1. Novel Role of Y1 Receptors in the Coordinated Regulation of Bone and Energy Homeostasis
- Author
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Baldock, PA, Allison, SJ, Lundberg, P, Lee, NJ, Slack, S, Lin, EJD, Enriquez, RF, McDonald, MM, Zhang, L, During, MJ, Little, DG, Eisman, JA, Gardiner, EM, Yulyaningsih, E, Lin, S, Herzog, H, and Sainsbury, Amanda
- Abstract
The importance of neuropeptide Y (NPY) and Y2 receptors in the regulation of bone and energy homeostasis has recently been demonstrated. However, the contributions of the other Y recep- tors are less clear. Here we show that Y1 receptors are expressed on osteoblastic cells. Moreover, bone and adipose tissue mass are elevated in Y1/ mice with a generalized increase in bone formation on cortical and cancellous surfaces. Importantly, the inhibitory effects of NPY on bone marrow stromal cells in vitro are absent in cells derived from Y1/ mice, indicating a direct action of NPY on bone cells via this Y receptor. Interestingly, in contrast to Y2 receptor or germ line Y1 receptor deletion, con- ditional deletion of hypothalamic Y1 receptors in adult mice did not alter bone homeostasis, food intake, or adiposity. Further- more, deletion of both Y1 and Y2 receptors did not produce additive effects in bone or adiposity. Thus Y1 receptor pathways act powerfully to inhibit bone production and adiposity by non- hypothalamic pathways, with potentially direct effects on bone tissue through a single pathway with Y2 receptors.
- Published
- 2007