Search

The article discusses four cases of extensive tinea infections caused by Trichophyton indotineae in patients from Spain who had traveled to India or Bangladesh. The patients did not respond to terbinafine or itraconazole treatment but showed complete resolution with posaconazole therapy. Molecular methods are necessary for accurate identification of T. indotineae due to its recent evolution in genome architecture. The article highlights the importance of antifungal susceptibility testing and considering alternative treatments like posaconazole for cases of terbinafine-resistant tinea infections. [Extracted from the article]

Photodynamic therapy (PDT) involves the topical application of a photosensitizer and its activation by visible light, leading to the generation of protoporphyrin IX (PpIX) and reactive oxygen species. Daylight photodynamic therapy (dPDT), a variant utilizing natural sunlight as the energy source, enhances procedural flexibility by eliminating the need for specialized equipment. dPDT has been effectively used in dermatology to treat various cutaneous disorders, including neoplastic and infectious diseases. Traditionally, skin preparation and photosensitizer application are performed by trained practitioners, limiting the accessibility of dPDT for broader populations. However, recent studies suggest that these preparatory steps can be managed by patients or caregivers, enabling fully self-applied, home-based dPDT protocols. This review systematically examines the current evidence on self-applied dPDT (SA-dPDT), emphasizing molecular mechanisms and its efficacy in managing premalignant and other cutaneous conditions. [ABSTRACT FROM AUTHOR]

The detrimental effects of ultraviolet radiation (UVR) on human skin are well-documented, encompassing DNA damage, oxidative stress, and an increased risk of carcinogenesis. Conventional photoprotective measures predominantly rely on filters, which scatter or absorb UV radiation, yet fail to address the cellular damage incurred post-exposure. To fill this gap, antioxidant molecules and DNA–repair enzymes have been extensively researched, offering a paradigm shift towards active photoprotection capable of both preventing and reversing UV–induced damage. In the current review, we focused on "active photoprotection", assessing the state-of-the-art, latest advancements and scientific data from clinical trials and in vivo models concerning the use of DNA-repair enzymes and naturally occurring antioxidant molecules. [ABSTRACT FROM AUTHOR]

The article explores the potential link between residues of leave-on facial products and the clinical pattern of frontal fibrosing alopecia (FFA). Through an experimental model involving healthy volunteers, the study found that residues of facial products tended to persist in areas commonly affected by FFA, such as the frontotemporal hairline and eyebrows. While the role of facial products in FFA pathogenesis remains controversial, the study provides a plausible hypothesis for the observed clinical pattern. The authors emphasize the need for further research in this area to better understand the relationship between facial skincare products and FFA. [Extracted from the article]

The article discusses the efficacy of BF‐200 ALA PDT with half‐ versus full‐light dose in treating actinic keratosis with large field cancerization. A study was conducted on 15 male patients with severe scalp field cancerization, showing comparable lesion clearance rates between the two illumination protocols. Adverse effects were similar between the treatment arms, and the study suggests the potential for a half‐light dose protocol to reduce pain duration while maintaining efficacy in PDT treatment. Further research with larger sample sizes is recommended for broader clinical application. [Extracted from the article]

Sexual intercourses, probably through skin-to-skin contact, may be playing a key role in the transmission of the disease.[3] Conversely, our patient had no genital lesions, and skin rash showed some clinical particularities: (1) Truncal syphilitic-roseola-like maculopapular rash admixed with some pustules; (2) Lineal distribution of plaques on the flank reminiscent of Koebner phenomenon. A 48-year-old man attended to the Emergency Department with a one-week history of high fever, odynophagia, arthralgias and generalized skin lesions with mild pruritus. Monkeypox virus infection with a syphilitic-roseola-like rash and its histopathologic characterization during 2022 outbreak. [Extracted from the article]

Physical examination demonstrated oral erosions (Figure 1A) and tense serous blisters on her left submammary fold (Figure 1B), abdomen, and right forearm. Piperacillin-tazobactam-induced linear IgA bullous dermatosis presenting clinically as Stevens-Johnson syndrome/toxic epidermal necrolysis overlap. Data sharing not applicable to this article as no datasets were generated or analysed during the current study. [Extracted from the article]