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2. How to design nutritional intervention trials to slow cognitive decline in apparently healthy populations and apply for efficacy claims: A statement from the international academy on nutrition and aging task force

Author

Ferry, M., Coley, N., Andrieu, S., Bonhomme, C., Caubere, J.P., Cesari, M., Gautry, J., Garcia Sanchez, I., Hugonot, L., Mansuy, L., Pahor, M., Pariente, J., Ritz, P., Salva, A., Sijben, J., Wieggers, R., Ythier-Moury, P., Zaim, M., Zetlaoui, J., and Vellas, B.

Published
2013
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5. Vena cava filters in patients presenting with major bleeding during anticoagulation for venous thromboembolism

Author

Mellado, M, Trujillo-Santos, J, Bikdeli, B, Jimenez, D, Nunez, MJ, Ellis, M, Marchena, PJ, Vela, JR, Clara, A, Moustafa, F, Monreal, M, Adarraga, MD, Aibar, MA, Alfonso, M, Arcelus, JI, Ballaz, A, Banos, P, Barba, R, Barron, M, Bascunana, J, Blanco-Molina, A, Camon, AM, Carrasco, C, Chasco, L, Cruz, AJ, Del, PR, Del, TJ, Diaz-Pedroche, MC, Diaz-Peromingo, JA, Encabo, M, Falga, C, Fernandez-Aracil, C, Fernandez-Capitan, C, Fidalgo, MA, Font, C, Font, L, Furest, I, Garcia, MA, Garcia-Bragado, F, Garcia-Morillo, M, Garcia-Raso, A, Garcia-Sanchez, I, Gavin, O, Gomez, C, Gomez, V, Gonzalez, J, Grau, E, Guijarro, R, Guirado, L, Gutierrez, J, Hernandez-Blasco, L, Hernando, E, Isern, V, Jara-Palomares, L, Jaras, MJ, Joya, MD, Lima, J, Llamas, P, Lobo, JL, Lopez-Jimenez, L, Lopez-Reyes, R, Lopez-Saez, JB, Lorente, MA, Lorenzo, A, Loring, M, Lumbierres, M, Madridano, O, Maestre, A, Martin, M, Martin-Martos, F, Morales, MV, Nieto, JA, Olivares, MC, Otalora, S, Otero, R, Pedrajas, JM, Pellejero, G, Perez-Ductor, C, Peris, ML, Pons, I, Porras, JA, Riera-Mestre, A, Rivas, A, Rodriguez-Davila, MA, Rodriguez-Galan, I, Rosa, V, Rubio, CM, Ruiz-Artacho, P, Sahuquillo, JC, Sala-Sainz, MC, Samperiz, A, Sanchez-Artola, B, Sanchez-Martinez, R, Sancho, T, Soler, S, Soto, MJ, Surinach, JM, Tolosa, C, Torres, MI, Uresandi, F, Usandizaga, E, Valero, B, Valle, R, Vela, J, Vidal, G, Villalobos, A, Xifre, B, Vazquez, FJ, Vilaseca, A, Vanassche, T, Vandenbriele, C, Verhamme, P, Yoo, HHB, Wells, P, Hirmerova, J, Maly, R, Salgado, E, Benzidia, I, Bertoletti, L, Bura-Riviere, A, Falvo, N, Farge-Bancel, D, Hij, A, Merah, A, Mahe, I, Quere, I, Braester, A, Brenner, B, Tzoran, I, Antonucci, G, Bilora, F, Bucherini, E, Cattabiani, C, Ciammaichella, M, Dentali, F, Di Micco, P, Doddi, M, Duce, R, Giorgi-Pierfranceschi, M, Grandone, E, Imbalzano, E, Lessiani, G, Maggi, F, Maida, R, Mastroiacovo, D, Pace, F, Pesavento, R, Poggio, R, Prandoni, P, Quintavalla, R, Rocci, A, Siniscalchi, C, Tiraferri, E, Tonello, D, Visona, A, Zalunardo, B, Gibietis, V, Skride, A, Vitola, B, Zdraveska, M, Bounameaux, H, Calanca, L, Fresa, M, and Mazzolai, L

Subjects
Male, medicine.medical_specialty, Vena Cava Filters, Inferior vena cava filter, Hemorrhage, 030204 cardiovascular system & hematology, Lower risk, Statistics, Nonparametric, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Thromboembolism, Anticoagulants, Bleeding, Mortality, Vena cava filter, Venous thromboembolism, Internal Medicine, medicine, Humans, Registries, 030212 general & internal medicine, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Mortality rate, Heparin, Middle Aged, Surgery, Clinical trial, Treatment Outcome, Propensity score matching, Emergency Medicine, Female, business, Major bleeding, medicine.drug
Abstract

The association between inferior vena cava filter (IVC) use and outcome in patients presenting with major bleeding during anticoagulation for venous thromboembolism (VTE) has not been thoroughly investigated. We used the RIETE registry to compare the 30-day outcomes (death, major re-bleeding or VTE recurrences) in VTE patients who bled during the first 3 months of therapy, regarding the insertion of an IVC filter. A propensity score matched (PSM) analysis was performed to adjust for potential confounders. From January 2001 to September 2016, 1065 VTE patients had major bleeding during the first 3 months of anticoagulation (gastrointestinal 370; intracranial 124). Of these, 122 patients (11%) received an IVC filter. Patients receiving a filter restarted anticoagulation later (median, 4 vs. 2 days) and at lower doses (95 +/- 52 IU/kg/day vs. 104 +/- 55 of low-molecular-weight heparin) than those not receiving a filter. During the first 30 days after bleeding (after excluding 246 patients who died within the first 24 h), 283 patients (27%) died, 63 (5.9%) had non-fatal re-bleeding and 19 (1.8%) had recurrent pulmonary embolism (PE). In PSM analysis, patients receiving an IVC filter (n = 122) had a lower risk for all-cause death (HR 0.49; 95% CI 0.31-0.77) or fatal bleeding (HR 0.16; 95% CI 0.07-0.49) and a similar risk for re-bleeding (HR 0.55; 95% CI 0.23-1.40) or PE recurrences (HR 1.57; 95% CI 0.38-6.36) than those not receiving a filter (n = 429). In VTE patients experiencing major bleeding during the first 3 months, use of an IVC filter was associated with reduced mortality rates. Clinical Trial Registration NCT02832245.

Published
2019

6. Venous thrombosis and relapses in patients with Behcet's disease. Descriptive analysis from Spanish network of Behcet's disease (REGEB cohort)

Author

Rodriguez-Carballeira, M, Solans, R, Larranaga, JR, Garcia-Hernandez, FJ, Rios-Fernandez, R, Nieto, J, Solanich, X, Martinez-Valle, F, Fonseca, E, Munoz, FJ, Fraile, G, de Escalante, B, Boldova, R, Hurtado, R, Espinosa, G, Callejas, JL, Hernandez, FG, Garrido, SL, Vidaller, A, de la Torre, RG, Herranz, MT, Todoli, J, Munoz-Rodriguez, F, Fanlo, P, Garcia-Sanchez, I, Trapiella, L, de Miguel, B, Domingo, S, Vilaplana, R, and Cusacovich, I

Subjects
relapse, immunosuppression, thrombotic recurrence, Behcet's disease, anticoagulation, thrombosis
Abstract

Objective. To describe the characteristics of patients with Behfet's disease (BD) who presented with venous thrombosis. In addition, we identified the factors associated with this venous involvement and those related with recurrent venous thrombosis. Methods. Up to January 2015, 544 BD patients from 20 Spanish hospitals had been included in the REGEB (REGistro de la Enfermedad de Behqet as Spanish nomenclature). We selected those patients who presented venous thrombosis. Descriptive analysis was performed and factors related with venous thrombosis were identified. Results. Overall, 99 (18.2%) BD patients had vascular thrombosis, 91 (16.7%) of them (16.7%) involving venous vessels and 18 (19.7%) suffered from venous thrombotic relapse. Lower limbs were the most common location of deep venous thrombosis present in up to 60% of patients. In 12 (13.2%) patients, venous thrombosis affected two vascular territories simultaneously and in 6 (6.6%) the venous and arterial involvement coincided in time. Overall, at the diagnosis of venous thrombosis, 97.6% of patients presented concomitantly other clinical symptoms attributable to BD. In logistic regression multivariate analysis factors associated to venous thrombosis were male sex (Odds ratio [OR] 4.3, 95% confidence interval [CI] 2.5-7.7), erythema nodosum (OR 2.4, 95% CI 1.4-4.1), fever (OR 2.0, 95% CI 1.1-3.8), and central nervous system (CNS) involvement (OR 2.5, 95% CI 1.3-4.8). Considering relapses, CNS involvement was an independent risk factor according logistic regression. However, Cox multivariate analysis did not confirm this finding. Conclusion. We identified factors related with venous involvement in patients included in the REGEB cohort.

Published
2018

7. KEY MESSAGES FOR A FRAILTY PREVENTION AND MANAGEMENT POLICY IN EUROPE FROM THE ADVANTAGE JOINT ACTION CONSORTIUM

Author

Manas L, Garcia-Sanchez I, Hendry A, Bernabei R, Roller-Wirnsberger R, Gabrovec B, Liew A, Carriazo A, Redon J, Galluzzo L, Vina J, Antoniadou E, Targowski T, di Furia L, Lattanzio F, Bozdog E, Telo M, and ADVANTAGE Joint Action Partners

Abstract

In the 2015 Ageing Report, the European Commission (EC) and the Economic Policy Committee stated that coping with the challenge posed by an ageing population will require determined policy action in Europe, particularly in reforming pension, health care and long-term care systems. The concern for this situation motivated the EC, the Parliament and many of the Member States (MS) to co-fund, in the 2015 call of the Third European Health Programme of the European Union 2014-2020, the first Joint Action (JA) on the prevention of frailty. ADVANTAGE JA brings together 33 partners from 22 MSs for 3 years. It aims to build a common understanding on frailty to be used in the MSs by policy makers and other stakeholders involved in the management, both at individual and population level, of older people who are frail or at risk for developing frailty throughout the European Union (EU). It is a formidable challenge but also a great opportunity for concerted action resulting in fostering effective and successful policies in frailty prevention and management in the participating MS. The Consortium has 2 years of hard work ahead to contribute to the needed change for frailty related disability free Europe. The first practical step towards this aim was the preparation of a document: the State of the Art on Frailty Report to support an overview of evidence of what works and what does not work on frailty prevention and management. Subsequently, this will be reflected in the advice that the JA will give to policy makers at MS level. Overall, these messages intend to be an instrument of added value to advocate for policy driven decisions on frailty prevention and management in the JA participating MSs and subsequently towards a frailty related disability free older population in Europe. The aim of this paper is to describe ADVANTAGE JA general structure, approach and recommendations towards a European health and social policy which will support frailty prevention in the participating MS.

Published
2018

12. THE REFERENCE SITE COLLABORATIVE NETWORK OF THE EUROPEAN INNOVATION PARTNERSHIP ON ACTIVE AND HEALTHY AGEING

Author

Bousquet, J., Illario, M., Farrell, J., Batey, N., Carriazo, A. M., Malva, J., Hajjam, J., Colgan, E., Guldemond, N., Perala-Heape, M., Onorato, G. L., Bedbrook, A., Leonardini, L., Stroetman, V., Birov, S., Abreu, C., Abrunhosa, A., Agrimi, A., Alalaakkola, T., Allegretti, N., Alonso-Trujillo, F., Alvarez-Benito, M., Angioli, S., Apostolo, J., Armitage, G., Arnavielhe, S., Baena-Parejo, M., Bamidis, P. D., Balenovic, A., Barbolini, M., Baroni, I., Blain, H., Bernard, P. L., Bersani, M., Berti, E., Bogatyrchuk, L., Bourret, R., Brehm, J., Brussino, L., Buhr, D., Bultje, D., Cabeza, E., Cano, A., Capitani, C., Carantona, E., Cardoso, A., Coll Clavero, J., Combe, B., Conforti, D., Coppola, L., Corti, F., Coscioni, E., Costa, E., Crooks, G., Cunha, A., Daien, C., Dantas, Darpon Sierra, J., Davoli, M., Dedeu Baraldes, A., Luca, V., Nardi, L., Di Ciano, M., Dozet, A., Ekinci, B., Erve, S., Espinoza Almendro, J. M., Fait, A., Fensli, R., Fernandez Nocelo, S., Galvez-Daza, P., Gamez-Paya, J., Garcia Saez, M., Garcia Sanchez, I., Gemicioglu, B., Goetzke, W., Goossens, E., Geurdens, M., Gutter, Z., Hansen, H., Hartman, S., Hegendorfer, G., Heikka, H., Henderson, D., Heran, D., Hirvonen, S., Iaccarino, G., Jansson, N., Kallasvaara, H., Kalyoncu, F., Kirchmayer, U., Kokko, J. A., Korpelainen, J., Kostka, T., Kuna, P., Lajarin Ortega, T., Lama, C. M., Laune, D., Lauri, D., Ledroit, V., Levato, G., Lewis, L., Liotta, G., Lundgren, L., Lupianez-Villanueva, F., Mc Garry, P., Maggio, M., Manuel Keenoy, E., Martinez, C., Martinez-Domene, M., Martinez-Lozano Aranaga, B., Massimilliano, M., Maurizio, A., Mayora, O., Melle, C., Mendez-Zorilla, A., Mengon, H., Mercier, G., Mercier, J., Meyer, I., Millet Pi-Figueras, A., Mitsias, P., Molloy, D. W., Monti, R., Moro, M. L., Muranko, H., Nalin, M., Nobili, A., Nogues, M., O Caoimh, R., Pais, S., Papini, D., Parkkila, P., Pattichis, C., Pavlickova, A., Peiponen, A., Pereira, S., Pepin, J. L., Piera Jimenez, J., Portheine, P., Potel, L., Pozzi, A. C., Quinonez, P., Lauritsen, Ramirez X., Ramos, M. J., Rannali-Kontturi, A., Risino, A., Robalo-Cordeiro, C., Rolla, G., Roller, R., Romano, M., Romano, V., Ruiz-Fernandez, J., Saccavini, C., Sachinopoulou, A., Sanchez Rubio, M. J., Santos, L., simonetta scalvini, Scopetani, E., Smedberg, D., Solana-Lara, R., Soltysik, B., Sorlini, M., Stericker, S., Badiale, Stramba M., Taillieu, I., Tervahauta, M., Teixeira, A., Tikanmaki, H., Todo-Bom, A., Tooley, A., Tuulonen, A., Tziraki, C., Ussai, S., Veen, S., Venchiarutti, A., Verdoy-Berastegi, D., Verissimo, M., Visconti, L., Vollenbroek-Hutten, M., Weinzerl, K., Wozniak, L., Yorgancioglu, A., Zavagli, V., Zurkuhlen, A. J., Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Department of Hydraulic and Environmental Engineering, University of Pavia, Department of Geriatrics - Efficiency and Deficiency Laboratory, Università degli Studi di Firenze [Firenze], Groupe d'étude de l'atmosphère météorologique (CNRM-GAME), Institut national des sciences de l'Univers (INSU - CNRS)-Météo France-Centre National de la Recherche Scientifique (CNRS), Mineralogisch-Petrographisches Institut (MPI), Mineralogisch-Petrographisches Institut, University of Coimbra [Portugal] (UC), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Laboratoire d'océanographie de Villefranche (LOV), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Istituto di Astrofisica Spaziale, Hôpital Lapeyronie [Montpellier] (CHU), Centre d’Expertise National des Technologies de l’Information et de la Communication pour l’autonomie - CENTICH (FRANCE), Center for Turbulence Research (CTR), Stanford University [Stanford], Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Station de Palavas, Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de magnétisme et d'optique de Versailles (LMOV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire [Grenoble] (CHU), Epidemiology Unit, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Istituto Nazionale di Geofisica e Vulcanologia, Sezione di Palermo, Centre d'EPistémologie et d'ERgologie Comparatives - UMR 7304 (CEPERC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Ethics, Law & Medical humanities, APH - Aging & Later Life, Bousquet, J, Illario, M, Farrell, J, Batey, N, Carriazo, A M, Malva, J, Hajjam, J, Colgan, E, Guldemond, N, Perälä-Heape, M, Onorato, G L, Bedbrook, A, Leonardini, L, Stroetman, V, Birov, S, Abreu, C, Abrunhosa, A, Agrimi, A, Alalääkkölä, T, Allegretti, N, Alonso-Trujillo, F, Álvarez-Benito, M, Angioli, S, Apóstolo, J, Armitage, G, Arnavielhe, S, Baena-ParejoI, M, Bamidis, P D, Balenović, A, Barbolini, M, Baroni, I, Blain, H, Bernard, P L, Bersani, M, Berti, E, Bogatyrchuk, L, Bourret, R, Brehm, J, Brussino, L, Buhr, D, Bultje, D, Cabeza, E, Cano, A, De Capitani, C, Carantoña, E, Cardoso, A, Coll Clavero, J I, Combe, B, Conforti, D, Coppola, L, Corti, F, Coscioni, E, Costa, E, Crooks, G, Cunha, A, Daien, C, Dantas, Null, Darpón Sierra, J, Davoli, M, Dedeu Baraldes, A, De Luca, V, De Nardi, L, Di Ciano, M, Dozet, A, Ekinci, B, Erve, S, Espinoza Almendro, J M, Fait, A, Fensli, R, Fernandez Nocelo, S, Gálvez-Daza, P, Gámez-Payá, J, García Sáez, M, Garcia Sanchez, I, Gemicioğlu, B, Goetzke, W, Goossens, E, Geurdens, M, Gütter, Z, Hansen, H, Hartman, S, Hegendörfer, G, Heikka, H, Henderson, D, Héran, D, Hirvonen, S, Iaccarino, G, Jansson, N, Kallasvaara, H, Kalyoncu, F, Kirchmayer, U, Kokko, J A, Korpelainen, J, Kostka, T, Kuna, P, Lajarín Ortega, T, Lama, C M, Laune, D, Lauri, D, Ledroit, V, Levato, G, Lewis, L, Liotta, G, Lundgren, L, Lupiañez-Villanueva, F, Mc Garry, P, Maggio, M, Manuel de Keenoy, E, Martinez, C, Martínez-Domene, M, Martínez-Lozano Aranaga, B, Massimilliano, M, Maurizio, A, Mayora, O, Melle, C, Mendez-Zorilla, A, Mengon, H, Mercier, G, Mercier, J, Meyer, I, Millet Pi-Figueras, A, Mitsias, P, Molloy, D W, Monti, R, Moro, M L, Muranko, H, Nalin, M, Nobili, A, Noguès, M, O'Caoimh, R, Pais, S, Papini, D, Parkkila, P, Pattichis, C, Pavlickova, A, Peiponen, A, Pereira, S, Pépin, J L, Piera Jiménez, J, Portheine, P, Potel, L, Pozzi, A C, Quiñonez, P, Ramirez Lauritsen, X, Ramos, M J, Rännäli-Kontturi, A, Risino, A, Robalo-Cordeiro, C, Rolla, G, Roller, R, Romano, M, Romano, V, Ruiz-Fernández, J, Saccavini, C, Sachinopoulou, A, Sánchez Rubio, M J, Santos, L, Scalvini, S, Scopetani, E, Smedberg, D, Solana-Lara, R, Sołtysik, B, Sorlini, M, Stericker, S, Stramba Badiale, M, Taillieu, I, Tervahauta, M, Teixeira, A, Tikanmäki, H, Todo-Bom, A, Tooley, A, Tuulonen, A, Tziraki, C, Ussai, S, Van der Veen, S, Venchiarutti, A, Verdoy-Berastegi, D, Verissimo, M, Visconti, L, Vollenbroek-Hutten, M, Weinzerl, K, Wozniak, L, Yorgancıoğlu, A, Zavagli, V, Zurkuhlen, A J, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Università degli Studi di Pavia = University of Pavia (UNIPV), Università degli Studi di Firenze = University of Florence (UniFI), Center for Turbulence Research [Stanford] (CTR), Stanford University, KYomed INNOV, Centre d'EPistémologie et d'ERgologie Comparatives (CEPERC), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Observatoire océanologique de Villefranche-sur-mer (OOVM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), and Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Active and healthy ageing, DG CONNECT, DG Santé, EIP on AHA, European Innovation Partnership on Active and Healthy Ageing, Allergic Rhinitis, Operational Definition, Program, Turkey, DG Sante, [SDV]Life Sciences [q-bio], Eip, Diseases, Articles, 03 medical and health sciences, 0302 clinical medicine, Synergies, 030228 respiratory system, Aha, Settore MED/42, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, and the development of sustainable economic growth and the creation of jobs.

13. The interplay between infection risk factors of SARS-CoV-2 and mortality: a cross-sectional study from a cohort of long-term care nursing home residents.

Author

Soldevila L, Prat N, Mas MÀ, Massot M, Miralles R, Bonet-Simó JM, Isnard M, Expósito-Izquierdo M, Garcia-Sanchez I, Rodoreda-Noguerola S, Moreno N, Badia E, López G, Sevilla J, Estrada O, and Vallès X

Subjects
Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Long-Term Care, Male, Nursing Homes, Pandemics, Risk Factors, COVID-19, SARS-CoV-2
Abstract

Background: Covid-19 pandemic has particularly affected older people living in Long-term Care settings in terms of infection and mortality., Methods: We carried out a cross-sectional analysis within a cohort of Long-term care nursing home residents between March first and June thirty, 2020, who were ≥ 65 years old and on whom at least one PCR test was performed. Socio-demographic, comorbidities, and clinical data were recorded. Facility size and community incidence of SARS-CoV-2 were also considered. The outcomes of interest were infection (PCR positive) and death., Results: A total of 8021 residents were included from 168 facilities. Mean age was 86.4 years (SD = 7.4). Women represented 74.1%. SARS-CoV-2 infection was detected in 27.7% of participants, and the overall case fatality rate was 11.3% (24.9% among those with a positive PCR test). Epidemiological factors related to risk of infection were larger facility size (pooled aOR 1.73; P < .001), higher community incidence (pooled aOR 1.67, P = .04), leading to a higher risk than the clinical factor of low level of functional dependence (aOR 1.22, P = .03). Epidemiological risk factors associated with mortality were male gender (aOR 1.75; P < .001), age (pooled aOR 1.16; P < .001), and higher community incidence (pooled aOR 1.19, P = < 0.001) whereas clinical factors were low level of functional dependence (aOR 2.42, P < .001), Complex Chronic Condition (aOR 1.29, P < .001) and dementia (aOR 1.33, P <0.001). There was evidence of clustering for facility and health area when considering the risk of infection and mortality (P < .001)., Conclusions: Our results suggest a complex interplay between structural and individual factors regarding Covid-19 infection and its impact on mortality in nursing-home residents., (© 2022. The Author(s).)

Published
2022
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15. The Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing.

Author

Bousquet J, Illario M, Farrell J, Batey N, Carriazo AM, Malva J, Hajjam J, Colgan E, Guldemond N, Perälä-Heape M, Onorato GL, Bedbrook A, Leonardini L, Stroetman V, Birov S, Abreu C, Abrunhosa A, Agrimi A, Alalääkkölä T, Allegretti N, Alonso-Trujillo F, Álvarez-Benito M, Angioli S, Apóstolo J, Armitage G, Arnavielhe S, Baena-ParejoI M, Bamidis PD, Balenović A, Barbolini M, Baroni I, Blain H, Bernard PL, Bersani M, Berti E, Bogatyrchuk L, Bourret R, Brehm J, Brussino L, Buhr D, Bultje D, Cabeza E, Cano A, De Capitani C, Carantoña E, Cardoso A, Coll Clavero JI, Combe B, Conforti D, Coppola L, Corti F, Coscioni E, Costa E, Crooks G, Cunha A, Daien C, Dantas, Darpón Sierra J, Davoli M, Dedeu Baraldes A, De Luca V, De Nardi L, Di Ciano M, Dozet A, Ekinci B, Erve S, Espinoza Almendro JM, Fait A, Fensli R, Fernandez Nocelo S, Gálvez-Daza P, Gámez-Payá J, García Sáez M, Garcia Sanchez I, Gemicioğlu B, Goetzke W, Goossens E, Geurdens M, Gütter Z, Hansen H, Hartman S, Hegendörfer G, Heikka H, Henderson D, Héran D, Hirvonen S, Iaccarino G, Jansson N, Kallasvaara H, Kalyoncu F, Kirchmayer U, Kokko JA, Korpelainen J, Kostka T, Kuna P, Lajarín Ortega T, Lama CM, Laune D, Lauri D, Ledroit V, Levato G, Lewis L, Liotta G, Lundgren L, Lupiañez-Villanueva F, Mc Garry P, Maggio M, Manuel de Keenoy E, Martinez C, Martínez-Domene M, Martínez-Lozano Aranaga B, Massimilliano M, Maurizio A, Mayora O, Melle C, Mendez-Zorilla A, Mengon H, Mercier G, Mercier J, Meyer I, Millet Pi-Figueras A, Mitsias P, Molloy DW, Monti R, Moro ML, Muranko H, Nalin M, Nobili A, Noguès M, O'Caoimh R, Pais S, Papini D, Parkkila P, Pattichis C, Pavlickova A, Peiponen A, Pereira S, Pépin JL, Piera Jiménez J, Portheine P, Potel L, Pozzi AC, Quiñonez P, Ramirez Lauritsen X, Ramos MJ, Rännäli-Kontturi A, Risino A, Robalo-Cordeiro C, Rolla G, Roller R, Romano M, Romano V, Ruiz-Fernández J, Saccavini C, Sachinopoulou A, Sánchez Rubio MJ, Santos L, Scalvini S, Scopetani E, Smedberg D, Solana-Lara R, Sołtysik B, Sorlini M, Stericker S, Stramba Badiale M, Taillieu I, Tervahauta M, Teixeira A, Tikanmäki H, Todo-Bom A, Tooley A, Tuulonen A, Tziraki C, Ussai S, Van der Veen S, Venchiarutti A, Verdoy-Berastegi D, Verissimo M, Visconti L, Vollenbroek-Hutten M, Weinzerl K, Wozniak L, Yorgancıoğlu A, Zavagli V, and Zurkuhlen AJ

Abstract

Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, and the development of sustainable economic growth and the creation of jobs.

Published
2019

16. An international investigation of an outbreak of Legionnaires disease among UK and French tourists.

Author

Joseph C, Morgan D, Birtles R, Pelaz C, Martín-Bourgón C, Black M, Garcia-Sanchez I, Griffin M, Bornstein N, and Bartlett C

Subjects
Aged, Europe epidemiology, Female, Humans, Legionella pneumophila isolation & purification, Legionnaires' Disease microbiology, Legionnaires' Disease prevention & control, Male, Middle Aged, Spain epidemiology, Water Supply, Disease Outbreaks, International Cooperation, Legionnaires' Disease epidemiology, Population Surveillance methods, Travel
Abstract

Five cases of legionnaires disease and one death were associated with four members of a tour group from the United Kingdom (UK) and one French tourist who all visited Spain in the spring of 1993. The UK group stayed at four hotels, one of which was also used by the French tourist. Phenotypic and genotypic comparison of isolates of Legionella pneumophila obtained from one of the UK cases and the French patient demonstrated that they were indistinguishable from each other and from environmental isolates obtained from the water supply of the hotel at which all five cases had stayed. A cohort study of the UK tour group was carried out to determine the extent of the outbreak and showed that three further members of the group had respiratory illness but were serologically negative to legionella infection. International participation in this investigation has highlighted the value of a European surveillance scheme and the benefit of microbiological collaboration between legionella reference laboratories in Europe.

Published
1996
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