Search

Your search keyword '"Garcia-Gerique, Laura"' showing total 30 results
Start Over Author "Garcia-Gerique, Laura"
30 results on '"Garcia-Gerique, Laura"'

1. CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma

Author

Pascual-Pasto, Guillem, McIntyre, Brendan, Hines, Margaret G., Giudice, Anna M., Garcia-Gerique, Laura, Hoffmann, Jennifer, Mishra, Pamela, Matlaga, Stephanie, Lombardi, Simona, Shraim, Rawan, Schürch, Patrick M., Yarmarkovich, Mark, Hofmann, Ted J., Alikarami, Fatemeh, Martinez, Daniel, Tsang, Matthew, Gil-de-Gómez, Luis, Spear, Timothy T., Bernt, Kathrin M., Wolpaw, Adam J., Dimitrov, Dimiter S., Li, Wei, and Bosse, Kristopher R.

Published
2024
Full Text
View/download PDF

2. Ferroptosis of tumour neutrophils causes immune suppression in cancer

Author

Kim, Rina, Hashimoto, Ayumi, Markosyan, Nune, Tyurin, Vladimir A., Tyurina, Yulia Y., Kar, Gozde, Fu, Shuyu, Sehgal, Mohit, Garcia-Gerique, Laura, Kossenkov, Andrew, Gebregziabher, Bereket A., Tobias, John W., Hicks, Kristin, Halpin, Rebecca A., Cvetesic, Nevena, Deng, Hui, Donthireddy, Laxminarasimha, Greenberg, Andrew, Nam, Brian, Vonderheide, Robert H., Nefedova, Yulia, Kagan, Valerian E., and Gabrilovich, Dmitry I.

Published
2022
Full Text
View/download PDF

3. MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment

Author

Garcia-Gerique, Laura, García, Marta, Garrido-Garcia, Alícia, Gómez-González, Soledad, Torrebadell, Montserrat, Prada, Estela, Pascual-Pasto, Guillem, Muñoz, Oscar, Perez-Jaume, Sara, Lemos, Isadora, Salvador, Noelia, Vila-Ubach, Monica, Doncel-Requena, Ana, Suñol, Mariona, Carcaboso, Angel M., Mora, Jaume, and Lavarino, Cinzia

Published
2022
Full Text
View/download PDF

4. Pioneres en ciència: un aquari, una rata i un càncer pediàtric

Author

Garcia Gerique, Laura and Garcia Gerique, Laura

Abstract

La contribució de les dones al coneixement científic ha estat sistemàticament silenciada al llarg de la història. En l’actualitat, encara moltes de les seves con­tribucions i autories continuen a l’ombra. A través d’un relat en primera perso­na, es repassen les biografies d’algunes científiques capdavanteres que han fet contribucions clau per al progrés de la biologia i la medicina actual. Com a científics, ens cal conèixer el seu llegat per a poder construir una ciència més justa. Només així podrem oposar les desigualtats que encara trobem en la car­rera acadèmica i ajudar a crear una societat sense barreres de gènere., History has systematically silenced women’s contributions to science. Indeed, many women’s contributions and authorships are still unrecognized today. In this essay we review various biographies of pioneering women scientists who have made key contributions to the progress of contemporary medicine and biology. Their recognition is essential to achieve a more equitable science. This is the only way that we will be able to do away with the inequalities which are still present in academia and to create societies free of gender barriers.

Published
2024

5. Data from Syntaphilin Regulates Neutrophil Migration in Cancer

Author

Fu, Shuyu, primary, Deng, Hui, primary, Bertolini, Irene, primary, Perego, Michela, primary, Chen, Eric S., primary, Sanseviero, Emilio, primary, Mostafa, Ali, primary, Alicea-Torres, Kevin, primary, Garcia-Gerique, Laura, primary, Stone, Erica L., primary, Kossenkov, Andrew V., primary, Schug, Zachary T., primary, Nam, Brian, primary, Mulligan, Charles, primary, Altieri, Dario C., primary, Nefedova, Yulia, primary, and Gabrilovich, Dmitry I., primary

Published
2023
Full Text
View/download PDF

6. Data from S100A8/S100A9 Promote Progression of Multiple Myeloma via Expansion of Megakaryocytes

Author

Lin, Cindy, primary, Garcia-Gerique, Laura, primary, Bonner, Erin E., primary, Mastio, Jerome, primary, Rosenwasser, Matthew, primary, Cruz, Zachary, primary, Lawler, Michael, primary, Bernabei, Luca, primary, Muthumani, Kar, primary, Liu, Qin, primary, Poncz, Mortimer, primary, Vogl, Thomas, primary, Törngren, Marie, primary, Eriksson, Helena, primary, Vogl, Dan T., primary, Gabrilovich, Dmitry I., primary, and Nefedova, Yulia, primary

Published
2023
Full Text
View/download PDF

7. Supplemental Video from Syntaphilin Regulates Neutrophil Migration in Cancer

Author

Fu, Shuyu, primary, Deng, Hui, primary, Bertolini, Irene, primary, Perego, Michela, primary, Chen, Eric S., primary, Sanseviero, Emilio, primary, Mostafa, Ali, primary, Alicea-Torres, Kevin, primary, Garcia-Gerique, Laura, primary, Stone, Erica L., primary, Kossenkov, Andrew V., primary, Schug, Zachary T., primary, Nam, Brian, primary, Mulligan, Charles, primary, Altieri, Dario C., primary, Nefedova, Yulia, primary, and Gabrilovich, Dmitry I., primary

Published
2023
Full Text
View/download PDF

8. Figure S4 from S100A8/S100A9 Promote Progression of Multiple Myeloma via Expansion of Megakaryocytes

Author

Lin, Cindy, primary, Garcia-Gerique, Laura, primary, Bonner, Erin E., primary, Mastio, Jerome, primary, Rosenwasser, Matthew, primary, Cruz, Zachary, primary, Lawler, Michael, primary, Bernabei, Luca, primary, Muthumani, Kar, primary, Liu, Qin, primary, Poncz, Mortimer, primary, Vogl, Thomas, primary, Törngren, Marie, primary, Eriksson, Helena, primary, Vogl, Dan T., primary, Gabrilovich, Dmitry I., primary, and Nefedova, Yulia, primary

Published
2023
Full Text
View/download PDF

9. Supplemental Figures and Tables from Syntaphilin Regulates Neutrophil Migration in Cancer

Author

Fu, Shuyu, primary, Deng, Hui, primary, Bertolini, Irene, primary, Perego, Michela, primary, Chen, Eric S., primary, Sanseviero, Emilio, primary, Mostafa, Ali, primary, Alicea-Torres, Kevin, primary, Garcia-Gerique, Laura, primary, Stone, Erica L., primary, Kossenkov, Andrew V., primary, Schug, Zachary T., primary, Nam, Brian, primary, Mulligan, Charles, primary, Altieri, Dario C., primary, Nefedova, Yulia, primary, and Gabrilovich, Dmitry I., primary

Published
2023
Full Text
View/download PDF

10. Supplementary Tables S1 and S2 from S100A8/S100A9 Promote Progression of Multiple Myeloma via Expansion of Megakaryocytes

Author

Lin, Cindy, primary, Garcia-Gerique, Laura, primary, Bonner, Erin E., primary, Mastio, Jerome, primary, Rosenwasser, Matthew, primary, Cruz, Zachary, primary, Lawler, Michael, primary, Bernabei, Luca, primary, Muthumani, Kar, primary, Liu, Qin, primary, Poncz, Mortimer, primary, Vogl, Thomas, primary, Törngren, Marie, primary, Eriksson, Helena, primary, Vogl, Dan T., primary, Gabrilovich, Dmitry I., primary, and Nefedova, Yulia, primary

Published
2023
Full Text
View/download PDF

11. Supplementary Data from A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression

Author

Deng, Hui, primary, Lin, Cindy, primary, Garcia-Gerique, Laura, primary, Fu, Shuyu, primary, Cruz, Zachary, primary, Bonner, Erin E., primary, Rosenwasser, Matthew, primary, Rajagopal, Sridharan, primary, Sadhu, M Naveen, primary, Gajendran, Chandru, primary, Zainuddin, Mohd, primary, Gosu, Ramachandraiah, primary, Sivanandhan, Dhanalakshmi, primary, Shelef, Miriam A., primary, Nam, Brian, primary, Vogl, Dan T., primary, Gabrilovich, Dmitry I., primary, and Nefedova, Yulia, primary

Published
2023
Full Text
View/download PDF

12. Data from A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma

Author

Gómez, Soledad, primary, Garrido-Garcia, Alícia, primary, Garcia-Gerique, Laura, primary, Lemos, Isadora, primary, Suñol, Mariona, primary, de Torres, Carmen, primary, Kulis, Marta, primary, Pérez-Jaume, Sara, primary, Carcaboso, Ángel M., primary, Luu, Betty, primary, Kieran, Mark W., primary, Jabado, Nada, primary, Kozlenkov, Alexey, primary, Dracheva, Stella, primary, Ramaswamy, Vijay, primary, Hovestadt, Volker, primary, Johann, Pascal, primary, Jones, David T.W., primary, Pfister, Stefan M., primary, Morales La Madrid, Andrés, primary, Cruz, Ofelia, primary, Taylor, Michael D., primary, Martin-Subero, Jose-Ignacio, primary, Mora, Jaume, primary, and Lavarino, Cinzia, primary

Published
2023
Full Text
View/download PDF

13. Supplementary Appendix from A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma

Author

Gómez, Soledad, primary, Garrido-Garcia, Alícia, primary, Garcia-Gerique, Laura, primary, Lemos, Isadora, primary, Suñol, Mariona, primary, de Torres, Carmen, primary, Kulis, Marta, primary, Pérez-Jaume, Sara, primary, Carcaboso, Ángel M., primary, Luu, Betty, primary, Kieran, Mark W., primary, Jabado, Nada, primary, Kozlenkov, Alexey, primary, Dracheva, Stella, primary, Ramaswamy, Vijay, primary, Hovestadt, Volker, primary, Johann, Pascal, primary, Jones, David T.W., primary, Pfister, Stefan M., primary, Morales La Madrid, Andrés, primary, Cruz, Ofelia, primary, Taylor, Michael D., primary, Martin-Subero, Jose-Ignacio, primary, Mora, Jaume, primary, and Lavarino, Cinzia, primary

Published
2023
Full Text
View/download PDF

14. Supplementary Figure from A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression

Author

Deng, Hui, primary, Lin, Cindy, primary, Garcia-Gerique, Laura, primary, Fu, Shuyu, primary, Cruz, Zachary, primary, Bonner, Erin E., primary, Rosenwasser, Matthew, primary, Rajagopal, Sridharan, primary, Sadhu, M Naveen, primary, Gajendran, Chandru, primary, Zainuddin, Mohd, primary, Gosu, Ramachandraiah, primary, Sivanandhan, Dhanalakshmi, primary, Shelef, Miriam A., primary, Nam, Brian, primary, Vogl, Dan T., primary, Gabrilovich, Dmitry I., primary, and Nefedova, Yulia, primary

Published
2023
Full Text
View/download PDF

15. Data from A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression

Author

Deng, Hui, primary, Lin, Cindy, primary, Garcia-Gerique, Laura, primary, Fu, Shuyu, primary, Cruz, Zachary, primary, Bonner, Erin E., primary, Rosenwasser, Matthew, primary, Rajagopal, Sridharan, primary, Sadhu, M Naveen, primary, Gajendran, Chandru, primary, Zainuddin, Mohd, primary, Gosu, Ramachandraiah, primary, Sivanandhan, Dhanalakshmi, primary, Shelef, Miriam A., primary, Nam, Brian, primary, Vogl, Dan T., primary, Gabrilovich, Dmitry I., primary, and Nefedova, Yulia, primary

Published
2023
Full Text
View/download PDF

16. Supplementary Tables from A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma

Author

Gómez, Soledad, primary, Garrido-Garcia, Alícia, primary, Garcia-Gerique, Laura, primary, Lemos, Isadora, primary, Suñol, Mariona, primary, de Torres, Carmen, primary, Kulis, Marta, primary, Pérez-Jaume, Sara, primary, Carcaboso, Ángel M., primary, Luu, Betty, primary, Kieran, Mark W., primary, Jabado, Nada, primary, Kozlenkov, Alexey, primary, Dracheva, Stella, primary, Ramaswamy, Vijay, primary, Hovestadt, Volker, primary, Johann, Pascal, primary, Jones, David T.W., primary, Pfister, Stefan M., primary, Morales La Madrid, Andrés, primary, Cruz, Ofelia, primary, Taylor, Michael D., primary, Martin-Subero, Jose-Ignacio, primary, Mora, Jaume, primary, and Lavarino, Cinzia, primary

Published
2023
Full Text
View/download PDF

18. S100A8/S100A9 promote progression of multiple myeloma via expansion of megakaryocytes

Author

Lin, Cindy, primary, Garcia-Gerique, Laura, additional, Bonner, Erin E, additional, Mastio, Jérôme, additional, Rosenwasser, Matthew, additional, Cruz, Zachary, additional, Lawler, Michael E., additional, Bernabei, Luca, additional, Muthumani, Kar, additional, Liu, Qin, additional, Poncz, Mortimer, additional, Vogl, Thomas, additional, Törngren, Marie, additional, Eriksson, Helena, additional, Vogl, Dan T, additional, Gabrilovich, Dmitry I, additional, and Nefedova, Yulia, additional

Published
2023
Full Text
View/download PDF

19. Syntaphilin Regulates Neutrophil Migration in Cancer

Author

Fu, Shuyu, primary, Deng, Hui, additional, Bertolini, Irene, additional, Perego, Michela, additional, Chen, Eric S., additional, Sanseviero, Emilio, additional, Mostafa, Ali, additional, Alicea-Torres, Kevin, additional, Garcia-Gerique, Laura, additional, Stone, Erica L., additional, Kossenkov, Andrew V., additional, Schug, Zachary T., additional, Nam, Brian, additional, Mulligan, Charles, additional, Altieri, Dario C., additional, Nefedova, Yulia, additional, and Gabrilovich, Dmitry I., additional

Published
2023
Full Text
View/download PDF

21. GPC2 antibody–drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies

Author

Pascual-Pasto, Guillem, primary, McIntyre, Brendan, additional, Shraim, Rawan, additional, Buongervino, Samantha N, additional, Erbe, Amy K, additional, Zhelev, Doncho V, additional, Sadirova, Shakhnozakhon, additional, Giudice, Anna M, additional, Martinez, Daniel, additional, Garcia-Gerique, Laura, additional, Dimitrov, Dimiter S, additional, Sondel, Paul M, additional, and Bosse, Kristopher R, additional

Published
2022
Full Text
View/download PDF

22. Abstract C046: Polymorphonuclear myeloid derived suppressor cells die by ferroptosis in the tumor microenvironment

Author

Kim, Rina, primary, Hashimoto, Ayumi, additional, Markosyan, Nune, additional, Tyurin, Vladimir A., additional, Tyurina, Yulia Y., additional, Fu, Shuyu, additional, Sehgal, Mohit, additional, Garcia-Gerique, Laura, additional, Kar, Gozde, additional, Kossenkov, Andrew, additional, Gebregziabher, Bereket A., additional, Tobias, John W., additional, Hicks, Kristin, additional, Deng, Hui, additional, Donthireddy, Laxminarasimha, additional, Greenberg, Andrew, additional, Nam, Brian, additional, Nefedova, Yulia, additional, Kagan, Valerian E., additional, Vonderheide, Robert H., additional, and Gabrilovich, Dmitry, additional

Published
2022
Full Text
View/download PDF

23. 1189 A GPC2 antibody-drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies

Author

Pascual-Pasto, Guillem, primary, McIntyre, Brendan, additional, Shraim, Rawan, additional, Buongervino, Samantha, additional, Erbe, Amy, additional, Jelev, Dontcho, additional, Giudice, Anna, additional, Martinez, Daniel, additional, Garcia-Gerique, Laura, additional, Dimitrov, Dimiter, additional, Sondel, Paul, additional, and Bosse, Kristopher, additional

Published
2022
Full Text
View/download PDF

24. A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression

Author

Deng, Hui, primary, Lin, Cindy, additional, Garcia-Gerique, Laura, additional, Fu, Shuyu, additional, Cruz, Zachary, additional, Bonner, Erin E., additional, Rosenwasser, Matthew, additional, Rajagopal, Sridharan, additional, Sadhu, M Naveen, additional, Gajendran, Chandru, additional, Zainuddin, Mohd, additional, Gosu, Ramachandraiah, additional, Sivanandhan, Dhanalakshmi, additional, Shelef, Miriam A., additional, Nam, Brian, additional, Vogl, Dan T., additional, Gabrilovich, Dmitry I., additional, and Nefedova, Yulia, additional

Published
2022
Full Text
View/download PDF

25. Study of disseminated high-risk neuroblastoma in the bone marrow niche; from microenvironmental modelling to therapeutic targeting

Author

Garcia Gerique, Laura, Lavarino, Cinzia, Marfany i Nadal, Gemma, and Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística

Subjects
Anoxemia, Tumors in children, Medul·la òssia, Médula ósea, Oncologia pediàtrica, Anoxèmia, Bone marrow, Ciències de la Salut, Oncología pediátrica
Abstract

Neuroblastoma (NB) is the most common extracraneal solid tumor diagnosed in the first 5 years of childhood and accounts for approximately 15% of all pediatric cancer-related deaths. At the time of diagnosis, about half of NB patients present disseminated disease, being the bone marrow (BM) the most common site of dissemination. The persistence of infiltrated BM during treatment or relapse is predictive of patient poor outcome. The BM microenvironment has unique biologic properties that favor progression of disseminated NB tumor cells. In this environment, the receptor CXCR4 has a pivotal role for BM homeostasis and is involved in metastatic dissemination in several cancers. In NB, CXCR4 is expressed in tumor cells; however, its oncogenic role in relation with its ligand CXCL12 has shown contradictory results. Using an in vitro model that recapitulates low oxygen levels and chemokine signaling present in the BM environment, we explored whether CXCR4 together with MIF, a second ligand, is critical for NB survival and proliferation in the niche. We also evaluated MIF inhibition as a therapeutic option for NB. To develop a BM-based in vitro model, NB cells were cultured in different conditioned media (CMs) derived from supernatants of patient-derived BM primary cells (CM-BM) and NB cell lines (CM-NB) cultured alone, or in combination (CM-BM/NB). To mimic BM oxygen levels, NB cells were cultured under hypoxia (1% O2), as compared to cell culture normoxia (21% O2). Expanded BM cultures used to generate CMs contained a heterogenic population with a predominant cellularity positive for mesenchymal stromal markers measured by flow cytometry. Cytokine arrays and ELISA assays of CMs revealed MIF as the highest NB released cytokine, whereas CXCL12 was not detected. The expression of MIF and CXCL12 signaling pathways was analyzed with different public NB databases. Among the analyzed genes, the high expression of CXCR4 and MIF was associated with patient poor outcome and high-risk disseminated staging. To further explore the role of CXCR4/MIF axis in high- risk disseminated NB, in vitro and in vivo functional studies were performed with or without the covalent MIF inhibitor 4-IPP and the CXCR4 antagonist AMD3100. When exposed to BM-derived CMs and hypoxia, BM-derived NB cell lines showed increased surface expression of CXCR4 by flow cytometry. The same culture condition increased phosphorylated levels of AKT/PI3K and ERK/MAPK measured by western blot. Cell viability assays showed that hypoxic conditions and BM-derived CMs enhanced NB cell proliferation at different time points. Similarly, in vivo, the co-injection of BM cells favored NB tumor progression by reducing engraftment times in contrast to NB injection alone. Using wound healing assays and Matrigel-coated Transwells, CM-BM/NB chemoattracted and enhanced migration and invasion of LAN-1 cells cultured under hypoxic conditions. These aggressive phenotypes promoted by the BM-based model were reverted by adding sub-lethal concentrations of the MIF inhibitor 4-IPP. We also explored whether MIF present in our CMs affected response to chemotherapy. After treatment with doxorubicin and etoposide at IC50 values LAN-1 cell viability increased in CM-BM/NB compared to control media. In both cases, chemo-sensitivity was restored when 4-IPP was added to CM-BM/NB. Finally, the administration of 4-IPP delayed the tumor progression and increased mice survival in a LAN- 1 subcutaneous xenograft model. In conclusion, our findings provide new understanding of the contribution of BM microenvironment to NB progression. Based on our BM-model, the relationship between the BM microenvironment and NB cells appears mediate, in part, by the autocrine CXCR4/MIF signaling axis. Furthermore, our results suggested that MIF could represent a therapeutic target for the treatment of patients with high-risk NB.

Published
2020

26. Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors

Author

Ministerio de Economía y Competitividad (España), Wellcome Trust, Royal Society (UK), Campbell, Kyra, Rossi, Fabrizio, Adams, Jamie, Pitsidianaki, Ioanna, Barriga, Francisco M., Garcia-Gerique, Laura, Batlle, Eduard, Casanova, Jordi, Casali, Andreu, Ministerio de Economía y Competitividad (España), Wellcome Trust, Royal Society (UK), Campbell, Kyra, Rossi, Fabrizio, Adams, Jamie, Pitsidianaki, Ioanna, Barriga, Francisco M., Garcia-Gerique, Laura, Batlle, Eduard, Casanova, Jordi, and Casali, Andreu

Abstract

Metastasis underlies the majority of cancer-related deaths yet remains poorly understood due, in part, to the lack of models in vivo. Here we show that expression of the EMT master inducer Snail in primary adult Drosophila intestinal tumors leads to the dissemination of tumor cells and formation of macrometastases. Snail drives an EMT in tumor cells, which, although retaining some epithelial markers, subsequently break through the basal lamina of the midgut, undergo a collective migration and seed polyclonal metastases. While metastases re-epithelialize over time, we found that early metastases are remarkably mesenchymal, discarding the requirement for a mesenchymal-to-epithelial transition for early stages of metastatic growth. Our results demonstrate the formation of metastases in adult flies, and identify a key role for partial-EMTs in driving it. This model opens the door to investigate the basic mechanisms underlying metastasis, in a powerful in vivo system suited for rapid genetic and drug screens.

Published
2019

27. Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01

Author

Pascual-Pasto, Guillem, primary, Bazan-Peregrino, Miriam, additional, Olaciregui, Nagore G., additional, Restrepo-Perdomo, Camilo A., additional, Mato-Berciano, Ana, additional, Ottaviani, Daniela, additional, Weber, Klaus, additional, Correa, Genoveva, additional, Paco, Sonia, additional, Vila-Ubach, Monica, additional, Cuadrado-Vilanova, Maria, additional, Castillo-Ecija, Helena, additional, Botteri, Gaia, additional, Garcia-Gerique, Laura, additional, Moreno-Gilabert, Helena, additional, Gimenez-Alejandre, Marta, additional, Alonso-Lopez, Patricia, additional, Farrera-Sal, Marti, additional, Torres-Manjon, Silvia, additional, Ramos-Lozano, Dolores, additional, Moreno, Rafael, additional, Aerts, Isabelle, additional, Doz, François, additional, Cassoux, Nathalie, additional, Chapeaublanc, Elodie, additional, Torrebadell, Montserrat, additional, Roldan, Monica, additional, König, Andrés, additional, Suñol, Mariona, additional, Claverol, Joana, additional, Lavarino, Cinzia, additional, Carmen de, Torres, additional, Fu, Ligia, additional, Radvanyi, François, additional, Munier, Francis L., additional, Catalá-Mora, Jaume, additional, Mora, Jaume, additional, Alemany, Ramón, additional, Cascalló, Manel, additional, Chantada, Guillermo L., additional, and Carcaboso, Angel M., additional

Published
2019
Full Text
View/download PDF

28. A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma

Author

Gómez, Soledad, primary, Garrido-Garcia, Alícia, additional, Garcia-Gerique, Laura, additional, Lemos, Isadora, additional, Suñol, Mariona, additional, de Torres, Carmen, additional, Kulis, Marta, additional, Pérez-Jaume, Sara, additional, Carcaboso, Ángel M., additional, Luu, Betty, additional, Kieran, Mark W., additional, Jabado, Nada, additional, Kozlenkov, Alexey, additional, Dracheva, Stella, additional, Ramaswamy, Vijay, additional, Hovestadt, Volker, additional, Johann, Pascal, additional, Jones, David T.W., additional, Pfister, Stefan M., additional, Morales La Madrid, Andrés, additional, Cruz, Ofelia, additional, Taylor, Michael D., additional, Martin-Subero, Jose-Ignacio, additional, Mora, Jaume, additional, and Lavarino, Cinzia, additional

Published
2018
Full Text
View/download PDF

29. Effects of Hyperoxia on Oxygen-Related Inflammation with a Focus on Obesity

Author

González-Muniesa, Pedro, Garcia-Gerique, Laura, Quintero, Pablo, Arriaza, Suyen, Lopez-Pascual, Amaya, and Martinez, J. Alfredo

Subjects
Article Subject
Abstract

Several studies have shown a pathological oxygenation (hypoxia/hyperoxia) on the adipose tissue in obese subjects. Additionally, the excess of body weight is often accompanied by a state of chronic low-degree inflammation. The inflammation phenomenon is a complex biological response mounted by tissues to combat injurious stimuli in order to maintain cell homeostasis. Furthermore, it is believed that the abnormal oxygen partial pressure occurring in adipose tissue is involved in triggering inflammatory processes. In this context, oxygen is used in modern medicine as a treatment for several diseases with inflammatory components. Thus, hyperbaric oxygenation has demonstrated beneficial effects, apart from improving local tissue oxygenation, on promoting angiogenesis, wound healing, providing neuroprotection, facilitating glucose uptake, appetite, and others. Nevertheless, an excessive hyperoxia exposure can lead to deleterious effects such as oxidative stress, pulmonary edema, and maybe inflammation. Interestingly, some of these favorable outcomes occur under high and low oxygen concentrations. Hereby, we review a potential therapeutic approach to the management of obesity as well as the oxygen-related inflammation accompanying expanded adipose tissue, based on elevated oxygen concentrations. To conclude, we highlight at the end of this review some areas that need further clarification.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results