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1. Detection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar squamous cell carcinoma survivors: a cross-sectional internally-matched carotid isodose analysis

Author

Koutroumpakis, Efstratios, Naser, Mohamed A., Radwan Mohamed, Abdallah Sherif, Eraj, Salman A., Jarre, Andrea, Shiao, Jay C., Kamal, Mona, Perni, Subha, Phan, Jack P., Morrison, William H., Frank, Steven J., Gunn, G.Brandon, Garden, Adam S., Deswal, Anita, Abe, Jun-ichi, Rosenthal, David I., Mouhayar, Elie, and Fuller, Clifton D.

Published
2025
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2. Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer

Author

Bronk, Julianna K., Augustyn, Alexander, Mohamed, Abdallah S.R., David Fuller, C., Garden, Adam S., Moreno, Amy C., Lee, Anna, Morrison, William H., Phan, Jack, Reddy, Jay P., Rosenthal, David I., Spiotto, Michael T., Frank, Steven J., Dadu, Ramona, Busaidy, Naifa, Zafereo, Mark, Wang, Jennifer R., Maniakas, Anastasios, Ferrarotto, Renata, Iyer, Priyanka C., Cabanillas, Maria E., and Gunn, G. Brandon

Published
2025
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3. Deep Learning-Based Dose Prediction for Automated, Individualized Quality Assurance of Head and Neck Radiation Therapy Plans

Author

Gronberg, Mary P., Beadle, Beth M., Garden, Adam S., Skinner, Heath, Gay, Skylar, Netherton, Tucker, Cao, Wenhua, Cardenas, Carlos E., Chung, Christine, Fuentes, David, Fuller, Clifton D., Howell, Rebecca M., Jhingran, Anuja, Lim, Tze Yee, Marquez, Barbara, Mumme, Raymond, Olanrewaju, Adenike M., Peterson, Christine B., Vazquez, Ivan, Whitaker, Thomas J., Wooten, Zachary, Yang, Ming, and Court, Laurence E.

Subjects
Physics - Medical Physics
Abstract

Purpose: This study aimed to use deep learning-based dose prediction to assess head and neck (HN) plan quality and identify suboptimal plans. Methods: A total of 245 VMAT HN plans were created using RapidPlan knowledge-based planning (KBP). A subset of 112 high-quality plans was selected under the supervision of an HN radiation oncologist. We trained a 3D Dense Dilated U-Net architecture to predict 3-dimensional dose distributions using 3-fold cross-validation on 90 plans. Model inputs included CT images, target prescriptions, and contours for targets and organs at risk (OARs). The model's performance was assessed on the remaining 22 test plans. We then tested the application of the dose prediction model for automated review of plan quality. Dose distributions were predicted on 14 clinical plans. The predicted versus clinical OAR dose metrics were compared to flag OARs with suboptimal normal tissue sparing using a 2 Gy dose difference or 3% dose-volume threshold. OAR flags were compared to manual flags by 3 HN radiation oncologists. Results: The predicted dose distributions were of comparable quality to the KBP plans. The differences between the predicted and KBP-planned D1%, D95%, and D99% across the targets were within -2.53%(SD=1.34%), -0.42%(SD=1.27%), and -0.12%(SD=1.97%), respectively, and the OAR mean and maximum doses were within -0.33Gy(SD=1.40Gy) and -0.96Gy(SD=2.08Gy). For the plan quality assessment study, radiation oncologists flagged 47 OARs for possible plan improvement. There was high interphysician variability; 83% of physician-flagged OARs were flagged by only one of 3 physicians. The comparative dose prediction model flagged 63 OARs, including 30 of 47 physician-flagged OARs. Conclusion: Deep learning can predict high-quality dose distributions, which can be used as comparative dose distributions for automated, individualized assessment of HN plan quality., Comment: updated to reflect the published peer-reviewed article

Published
2022
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5. Radiation Therapy for HPV-Positive Oropharyngeal Squamous Cell Carcinoma: An ASTRO Clinical Practice Guideline

Author

Margalit, Danielle N., Anker, Christopher J., Aristophanous, Michalis, Awan, Musaddiq, Bajaj, Gopal K., Bradfield, Lisa, Califano, Joseph, Caudell, Jimmy J., Chapman, Christina H., Garden, Adam S., Harari, Paul M., Helms, Amanda, Lin, Alexander, Maghami, Ellie, Mehra, Ranee, Parker, Lance, Shnayder, Yelizaveta, Spencer, Sharon, Swiecicki, Paul L., Tsai, Jillian Chiaojung, and Sher, David J.

Published
2024
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8. Surrogate endpoints in clinical trials of p16-positive squamous cell carcinoma of the oropharynx: an individual patient data meta-analysis

Author

Gharzai, Laila A, Morris, Emily, Suresh, Krithika, Nguyen-Tân, Phuc Felix, Rosenthal, David I, Gillison, Maura L, Harari, Paul M, Garden, Adam S, Koyfman, Shlomo, Caudell, Jimmy J, Jones, Christopher U, Mitchell, Darrion L, Krempl, Greg, Ridge, John A, Gensheimer, Michael F, Bonner, James A, Filion, Edith, Dunlap, Neal E, Stokes, William A, Le, Quynh-Thu, Torres-Saavedra, Pedro, Mierzwa, Michelle, and Schipper, Matthew J

Published
2024
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9. Clinical acceptability of automatically generated lymph node levels and structures of deglutition and mastication for head and neck radiation therapy

Author

Maroongroge, Sean, Mohamed, Abdallah SR., Nguyen, Callistus, Guma De la Vega, Jean, Frank, Steven J., Garden, Adam S., Gunn, Brandon G., Lee, Anna, Mayo, Lauren, Moreno, Amy, Morrison, William H., Phan, Jack, Spiotto, Michael T., Court, Laurence E., Fuller, Clifton D., Rosenthal, David I., and Netherton, Tucker J.

Published
2024
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11. The impact of age on outcome in phase III NRG Oncology/RTOG trials of radiotherapy (XRT) +/− systemic therapy in locally advanced head and neck cancer

Author

Kish, Julie A, Zhang, Qiang, Langer, Corey J, Nguyen-Tân, Phuc Felix, Rosenthal, David I, Weber, Randal S, List, Marcy A, Wong, Stuart J, Garden, Adam S, Hu, Kenneth, Trotti, Andy M, Bonner, James A, Jones, Christopher U, Yom, Sue S, Thorstad, Wade, Schultz, Christopher J, Ridge, John A, Shenouda, George, Harris, Jonathan, and Le, Quynh-Thu

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Trials and Supportive Activities, Dental/Oral and Craniofacial Disease, Cancer, Rare Diseases, Clinical Research, Aged, Chemoradiotherapy, Head and Neck Neoplasms, Humans, Prognosis, Proportional Hazards Models, Retrospective Studies, Locally advanced head and neck cancer, Chemotherapy, Radiation, Older Adult, Age, Toxicity, CSS, OS, Retrospective analysis, Oncology and carcinogenesis
Abstract

PurposeTo examine the role age plays in the treatment and prognosis of locally advanced head and neck cancer (LAHNC) treated definitively with radiation alone or combined modality therapy.MethodsA retrospective analysis was performed of three NRG/RTOG trials examining either radiation alone or combined radiation and systemic therapy for LAHNC. The effect of age (≥70 yrs.) on cause-specific survival (CSS), overall survival (OS), and toxicity was evaluated.ResultsA total of 2688 patients were analyzed, of whom 309 patients (11.5%) were ≥ 70. For all studies combined, the hazard ratio (HR) for CSS for patients age ≥ 70 vs. those

Published
2021

12. Primary tumor site for localized Merkel cell carcinoma drives different management strategies without impacting oncologic outcomes

Author

Cass, Samuel, Cope, Brandon, Bishop, Andrew J., Chiang, Yi-Ju, Ashleigh Guadagnolo, B., Farooqi, Ahsan, Morrison, William, Witt, Russell G., Seervai, Riyad N.H., Garden, Adam S., Fuller, Clifton D., Goepfert, Ryan P., Ross, Merrick, Gershenwald, Jeffrey E., Wong, Michael, Aung, Phyu P., Keung, Emily Z., and Mitra, Devarati

Published
2023
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13. Feasibility of Mobile and Sensor Technology for Remote Monitoring in Cancer Care and Prevention.

Author

Peterson, Susan K, Basen-Engquist, Karen, Demark-Wahnefried, Wendy, Prokhorov, Alexander V, Shinn, Eileen H, Martch, Stephanie L, Beadle, Beth M, Garden, Adam S, Farcas, Emilia, Brandon Gunn, G, Fuller, Clifton D, Morrison, William H, Rosenthal, David I, Phan, Jack, Eng, Cathy, Cinciripini, Paul M, Karam-Hage, Maher A, Camero Garcia, Maria, and Patrick, Kevin

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Prevention, Clinical Research, Clinical Trials and Supportive Activities, Rare Diseases, Dental/Oral and Craniofacial Disease, Cancer, Colo-Rectal Cancer, Digestive Diseases, Good Health and Well Being, Cancer Survivors, Deglutition Disorders, Feasibility Studies, Head and Neck Neoplasms, Humans, Technology
Abstract

Objectives. Remote monitoring (RM) of health-related outcomes may optimize cancer care and prevention outside of clinic settings. CYCORE is a software-based system for collection and analyses of sensor and mobile data. We evaluated CYCORE's feasibility in studies assessing: (1) physical functioning in colorectal cancer (CRC) patients; (2) swallowing exercise adherence in head and neck cancer (HNC) patients during radiation therapy; and (3) tobacco use in cancer survivors post-tobacco treatment (TTP). Methods. Participants completed RM: for CRC, blood pressure, activity, GPS; for HNC, video of swallowing exercises; for TTP, expired carbon monoxide. Patient-reported outcomes were assessed daily. Results. For CRC, HNC and TTP, respectively, 50, 37, and 50 participants achieved 96%, 84%, 96% completion rates. Also, 91-100% rated ease and self-efficacy as highly favorable, 72-100% gave equivalent ratings for overall satisfaction, 72-93% had low/no data privacy concerns. Conclusion. RM was highly feasible and acceptable for patients across diverse use cases.

Published
2021

14. Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement

Author

Thomson, David J, Palma, David, Guckenberger, Matthias, Balermpas, Panagiotis, Beitler, Jonathan J, Blanchard, Pierre, Brizel, David, Budach, Wilfred, Caudell, Jimmy, Corry, June, Corvo, Renzo, Evans, Mererid, Garden, Adam S, Giralt, Jordi, Gregoire, Vincent, Harari, Paul M, Harrington, Kevin, Hitchcock, Ying J, Johansen, Jorgen, Kaanders, Johannes, Koyfman, Shlomo, Langendijk, JA, Le, Quynh-Thu, Lee, Nancy, Margalit, Danielle, Mierzwa, Michelle, Porceddu, Sandro, Soong, Yoke Lim, Sun, Ying, Thariat, Juliette, Waldron, John, and Yom, Sue S

Subjects
Medical and Biological Physics, Biomedical and Clinical Sciences, Clinical Sciences, Physical Sciences, Oncology and Carcinogenesis, Dental/Oral and Craniofacial Disease, Cancer, Prevention, Clinical Research, Good Health and Well Being, Other Physical Sciences, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis, Medical and biological physics
Abstract

PurposeBecause of the unprecedented disruption of health care services caused by the COVID-19 pandemic, the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) identified an urgent need to issue practice recommendations for radiation oncologists treating head and neck cancer (HNC) in a time of limited resources and heightened risk for patients and staff.Methods and materialsA panel of international experts from ASTRO, ESTRO, and select Asia-Pacific countries completed a modified rapid Delphi process. Topics and questions were presented to the group, and subsequent questions were developed from iterative feedback. Each survey was open online for 24 hours, and successive rounds started within 24 hours of the previous round. The chosen cutoffs for strong agreement (≥80%) and agreement (≥66%) were extrapolated from the RAND methodology. Two pandemic scenarios, early (risk mitigation) and late (severely reduced radiation therapy resources), were evaluated. The panel developed treatment recommendations for 5 HNC cases.ResultsIn total, 29 of 31 of those invited (94%) accepted, and after a replacement 30 of 30 completed all 3 surveys (100% response rate). There was agreement or strong agreement across a number of practice areas, including treatment prioritization, whether to delay initiation or interrupt radiation therapy for intercurrent SARS-CoV-2 infection, approaches to treatment (radiation dose-fractionation schedules and use of chemotherapy in each pandemic scenario), management of surgical cases in event of operating room closures, and recommended adjustments to outpatient clinic appointments and supportive care.ConclusionsThis urgent practice recommendation was issued in the knowledge of the very difficult circumstances in which our patients find themselves at present, navigating strained health care systems functioning with limited resources and at heightened risk to their health during the COVID-19 pandemic. The aim of this consensus statement is to ensure high-quality HNC treatments continue, to save lives and for symptomatic benefit.

Published
2020

15. Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic: An ASTRO-ESTRO Consensus Statement

Author

Thomson, David J, Palma, David, Guckenberger, Matthias, Balermpas, Panagiotis, Beitler, Jonathan J, Blanchard, Pierre, Brizel, David, Budach, Wilfred, Caudell, Jimmy, Corry, June, Corvo, Renzo, Evans, Mererid, Garden, Adam S, Giralt, Jordi, Gregoire, Vincent, Harari, Paul M, Harrington, Kevin, Hitchcock, Ying J, Johansen, Jorgen, Kaanders, Johannes, Koyfman, Shlomo, Langendijk, JA, Le, Quynh-Thu, Lee, Nancy, Margalit, Danielle, Mierzwa, Michelle, Porceddu, Sandro, Soong, Yoke Lim, Sun, Ying, Thariat, Juliette, Waldron, John, and Yom, Sue S

Subjects
Clinical Research, Dental/Oral and Craniofacial Disease, Cancer, Prevention, Good Health and Well Being, COVID-19, Consensus, Coronavirus Infections, Head and Neck Neoplasms, Humans, Medical Oncology, Pandemics, Pneumonia, Viral, Practice Guidelines as Topic, Societies, Medical, Other Physical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeBecause of the unprecedented disruption of health care services caused by the COVID-19 pandemic, the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) identified an urgent need to issue practice recommendations for radiation oncologists treating head and neck cancer (HNC) in a time of limited resources and heightened risk for patients and staff.Methods and materialsA panel of international experts from ASTRO, ESTRO, and select Asia-Pacific countries completed a modified rapid Delphi process. Topics and questions were presented to the group, and subsequent questions were developed from iterative feedback. Each survey was open online for 24 hours, and successive rounds started within 24 hours of the previous round. The chosen cutoffs for strong agreement (≥80%) and agreement (≥66%) were extrapolated from the RAND methodology. Two pandemic scenarios, early (risk mitigation) and late (severely reduced radiation therapy resources), were evaluated. The panel developed treatment recommendations for 5 HNC cases.ResultsIn total, 29 of 31 of those invited (94%) accepted, and after a replacement 30 of 30 completed all 3 surveys (100% response rate). There was agreement or strong agreement across a number of practice areas, including treatment prioritization, whether to delay initiation or interrupt radiation therapy for intercurrent SARS-CoV-2 infection, approaches to treatment (radiation dose-fractionation schedules and use of chemotherapy in each pandemic scenario), management of surgical cases in event of operating room closures, and recommended adjustments to outpatient clinic appointments and supportive care.ConclusionsThis urgent practice recommendation was issued in the knowledge of the very difficult circumstances in which our patients find themselves at present, navigating strained health care systems functioning with limited resources and at heightened risk to their health during the COVID-19 pandemic. The aim of this consensus statement is to ensure high-quality HNC treatments continue, to save lives and for symptomatic benefit.

Published
2020

16. Head and neck cancer predictive risk estimator to determine control and therapeutic outcomes of radiotherapy (HNC-PREDICTOR): development, international multi-institutional validation, and web implementation of clinic-ready model-based risk stratification for head and neck cancer

Author

van Dijk, Lisanne V., Mohamed, Abdallah SR., Ahmed, Sara, Nipu, Nafiul, Marai, G. Elisabeta, Wahid, Kareem, Sijtsema, Nanna M., Gunn, Brandon, Garden, Adam S., Moreno, Amy, Hope, Andrew J., Langendijk, Johannes A., and Fuller, Clifton D.

Published
2023
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17. Advanced External Beam Stereotactic Radiotherapy for Skull Base Reirradiation.

Author

Wang, He, Alsanea, Fahed M., Rhee, Dong Joo, Zhang, Xiaodong, Liu, Wei, Yang, Jinzhong, Wen, Zhifei, Zhao, Yao, Williamson, Tyler D., Hunter, Rachel A., Balter, Peter A., Briere, Tina M., Zhu, Ronald X., Lee, Anna, Moreno, Amy C., Reddy, Jay P., Garden, Adam S., Rosenthal, David I., Gunn, Gary B., and Phan, Jack

Subjects
PROTON therapy, RADIOTHERAPY, RADIOSURGERY, CATASTROPHIC illness, RADIATION dosimetry, CANCER patients, TREATMENT effectiveness, SKULL tumors, COMPUTERS in medicine, RADIATION doses
Abstract

Simple Summary: Skull base stereotactic radiotherapy (RT) is particularly challenging due to prior radiation and the proximity of several critical organs. This study reviewed four advanced external beam RT modalities and their corresponding or available modern treatment planning systems (TPSs). The plan quality and potentials were evaluated in terms of target coverage and dose gradient. The steepest border gradient was used to assess the fall-off speed achievable near the target to spare adjacent critical structures, while the volume gradient was used to evaluate dose spread at a distance. Gamma Knife demonstrated the highest border gradient, followed by small-spot-size proton beams and CyberKnife. The proton beam exhibited the least dose spread in the low-dose region. Background/Objectives: Stereotactic body radiation therapy (SBRT) for skull base reirradiation is particularly challenging, as patients have already received substantial radiation doses to the region, and nearby normal organs may have approached their tolerance limit from prior treatments. In this study, we reviewed the characteristics and capabilities of four advanced external beam radiation delivery systems and four modern treatment planning systems and evaluated the treatment plan quality of each technique using skull base reirradiation patient cases. Methods: SBRT plans were generated for sixteen skull base reirradiation patients using four modalities: the GK plan for the Elekta Leksell Gamma Knife Perfexion/ICON, the CyberKnife (CK) plan for the Accuray CyberKnife, the intensity-modulated proton therapy (IMPT) plan for the Hitachi ProBeat-FR proton therapy machine, and the volumetric-modulated arc therapy (VMAT) plan for the Varian TrueBeam STx. These plans were evaluated and compared using two novel gradient indices in addition to traditional dosimetry metrics for targets and organs at risk (OARs). The steepest border gradient quantified the percent prescription dose fall-off per millimeter at the boundary between the target and adjacent critical structures. This gradient index highlighted the system's ability to spare nearby critical OARs. The volume gradient assessed the extent of dose spread outside the target toward the patient's body. Results: All plans achieved comparable target coverage and conformity, while IMPT and VMAT demonstrated significantly better uniformity. The GK plans exhibited the highest border gradient, up to 20.9%/mm, followed by small-spot-size IMPT plans and CK plans. Additionally, IMPT plans showed the benefit of reduced dose spread in low-dose regions and the lowest maximum and mean doses to the brainstem and carotid artery. Conclusions: The advanced external beam radiotherapy modalities evaluated in this study are well-suited for SBRT in skull base reirradiation, which demands precise targeting of tumors with highly conformal doses and steep dose gradients to protect nearby normal structures. [ABSTRACT FROM AUTHOR]

Published
2025
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18. A prospective cohort study on stereotactic radiotherapy in the management of dural recurrence of olfactory neuroblastoma.

Author

Goodman, Christopher D., DeMonte, Franco, Nguyen, Theresa P., Garden, Adam S., Wang, Catherine He, Wang, Xin A., Diao, Kevin, Lee, Anna, Reddy, Jay, Moreno, Amy, Spiotto, Michael, Fuller, Clifton D., Rosenthal, David, Ferrarotto, Renata, Raza, Shaan M., Su, Shirley Y., Warner, Andrew, Hanna, Ehab, and Phan, Jack

Subjects
STEREOTACTIC radiotherapy, NEUROBLASTOMA, DISEASE relapse, QUALITY of life, COHORT analysis
Abstract

Background: Treatment for dural recurrence of olfactory neuroblastoma (ONB) is not standardized. We assess the outcomes of stereotactic body radiotherapy (SBRT) in this population. Methods: ONB patients with dural recurrences treated between 2013 and 2022 on a prospective registry were included. Tumor control, survival, and patient‐reported quality of life were analyzed. Results: Fourteen patients with 32 dural lesions were evaluated. Time to dural recurrence was 58.3 months. Thirty lesions (94%) were treated with SBRT to a median dose of 27 Gy in three fractions. Two patients (3 of 32 lesions; 9%) developed in‐field radiographic progression, five patients (38%) experienced progression in non‐contiguous dura. Two‐year local control was 85% (95% CI: 51–96%). There were no >grade 3 acute toxicities and 1 case of late grade 3 brain radionecrosis. Conclusion: In this largest study of SBRT reirradiation for ONB dural recurrence to date, high local control rates with minimal toxicity were attainable. [ABSTRACT FROM AUTHOR]

Published
2025
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19. Proton Image-guided Radiation Assignment for Therapeutic Escalation via Selection of locally advanced head and neck cancer patients [PIRATES]: A Phase I safety and feasibility trial of MRI-guided adaptive particle radiotherapy

Author

van Dijk, Lisanne V., Frank, Steven J., Yuan, Ying, Gunn, Brandon, Moreno, Amy C., Mohamed, Abdallah S.R., Preston, Kathryn E., Qing, Yun, Spiotto, Michael T., Morrison, William H., Lee, Anna, Phan, Jack, Garden, Adam S., Rosenthal, David I., Langendijk, Johannes A., and Fuller, Clifton D.

Published
2022
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21. 18FDG positron emission tomography mining for metabolic imaging biomarkers of radiation-induced xerostomia in patients with oropharyngeal cancer

Author

Elhalawani, Hesham, Cardenas, Carlos E., Volpe, Stefania, Barua, Souptik, Stieb, Sonja, Rock, Calvin B., Lin, Timothy, Yang, Pei, Wu, Haijun, Zaveri, Jhankruti, Elgohari, Baher, Abdallah, Lamiaa E., Jethanandani, Amit, Mohamed, Abdallah S.R., Court, Laurence E., Hutcheson, Katherine A., Brandon Gunn, G., Rosenthal, David I., Frank, Steven J., Garden, Adam S., Rao, Arvind, and Fuller, Clifton D.

Published
2021
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24. Work Outcomes after Intensity-Modulated Proton Therapy (IMPT) versus Intensity-Modulated Photon Therapy (IMRT) for Oropharyngeal Cancer

Author

Smith, Grace L., Fu, Shuangshuang, Ning, Matthew S., Nguyen, Diem-Khanh, Busse, Paul M., Foote, Robert L., Garden, Adam S., Gunn, Gary B., Fuller, Clifton D., Morrison, William H., Chronowski, Gregory M., Shah, Shalin J., Mayo, Lauren L., Phan, Jack, Reddy, Jay P., Snider, James W., III, Patel, Samir H., Katz, Sanford R., Lin, Alexander, Mohammed, Nasiruddin, Dagan, Roi, Lee, Nancy Y., Rosenthal, David I., and Frank, Steven J.

Published
2021
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28. Proton Therapy for Head and Neck Cancer: A 12-Year, Single-Institution Experience

Author

Gunn, G. Brandon, Garden, Adam S., Ye, Rong, Ausat, Noveen, Dahlstrom, Kristina R., Morrison, William H., Fuller, C. David, Phan, Jack, Reddy, Jay P., Shah, Shalin J., Mayo, Lauren L., Chun, Stephen G., Chronowski, Gregory M., Moreno, Amy C., Myers, Jeffery N., Hanna, Ehab Y., Esmaeli, Bita, Gillison, Maura L., Ferrarotto, Renata, Hutcheson, Katherine A., Chambers, Mark S., Ginsberg, Lawrence E., El-Naggar, Adel K., Rosenthal, David I., Zhu, Xiaorong Ronald, and Frank, Steven J.

Published
2021
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33. Self‐management intervention improves patient adherence to swallowing exercises during radiation for head and neck cancer.

Author

Shinn, Eileen H., Garden, Adam S., Chen, Minxing, Basen‐Engquist, Karen, Fellman, Bryan, Hutcheson, Kate, Morrison, William H., Peterson, Susan, and Li, Liang

Subjects
PATIENT compliance, HEAD & neck cancer, PHARYNGEAL cancer, SPEECH therapists, LARYNGEAL cancer
Abstract

Background: While preventive swallowing exercises reduce the risk of radiation‐associated dysphagia in patients with head and neck cancer, strategies are needed to improve patient adherence. Methods: Before radiation, all participants were taught preventive swallowing exercises and randomized to either an adherence intervention or enhanced usual care. During radiation, all participants met twice with a speech pathologist for swallowing assessment and reinforcement of exercises. Intervention participants met weekly with a counselor in‐person or by phone. At 6‐week post‐radiation follow‐up, all participants completed a follow‐up assessment of self‐reported adherence, which was then corroborated with medical record documentation. Results: Newly diagnosed pharyngeal and laryngeal cancer patients without distant metastases were randomized (n = 265; 135 to intervention, and 130 to usual care). Intervention participants were more likely to adhere to exercises during radiation compared to the control group (p < 0.0001). Conclusion: The weekly in‐person adherence intervention program significantly increased patient's adherence to preventive swallowing exercises during radiation. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement

Author

Thomson, David J., Palma, David, Guckenberger, Matthias, Balermpas, Panagiotis, Beitler, Jonathan J., Blanchard, Pierre, Brizel, David, Budach, Wilfred, Caudell, Jimmy, Corry, June, Corvo, Renzo, Evans, Mererid, Garden, Adam S., Giralt, Jordi, Gregoire, Vincent, Harari, Paul M., Harrington, Kevin, Hitchcock, Ying J., Johansen, Jorgen, Kaanders, Johannes, Koyfman, Shlomo, Langendijk, J.A., Le, Quynh-Thu, Lee, Nancy, Margalit, Danielle, Mierzwa, Michelle, Porceddu, Sandro, Soong, Yoke Lim, Sun, Ying, Thariat, Juliette, Waldron, John, and Yom, Sue S.

Published
2020
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36. Patterns of Failure After Intensity Modulated Radiation Therapy in Head and Neck Squamous Cell Carcinoma of Unknown Primary: Implication of Elective Nodal and Mucosal Dose Coverage

Author

Kamal, Mona, Mohamed, Abdallah S.R., Fuller, Clifton David, Sturgis, Erich M., Johnson, Faye M., Morrison, William H., Gunn, G. Brandon, Hutcheson, Katherine A., Phan, Jack, Volpe, Stefania, Ng, Sweet Ping, Phan, Jae, Cardenas, Carlos, Ferrarotto, Renata, Frank, Steven J., Rosenthal, David I., and Garden, Adam S.

Published
2020
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37. The impact of tongue-deviating and tongue-depressing oral stents on long-term radiation-associated symptoms in oropharyngeal cancer survivors

Author

Stieb, Sonja, Perez-Martinez, Ismael, Mohamed, Abdallah S.R., Rock, Stockton, Bajaj, Nimit, Deshpande, Tanaya S., Zaid, Mohamed, Garden, Adam S., Goepfert, Ryan P., Cardoso, Richard, Ferrarotto, Renata, Reddy, Jay P., Phan, Jack, Morrison, William H., Rosenthal, David I., Koay, Eugene J., Frank, Steven J., Fuller, C. David, and Gunn, G. Brandon

Published
2020
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39. Progression-free survival is a suboptimal predictor for overall survival among metastatic solid tumour clinical trials

Author

Pasalic, Dario, McGinnis, Gwendolyn J., Fuller, C. David, Grossberg, Aaron J., Verma, Vivek, Mainwaring, Walker, Miller, Austin B., Lin, Timothy A., Jethanandani, Amit, Espinoza, Andres F., Diefenhardt, Markus, Das, Prajnan, Subbiah, Vivek, Subbiah, Ishwaria M., Jagsi, Reshma, Garden, Adam S., Fokas, Emmanouil, Rödel, Claus, Thomas, Charles R., Jr., Minsky, Bruce D., and Ludmir, Ethan B.

Published
2020
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40. A prospective parallel design study testing non-inferiority of customized oral stents made using 3D printing or manually fabricated methods

Author

Zaid, Mohamed, Koay, Eugene J., Bajaj, Nimit, Mathew, Ryan, Xiao, Lianchun, Agrawal, Anshuman, Fernandes, Pearl, Burrows, Hannah, Roach, Millicent A., Wilke, Christopher T., Chung, Caroline, Fuller, Clifton D., Phan, Jack, Gunn, G. Brandon, Morrison, William H., Garden, Adam S., Frank, Steven J., Rosenthal, David I., Andersen, Michael, Otun, Adegbenga, and Chambers, Mark S.

Published
2020
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41. Patient-reported outcomes, physician-reported toxicities, and treatment outcomes in a modern cohort of patients with sinonasal cancer treated using proton beam therapy

Author

Pasalic, Dario, Ludmir, Ethan B., Allen, Pamela K., Thaker, Nikhil G., Chapman, Bhavana V., Hanna, Ehab Y., Su, Shirley Y., Ferrarotto, Renata, Glisson, Bonnie S., Reddy, Jay P., Brandon Gunn, G., Fuller, C. David, Phan, Jack, Rosenthal, David I., Morrison, William H., Garden, Adam S., and Frank, Steven J.

Published
2020
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43. Prospective observational evaluation of radiation-induced late taste impairment kinetics in oropharyngeal cancer patients: Potential for improvement over time?

Author

Stieb, Sonja, Mohamed, Abdallah S.R., Deshpande, Tanaya S., Harp, Jared, Greiner, Benjamin, Garden, Adam S., Goepfert, Ryan P., Cardoso, Richard, Ferrarotto, Renata, Phan, Jack, Reddy, Jay P., Morrison, William H., Rosenthal, David I., Frank, Steven J., Fuller, C. David, and Brandon Gunn, G.

Published
2020
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44. Comparison of tumor delineation using dual energy computed tomography versus magnetic resonance imaging in head and neck cancer re-irradiation cases

Author

Ng, Sweet Ping, Cardenas, Carlos E, Elhalawani, Hesham, Pollard, Courtney, III, Elgohari, Baher, Fang, Penny, Meheissen, Mohamed, Guha-Thakurta, Nandita, Bahig, Houda, Johnson, Jason M., Kamal, Mona, Garden, Adam S, Reddy, Jay P., Su, Shirley Y., Ferrarotto, Renata, Frank, Steven J., Brandon Gunn, G., Moreno, Amy C., Rosenthal, David I., Fuller, Clifton D., and Phan, Jack

Published
2020
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45. Lymphopenia during radiotherapy in patients with oropharyngeal cancer

Author

Ng, Sweet Ping, Bahig, Houda, Jethanandani, Amit, Pollard, Courtney, Berends, Joel, Sturgis, Erich M., Johnson, Faye M., Elgohari, Baher, Elhalawani, Hesham, Rosenthal, David I., Skinner, Heath D., Gunn, G. Brandon, Phan, Jack, Frank, Steven J., Mohamed, Abdallah S.R., Fuller, Clifton D., and Garden, Adam S.

Published
2020
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46. Neoadjuvant immunotherapy for oropharynx cancer: Correlative studies and long-term outcomes from the CIAO trial.

Author

McGrail, Daniel, primary, Li, Kaiyi, additional, Nipper, Allison, additional, Johnson, Faye M., additional, Santana, Erison, additional, Bell, Diana, additional, Lee, Minjung, additional, Haymaker, Cara L, additional, Garden, Adam S., additional, Lin, Shiaw-Yih, additional, Lee, J. Jack, additional, Gillison, Maura L., additional, Gross, Neil D., additional, Sikora, Andrew G., additional, and Ferrarotto, Renata, additional

Published
2024
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50. Chronic radiation-associated dysphagia in oropharyngeal cancer survivors: Towards age-adjusted dose constraints for deglutitive muscles

Author

Christopherson, Kaitlin M., Ghosh, Alokananda, Mohamed, Abdallah Sherif Radwan, Kamal, Mona, Gunn, G. Brandon, Dale, Timothy, Kalpathy-Cramer, Jayashree, Messer, Jay, Garden, Adam S., Elhalawani, Hesham, Frank, Steven J., Lewin, Jan, Morrison, William H., Phan, Jack, Gross, Neil, Ferrarotto, Renata, Weber, Randal S., Rosenthal, David I., Lai, Stephen Y., Hutcheson, Katherine, Fuller, Clifton David, Radwan Mohamed, Abdallah Sherif, Marai, G. Elisabeta (Liz), Canahuate, Guadalupe, Vock, David M., and Fuller, David

Published
2019
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