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Your search keyword '"Garcia-Rodriguez, Luis A."' showing total 307 results
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307 results on '"Garcia-Rodriguez, Luis A."'

7. Turbulence effects in the topology optimization of compressible subsonic flow.

Author

Garcia‐Rodriguez, Luis Fernando, Alonso, Diego Hayashi, and Silva, Emilio Carlos Nelli

Subjects
INCOMPRESSIBLE flow, TURBULENT flow, FLUID flow, TURBULENCE, OPTIMIZATION algorithms
Abstract

Turbulence significantly influences fluid flow topology optimization, and this has already been verified under the incompressible flow regime. However, the same cannot be said about the compressible flow regime, in which the density field now affects and couples all of the fluid flow and turbulence equations and makes obtaining the adjoint model, which is necessary for topology optimization, extremely difficult. Up to now, the turbulence phenomenon has still not been considered in compressible flow topology optimization, which is what is being proposed and analyzed here. Rather than being based in the Reynolds‐Averaged Navier–Stokes (RANS) equations which are defined only for incompressible flow, the equations are now based on the Favre‐Averaged Navier–Stokes (FANS) equations, which are the counterpart of the RANS equations for compressible flow and feature different dependencies and terms. The compressible turbulence model being considered is the compressible version of the Spalart–Allmaras model, which differs from the usual Spalart–Allmaras model, since now there are some new spatially varying density and specific heat terms that depend on the primal variables and that act over some of the turbulence terms of the overall model. The adjoint equations are obtained by using an automatic differentiation scheme through a coupled software platform. The optimization algorithm is IPOPT, and some examples are presented to show the effect of turbulence in the compressible flow topology optimization. [ABSTRACT FROM AUTHOR]

Published
2025
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12. Risk of cardiovascular events and death associated with initiation of SGLT2 inhibitors compared with DPP-4 inhibitors: an analysis from the CVD-REAL 2 multinational cohort study

Author

Kosiborod, Mikhail, Cavender, Matthew A, Wilding, John P, Khunti, Kamlesh, Norhammar, Anna, Birkeland, Kåre, Jørgensen, Marit Eika, Holl, Reinhard W., Lam, Carolyn SP, Gulseth, Hanne Løvdal, Carstensen, Bendix, Bollow, Esther, Franch-Nadal, Josep, García Rodríguez, Luis Alberto, Karasik, Avraham, Tangri, Navdeep, Kohsaka, Shun, Kim, Dae Jung, Shaw, Jonathan, Arnold, Suzanne, Goh, Su-Yen, Fenici, Peter, Bodegård, Johan, Chen, Hungta, Surmont, Filip, Blak, Betina T., Wittbrodt, Eric T., Saathoff, Matthias, Noguchi, Yusuke, Tan, Donna, Williams, Maro, Lee, Hye Won, Greenbloom, Maya, Kaidanovich-Beilin, Oksana, Yeo, Khung Keong, Bee, Yong Mong, Khoo, Joan, Koong, Agnes, Lau, Yee How, Gao, Fei, Tan, Wee Boon, Kadir, Hanis Abdul, Ha, Kyoung Hwa, Lee, Jinhee, Chodick, Gabriel, Melzer-Cohen, Cheli, Whitlock, Reid, Cea-Soriano, Lucia, Cantero, Oscar Fernándex, Menzin, Jordan A., Guthrie, Matthew, Ilomaki, Jennie, Magliano, Dianna, Lam, Carolyn S P, Jørgensen, Marit E, Birkeland, Kåre I, Holl, Reinhard W, Shaw, Jonathan E, Ilomäki, Jenni, Chiang, Chern-En, Thuresson, Marcus, and Wittbrodt, Eric

Published
2020
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15. Kidney outcomes associated with use of SGLT2 inhibitors in real-world clinical practice (CVD-REAL 3): a multinational observational cohort study

Author

Heerspink, Hiddo J L, Karasik, Avraham, Thuresson, Marcus, Melzer-Cohen, Cheli, Chodick, Gabriel, Khunti, Kamlesh, Wilding, John P H, Garcia Rodriguez, Luis Alberto, Cea-Soriano, Lucia, Kohsaka, Shun, Nicolucci, Antonio, Lucisano, Giuseppe, Lin, Fang-Ju, Wang, Chih-Yuan, Wittbrodt, Eric, Fenici, Peter, and Kosiborod, Mikhail

Published
2020
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31. SCPL: A Social Cooperative Programming Language to Automate Cooperative Processes

Author

Conejero, José María, Sánchez-Figueroa, Fernando, García-Rodríguez, Luis-María, Rodríguez-Echeverría, Roberto, Preciado, Juan Carlos, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, and Luo, Yuhua, editor

Published
2015
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42. Impact of non-adherence to direct oral anticoagulants amongst Swedish patients with non-valvular atrial fibrillation: results from a real-world cost-utility analysis

Author

Blomström Lundqvist, Carina, primary, Själander, Sara, additional, Garcia Rodriguez, Luis A., additional, Åkerborg, Örjan, additional, Jin, Guanyi, additional, Caleyachetty, Amrit, additional, Huelsebeck, Maria, additional, Bowrin, Kevin, additional, Schaefer, Bernhard, additional, Mahdessian, Hovsep, additional, Hofmeister, Lucas, additional, and Levin, Lars-Åke, additional

Published
2022
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45. Impact of non-adherence to direct oral anticoagulants amongst Swedish patients with non-valvular atrial fibrillation: results from a real-world cost-utility analysis

Author

Lundqvist, Carina Blomström, Själander, Sara, Garcia Rodriguez, Luis A., Åkerborg, Örjan, Jin, Guanyi, Caleyachetty, Amrit, Huelsebeck, Maria, Bowrin, Kevin, Schaefer, Bernhard, Mahdessian, Hovsep, Hofmeister, Lucas, Levin, Lars-Åke, Lundqvist, Carina Blomström, Själander, Sara, Garcia Rodriguez, Luis A., Åkerborg, Örjan, Jin, Guanyi, Caleyachetty, Amrit, Huelsebeck, Maria, Bowrin, Kevin, Schaefer, Bernhard, Mahdessian, Hovsep, Hofmeister, Lucas, and Levin, Lars-Åke

Abstract

Aims A third of non-valvular atrial fibrillation (NVAF) patients are non-adherent to direct oral anticoagulants (DOACs). Estimates of the economic value of full adherence and the cost of two types of adherence improving interventions are important to healthcare planners and decision-makers. Methods A cost-utility analysis estimated the impact of non-adherence over a 20-year horizon, for a patient cohort with a mean age of 77 years, based on data from the Stockholm Healthcare database of NVAF patients with incident stroke between 2011 and 2018. Adherence was defined using a medication possession ratio (MPR) cut-off of 90%; primary outcomes were the number of ischemic strokes and associated incremental cost-utility ratio. Results Hypothetical comparisons between cohorts of 1,000 patients with varying non-adherence levels and full adherence (MPR >90%) predicted an additional number of strokes ranging from 117 (MPR = 81-90%) to 866 (MPR <60%), and years of life lost ranging from 177 (MPR = 81- 90%) to 1,318 (MPR < 60%; discounted at 3%). Chronic disease co-management intervention occurring during each DOAC prescription renewal and patient education intervention at DOAC initiation will be cost-saving to the health system if its cost is below SEK 143 and SEK 4,655, and cost-effective if below SEK 858 and SEK 28,665, respectively. Conclusion Adherence improving interventions for NVAF patients on DOACs such as chronic disease co-management and patient education can be cost-saving and cost-effective, within a range of costs that appear reasonable to the Swedish healthcare system. PLAIN LANGUAGE SUMMARY Atrial fibrillation (AF) is the most common type of chronic cardiac arrhythmia and a major risk factor for ischemic stroke (IS). The objective of this study was to compare the costs and health outcomes associated with adherence to direct oral anticoagulant (DOAC) therapy in Sweden. The study also aimed to demonstrate the potential benefits of developing in

Published
2022
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46. Impact of non-adherence to direct oral anticoagulants amongst Swedish patients with non-valvular atrial fibrillation: results from a real-world cost-utility analysis

Author

Blomström Lundqvist, Carina, Själander, Sara, Garcia Rodriguez, Luis A., Åkerborg, Örjan, Jin, Guanyi, Caleyachetty, Amrit, Huelsebeck, Maria, Bowrin, Kevin, Schaefer, Bernhard, Mahdessian, Hovsep, Hofmeister, Lucas, Levin, Lars-Åke, Blomström Lundqvist, Carina, Själander, Sara, Garcia Rodriguez, Luis A., Åkerborg, Örjan, Jin, Guanyi, Caleyachetty, Amrit, Huelsebeck, Maria, Bowrin, Kevin, Schaefer, Bernhard, Mahdessian, Hovsep, Hofmeister, Lucas, and Levin, Lars-Åke

Abstract

Aims: A third of non-valvular atrial fibrillation (NVAF) patients are non-adherent to direct oral anticoagulants (DOACs). Estimates of the economic value of full adherence and the cost of two types of adherence improving interventions are important to healthcare planners and decision-makers. Methods: A cost-utility analysis estimated the impact of non-adherence over a 20-year horizon, for a patient cohort with a mean age of 77 years, based on data from the Stockholm Healthcare database of NVAF patients with incident stroke between 2011 and 2018. Adherence was defined using a medication possession ratio (MPR) cut-off of 90%; primary outcomes were the number of ischemic strokes and associated incremental cost–utility ratio. Results: Hypothetical comparisons between cohorts of 1,000 patients with varying non-adherence levels and full adherence (MPR >90%) predicted an additional number of strokes ranging from 117 (MPR = 81–90%) to 866 (MPR <60%), and years of life lost ranging from 177 (MPR = 81– 90%) to 1,318 (MPR < 60%; discounted at 3%). Chronic disease co-management intervention occurring during each DOAC prescription renewal and patient education intervention at DOAC initiation will be cost-saving to the health system if its cost is below SEK 143 and SEK 4,655, and cost-effective if below SEK 858 and SEK 28,665, respectively. Conclusion: Adherence improving interventions for NVAF patients on DOACs such as chronic disease co-management and patient education can be cost-saving and cost-effective, within a range of costs that appear reasonable to the Swedish healthcare system.

Published
2022
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