121 results on '"Garcia RE"'
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2. VETERANS HOSPITALIZED AT VA MEDICAL CENTERS WHILE ENROLLED IN MEDICARE RISK CONTRACT HMOs: HOW BIG A PROBLEM? A PILOT ANALYSIS
- Author
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Passman, LJ, Garcia, RE, Campbell, L, and Winter, E
- Published
- 1996
3. Search for Heavy Higgs Bosons A/H Decaying to a Top Quark Pair in pp Collisions at root s=8 TeV with the ATLAS Detector
- Author
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Aaboud, M, Aad, C, Abbott, B, Abdinov, O, Abeloos, B, Abidi, SH, AbouZeid, OS, Abraham, NL, Abramowicz, H, Abreu, H, Abreu, R, Abulaiti, Y, Acharya, BS, Adachi, S, Adamczyk, L, Adelman, J, Adersberger, M, Adye, T, Affolder, AA, Agatonovic-Jovin, T, Agheorghiesei, C, Aguilar-Saavedra, JA, Ahlen, SP, Ahmadov, F, Aielli, G, Akatsuka, S, Akerstedt, H, Akesson, TPA, Akilli, E, Akimov, AV, Alberghi, GL, Albert, J, Albicocco, P, Alconada Verzini, MJ, Alderweireldt, SC, Aleksa, M, Aleksandrov, IN, Alexa, C, Alexander, G, Alexopoulos, T, Alhroob, M, Ali, B, Aliev, M, Alimonti, G, Alison, J, Alkire, SP, Allbrooke, BMM, Allen, BW, Allport, PP, Aloisio, A, Alonso, A, Alonso, F, Alpigiani, C, Alshehri, AA, Alstaty, MI, Gonzalez, B Alvarez, Alvarez Piqueras, D, Alviggi, MG, Amadio, BT, Amaral Coutinho, Y, Amelung, C, Amidei, D, Amor Dos Santos, SP, Amoroso, S, Amundsen, G, Anastopoulos, C, Ancu, LS, Andari, N, Andeen, T, Anders, CF, Anders, JK, Anderson, KJ, Andreazza, A, Andrei, V, Angelidakis, S, Angelozzi, I, Angerami, A, Anisenkov, AV, Anjos, N, Annovi, A, Antel, C, Antonelli, M, Antonov, A, Antrim, DJ, Anulli, F, Aoki, M, Bella, L Aperio, Arabidze, G, Arai, Y, Araque, JP, Araujo Ferraz, V, Arce, ATH, Ardell, RE, Arduh, FA, Arguin, J-F, Argyropoulos, S, Arik, M, Armbruster, AJ, Armitage, LJ, Arnaez, O, Arnold, H, Arratia, M, Arslan, O, Artamonov, A, Artoni, G, Artz, S, Asai, S, Asbah, N, Ashkenazi, A, Asquith, L, Assamagan, K, Astalos, R, Atkinson, M, Atlay, NB, Augsten, K, Avolio, G, Axen, B, Ayoub, MK, Azuelos, G, Baas, AE, Baca, MJ, Bachacou, H, Bachas, K, Backes, M, Backhaus, M, Bagnaia, P, Bahmani, M, Bahrasemani, H, Baines, JT, Bajic, M, Baker, OK, Baldin, EM, Balek, P, Balli, F, Balunas, WK, Banas, E, Bandyopadhyay, A, Banerjee, Sw, Bannoura, AAE, Barak, L, Barberio, EL, Barberis, D, Barbero, M, Barillari, T, Barisits, M-S, Barkeloo, JT, Barklow, T, Barlow, N, Barnes, SL, Barnett, BM, Barnett, RM, Barnovska-Blenessy, Z, Baroncelli, A, Barone, G, Barr, AJ, Barranco Navarro, L, Barreiro, F, da Costa, J Barreiro Guimaraes, Bartoldus, R, Barton, AE, Bartos, P, Basalaev, A, Bassalat, A, Bates, RL, Batista, SJ, Batley, JR, Battaglia, M, Bauce, M, Bauer, F, Bawa, HS, Beacham, JB, Beattie, MD, Beau, T, Beauchemin, PH, Bechtle, P, Beck, HP, Beck, HC, Becker, K, Becker, M, Beckingham, M, Becot, C, Beddall, AJ, Beddall, A, Bednyakov, VA, Bedognetti, M, Bee, CP, Beermann, TA, Begalli, M, Begel, M, Behr, JK, Bell, AS, Bella, G, Bellagamba, L, Bellerive, A, Bellomo, M, Belotskiy, K, Beltramello, O, Belyaev, NL, Benary, O, Benchekroun, D, Bender, M, Bendtz, K, Benekos, N, Benhammou, Y, Noccioli, E Benhar, Benitez, J, Benjamin, DP, Benoit, M, Bensinger, JR, Bentvelsen, S, Beresford, L, Beretta, M, Berge, D, Kuutmann, E Bergeaas, Berger, N, Beringer, J, Berlendis, S, Bernard, NR, Bernardi, G, Bernius, C, Bernlochner, FU, Berry, T, Berta, P, Bertella, C, Bertoli, G, Bertolucci, F, Bertram, IA, Bertscile, C, Bertsche, D, Besjes, GJ, Bylund, O Bessidskaia, Bessner, M, Besson, N, Betancourt, C, Bethani, A, Bethke, S, Bevan, AJ, Beyer, J, Bianchi, RM, Biebel, O, Biedermann, D, Bielski, R, Bierwagen, K, Biesuz, NV, Biglietti, M, Billoud, TRV, Bilokon, H, Bindi, M, Bingul, A, Bini, C, Biondi, S, Bisanz, T, Bittrich, C, Bjergaard, DM, Black, CW, Black, JE, Black, KM, Blair, RE, Blazek, T, Bloch, I, Blocker, C, Blue, A, Blum, W, Blumenschein, U, Blunier, S, Bobbink, GJ, Bobrovnikov, VS, Bocchetta, SS, Bocci, A, Bock, C, Boehler, M, Boerner, D, Bogavac, D, Bogdanchikov, AG, Bohm, C, Boisvert, V, Bokan, P, Bold, T, Boldyrev, AS, Bolz, AE, Bomben, M, Bona, M, Boonekamp, M, Borisov, A, Borissov, G, Bortfeldt, J, Bortoletto, D, Bortolotto, V, Boscherini, D, Bosman, M, Bossio Sola, JD, Boudreau, J, Bouffard, J, Bouhova-Thacker, EV, Boumediene, D, Bourdarios, C, Boutle, SK, Boveia, A, Boyd, J, Boyko, IR, Bracinik, J, Brandt, A, Brandt, C, Brandt, O, Bratzler, U, Brau, B, Brau, JE, Madden, WD Breaden, Brendlinger, K, Brennan, AJ, Brenner, L, Brenner, R, Bressler, S, Briglin, DL, Bristow, TM, Britton, D, Britzger, D, Brochu, FM, Brock, I, Brock, R, Brooijmans, G, Brooks, T, Brooks, WK, Brosamer, J, Brost, E, Broughton, JH, de Renstrom, PA Bruckman, Bruncko, D, Bnini, A, Bruni, G, Bruni, LS, Brunt, BH, Bruschi, M, Bruscino, N, Bryant, P, Bryngemark, L, Buanes, T, Buat, Q, Buchholz, P, Buckley, AG, Budagov, IA, Buehrer, F, Bugge, MK, Bulekov, O, Bullock, D, Burch, TJ, Burdin, S, Burgard, CD, Burger, AM, Burghgrave, B, Burka, K, Burke, S, Burmeister, I, Burr, JTP, Busato, E, Buescher, D, Buescher, V, Bussey, P, Butler, JM, Buttar, CM, Butterworth, JM, Butti, P, Buttinger, W, Buzatu, A, Buzykaev, AR, Cabrera Urban, S, Caforio, D, Cairo, VM, Cakir, O, Calace, N, Calafiura, P, Calandri, A, Calderini, C, Calfayan, P, Callea, C, Caloba, LP, Calvente Lopez, S, Calvet, D, Calvet, S, Calvet, TP, Toro, R Camacho, Camarda, S, Camarri, P, Cameron, D, Armadans, R Caminal, Camincher, C, Campana, S, Campanelli, M, Camplani, A, Campoverde, A, Canale, V, Bret, M Cano, Cantero, J, Cao, T, Garrido, MDM Capeans, Caprini, I, Caprini, M, Capua, M, Carbone, RM, Cardarelli, R, Cardillo, F, Carli, I, Carli, T, Carlino, G, Carlson, BT, Carminati, L, Carney, RMD, Caron, S, Carquin, E, Carra, S, Carrillo-Montoya, GD, Casadei, D, Casado, MP, Casolino, M, Casper, DW, Castelijn, R, Castillo Gimenez, V, Castro, NF, Catinaccio, A, Catmore, JR, Cattai, A, Caudron, J, Cavaliere, V, Cavallaro, E, Cavalli, D, Cavalli-Sforza, M, Cavasinni, V, Celebi, E, Ceradini, F, Cerda Alberich, L, Cerqueira, AS, Cerri, A, Cerrito, L, Cerutti, F, Cervelli, A, Cetin, SA, Chafaq, A, Chakraborty, D, Chan, SK, Chan, WS, Chan, YL, Chang, P, Chapman, JD, Charlton, DG, Chau, CC, Barajas, CA Chavez, Che, S, Cheatham, S, Chegwidden, A, Chekanov, S, Chekulaev, SV, Chelkov, GA, Chelstowska, MA, Chen, C, Chen, H, Chen, J, Chen, S, Chen, X, Chen, Y, Cheng, HC, Cheng, HJ, Cheplakov, A, Cheremushkina, E, Cherkaoui El Moursli, R, Cheu, E, Cheung, K, Chevalier, L, Chiarella, V, Chiarelli, G, Chiodini, G, Chisholm, AS, Chitan, A, Chiu, YH, Chizhov, MV, Choi, K, Chomont, AR, Chouridou, S, Chow, YS, Christodoulou, V, Chu, MC, Chudoba, J, Chuinard, AJ, Chwastowski, JJ, Chytka, L, Ciftci, AK, Cinca, D, Cindro, V, Cioara, IA, Ciocca, C, Ciocio, A, Cirotto, F, Citron, ZH, Citterio, M, CillballCall, M, Clark, A, Clark, BL, Clark, MR, Clark, PJ, Clarke, RN, Clement, C, Coadou, Y, Cobal, M, Coccaro, A, Cochran, J, Colasurdo, L, Cole, B, Colijn, AP, Collot, J, Colombo, T, Conde Muino, P, Coniavitis, E, Connell, SH, Connelly, IA, Constantinescu, S, Conti, G, Conventi, F, Cooke, M, Cooper-Sarkar, AM, Cormier, F, Cormier, KJR, Corradi, M, Corriveau, F, Cortes-Gonzalez, A, Cortiana, G, Costa, G, Costa, MJ, Costanzo, D, Cottin, G, Cowan, G, Cox, BE, Cranmer, K, Crawley, SJ, Creager, RA, Cree, G, Crepe-Renaudin, S, Crescioli, F, Cribbs, WA, Cristinziani, M, Croft, V, Crosetti, G, Cueto, A, Donszelmann, T Cuhadar, Cukierman, AR, Cummings, J, Curatolo, M, Cuth, J, Czekierda, S, Czodrowski, P, D'amen, G, D'Auria, S, D'eramo, L, D'Onofrio, M, Da Cunha Sargedas De Sousa, MJ, Da Via, C, Dabrowski, W, Dado, T, Dai, T, Dale, O, Dallaire, F, Dallapiccola, C, Dam, M, Dandoy, JR, Daneri, MF, Dang, NP, Daniells, AC, Dann, NS, Danninger, M, Hoffmann, M Dano, Dao, V, Darbo, G, Dannora, S, Dassoulas, J, Dattagupta, A, Daubney, T, Davey, W, David, C, Davidek, T, Davis, DR, Davison, P, Dawe, E, Dawson, I, De, K, de Asmundis, R, De Benedetti, A, De Castro, S, De Cecco, S, De Groot, N, de Jong, P, De la Torre, H, De Lorenzi, F, De Maria, A, De Pedis, D, De Salvo, A, De Sanctis, U, De Santo, A, Corga, K De Vasconcelos, De Regie, JB De Vivie, Dearnaley, WJ, Debbe, R, Debenedetti, C, Dedovich, DV, Dehghanian, N, Deigaard, I, Del Gaudio, M, Del Peso, J, Delgove, D, Deliot, F, Delitzsch, CM, Dell'Acqua, A, Dell'Asta, L, Dell'Orso, M, Della Pietra, M, della Volpe, D, Delmastro, M, Delporte, C, Delsart, PA, DeMarco, DA, Demers, S, Demichev, M, Demilly, A, Denisov, SP, Denysiuk, D, Derendarz, D, Derkaoui, JE, Derue, F, Dervan, P, Desch, K, Deterre, C, Dette, K, Devesa, MR, Deviveiros, PO, Dewhurst, A, Dhaliwal, S, Di Bello, FA, Di Ciaccio, A, Di Ciaccio, L, Di Clemente, WK, Di Donato, C, Di Girolamo, A, Di Girolamo, B, Di Micco, B, Di Nardo, R, Di Petrillo, KF, Di Simone, A, Di Sipio, R, Di Valentino, D, Diaconu, C, Diamond, M, Dias, FA, Diaz, MA, Diehl, EB, Dietrich, J, Cornell, S Diez, Dimitrievska, A, Dingfelder, J, Dita, P, Dita, S, Dittus, F, Djama, F, Djobava, T, Djuvsland, JI, do Vale, MAB, Dobos, D, Dobre, M, Doglioni, C, Dolejsi, J, Dolezal, Z, Donadelli, M, Donati, S, Dondero, P, Donini, J, Dopke, J, Doria, A, Dova, MT, Doyle, AT, Drechsler, E, Dris, M, Du, Y, Duarte-Campderros, J, Dubreuil, A, Duchovni, E, Duckeck, Ci, Ducourthial, A, Ducu, OA, Duda, D, Dudarev, A, Dudder, A Chr, Duffield, EM, Duflot, L, Duhrssen, M, Dumancic, M, Dignitriu, AE, Duncan, AK, Dunford, M, Yildiz, H Duran, Dueren, M, Durglishvili, A, Duschinger, D, Dutta, B, Duvnjak, D, Dynda, M, Dziedzic, BS, Eckardt, C, Ecker, KM, Edgar, RC, Eifert, T, Eigen, G, Einsweiler, K, Ekelof, T, El Kacimi, M, El Kosseifi, R, Ellajosyula, V, Ellert, M, Elles, S, Ellinghaus, F, Elliot, AA, Ellis, N, Elmsheuser, J, Elsing, M, Emeliyanov, D, Enari, Y, Endner, OC, Ennis, JS, Erdmann, J, Ereditato, A, Ernst, M, Errede, S, Escalier, M, Escobar, C, Esposito, B, Estrada Pastor, O, Etienvre, AI, Etzion, E, Evans, H, Ezhilov, A, Ezzi, M, Fabbri, F, Fabbri, L, Fabiani, V, Facini, G, Fakhrutdinov, RM, Falciano, S, Falla, RJ, Faltova, J, Fang, Y, Fanti, M, Farbin, A, Farilla, A, Farina, C, Farina, EM, Farooque, T, Farrell, S, Farrington, SM, Farthouat, P, Fassi, F, Fassnacht, P, Fassouliotis, D, Giannelli, M Faucci, Favareto, A, Fawcett, WJ, Fayard, L, Fedin, OL, Fedorko, W, Feigl, S, Feligioni, L, Feng, C, Feng, EJ, Feng, H, Fenton, MJ, Fenyuk, AB, Feremenga, L, Fernandez Martinez, P, Fernandez Perez, S, Ferrando, J, Ferrari, A, Ferrari, P, Ferrari, R, de Lima, DE Ferreira, Ferrer, A, Ferrere, D, Ferretti, C, Fiedler, F, Filipcic, A, Filipuzzi, M, Filthaut, F, Fincke-Keeler, M, Finelli, KD, Fiolhais, MCN, Fiorini, L, Fischer, A, Fischer, C, Fischer, J, Fisher, WC, Flasche, N, Fleck, I, Fleischmann, P, Fletcher, RRM, Flick, T, Flierl, BM, Castillo, LR Flores, Flowerdew, MJ, Forcolin, GT, Formica, A, Forster, FA, Forti, A, Foster, AG, Fournier, D, Fox, H, Fracchia, S, Francavilla, P, Franchini, M, Franchino, S, Francis, D, Franconi, L, Franklin, M, Frate, M, Fraternali, M, Freeborn, D, Fressard-Batraneanu, SM, Freund, B, Froidevaux, D, Frost, JA, Fukunaga, C, Fusayasu, T, Fuster, J, Gabaldon, C, Gabizon, O, Gabrielli, A, Gach, GP, Gadatsch, S, Gadomski, S, Gagliardi, G, Gagnon, LG, Galea, C, Galhardo, B, Gallas, EJ, Gallop, BJ, Gallus, P, Galster, G, Gan, KK, Ganguly, S, Gao, Y, Gao, YS, Walls, FM Garay, Garcia, C, Garcia Navarro, JE, Pascual, JA Garcia, Garcia-Sciveres, M, Gardner, RW, Garelli, N, Garonne, V, Bravo, A Gascon, Gasnikova, K, Gatti, C, Gaudiello, A, Gaudio, G, Gavrilenko, IL, Gay, C, Gaycken, G, Gazis, EN, Gee, CNP, Geisen, J, Geisen, M, Geisler, MP, Gellerstedt, K, Gemme, C, Genest, MH, Geng, C, Gentile, S, Gentsos, C, George, S, Gerbaudo, D, Gershon, A, Gessner, G, Ghasemi, S, Ghneimat, M, Giacobbe, B, Giagu, S, Giangiacomi, N, Giannetti, P, Gibson, SM, Gignac, M, Gilchriese, M, Gillberg, D, Gilles, G, Gingrich, DM, Giokaris, N, Giordani, MP, Giorgi, FM, Giraud, PF, Giromini, P, Giugliarelli, G, Giugni, D, Giuli, F, Giuliani, C, Giulini, M, Gjelsten, BK, Gkaitatzis, S, Gkialas, I, Gkougkousis, EL, Gkountoumis, P, Gladilin, LK, Glasman, C, Glatzer, J, Glaysher, PCF, Glazov, A, Goblirsch-Kolb, M, Godlewski, J, Goldfarb, S, Golling, T, Golubkov, D, Gomes, A, Goncalo, R, Goncalves Gama, R, Da Costa, J Goncalves Pinto Firmino, Gonella, G, Gonella, L, Gongadze, A, Gonzalez de la Hoz, S, Gonzalez-Sevilla, S, Goossens, L, Gorbounov, PA, Gordon, HA, Gorelov, I, Gorini, B, Gorini, E, Gorisek, A, Goshaw, AT, Goessling, C, Gostkin, MI, Gottardo, CA, Goudet, CR, Goujdami, D, Goussiou, AG, Govender, N, Gozani, E, Graber, L, Grabowska-Bold, I, Gradin, POJ, Gramling, J, Gramstad, E, Grancagnolo, S, Gratchey, V, Gravila, PM, Gray, C, Gray, HM, Greenwood, ZD, Grefe, C, Gregersen, K, Gregor, M, Grenier, P, Grevtsov, K, Griffiths, J, Grillo, AA, Grimm, K, Grinstein, S, Gris, Ph, Grivaz, J-F, Groh, S, Gross, E, Grosse-Knetter, J, Grossi, GC, Grout, ZJ, Grummer, A, Guan, L, Guan, W, Guenther, J, Guescini, F, Guest, D, Gueta, O, Gui, B, Guido, E, Guillemin, T, Guindon, S, Gul, U, Gumpert, C, Guo, J, Guo, W, Guo, Y, Gupta, R, Gupta, S, Gustavino, G, Gutierrez, P, Ortiz, NG Gutierrez, Gutschow, C, Guyot, C, Guzik, MP, Gwenlan, C, Gwilliam, CB, Haas, A, Haber, C, Hadavand, HK, Haddad, N, Hadef, A, Hageboeck, S, Hagihara, M, Hakobyan, H, Haleem, M, Haley, J, Halladjian, G, Hallewel, GD, Hamacher, K, Hamal, P, Hamano, K, Hamilton, A, Hamity, GN, Hamnett, PG, Han, L, Han, S, Hanagaki, K, Hanawa, K, Hance, M, Haney, B, Hanke, P, Hansen, JB, Hansen, JD, Hansen, MC, Hansen, PH, Hara, K, Hard, AS, Harenberg, T, Hariri, F, Harkusha, S, Harrington, RD, Harrison, PF, Hartmann, NM, Hasegawa, M, Hasegawa, Y, Hasib, A, Hassani, S, Haug, S, Hauser, R, Hauswald, L, Havener, LB, Havranek, M, Hawkes, CM, Hawkings, RJ, Hayakawa, D, Hayden, D, Hays, CP, Hays, JM, Hayward, HS, Haywood, SJ, Head, SJ, Heck, T, Hedberg, V, Heelan, L, Heer, S, Heidegger, KK, Heim, S, Heim, T, Heinemann, B, Heinrich, JJ, Heinrich, L, Heinz, C, Hejbal, J, Helary, L, Held, A, Hellman, S, Helsens, C, Henderson, RCW, Heng, Y, Henkelmann, S, Correia, AM Henriques, Henrot-Versille, S, Herbert, GH, Herde, H, Herget, V, Jimenez, Y Hernandez, Herr, H, Herten, G, Hertenberger, R, Hervas, L, Herwig, TC, Hesketh, GG, Hessey, NP, Hetherly, JW, Higashino, S, Higon-Rodriguez, E, Hildebrand, K, Hi, E, Hi, JC, Hiller, KH, Hillier, SJ, Hils, M, Hinchliffe, I, Hirose, M, Hirschbueh, D, Hiti, B, Hladik, O, Hoad, X, Hobbs, J, Hod, N, Hodgkinson, MC, Hodgson, P, Hoecker, A, Hoeferkamp, MR, Hoenig, F, Hohn, D, Holmes, TR, Homann, M, Honda, S, Honda, T, Hong, TM, Hooberman, BH, Hopkins, WH, Horii, Y, Horton, AJ, Hostachy, J-Y, Hou, S, Hoummada, A, Howarth, J, Hoya, J, Hrabovsky, M, Hrdinka, J, Hristova, I, Hrivnac, J, Hryn'ova, T, Hrynevich, A, Hsu, PJ, Hsu, S-C, Hu, Q, Hu, S, Huang, Y, Hubacek, Z, Hubaut, F, Huegging, F, Huffman, TB, Hughes, EW, Hughes, G, Huhtinen, M, Huo, P, Huseynov, N, Huston, J, Huth, J, Iacobucci, G, Iakovidis, G, Ibragimov, I, Iconomidou-Fayard, L, Idrissi, Z, Iengo, P, Igonkina, O, Iizawa, T, Ikegami, Y, Ikeno, M, Ilchenko, Y, Iliadis, D, Ilic, N, Introzzi, G, Ioannou, P, Iodice, M, Iordanidou, K, Ippolito, V, Isacson, MF, Ishijima, N, Ishino, M, Ishitsuka, M, Issever, C, Istin, S, Ito, F, Ponce, JM Iturbe, Iuppa, R, Iwasaki, H, Izen, JM, Izzo, V, Jabbar, S, Jackson, P, Jacobs, RM, Jain, V, Jakobi, KB, Jakobs, K, Jakobsen, S, Jakoubek, T, Jamin, DO, Jana, DK, Jansky, R, Janssen, J, Janus, M, Janus, PA, Jarlskog, G, 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E, Taiblum, N, Takai, H, Takashima, R, Takasugi, EH, Takeshita, T, Takubo, Y, Talby, M, Talyshey, AA, Tanaka, J, Tanaka, M, Tanaka, R, Tanaka, S, Tanioka, R, Tannenwald, BB, Tapia Araya, S, Tapprogge, S, Tarem, S, Tartarelli, GF, Tas, P, Tasevsky, M, Tashiro, T, Tassi, E, Delgado, A Tavares, Tayalati, Y, Taylor, AC, Taylor, GN, Taylor, PTE, Taylor, W, Teixeira-Dias, P, Temple, D, Ten Kate, H, Teng, PK, Teoh, JJ, Tepel, F, Terada, S, Terashi, K, Terron, J, Terzo, S, Testa, M, Teuscher, RJ, Theveneaux-Pelzer, T, Thiele, F, Thomas, JP, Thomas-Wilskers, J, Thompson, PD, Thompson, AS, Thomsen, LA, Thomson, E, Tibbetts, MJ, Torres, RE Ticse, Tikhomirov, VO, Tikhonov, Yu A, Timoshenko, S, Tipton, P, Tisserant, S, Todome, K, Todorova-Nova, S, Todt, S, Tojo, J, Tokar, S, Tokushuku, K, Tolley, E, Tomlinson, L, Tomoto, M, Tompkins, L, Toms, K, Tong, B, Tornambe, P, Torrence, E, Torres, H, Pastor, E Torro, Toth, J, Touchard, F, Tovey, DR, Treado, CJ, Trefzger, T, Tresoldi, F, Tricoli, A, Trigger, IM, Trincaz-Duvoid, S, Tripiana, MF, Trischuk, W, Trocme, B, Trofymov, A, Troncon, C, Trottier-McDonald, M, Trovatelli, M, Truong, L, Trzebinski, M, Trzupek, A, Tsang, KW, Tseng, JC-L, Tsiareshka, PV, Tsipolitis, G, Tsirintanis, N, Tsiskaridze, S, Tsiskaridze, V, Tskhadadze, EG, Tsui, KM, Tsukerman, II, Tsulaia, V, Tsuno, S, Tsybychev, D, Tu, Y, Tudorache, A, Tudorache, V, Tulbure, TT, Tuna, AN, Tupputi, SA, Turchikhin, S, Turgeman, D, Cakir, I Turk, Turra, R, Tuts, PM, Ucchielli, G, Ueda, I, Ughetto, M, Ukegawa, F, Unal, G, Undrus, A, Unel, G, Ungaro, FC, Unno, Y, Unverdorben, C, Urban, J, Urquijo, P, Urrejola, P, Usai, G, Usui, J, Vacavant, L, Vacek, V, Vachon, B, Vadla, KOH, Vaidya, A, Valderanis, C, Santurio, E Valdes, Valente, M, Valentinetti, S, Valero, A, Valery, L, Valkar, S, Vallier, A, Valls Ferrer, JA, Van Den Wollenberg, W, van der Graaf, H, van Gemmeren, P, van Nieuwkoop, J, van Vulpen, I, van Woerden, MC, Vanadia, M, Vandelli, W, Vaniachine, A, Vankov, P, Vardanyan, G, Vari, R, Varnes, EW, Varni, C, Varol, T, Varouchas, D, Vartapetian, A, Varvell, KE, Vasquez, JG, Vasquez, GA, Vazeille, F, Schroeder, T Vazquez, Veatch, J, Veeraraghavan, V, Veloce, LM, Veloso, F, Veneziano, S, Ventura, A, Venturi, M, Venturi, N, Venturini, A, Vercesi, V, Verducci, M, Verkerke, W, Vermeulen, AT, Vermeulen, JC, Vetterli, MC, Viaux Maira, N, Viazlo, O, Vichou, I, Vickey, T, Boeriu, OE Vickey, Viehhauser, GHA, Viel, S, Vigani, L, Villa, M, Perez, M Villaplana, Vilucchi, E, Vincter, MG, Vinogradov, VB, Vishwakamia, A, Vittori, C, Vivarelli, I, Vlachos, S, Vogel, M, Vokac, P, Volpi, G, von der Schmitt, H, von Toerne, E, Vorobel, V, Vorobev, K, Vos, M, Voss, R, Vossebeld, JH, Vranjes, N, Milosavljevic, M Vranjes, Vrba, V, Vreeswijk, M, Vuillermet, R, Vukotic, I, Wagner, P, Wagner, W, Wagner-Kuhr, J, Wahlberg, H, Wahrmund, S, Wakabayashi, J, Walder, J, Walker, R, Walkowiak, W, Wallangen, V, Wang, C, Wang, F, Wang, H, Wang, J, Wang, Q, Wang, R, Wang, SM, Wang, T, Wang, W, Wang, Z, Wanotayaroj, C, Warburton, A, Ward, CP, Wardrope, DR, Washbrook, A, Watkins, PM, Watson, AT, Watson, MF, Watts, G, Watts, S, Waugh, BM, Webb, AF, Webb, S, Weber, MS, Weber, SW, Weber, SA, Webster, JS, Weidberg, AR, Weinert, B, Weingarten, J, Weirich, M, Weiser, C, Weits, H, Wells, PS, Wenaus, T, Wengler, T, Wenig, S, Wermes, N, Werner, MD, Werner, P, Wessels, M, Weston, TD, Whalen, K, Whallon, NL, Wharton, AM, White, AS, White, A, White, MJ, White, R, Whiteson, D, Whitmore, BW, Wickens, FJ, Wiedenmann, W, Wielers, M, Wiglesworth, C, Wiik-Fuchs, LAM, Wildauer, A, Wilk, F, Wilkens, HG, Williams, HH, Williams, S, Willis, C, Willocq, S, Wilson, JA, Wingerter-Seez, I, Winkels, E, Winklmeier, F, Winston, OJ, Winter, BT, Wittgen, M, Wobisch, M, Wolf, TMH, Wolff, R, Wolter, MW, Wolters, H, Wong, VWS, Worm, SD, Wosiek, BK, Wotschack, J, Wozniak, KW, Wu, M, Wu, SL, Wu, X, Wu, Y, Wyatt, TR, Wynne, BM, Xella, S, Xi, Z, Xia, L, Xu, D, Xu, L, Xu, T, Yabsley, B, Yacoob, S, Yamaguchi, D, Yamaguchi, Y, Yamamoto, A, Yamamoto, S, Yamanaka, T, Yamatani, M, Yamauchi, K, Yamazaki, Y, Yan, Z, Yang, H, Yang, Y, Yang, Z, Yao, W-M, Yap, YC, Yasu, Y, Yatsenko, E, Wong, KH Yau, Ye, J, Ye, S, Yeletskikh, I, Yigitbasi, E, Yildirim, E, Yorita, K, Yoshihara, K, Young, C, Young, CJS, Yu, J, Yuen, SPY, Yusuff, I, Zabinski, B, Zacharis, G, Zaidan, R, Zaitsev, AM, Zakharchuk, N, Zalieckas, J, Zaman, A, Zambito, S, Zanzi, D, Zeitnitz, C, Zemaityte, G, Zemla, A, Zeng, JC, Zeng, Q, Zenin, O, Zenis, T, Zerwas, D, Zhang, D, Zhang, F, Zhang, G, Zhang, H, Zhang, J, Zhang, L, Zhang, M, Zhang, P, Zhang, R, Zhang, X, Zhang, Y, Zhang, Z, Zhao, X, Zhao, Y, Zhao, Z, Zhemchugov, A, Zhou, B, Zhou, C, Zhou, L, Zhou, M, Zhou, N, Zhu, CG, Ziu, H, Zhu, J, Ziu, Y, Zhuang, X, Zhukov, K, Zibell, A, Zieminska, D, Zimine, NI, Zimmermann, C, Zimmermann, S, Zinonos, Z, Zinser, M, Ziolkowski, M, Zivkovic, L, Zobernig, G, Zoccoli, A, Zou, R, zur Nedden, M, Zwalinski, L, and Collaboration, ATLAS
- Subjects
High Energy Physics::Phenomenology ,High Energy Physics::Experiment - Abstract
A search for heavy pseudoscalar (A) and scalar (H) Higgs bosons decaying into a top quark pair (t (t) over bar) has been performed with 20.3 fb(-1) of proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider at a center-of-mass energy root s = 8 TeV. Interference effects between the signal process and standard model t (t) over bar production, which are expected to distort the signal shape from a single peak to a peak-dip structure, are taken into account. No significant deviation from the standard model prediction is observed in the t (t) over bar invariant mass spectrum in final states with an electron or muon, large missing transverse momentum, and at least four jets. The results are interpreted within the context of a type-II two-Higgs-doublet model. Exclusion limits on the signal strength are derived as a function of the mass m(A/H) and the ratio of the vacuum expectation values of the two Higgs fields, tan beta, for m(A/H) > 500 GeV.
- Published
- 2017
4. Neuroestimulación de cordones posteriores y gestación. Evidencia y recomendaciones sobre el uso de la neuroestimulación durante el embarazo y el parto
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López Ortín, P., García Ré, M.E., Yepes Carrillo, A., and García Andrés, M.R.
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- 2017
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5. Microbiological Quality of Apis mellifera L. Honey Samples from Western Paraná, Southern Brazil
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Galhardo Douglas, Garcia Regina C., Schneider Cibele R., Ströher Sandra M., Cerny Bruna L. M., and Chambó Emerson D.
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cladosporium ,denomination of origen ,honeybee ,microbiological safety ,Zoology ,QL1-991 - Abstract
Honey from the western region of Paraná receives the seal of origin and in-process denomination of origin because it is mostly produced in permanent preservation areas, adherence to hygiene and sanitary standards, proper management techniques and agro-industrial management. The objective of this study was to verify the microbiological quality of honey produced by beekeepers associated with Cooperative. Sixty-seven honey samples were evaluated for microbiological quality, and the mean values observed to total aerobic mesophiles were 2.52 log CFU/g; Clostridium spp. 1.46 log CFU/g; total coliforms 0.78 log CFU/g; fecal coliforms 0.50 log CFU/g; total yeasts 0.46 log CFU/g, and 2.95 log CFU/g total molds. The evaluations showed the incidence of anaerobic mesophilic in 70% of the samples, Clostridium spp. 77%; total coliforms 60%, fecal coliforms 62%, molds 83% and 34% yeasts. Five genera of the isolated molds commonly found in honey were Fusarium spp. 0.35 log CFU/g; Aspergillus spp. 0.52 log CFU/g; Cladosporium spp. 1.2 log CFU/g, Phoma spp. 0.71 log CFU/g and 0.16 log CFU/g Penicillium spp. Multivariate analysis showed the formation of two groups and indicated the heterogeneity in the bacterial load of the samples. Although microbiological analyses were not mandatory for honey, these results demonstrated the hygienic-sanitary quality of the samples of honey produced. For the reduction of secondary-origin microorganisms, the handlers were recommended to follow the sanitary hygiene norms and handling techniques.
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- 2020
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6. Factores determinantes en la adopción de crédito de proveedores de las pequeñas empresas manufactureras del Ecuador y su efecto en el incremento de su producción || Determinant factors in adoption of suppliers credit of small manufacturing companies and its effects on the increase of their production
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García Regalado, Jorge Osiris, Zavala Vinces, Jorge, and Sánchez Giler, Sunny
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crédito de proveedores ,teoría fundamentada ,mapa relacional ,instituciones financieras ,factores determinantes ,suppliers credit ,fundamented theory ,relational map ,financial institutions ,determinant factors ,Applied mathematics. Quantitative methods ,T57-57.97 ,Mathematics ,QA1-939 ,Business ,HF5001-6182 - Abstract
En Ecuador el crédito comercial actúa como fuente de financiación entre las pequeñas empresas, sin embargo, existe evidencia acerca del bajo acceso y uso de este tipo de crédito por parte de las pertenecientes al sector de manufacturas, además de que provoca un efecto positivo en la producción de las mismas. El presente trabajo revisa datos secundarios de fuentes oficiales analizando la evolución de la relación entre la producción, medida por sus ventas, y las cuentas por pagar a proveedores e instituciones financieras (2007-2017) de las pequeñas empresas manufactureras ecuatorianas. Se observó que existe una relación directa-positiva de los ingresos y el uso del crédito de proveedores. A través de una modelación econométrica que postula una extensión a la función de producción Cobb-Douglas de carácter modificada, se consideró como argumento adicional la variable “S” crédito de proveedores. Mediante entrevistas en profundidad a gerentes de pequeñas empresas, se exploraron los factores que determinan el uso de crédito de proveedores como alternativa de financiamiento. De esta manera se pudo caracterizar el crédito comercial acorde con la facilidad de obtención, orígenes, fidelidad, mecanismo de pago, que son aspectos que influyen en la decisión del volumen del crédito y el plazo a convenir para tal operación. Así mismo se pudo evidenciar las limitaciones que los empresarios tienen para el acceso hacia el crédito bancario. || In Ecuador the commercial credit acts as a financing source between the small companies, however, exists evidence about the low access and uses of this type of credit by firms belonged to manufacturing sector, furthermore it causes a positive effect on the production of them. In this paper, a review of secondary data from official sources was developed in which series of evolution data about the relationship between production, measured by sales, and accounts payable to suppliers and financial institutions were analyzed. (2007-2017) of the small Ecuadorian manufacturing companies, it was observed that there is a direct-positive relationship between income and the use of credit from suppliers. Through an econometric modeling that postulates an extension to the Cobb-Douglas production function of a modified nature, the variable "S" supplier credit was considered as an additional argument. Through in-depth interviews with managers of small companies, the factors that determine the use of credit from suppliers as an alternative to financing were explored. In this way, commercial credit could be characterized according to the ease of obtaining, origins, loyalty, payment mechanism, that they are aspects that influence in the decision of the volume of the credit and the term to agree for such operation; Likewise, it was possible to demonstrate the limitations that entrepreneurs have for access to bank credit, such as guarantees, high interest rates and non-competitive conditions.
- Published
- 2020
7. Strategic Management of IT Practices in Tourism for Operation and Service Enhancement
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Rubio Sánchez Juan Luis, García Revilla Mercedes Raquel, and Martínez Moure Olga
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IT service administration ,business information ,optimization ,Political institutions and public administration (General) ,JF20-2112 - Abstract
The information technology infrastructure library (ITIL) standard describes processes that should be implemented in Information Technology (IT) departments for proper operations management, which includes human resources management, economic management, and strategic management, among others. This should be especially considered in the business management of industries with no relation to information technologies (IT), such as tourism and hospitality companies. This work aims to present a method to establish the order of adoption of the IT management processes in companies that belong to the tourism industry. We conducted a survey to obtain the necessary data and developed a methodology that is based on an optimization procedure. This procedure generates the optimal sequence of IT tasks to adopt in a generic small company in the tourism industry. The methodology was then applied to a representative tourism company. Through the sequence obtained, it is shown that it is necessary to implement operative processes, and subsequently, strategic processes. A comparative study was developed to find the differences with other authors’ proposals. The most important result we found was the possibility of efficient use of organizations’ information to build an optimized list of IT procedures to improve their administration. The obtained list of processes is specific for each organization, and not dependent on the solutions offered by other authors who proposed a general or underoptimal list of processes.
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- 2022
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8. Transmission Electron Microscopy Study of Defects in Nanopyramidal InGaN LEDs Structures
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Zakharov, DN, primary, Colby, R, additional, Wildeson, IH, additional, Ewoldt, DA, additional, Liang, Z, additional, Zaluzec, NJ, additional, Garcia, RE, additional, Sands, THD, additional, and Stach, EA, additional
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- 2010
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9. Segmentación y valoración del mercado turístico: Estudio del destino Patrimonio de la Humanidad Trinidad de Cuba
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García Reinoso, Nelson
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segmentación de mercado ,turismo cultural ,motivaciones turísticas ,Commerce ,HF1-6182 ,Business ,HF5001-6182 - Abstract
El presente artículo tiene como objetivo identificar los perfiles de los diferentes segmentos de turistas que visitan el destino turístico Trinidad de Cuba, declarada Patrimonio de la Humanidad por la UNESCO en 1998. La metodología parte de un análisis factorial exploratorio y luego una clasificación basada en un algoritmo mixto: clasificación jerárquica con el método de Ward y agregación alrededor de centros móviles (K-medias), se realizó una encuesta aplicada por cuestionario a 484 turistas y excursionistas que visitan el destino por motivaciones turísticas. Los resultados obtenidos permitieron la identificación de dos segmentos de turistas: Turismo cultural patrimonial y Turismo de Naturaleza, que según los resultados de los test estadísticos, ambos grupos difieren significativamente en cuanto a sus rasgos demográficos; características del viaje; relación con el producto o servicio (motivaciones) y evaluación y fidelidad del destino. Este artículo brinda información relevante a actores territoriales involucrados en el turismo, para que puedan mejorar la calidad de sus productos y servicios. Permite renovar productos segmentados para alcanzar un mejor posicionamiento turístico en correspondencia con los perfiles de turistas y el mercado objetivo
- Published
- 2019
10. Radiology Quiz Case 1
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Garcia Re and Smith Jl nd
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medicine.medical_specialty ,Double aortic arch ,Otorhinolaryngology ,business.industry ,medicine ,Surgery ,General Medicine ,TRACHEAL COMPRESSION ,Radiology ,medicine.disease ,business - Published
- 2004
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11. Efectos del canal del crédito sobre el precio de la vivienda nueva en Medellín – Colombia || Credit channel effects on new residential property prices: Evidence from Medellín, Colombia
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García Rendon, John Jairo, Cossio Sepúlveda, Daniel Mateo, and Mesa Urhan, Ricardo
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vivienda nueva ,modelo de oferta y demanda ,UVR ,VARE ,SANR ,MC3E ,Medellín ,Colombia ,new housing ,supply and demand model ,URV ,SVAR ,SUR ,3SLS ,Applied mathematics. Quantitative methods ,T57-57.97 ,Mathematics ,QA1-939 ,Business ,HF5001-6182 - Abstract
El objetivo de esta investigación es analizar el efecto que tiene el canal del crédito en la determinación del precio de la vivienda nueva en Medellín - Colombia. Utilizando un modelo de ecuaciones simultáneas, estimado por sistema de ecuaciones aparentemente no relacionadas y mínimos cuadrados en tres etapas, los principales resultados evidencian que la tasa de interés hipotecaria y el Fondo de Reserva para la Estabilización de la Cartera Hipotecaria (FRECH) son las variables que presentan mayor efecto sobre los precios de la demanda de vivienda nueva; mientras que la tasa de interés presenta una relación inversa con la demanda de vivienda, el FRECH tiene una relación positiva. Una caída del 1% de la tasa de interés hace que el precio del M2 aumente en $COP 46.865. Esto resalta la importancia que tiene el canal del crédito para incentivar el sector constructor de una economía. Además, por medio de un modelo de vectores autorregresivos estructurales, encontramos que el impacto de un choque de la Unidad de Valor Real (UVR) sobre el precio de la vivienda nueva en Medellín es que el precio del metro cuadrado es elástico ante variaciones en la UVR en el corto plazo (2 meses). || We analyze the credit channel effects on new residential property prices in Medellín, Colombia, using a simultaneous equations model. Our empirical results show that the main determinants of new residential properties prices are mortgage interest rates and the availability of government sponsored subsidies to homebuyers (GS). An increase of one percent in mortgage interest rates reduces the demand of new residential properties and increases their price by COP $46,865 per square meter. Greater availability of government of GS increases the demand for new residential properties. Using a structural VAR, we find that a positive shock to a proxy for the real interest rate (unit of real value, URV) of one standard deviation leads to a reduction of the price of new residential properties in Medellín.
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- 2018
12. DE LA UNIÓN SOVIÉTICA A LA COMUNIDAD DE ESTADOS INDEPENDIENTES
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García Reyes, Miguel
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- 1994
13. II. La perestroika: un intento de rescatar el socialismo real
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García Reyes, Miguel
- Published
- 1994
14. III. La transición hacia una economía de libre mercado en la URSS
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García Reyes, Miguel
- Published
- 1994
15. Portadilla
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García Reyes, Miguel
- Published
- 1994
16. Apéndices
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García Reyes, Miguel
- Published
- 1994
17. IV. El papel de las inversiones extranjeras en la transición económica
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García Reyes, Miguel
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- 1994
18. I. La crisis del socialismo real en la Unión Soviética
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García Reyes, Miguel
- Published
- 1994
19. Introducción
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García Reyes, Miguel
- Published
- 1994
20. Dedicatoria
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García Reyes, Miguel
- Published
- 1994
21. Créditos
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García Reyes, Miguel
- Published
- 1994
22. CUBA DESPUÃS DE LA ERA SOVIÃTICA
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García Reyes, Miguel and López de Llergo y Cornejo, María Guadalupe
- Published
- 1994
23. Bibliografía
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García Reyes, Miguel and López de Llergo y Cornejo, María Guadalupe
- Published
- 1994
24. III. Crisis económica y nueva estrategia de desarrollo
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García Reyes, Miguel and López de Llergo y Cornejo, María Guadalupe
- Published
- 1994
25. II. Cuba y la Unión Soviética en los ochenta
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García Reyes, Miguel and López de Llergo y Cornejo, María Guadalupe
- Published
- 1994
26. I. Estrategias económicas en Cuba
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García Reyes, Miguel and López de Llergo y Cornejo, María Guadalupe
- Published
- 1994
27. Índice de Cuadros
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García Reyes, Miguel and López de Llergo y Cornejo, María Guadalupe
- Published
- 1994
28. Síndrome paraneoplásico cerebeloso asociado con carcinoma de ovario
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Romero Fernández, M.C., Hens, M., Moreno Montesinos, J.M., Sánchez Hurtado, M., Gómez Arias, J., Ruiz, I., Rivera Acosta, M.D., García Re, E., and Gilabert, A.
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- 2003
- Full Text
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29. Dedifferentiated chondrosarcomas of the larynx: a report of two cases and review of the literature.
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Garcia RE, Gannon FH, and Thompson LDR
- Published
- 2002
30. Do patient consent procedures affect participation rates in health services research?
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Nelson K, Garcia RE, Brown J, Mangione CM, Louis TA, Keeler E, Cretin S, Nelson, Karin, Garcia, Rosa Elena, Brown, Julie, Mangione, Carol M, Louis, Thomas A, Keeler, Emmett, and Cretin, Shan
- Published
- 2002
- Full Text
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31. Association between telomere length and CYP19 TTTA repetition polymorphism in healthy and breast cancer-diagnosed women
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Murillo-Ortiz B, Martínez-Garza S, Suárez García D, Castillo Valenzuela RDC, García Regalado JF, and Cano Velázquez G
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Telomere length ,CYP19 polymorphism ,breast cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Blanca Murillo-Ortiz,1 Sandra Martínez-Garza,1 David Suárez García,1 Rosa del Carmen Castillo Valenzuela,2 Juan Francisco García Regalado,2 Gerardo Cano Velázquez1 1Institute Mexican of Social Security, Department Oncology, Unit of Research in Clinical Epidemiology, 2Department of Medical Sciences, University of Guanajuato, León Guanajuato, Mexico Introduction: Several studies have reported an increase in breast cancer (BC) risk when patients are carriers of the CYP19 TTA polymorphism with ≥10 repeats; moreover, it has been reported that telomere length is associated with a higher susceptibility of developing cancer. Objective: The objective of this study was to understand the relationship between CYP19 TTTA repetition polymorphism and telomere length and its effects on serum estradiol, estrone and follicle-stimulating hormone (FSH). Materials and methods: A total of 180 postmenopausal healthy and 70 BC-diagnosed women were included. Telomere length was determined through real-time quantitative polymerase chain reaction, and aromatase polymorphism was analyzed through DNA; both samples were obtained from circulating leukocytes. Serum estrone, estradiol and FSH were determined by enzyme-linked immunosorbent assay. Results: Patients with a BC diagnosis showed >10 repetitions more frequently, compared with that of healthy women (50% vs 23%, Χ2 =11.44, p=0.0007). A significant difference in telomere length between healthy and BC women was observed (5,042.7 vs 2,256.7 pb, Z=4.88, p10 repeats. Moreover, telomere length showed an inverse relationship with the number of repeats of the aromatase polymorphism in healthy women (R2=0.04, r= -0.24); in contrast, BC patients did not display this relationship. In addition, telomere length presented an inverse relationship with serum levels of estradiol and estrone in BC patients (p=0.02). Conclusion: Telomere length is shorter in BC patients than in healthy patients. The CYP19 TTTA repeat polymorphism is associated with serum levels of estradiol and estrone in both healthy women and BC patients, being higher in those with polymorphism carriers >10 repeats. Telomere length has an inverse correlation with the number of repeats of the aromatase polymorphism in healthy women but not in BC women. Estradiol and estrone levels in BC women have an inverse relationship with telomere length. Keywords: telomere length, CYP19 polymorphism, breast cancer
- Published
- 2017
32. Randomized, single-blinded comparative study of the efficacy of amoxicillin (40 mg/kg/day) versus standard-dose penicillin V in the treatment of group A streptococcal pharyngitis in children.
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Gopichand I, Williams GD, Medendorp SV, Saracusa C, Sabella C, Lampe JB, Garcia RE, Lebrun L, and Goldfarb J
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- 1998
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33. Molecular Signals in the Trafficking of Toxoplasma gondiiProtein MIC3 to the Micronemes
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El Hajj, Hiba, Papoin, Julien, Ce´re`de, Odile, Garcia-Re´guet, Nathalie, Soe^te, Martine, Dubremetz, Jean-Franc¸ois, and Lebrun, Maryse
- Abstract
ABSTRACTThe protozoan parasite Toxoplasma gondiiis equipped with a sophisticated secretory apparatus, including three distinct exocytic organelles, named micronemes, rhoptries, and dense granules. We have dissected the requirements for targeting the microneme protein MIC3, a key component of T. gondiiinfection. We have shown that MIC3 is processed in a post-Golgi compartment and that the MIC3 propeptide and epidermal growth factor (EGF) modules contain microneme-targeting information. The minimal requirement for microneme delivery is defined by the propeptide plus any one of the three EGF domains. We have demonstrated that the cleavage of the propeptide, the dimerization of MIC3, and the chitin binding-like sequence, which are crucial for host cell binding and virulence, are dispensable for proper targeting. Finally, we have shown that part of MIC3 is withheld in the secretory pathway in a cell cycle-dependent manner.
- Published
- 2008
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34. Estimación del precio de oferta de la energía eléctrica en Colombia mediante inteligencia artificial || Estimating the Spot Market Price Bid in Colombian Electricity Market by Using Artificial Intelligence
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Hurtado Moreno, Laura, Quintero Montoya, Olga Lucía, and García Rendón, John Jairo
- Subjects
mercado eléctrico al contado ,precio ofertado ,Inteligencia Artificial ,Lógica Difusa ,wholesale energy market ,price bid ,Artificial Intelligence ,Fuzzy Logic ,Applied mathematics. Quantitative methods ,T57-57.97 ,Mathematics ,QA1-939 ,Business ,HF5001-6182 - Abstract
Uno de los sectores económicos estratégicos más importantes en cualquier economía es el Mercado de Energía Mayorista, cuya característica fundamental es que se trata de un mercado oligopolístico, provocado por la barrera de entrada que supone tener economías de escala. De esta manera, los agentes pueden presentar comportamientos estratégicos que contribuyen a la maximización de sus utilidades, los cuales se ven reflejados en la oferta diaria del precio y de la cantidad de energía por hora en cada una de sus centrales de generación. En este trabajo se presenta una metodología para la estimación de los precios diarios a los que ofertan la energía que producen los principales recursos hídricos y térmicos en Colombia. Se emplean dos herramientas de Inteligencia Artificial: la Lógica Difusa y las Redes Neuronales. Dichas técnicas resultan ser parcialmente efectivas para seguir las tendencias de dichos precios. También se comparan los resultados con los de modelos autorregresivos, que resultan ser inapropiados para el caso de estudio. || One of the most important economic strategic sectors in any economy is the electricity market. Its main feature is its oligopolistic character favoured by the returns to scale which act as an entry barrier. As a result, the energy generators can use their power market in order to increase their benefits through the daily offered price and quantity of energy for each of their power plants. This paper presents a methodology for estimating the daily offered price of the most important power stations in Colombia (hydraulic and thermal) by applying artificial intelligence techniques: Fuzzy Logic and Neural Networks. Such techniques are found to be partially useful particularly for price tendencies. It also compares the results with autoregressive models that turned out inappropriate for the case of study.
- Published
- 2014
35. Serología en hepatitis virales = Serology in viral hepatitis
- Author
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Jaramillo Aristizábal, María Clara, García Rendón, María Valentina, and Restrepo Gutiérrez, Juan Carlos
- Subjects
Diagnóstico ,Hepatitis ,Hepatitis A ,Hepatitis B ,Hepatitis C ,Hepatitis D ,Serología ,Diagnosis ,Serology ,Medicine ,Medicine (General) ,R5-920 - Abstract
Cuando ocurre infección por el virus de hepatitis A (VHA), virus de hepatitits B (VHB), virus de hepatitis C (VHC) virus de hepatitis D o virus de hepatitis E (VHE) el cuadro clínico y bioquímico es similar, por lo que se hace necesario recurrir a pruebas de laboratorio diferentes a las de función hepática para identificar con certeza el agente etiológico; dentro de estas se encuentran: la serología, que permite detectar antígenos virales o anticuerpos contra estos y las pruebas moleculares que permiten detectar el genoma viral. Para diagnosticar la existencia de una infección actual por alguno de estos virus basta con la realización de pruebas serológicas, excepto en el caso del infección por VHC para la que es necesario realizar detección del genoma viral. Las pruebas moleculares son de gran utilidad para el seguimiento y la toma de decisiones terapéuticas en los pacientes con infección crónica por VHB o VHC.
- Published
- 2011
36. Hemoglobinuria paroxística nocturna y gestación
- Author
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García-Ré, M.E., Guilabert, A., Toledano, C., Hijona, J.J., Gómez-Arias, J., and Torres, J.
- Published
- 2004
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37. Cúpulas comerciais para produção de geléia real e rainhas em colméias de abelhas Apis mellifera
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Garcia Regina Conceição, Souza Darclet Teresinha Malerbo de, and Nogueira-Couto Regina Helena
- Subjects
Apis mellifera ,cúpula real ,produção de rainha ,Agriculture (General) ,S1-972 - Abstract
O objetivo do presente ensaio foi testar quatro tipos comerciais de cúpulas distintas quanto à coloração, altura, volume e diâmetro, na aceitação das larvas transferidas e na produção de geléia real e rainhas. A cúpula que apresentou maior aceitação foi a alaranjada (55,6%), seguida da amarela (37,3%), azul (36,5%) e branca (26,9%). As cúpulas que apresentaram maior peso de geléia real foram branca (347,7 mg), alaranjada (312,3 mg), amarela (284,0 mg) e azul (202,8 mg). O peso das larvas retiradas no momento da coleta de geléia real não apresentou diferença nas cúpulas de diferentes colorações sendo, em média, 42,0 ± 49,6 mg. O peso das rainhas recém-emergidas foi maior na cúpula branca (190,2 mg), seguida da alaranjada (181,0 mg), amarela (175,4 mg) e azul (147,5 mg). O volume das realeiras não apresentou diferença nas cúpulas de diferentes colorações sendo, em média, 822,5 mm³. Com relação às cúpulas de cera, tanto a porcentagem de aceitação quanto a quantidade de geléia real produzida não apresentaram diferença entre os tratamentos. A porcentagem de aceitação nas cúpulas de cera maiores foi 18,2% e nas cúpulas menores, 12,1%. A quantidade de geléia real produzida nas cúpulas de cera menores foi 151,4 mg e nas maiores foi 137,5 mg. As cúpulas branca, alaranjada e amarela apresentaram maior quantidade de geléia real por cúpula (347,7 mg, 312,3 mg e 284,0 mg, respectivamente), entretanto, a maior quantidade total de geléia real produzida por colméia, foi obtida com as cúpulas alaranjadas (1389,40 mg). Para a produção de rainhas também sugere-se o uso das cúpulas alaranjadas
- Published
- 2000
38. Generation and analysis of expressed sequence tags (ESTs) from cambium tissue cDNA libraries of contrasting genotypes of Eucalyptus globulus Labill
- Author
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Elissetche Juan, Salas-Burgos Alexis, Garcia Renan, Iturra Carola, Teixeira Regis, Rodriguez Jaime, and Valenzuela Sofia
- Subjects
Medicine ,Science - Published
- 2011
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39. Genomic of Eucalyptus globulus for pulp and biofuels
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Valenzuela Sofia, García Renán, Elissetche Juan, Rodríguez Jaime, Mendonca Regis, and Balocchi Claudio
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Medicine ,Science - Published
- 2011
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40. Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related virus
- Author
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Garcia Rebecca A, Tang Shaohua, Zheng HaoQiang, Jia Hongwei, Switzer William M, and Satterfield Brent C
- Subjects
Immunologic diseases. Allergy ,RC581-607 - Published
- 2011
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41. Preconceitos no cotidiano escolar - Ensino e medicalização
- Author
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Garcia Regina Leite
- Subjects
Education (General) ,L7-991 - Published
- 1997
42. Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related viruses
- Author
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Zheng HaoQiang, Tang Shaohua, Jia Hongwei, Garcia Rebecca A, Satterfield Brent C, and Switzer William M
- Subjects
Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract In 2009, a newly discovered human retrovirus, xenotropic murine leukemia virus (MuLV)-related virus (XMRV), was reported by Lombardi et al. in 67% of persons from the US with chronic fatigue syndrome (CFS) by PCR detection of gag sequences. Although six subsequent studies have been negative for XMRV, CFS was defined more broadly using only the CDC or Oxford criteria and samples from the US were limited in geographic diversity, both potentially reducing the chances of identifying XMRV positive CFS cases. A seventh study recently found polytropic MuLV sequences, but not XMRV, in a high proportion of persons with CFS. Here we tested blood specimens from 45 CFS cases and 42 persons without CFS from over 20 states in the United States for both XMRV and MuLV. The CFS patients all had a minimum of 6 months of post-exertional malaise and a high degree of disability, the same key symptoms described in the Lombardi et al. study. Using highly sensitive and generic DNA and RNA PCR tests, and a new Western blot assay employing purified whole XMRV as antigen, we found no evidence of XMRV or MuLV in all 45 CFS cases and in the 42 persons without CFS. Our findings, together with previous negative reports, do not suggest an association of XMRV or MuLV in the majority of CFS cases.
- Published
- 2011
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43. PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism
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Satterfield Brent C, Garcia Rebecca A, Gurrieri Fiorella, and Schwartz Charles E
- Subjects
Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirus implicated in prostate cancer and chronic fatigue syndrome (CFS). Press releases have suggested that it could contribute to autism spectrum disorder (ASD). In this study we used two PCR assays and one antibody assay to screen 25 blood samples from autistic children born to mothers with CFS and from 20 mixed controls including family members of the children assayed, people with fibromyalgia and people with chronic Lyme disease. Using a real-time PCR assay, we screened an additional 48 South Carolina autism disorder samples, 96 Italian ASD samples, 61 South Carolina ASD samples and 184 healthy controls. Despite having the ability to detect low copy number XMRV DNA in a large background of cellular DNA, none of the PCR assays found any evidence of XMRV infection in blood cells from patients or controls. Further, no anti-XMRV antibodies were detected, ruling out possible low level or abortive infections in blood or in other reservoirs. These results imply that XMRV is not associated with autism.
- Published
- 2010
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- View/download PDF
44. Body Checking Injuries in National Collegiate Athletic Association Men's Ice Hockey: Findings From the NCAA Injury Surveillance Program 2009/10 to 2019/20.
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Boltz AJ, Garcia RE, Alexander AS, Mihalik JP, Collins CL, and Chandran A
- Subjects
- Humans, Male, Universities, United States epidemiology, Brain Concussion epidemiology, Craniocerebral Trauma epidemiology, Young Adult, Hockey injuries, Athletic Injuries epidemiology
- Abstract
Objective: To describe the epidemiology of body checking injuries in the National Collegiate Athletic Association (NCAA) Men's Ice Hockey., Design: Secondary data analysis of historical cohort data., Setting: A convenience sample of injuries in NCAA Men's Ice Hockey during the 2009/10 to 2019/20 academic years., Patients or Participants: NCAA student-athletes., Independent Variables: Event type, season, time loss, body part, diagnosis, player position, and mechanism., Main Outcome Measures: This study examined injuries that occurred during practice or competition, regardless of time loss, reported to the NCAA Injury Surveillance Program. Injury counts, rates, and proportions were used. The injury rate and proportion ratios with 95% confidence intervals were also constructed. Three independent logistic regression models were constructed to examine differential odds of time loss (≥1 day; TL) injury and the 2 most common injuries, between body checking injuries and all other injuries., Results: Overall, 1290 body checking injuries (rate = 1.59/1000 athlete-exposures) were reported during the study period. Most were attributed to the upper extremity (42%) or head/neck (27%). The competition injury rate generally decreased after 2012/13. After adjusting for covariates, odds of (1) a TL injury was lower and (2) an acromioclavicular sprain was higher among body checking injuries as compared with injuries attributed to all other activities. Odds of concussion was not associated with body checking injuries., Conclusions: Body checking injuries were frequently attributed to the head/neck and upper extremities, and the rate of these injuries during competition appeared to be decreasing. Still, improvements in helmet and shoulder pad technology may further improve health and safety., Competing Interests: For complete transparency, the authors report the following potential conflicts of interest. Mr. A. J. Boltz has been on projects that have been funded by the Department of Defense, National Operating Committee on Standards from Athletic Equipment, National Athletic Trainer’s Association Research and Education Foundation, and National Collegiate Athletic Association. Dr. A. Chandran receives funding from the National Collegiate Athletics Association (NCAA) as Director of the NCAA Injury Surveillance Program and acknowledges funding from the Atlantic Coast Conference. Dr. J. P. Mihalik declares prior (but unrelated) grant support from the National Collegiate Athletic Association. Dr. J. P. Mihalik is a Co-Founder and Chief Science Officer for Senaptec Inc. for whom their technology/products are not discussed in the current study. All authors declare no other potential conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
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45. Sex differences in the association between skeletal muscle energetics and perceived physical fatigability: the Study of Muscle, Mobility and Aging (SOMMA).
- Author
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Gay EL, Coen PM, Harrison S, Garcia RE, Qiao YS, Goodpaster BH, Forman DE, Toledo FGS, Distefano G, Kramer PA, Ramos SV, Molina AJA, Nicklas BJ, Cummings SR, Cawthon PM, Hepple RT, Newman AB, and Glynn NW
- Abstract
Greater perceived physical fatigability and lower skeletal muscle energetics are both predictors of mobility decline. Characterizing associations between muscle energetics and perceived fatigability may provide insight into potential targets to prevent mobility decline. We examined associations of in vivo (maximal ATP production, ATPmax) and ex vivo (maximal carbohydrate supported oxidative phosphorylation [max OXPHOS] and maximal fatty acid supported OXPHOS [max FAO OXPHOS]) measures of mitochondrial energetics with two measures of perceived physical fatigability, Pittsburgh Fatigability Scale (PFS, 0-50, higher = greater) and Rating of Perceived Exertion (RPE Fatigability, 6-20, higher = greater) after a slow treadmill walk. Participants from the Study of Muscle, Mobility and Aging (N = 873) were 76.3 ± 5.0 years old, 59.2% women, and 85.3% White. Higher muscle energetics (both in vivo and ex vivo) were associated with lower perceived physical fatigability, all p < 0.03. When stratified by sex, higher ATPmax was associated with lower PFS Physical for men only; higher max OXPHOS and max FAO OXPHOS were associated with lower RPE Fatigability for both sexes. Higher skeletal muscle energetics were associated with 40-55% lower odds of being in the most (PFS ≥ 25, RPE Fatigability ≥ 12) vs least (PFS 0-4, RPE Fatigability 6-7) severe fatigability strata, all p < 0.03. Being a woman was associated with 2-3 times higher odds of being in the most severe fatigability strata when controlling for ATPmax but not the ex vivo measures (p < 0.05). Better mitochondrial energetics were linked to lower fatigability and less severe fatigability in older adults. Findings imply that improving skeletal muscle energetics may mitigate perceived physical fatigability and prolong healthy aging., (© 2024. The Author(s), under exclusive licence to American Aging Association.)
- Published
- 2024
- Full Text
- View/download PDF
46. Role of Walking Energetics and Perceived Fatigability Differs by Gait Speed: The Study of Muscle, Mobility and Aging (SOMMA).
- Author
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Garcia RE, Blackwell TL, Forman DE, Coen PM, Nicklas BJ, Qiao YS, Cawthon PM, Toledo FGS, Goodpaster BH, Cummings SR, Newman AB, and Glynn NW
- Subjects
- Humans, Male, Female, Aged, Exercise Test methods, Aging physiology, Middle Aged, Aged, 80 and over, Walking Speed physiology, Energy Metabolism physiology, Oxygen Consumption physiology, Fatigue physiopathology, Walking physiology
- Abstract
Background: Slower gait speed may be driven by greater energy deficits and fatigability among older adults. We examined associations of walking energetics and perceived physical fatigability with gait speed among slower and faster walkers. Additionally, we used statistical mediation to examine the role of fatigability in the associations of walking energetics and gait speed using the Study of Muscle, Mobility and Aging (SOMMA)., Methods: Perceived physical fatigability was assessed using the Pittsburgh Fatigability Scale (PFS) Physical score (range 0-50, higher = greater). A 3-phase cardiopulmonary exercise treadmill test collected peak oxygen consumption (VO2peak, mL/kg/min), energetic cost of walking (ECW, mL/kg/m), and cost-capacity ratio (VO2/VO2peak*100, %). Slower (<1.01 m/s) versus faster (≥1.01 m/s) walkers were classified using median 4-m gait speed. Linear regressions and statistical mediation analyses were conducted., Results: Slower walkers had lower VO2peak, higher ECW at preferred walking speed (PWS), and greater PFS Physical score compared to faster walkers (all p < .05; N = 849). One standard deviation (1-SD) higher VO2peak was associated with 0.1 m/s faster gait speed, while 1-SD higher ECW PWS, cost-capacity ratio at PWS and slow walking speed (SWS), and PFS Physical score were associated with 0.02-0.23 m/s slower gait speed. PFS Physical score was a significant statistical mediator in the associations between VO2peak (15.2%), SWS cost-capacity ratio (15.9%), and ECW PWS (10.7%) with gait speed and was stronger among slower walkers., Conclusions: Slower walkers may be more influenced by perceptions of fatigue in addition to walking energetics. Our work highlights the importance of targeting both energetics and perceived fatigability to prevent mobility decline., (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
- Published
- 2024
- Full Text
- View/download PDF
47. Epidemiology of Hamstring Tears in National Collegiate Athletic Association Athletes: Findings From the National Collegiate Athletic Association Injury Surveillance Program Between 2014/2015 and 2018/2019.
- Author
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Boltz AJ, Hooper N, Satalich J, Cheatham S, O'Connell R, Rao N, Garcia RE, Collins CL, and Chandran A
- Subjects
- Humans, Male, Female, United States epidemiology, Universities, Soccer injuries, Young Adult, Athletic Injuries epidemiology, Hamstring Muscles injuries
- Abstract
Objective: To describe the epidemiology of hamstring tears in National Collegiate Athletic Association (NCAA) sports., Design: Descriptive epidemiology study. Athletic trainers from NCAA schools reported injuries to the NCAA Injury Surveillance Program., Setting: A convenience sample of NCAA hamstring tear injuries during the 2014/2015 through 2018/2019 academic years., Patients or Participants: NCAA student-athletes., Independent Variables: Sport, sex, event type, season segment, injury history, and activity at the time of injury., Main Outcome Measures: Injury counts, rates, and proportions were used., Results: Two thousand ninety-six hamstring tears from 8 474 400 athlete-exposures (AEs) were reported (2.47 per 10 000 AEs). Rates were highest in Men's Soccer (5.97 per 10 000 AEs) and Women's Soccer (3.13 per 10 000 AEs), among all Men's and Women's sports, respectively. Competition-related rates in Men's and Women's sports were highest in 2015 to 2016 then followed a decreasing pattern across the remainder of the study period. Among sex-comparable sports, rates were higher in men's (compared with women's) Baseball/Softball, Soccer, and Track and Field. The prevalence of recurrent injuries was comparable among men's (14.8%) and women's (11.5%) sports. Time loss hamstring tears were more prevalent in Men's sports than Women's sports [injury proportion ratio = 1.33; 95% confidence interval, (1.21, 1.47)]., Conclusions: Overall, hamstring tear rates were higher across all Men's sports compared with Women's sports. Rates across event type were comparable in several sports; and so, adjustments to practice are needed considering that practice environments are more modifiable than competitions. Indeed, improving hamstring tear prevention programs to reduce the burden of this injury in NCAA athletes remains critical., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
48. Usual-paced 400 m long distance corridor walk estimates cardiorespiratory fitness among older adults: The Study of Muscle, Mobility and Aging.
- Author
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Garcia RE, Cawthon PM, Nicklas BJ, Goodpaster BH, Coen PM, Forman DE, Cummings SR, Newman AB, and Glynn NW
- Subjects
- Male, Humans, Female, Aged, Aging, Walking physiology, Exercise Test, Fatigue, Muscles, Oxygen Consumption physiology, Cardiorespiratory Fitness
- Abstract
Background: Cardiopulmonary exercise testing (CPET), the gold-standard method to quantify cardiorespiratory fitness (CRF), is not always feasible due to cost, access, and burden. The usual-paced 400 m long distance corridor walk (LDCW), a measure of mobility among older adults, may provide an alternate method to assess CRF. The purpose of this study was to develop and validate an estimating equation to estimate VO
2 peak from average 400 m walking speed (WS) among participants in the Study of Muscle, Mobility and Aging (SOMMA)., Methods: At baseline, women (58%) and men age 70 years and older enrolled in SOMMA (N = 820, 76.2 ± 4.9 years, 86% Non-Hispanic White) completed a 400 m LDCW (400 m WS = 400 m/completion time in seconds) and symptom-limited maximal CPET (Modified Balke Protocol). VO2 peak (mL/kg/min) was considered the highest 30-second average oxygen consumption during CPET. Other covariates included: age, sex, race, physical activity (7-day wrist-worn accelerometer), physical function (Short Physical Performance Battery, range 0-12), perceived physical fatigability (Pittsburgh Fatigability Scale, range 0-50), and Borg Rating of Perceived Exertion (RPE, range 6-20) at completion of the 400 m LDCW. Stepwise linear regression was used. Internal validation was completed using data-splitting method (70%; 30%)., Results: Mean VO2 peak was 20.2 ± 4.8 mL/kg/min and mean 400 m WS was 1.06 ± 0.2 m/s. Each 0.05 m/s increment in 400 m WS was associated with a 0.40 mL/kg/min higher VO2 peak after covariate adjustment. An estimating equation including 400 m WS, age, sex, race, and RPE was developed. Internal validation showed low overall bias (-0.26) and strong correlation (r = 0.71) between predicted and measured VO2 peak values. Bland-Altman plot and regression analyses indicated predicted VO2 peak was an acceptable alternative, despite mean underestimation of 4.53 mL/kg/min among the highly fit., Conclusions: Usual-paced 400 m LDCW strongly correlates with direct measures of CRF during CPET in older adults with lower fitness and can be used to test both fitness and function., (© 2023 The American Geriatrics Society.)- Published
- 2024
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49. A standard canulated screw may not fit up to 1/3 of the patients treated percutaneously for anterior column acetabular fractures-A pilot study.
- Author
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Ruzon UG, Uliana CS, Tomazini GC, Filho JML, Mizerkowski M, Garcia RE, and Abagge M
- Subjects
- Humans, Male, Female, Fracture Fixation, Internal methods, Pilot Projects, Acetabulum diagnostic imaging, Acetabulum surgery, Acetabulum injuries, Bone Screws, Hip Fractures surgery, Spinal Fractures, Fractures, Bone diagnostic imaging, Fractures, Bone surgery
- Abstract
A proper evaluation of the narrowings and length of the anterior acetabular column would offer better predictability and precision for implant insertion in the case of an acetabular fracture., Objective: To determine the diameter and length of the safety corridor of the anterior column of the acetabulum in patients with available pelvic computed tomography (CT), analyze the obtained measurements against those of a standard 6.5-mm implant, and verify possible sex differences regarding these measurements. A secondary aim was to develop a method for measurement of the anterior column of the acetabulum based on CT images., Materials and Methods: In 200 CT scans of hemipelvises we measured the diameter of two areas of narrowing and the length of the safety corridor of the anterior column. The images were submitted to multiplanar reformatting adjusted to a plane orthogonal to the bone corridor, drawn at the level of the superior pubic ramus., Results: Measurement #1 had a mean value of 8.12 (2.27) mm in the overall sample and median values of 9.03 (7.76-10.48) mm in men and 6.77 (5.44-7.19) mm in women. Measurement #2 had a mean value of 7.29 (2.19) mm and median values of 8.23 (7.18-9.82) mm in men and 5.9 (4.65-7.19) mm in women. Measurement #3 had a mean value of 109.53 (13.66) mm in the overall sample and median values of 117.17 (112.9-122.9) mm in men and 100.91 (90.95-111.17) mm in women (p<0.001 all three measurements). Measurement #1 was smaller than 6.5 mm in 22.5% of the patients (of whom 90% were women). Measurement #2 was smaller than 6.5 mm in 35% of the patients (of whom 80% were women)., Conclusions: This study proposed an anatomic evaluation of the anterior column of the acetabulum using conventional CT images The areas of narrowing in the anterior column had an average of 8.12 mm at the level of the pubic tubercle and 7.29 mm at the level of the acetabular fossa. The mean length of the safety corridor was 109.53 mm. In 35% of the cases, a 6.5 mm percutaneous screw would have violated the cortical bone of the safety corridor., Competing Interests: Declaration of Competing Interest The authors have no conflict of interest to declare., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
50. Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion.
- Author
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Sun X, Wu B, Chiang HC, Deng H, Zhang X, Xiong W, Liu J, Rozeboom AM, Harris BT, Blommaert E, Gomez A, Garcia RE, Zhou Y, Mitra P, Prevost M, Zhang D, Banik D, Isaacs C, Berry D, Lai C, Chaldekas K, Latham PS, Brantner CA, Popratiloff A, Jin VX, Zhang N, Hu Y, Pujana MA, Curiel TJ, An Z, and Li R
- Subjects
- Animals, Cell Line, Tumor, Discoidin Domain Receptor 1 antagonists & inhibitors, Discoidin Domain Receptor 1 deficiency, Discoidin Domain Receptor 1 genetics, Disease Models, Animal, Extracellular Matrix immunology, Female, Gene Deletion, Gene Knockout Techniques, Humans, Immunocompetence immunology, Immunotherapy, Mice, T-Lymphocytes cytology, T-Lymphocytes immunology, Triple Negative Breast Neoplasms therapy, Collagen metabolism, Discoidin Domain Receptor 1 metabolism, Extracellular Matrix metabolism, Triple Negative Breast Neoplasms immunology, Triple Negative Breast Neoplasms metabolism, Tumor Escape
- Abstract
Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-negative breast cancer (TNBC)
1 . The extracellular matrix (ECM) contributes to immune exclusion2 . However, strategies to reduce ECM abundance are largely ineffective or generate undesired outcomes3,4 . Here we show that discoidin domain receptor 1 (DDR1), a collagen receptor with tyrosine kinase activity5 , instigates immune exclusion by promoting collagen fibre alignment. Ablation of Ddr1 in tumours promotes the intratumoral penetration of T cells and obliterates tumour growth in mouse models of TNBC. Supporting this finding, in human TNBC the expression of DDR1 negatively correlates with the intratumoral abundance of anti-tumour T cells. The DDR1 extracellular domain (DDR1-ECD), but not its intracellular kinase domain, is required for immune exclusion. Membrane-untethered DDR1-ECD is sufficient to rescue the growth of Ddr1-knockout tumours in immunocompetent hosts. Mechanistically, the binding of DDR1-ECD to collagen enforces aligned collagen fibres and obstructs immune infiltration. ECD-neutralizing antibodies disrupt collagen fibre alignment, mitigate immune exclusion and inhibit tumour growth in immunocompetent hosts. Together, our findings identify a mechanism for immune exclusion and suggest an immunotherapeutic target for increasing immune accessibility through reconfiguration of the tumour ECM., (© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)- Published
- 2021
- Full Text
- View/download PDF
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