psychosocial questionnaires. Medical advances made through biobanking research have limited reach if tissues are not obtained from a diverse sample of individuals. Within, we describe the process of transitioning a small group of Hispanic community members who met regularly into a more formal Hispanic Community Advisory Board (HCAB) for the Genotype-Tissue Expression (GTEx) project. The sole purpose of the HCAB was to provide input and feedback on GTEx and, specifically, how researchers can best address the concerns of the Hispanic community related to tissue donation. This initial purpose was adapted to be responsive to the HCAB's request to include educating others in the Hispanic community who were not a part of the advisory board about genomic biobanking. While HCAB members' knowledge of biobanking was limited, a strong need for culturally tailored information about the impact of biobanking medical discoveries and their potential benefit to the Hispanic community was expressed. The HCAB's feedback guided revisions to GTEx study documents to specifically address concerns about language use, clarity, and context including the need for consent forms to address cultural concerns and fears. HCAB members also collaborated on the development of a walk-through exhibition which provided a visual, narrative-based explanation of GTEx and the process of tissue donation for research and biobanking purposes. The HCAB demonstrated the value of including community participation in scientific research projects, for both scientists and lay communities, and underscored the importance of developing community engagement approaches that are adaptable and responsive to community needs. Our experience with the HCAB serves as exemplar for a unique paradigm of community inclusiveness and education in research.
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- 2019
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40. In utero intervention for severe congenital heart disease.
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Gardiner HM
- Subjects
- Female, Fetal Diseases diagnosis, Fetal Heart diagnostic imaging, Heart Defects, Congenital diagnosis, Humans, Pregnancy, Prenatal Care methods, Prenatal Diagnosis, Ultrasonography, Prenatal, Fetal Diseases surgery, Fetal Heart surgery, Fetal Therapies methods, Heart Defects, Congenital surgery
- Abstract
The aim of foetal cardiac therapy is to treat an abnormality at the developmental stage so that the process of cardiac growth, which is complex and relies on the volume and direction of circulating blood as well as genetic determinants, can continue. In reality, most cardiac interventions are palliative; hence, major abnormalities are still present at birth. Nevertheless, tangible benefits following successful foetal intervention include improved haemodynamics and reduction in secondary damage leading to better postnatal outcomes. In cases of semilunar valve stenosis, or atresia, foetal valvuloplasty aims to achieve a biventricular, rather than univentricular, circulation. Opening and stenting a restrictive atrial foramen may preserve the pulmonary function in cases of hypoplastic left heart syndrome, thereby increasing the chances of successful postnatal surgery. More recent endeavours include percutaneous implantation of a miniaturised pacemaker to treat complete heart block and the promotion of left-sided heart growth by chronic maternal hyperoxygenation. The true clinical benefit of these interventions over natural history remains uncertain because of the paucity of appropriate randomised controlled trials (RCTs). Foetal cardiac therapy must now move from a pioneering approach to one that is supported by evidence, as has been done successfully for other foetal therapies., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2019
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41. Clinical Monitoring of Sacrococcygeal Teratoma.
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Wohlmuth C, Bergh E, Bell C, Johnson A, Moise KJ Jr, van Gemert MJC, van den Wijngaard JPHM, Wohlmuth-Wieser I, Averiss I, and Gardiner HM
- Subjects
- Clinical Decision-Making, Female, Fetal Death, Fetal Therapies, Gestational Age, Humans, Models, Cardiovascular, Patient Selection, Predictive Value of Tests, Pregnancy, Premature Birth mortality, Regional Blood Flow, Reproducibility of Results, Risk Assessment, Risk Factors, Sacrococcygeal Region, Spinal Neoplasms mortality, Spinal Neoplasms surgery, Teratoma mortality, Teratoma surgery, Term Birth, Treatment Outcome, Decision Support Techniques, Fetal Monitoring methods, Spinal Neoplasms blood supply, Spinal Neoplasms diagnostic imaging, Teratoma blood supply, Teratoma diagnostic imaging, Ultrasonography, Doppler, Ultrasonography, Prenatal
- Abstract
Background: Sacrococcygeal teratomas (SCT) are often highly vascularized and may result in high-output cardiac failure, polyhydramnios, fetal hydrops, and demise. Delivery is guided by the SCT to fetus volume ratio (SCTratio), SCT growth rate, and cardiac output indexed for weight (CCOi)., Methods: We compared measurements and outcome in 12 consecutive fetuses referred with SCT. Adverse outcomes were: fetal surgery, delivery < 32 gestational weeks or neonatal demise. Only SCTratio and CCOi were used to manage the cases. SCT vascularization index (VI%) was derived from the 3D virtual organ computer-aided analysis (VOCAL) software. The SCTModel (modified from acardiac twins) calculated a hypothetical SCT draining vein size and derived a risk line, using diameters of the superior and inferior vena cava, the azygous and umbilical veins. VI% and a model of systemic and umbilical venous volumes (SCTModel) were tested as indicators for outcome in SCT., Results: Fetuses were monitored from 20.1 to 36.4 gestational weeks and 5/12 had adverse outcomes: 1 had successful open fetal surgery at 23.8 weeks and delivered at term, 4 delivered at < 32 weeks with 3/4 having neonatal demise between 25 and 29 weeks. VI% was significantly higher in cases with adverse outcomes (mean 10.3 [8.9-11.6] vs. 4.4 [3.4-5.3], p < 0.0001). The additional fraction of the fetal cardiac output required to perfuse the SCT-draining vein (XSCO%) (p = 0.46), SCTratio (p = 0.08), and CCOi (p = 0.64) were not significant. All cases with adverse outcome had VI% > 8%. The SCTModel risk line predicted nonadverse outcomes well but lacked data in 2/5 cases with adverse outcomes., Conclusions: VI% is a significant indicator of SCT cases with adverse outcomes and combined with SCTratio may guide timing of delivery better than current measures., (© 2019 S. Karger AG, Basel.)
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- 2019
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42. Fetal hemodynamic response to aortic valvuloplasty and postnatal outcome: a European multicenter study.
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Kovacevic A, Öhman A, Tulzer G, Herberg U, Dangel J, Carvalho JS, Fesslova V, Jicinska H, Sarkola T, Pedroza C, Averiss IE, Mellander M, and Gardiner HM
- Subjects
- Aortic Valve Stenosis embryology, Aortic Valve Stenosis physiopathology, Coronary Circulation, Disease Progression, Female, Gestational Age, Hemodynamics, Humans, Hypoplastic Left Heart Syndrome embryology, Hypoplastic Left Heart Syndrome physiopathology, Infant, Newborn, Pregnancy, Pregnancy Outcome, Prenatal Care, Propensity Score, Retrospective Studies, Risk Assessment, Survival Rate, Aortic Valve Stenosis surgery, Balloon Valvuloplasty, Fetal Heart diagnostic imaging, Hypoplastic Left Heart Syndrome prevention & control
- Abstract
Objective: Fetal aortic stenosis may progress to hypoplastic left heart syndrome. Fetal valvuloplasty (FV) has been proposed to improve left heart hemodynamics and maintain biventricular (BV) circulation. The aim of this study was to assess FV efficacy by comparing survival and postnatal circulation between fetuses that underwent FV and those that did not., Methods: This was a retrospective multicenter study of fetuses with aortic stenosis that underwent FV between 2005 and 2012, compared with contemporaneously enrolled natural history (NH) cases sharing similar characteristics at presentation but not undergoing FV. Main outcome measures were overall survival, BV-circulation survival and survival after birth. Secondary outcomes were hemodynamic change and left heart growth. A propensity score model was created including 54/67 FV and 60/147 NH fetuses. Analyses were performed using logistic, Cox or linear regression models with inverse probability of treatment weighting (IPTW) restricted to fetuses with a propensity score of 0.14-0.9, to create a final cohort for analysis of 42 FV and 29 NH cases., Results: FV was technically successful in 59/67 fetuses at a median age of 26 (21-34) weeks. There were 7/72 (10%) procedure-related losses, and 22/53 (42%) FV babies were delivered at < 37 weeks. IPTW demonstrated improved survival of liveborn infants following FV (hazard ratio, 0.38; 95% CI, 0.23-0.64; P = 0.0001), after adjusting for circulation and postnatal surgical center. Similar proportions had BV circulation (36% for the FV cohort and 38% for the NH cohort) and survival was similar between final circulations. Successful FV cases showed improved hemodynamic response and less deterioration of left heart growth compared with NH cases (P ≤ 0.01)., Conclusions: We report improvements in fetal hemodynamics and preservation of left heart growth following successful FV compared with NH. While the proportion of those achieving a BV circulation outcome was similar in both cohorts, FV survivors showed improved survival independent of final circulation to 10 years' follow-up. However, FV is associated with a 10% procedure-related loss and increased prematurity compared with the NH cohort, and therefore the risk-to-benefit ratio remains uncertain. We recommend a carefully designed trial incorporating appropriate and integrated fetal and postnatal management strategies to account for center-specific practices, so that the benefits achieved by fetal therapy vs surgical strategy can be demonstrated clearly. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd., (Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.)
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- 2018
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43. Long-term outcomes for monochorionic twins after laser therapy in twin-to-twin transfusion syndrome.
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Hecher K, Gardiner HM, Diemert A, and Bartmann P
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- Cardiovascular System growth & development, Female, Forecasting, Heart Diseases congenital, Humans, Nervous System growth & development, Pregnancy, Time Factors, Treatment Outcome, Fetofetal Transfusion surgery, Laser Therapy
- Abstract
Twin-to-twin transfusion syndrome typically occurs in the second trimester in 10-15% of monochorionic twin pregnancies. Vascular anastomoses of monochorionic placentae are the underlying cause of the development of the syndrome. If a blood flow imbalance occurs, one fetus becomes the so-called donor twin and the other the recipient. If untreated, perinatal mortality is 80-90%. Fetoscopic laser coagulation of the vascular anastomoses destroys the cause of the syndrome and leads to dual twin survival rates of around 70% and more than 90% of pregnancies with at least one survivor. However, unequal placental sharing, intrauterine death, and severe prematurity are still limiting factors for further improvement of survival rates and decreases in long-term morbidity. Prematurity and neurodevelopmental impairment affect the donor and recipient twins, whereas cardiovascular failure and obstruction of the right ventricular outflow tract are typical complications of recipients, which can lead to long-term morbidity. In this Review, we summarise the literature on follow-up data for survivors of twin-to-twin-transfusion syndrome after laser therapy, including neurodevelopmental outcomes, cardiovascular outcomes, growth, renal function, and ischaemic events, as well as the potential effects of intrauterine programming on later life., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2018
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44. Consent to a Postmortem Tissue Procurement Study: Distinguishing Family Decision Makers' Knowledge of the Genotype-Tissue Expression Project.
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Siminoff LA, Wilson-Genderson M, Gardiner HM, Mosavel M, and Barker KL
- Abstract
Tissues from postmortem transplantation donors are a viable and productive option for genomic research. This entails obtaining authorization from the family decision makers (FDMs) of deceased donors. This study examined best practices for making such requests within the context of the Genotype-Tissue Expression (GTEx) project, a large national effort to collect reference tissues to establish a genomic biobank and database. Our study interviewed 413 FDMs about their donation experiences. We assessed FDM understanding of important consent concepts varied such as ability to withdraw tissues, the risks of donation, and return of results. Using latent class analysis applied to a subgroup of 188 FDMs who had agreed to participate in GTEx, three groups emerged, representing distinct patterns of comprehension of the GTEx project. Tissue requester gender and use of a GTEx brochure were associated with group membership. Results indicate that more research is needed to improve consent processes with FDMs to facilitate informed decision-making.
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- 2018
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45. Advances in fetal echocardiography.
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Gardiner HM
- Subjects
- Biomedical Research trends, Clinical Competence, Delayed Diagnosis trends, Diagnostic Errors prevention & control, Diagnostic Errors trends, Echocardiography adverse effects, Echocardiography trends, Female, Heart Defects, Congenital embryology, Humans, Imaging, Three-Dimensional methods, Imaging, Three-Dimensional trends, Male, Practice Guidelines as Topic, Pregnancy, Pregnancy Trimester, First, Pregnancy Trimester, Second, Referral and Consultation, Ultrasonography, Prenatal adverse effects, Ultrasonography, Prenatal trends, Echocardiography methods, Heart Defects, Congenital diagnostic imaging, Ultrasonography, Prenatal methods
- Abstract
The development of fetal echocardiography and success in prenatal cardiac screening programs over the past 30 years has been driven by technical innovation and influenced by the different approaches of the various specialties practicing it. Screening for congenital heart defects no longer focuses on examining a limited number of pregnant women thought to be at increased risk, but instead forms an integrated part of a high-quality anatomical ultrasound performed in the second trimester using the 'five-transverse view' protocol. A prenatal diagnosis is feasible in almost all cardiac lesions and the advantages to parents and to health professionals are well recognized. Prenatal evaluation can usually determine the level of care required at delivery, thereby reducing perinatal morbidity. However, only half of the babies undergoing surgery within the first year of life have a prenatal detection, and practical training programs to support and provide feedback to sonographers remain essential for continued improvement., (Copyright © 2017 Elsevier Ltd. All rights reserved.)
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- 2018
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46. Cardiac pathophysiology in twin-twin transfusion syndrome: new insights into its evolution.
- Author
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Wohlmuth C, Boudreaux D, Moise KJ Jr, Johnson A, Papanna R, Bebbington M, and Gardiner HM
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- Adult, Blood Flow Velocity, Female, Fetal Heart physiopathology, Fetofetal Transfusion embryology, Gestational Age, Heart Ventricles physiopathology, Hemodynamics, Humans, Pregnancy, Twins, Echocardiography, Doppler, Fetal Heart diagnostic imaging, Fetofetal Transfusion diagnostic imaging, Fetofetal Transfusion physiopathology, Ultrasonography, Prenatal
- Abstract
Objectives: In twin-twin transfusion syndrome (TTTS), unbalanced transfer of vasoactive mediators and fluid from the donor to the recipient cotwin alters their cardiovascular function. The aims of this study were to describe the impact of TTTS on fetal cardiac function in a large cohort of monochorionic-diamniotic (MCDA) pregnancies, and determine the early hemodynamic response to selective fetoscopic laser photocoagulation (SFLP)., Methods: Echocardiography was performed in 145 MCDA pregnancies, including 26 uncomplicated MCDA, 61 TTTS Stages I+II and 58 TTTS Stages III+IV pregnancies, prior to SFLP for TTTS. Echocardiographic data after SFLP were available in a subset of 41/119 (34%) TTTS cases at a mean of 1.7 ± 1.9 days. Mitral (MAPSE) and tricuspid (TAPSE) annular systolic excursion, myocardial performance index (MPI), tissue Doppler velocities (E', A', S') and filling pressures (E/E') were measured and transformed into Z-scores. Ventricular pressure was estimated from peak atrioventricular regurgitation velocity., Results: Left ventricular hemodynamics of the recipient twin were affected in early TTTS. In all stages of TTTS, left MPI and E/E' of the recipient twin were elevated in comparison to those of the donor (all P < 0.05), with reduced recipient left S' in TTTS Stages III+IV (P < 0.001). Ventricular pressure was elevated for gestational age (median, 42 mmHg (range, 20-65 mmHg)) in 11 of 14 recipients in which this parameter was measured. Between-group difference in right ventricular E/E' was significant only in TTTS Stages III+IV recipients compared with TTTS Stages I+II (P = 0.007) and uncomplicated MCDA (P = 0.041). Recipient left and right MPI decreased while S', MAPSE and TAPSE increased after SFLP; in donors, left E/E' and cardiac output increased., Conclusions: Cardiac function of the recipient twin in TTTS is abnormal, even in the early stages of the disease. Left ventricular filling pressures are elevated and systolic function is decreased before abnormalities in the right heart become apparent. SFLP produces rapid hemodynamic improvement. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd., (Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.)
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- 2018
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47. How Inaccurate Metrics Hide the True Potential for Organ Donation in the United States.
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Siminoff LA, Gardiner HM, Wilson-Genderson M, and Shafer TJ
- Subjects
- Forecasting, Humans, Registries, United States, Organ Transplantation statistics & numerical data, Organ Transplantation trends, Tissue Donors statistics & numerical data, Tissue Donors supply & distribution, Tissue and Organ Procurement statistics & numerical data, Tissue and Organ Procurement trends
- Abstract
Background: There is a discrepancy between the reported increase in donor conversion rates and the number of organs available for transplant., Methods: Secondary analysis of data obtained from the Scientific Registry of Transplant Recipients from January 2003 through December 2015 was performed. The primary outcomes were the (1) number of brain-dead donors from whom solid organs were recovered and (2) number of the organs transplanted. Descriptive statistics and growth plots were used to examine the trajectory of organ donation, recovery, and transplantation outcomes over the 11-year period., Results: From 2003 to 2006, the number of brain-dead donors increased from 6187 to 7375, remaining relatively stable at approximately 7200 thereafter. The average eligible deaths per organ procurement organization dropped from 182.7 (standard deviation [SD]: 131.3) in 2003 to 149.3 (SD: 111.4) in 2015. This suggests a total of 12 493 unrealized potential donors (2006-2015)., Conclusions: Since 2006, a steady decline in the number of donor-eligible deaths was reported. In 2003, the reported eligible deaths was 11 326. This number peaked in 2004 at 11 346, tumbling to 9781 eligible donors in 2015, despite a 9% increase in the US population. From 2006 to 2015, the data indicate an artificial depression and underestimation of the true potential of brain-dead donors in the United States of conservatively 12 493 donors or 39 728 missing organs. New metrics providing objective but verifiable counts of the donor pool are needed.
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- 2018
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48. The Influence of Blood Pressure on Fetal Aortic Distensibility: An Animal Validation Study.
- Author
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Wohlmuth C, Moise KJ Jr, Papanna R, Gheorghe C, Johnson A, Morales Y, and Gardiner HM
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- Animals, Aorta physiology, Female, Pregnancy, Sheep, Aorta diagnostic imaging, Blood Pressure, Ultrasonography, Prenatal
- Abstract
Background/aims: Aortic distension waveforms describe the change in diameter or cross-sectional area over the cardiac cycle. We aimed to validate the association of aortic fractional area change (AFAC) with blood pressure (BP) in a fetal lamb model., Methods: Four pregnant ewes underwent open fetal surgery under general anesthesia at 107-120 gestational days. A 4-Fr catheter was introduced into the fetal femoral artery and vein, or the carotid artery and jugular vein. The thoracic aorta was imaged using real-time ultrasound; AFAC was calculated using offline speckle tracking software. Measurements of invasive BP and AFAC were obtained simultaneously and averaged over 10 cardiac cycles. BP was increased by norepinephrine infusion and the association of aortic distensibility with BP was assessed., Results: Baseline measurements were obtained from 4 lambs, and changes in aortic distensibility with increasing BP were recorded from 3 of them. A positive correlation was found between AFAC and systolic BP (r = 0.692, p = 0.001), diastolic BP (r = 0.647, p = 0.004), mean BP (r = 0.692, p = 0.001), and BP amplitude (r = 0.558, p = 0.016) controlled for heart rate. No association was found between BP and maximum or minimum aortic area., Conclusion: AFAC provides a quantifiable measure of aortic distensibility and correlates with systolic BP, diastolic BP, mean BP, and BP amplitude in a fetal lamb model., (© 2017 S. Karger AG, Basel.)
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- 2018
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49. Authorization of tissues from deceased patients for genetic research.
- Author
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Wilson-Genderson M, Barker KL, Gardiner HM, Mosavel M, Thomas J, and Siminoff LA
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- Adult, Aged, Biological Specimen Banks legislation & jurisprudence, Biomedical Research ethics, Biomedical Research legislation & jurisprudence, Decision Making ethics, Female, Genetic Research legislation & jurisprudence, Health Knowledge, Attitudes, Practice, Humans, Male, Middle Aged, Socioeconomic Factors, Tissue Donors psychology, Tissue and Organ Procurement legislation & jurisprudence, Biological Specimen Banks ethics, Genetic Research ethics, Tissue and Organ Procurement ethics
- Abstract
Tissues from deceased donors provide important data for genomic research and Organ Procurement Organizations (OPOs) play a significant role. To understand the decisions of families who donated for transplantation and made decisions about donation to the Genotype-Tissue Expression Project (GTEx), we examined donation decisions of family decision makers (FDMs). 413 families were interviewed by telephone. The OPO staff who made the transplant and research requests completed self-administered surveys; a total of 309 matching surveys from 99 OPO staff were obtained. 76.8% of families donated to the GTEx project. Logistic regression analysis found that FDM consent to GTEx donation was associated with endorsement of policies to promote biobanking (OR = 1.35), positive attitudes about medical research (OR = 1.1), lack of concern regarding a breach of confidentiality (OR = 1.54), comfort with tissue donation (OR = 1.24), and prior authorization to solid organ donation (OR = 3.17). OPO staff characteristics associated with GTEx donation included being female (OR = 3.57), White (OR = 4.97), comfort with hospital staff role in donation (OR = 1.61), and number of topics discussed with families (OR = 57.9). Donor type, FDM attitudes, OPO staff sociodemographics, OPO comfort with the GTEx authorization process, and intensity of discussing research-specific issues were significantly associated with GTEx donation decisions.
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- 2018
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50. Prenatal diagnosis of double aortic arch: can we predict airway obstruction (pseudo-CHAOS) and need for airway EXIT?
- Author
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Naidu DP, Wohlmuth C, and Gardiner HM
- Subjects
- Airway Obstruction embryology, Airway Obstruction therapy, Aorta, Thoracic embryology, Aortic Arch Syndromes embryology, Delivery, Obstetric methods, Echocardiography, Female, Gestational Age, Humans, Predictive Value of Tests, Pregnancy, Airway Obstruction diagnosis, Aorta, Thoracic abnormalities, Aortic Arch Syndromes diagnosis, Ultrasonography, Prenatal
- Published
- 2017
- Full Text
- View/download PDF
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