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4. Primary monophasic synovial sarcoma of the duodenum confirmed by cytogenetic analysis with demonstration of t(X;18): a case report.

Author

Company Campins MM, Morales R, Dolz C, Garcia-Bonafe M, Vilella A, and Huguet P

Subjects
Adolescent, Adult, Aged, Biopsy, Duodenal Neoplasms genetics, Duodenal Neoplasms pathology, Duodenal Neoplasms therapy, Fatal Outcome, Female, Humans, Immunohistochemistry, Male, Middle Aged, Pancreaticoduodenectomy adverse effects, Radiotherapy, Adjuvant, Sarcoma, Synovial genetics, Sarcoma, Synovial pathology, Sarcoma, Synovial therapy, Tomography, X-Ray Computed, Treatment Failure, Young Adult, Chromosomes, Human, Pair 18, Chromosomes, Human, X, Duodenal Neoplasms diagnosis, Genetic Testing methods, In Situ Hybridization, Fluorescence, Sarcoma, Synovial diagnosis, Translocation, Genetic
Abstract

Synovial sarcoma (SS) is an uncommon malignant neoplasm of the soft tissues. It mainly affects the periarticular tissues of the extremities in young adults, but has been described at nearly all sites; nevertheless, the gastrointestinal tract is an exceptional location. We report a case of a primary synovial sarcoma of the duodenum in a 69-year-old woman. Histological study showed a monophasic pattern. The tumor cells demonstrated diffuse vimentin and Bcl-2 expression, partial EMA expression and focal AE1/3 positivity. The differential diagnosis includes gastrointestinal stromal tumors. Cytogenetic analysis confirmed the diagnosis, with detection of the X;18 translocation. The patient presented postoperative complications and died one month following the intervention.

Published
2009

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