4 results on '"Garcia JMP"'
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2. The stool antigen test for detection of Helicobacter pylori after eradication therapy.
- Author
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Vaira D, Vakil N, Menegatti M, van't Hoff B, Ricci C, Gatta L, Gasbarrini G, Quina M, Garcia JMP, van der Ende A, van der Hulst R, Anti M, Duarte C, Gisbert JP, Miglioli M, Tytgat G, Vaira, Dino, Vakil, Nimish, Menegatti, Marcello, and van't Hoff, Ben
- Abstract
Background: Current noninvasive tests to confirm the eradication of Helicobacter pylori must be performed 4 weeks or more after eradication therapy is completed.Objective: To determine whether the stool antigen test, a relatively new noninvasive test for H. pylori, administered at various times after eradication therapy correctly identifies persons with persistent H. pylori infection.Design: Prospective blinded study.Setting: Six clinical centers in the United States and Europe.Patients: 84 H. pylori --infected patients undergoing endoscopy for upper abdominal symptoms.Measurements: At baseline and on day 35 after the completion of triple eradication therapy, all patients underwent endoscopy with histologic examination, rapid urease test and culture, urea breath test, and a stool antigen test. The stool antigen test was also performed on days 3, 7, 15, 21, 28, and 35 after completion of therapy.Results: Compared with the gold-standard endoscopic tests on day 35 after antimicrobial therapy, the urea breath test had a sensitivity of 94% (95% CI, 71% to 100%) and a specificity of 100% (CI, 94% to 100%). The stool antigen test had a sensitivity of 94% (CI, 71% to 100%) and a specificity of 97% (CI, 89% to 100%). On day 7 after treatment, the stool antigen test was predictive of eradication (positive predictive value, 100% [CI, 69% to 100%]; negative predictive value, 91% [CI, 82% to 97%]).Conclusion: A positive result on the stool antigen test 7 days after completion of therapy identifies patients in whom eradication of H. pylori was unsuccessful. [ABSTRACT FROM AUTHOR]- Published
- 2002
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3. Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
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Khatri, C, Ward, AE, Nepogodiev, D, Ahmed, I, Chaudhry, D, Dhaif, F, Bankhad-Kendall, B, Kaafarani, H, Bretherton, C, Mahmood, A, Marais, L, Parsons, N, Bhangu, A, Metcalfe, A, Siaw-Acheampong, K, Dawson, BE, Evans, JP, Glasbey, JC, Gujjuri, RR, Heritage, E, Jones, CS, Kamarajah, SK, Keatley, JM, Lawday, S, Li, E, Mckay, SC, Pellino, G, Tiwari, A, Simoes, JFF, Trout, IM, Venn, ML, Wilkin, RJW, Ademuyiwa, AO, Agarwal, A, Al Ameer, E, Alderson, D, Alser, O, Arnaud, AP, Augestad, KM, Bankhead-Kendall, B, Benson, RA, Chakrabortee, S, Blanco-Colino, R, Brar, A, Bravo, A Minaya, Breen, KA, Buarque, I Lima, Caruana, E, Cunha, MF, Davidson, GH, Desai, A, Di Saverio, S, Edwards, J, Elhadi, M, Farik, S, Fiore, M, Fitzgerald, JE, Ford, S, Gallo, G, Ghosh, D, Gomes, GMA, Griffiths, E, Halkias, C, Harrison, EM, Hutchinson, P, Isik, A, Kolias, A, Lawani, I, Lederhuber, H, Leventoglu, S, Loffler, MW, Martin, J, Mashbari, H, Mazingi, D, Mohan, H, Moore, R, Moszkowicz, D, Ng-Kamstra, JS, Metallidis, S, 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Lacy, FB, Morales, X, Carreras-Castaner, A, Torner, P, Jornet-Gibert, M, Balaguer-Castro, M, Renau-Cerrillo, M, Camacho-Carrasco, P, Vives-Barquiel, M, Campuzano-Bitterling, B, Gracia, I, Pujol-Muncunill, R, Gomez, ME, Padilla-Valverde, D, Sanchez-Garcia, S, Sanchez-Pelaez, D, Higuera, EJ, Rodriguez, RP, Camunas, AF, Martinez-Pinedo, C, Santos, EPG, Munoz-Atienza, V, Perez, AM, Cano, CALD, Crego-Vita, D, Huecas-Martinez, M, Domenech, J, Anon, AR, Sanguesa, MJ, Bernal-Sprekelsen, JC, Bauset, JCC, Ferrer, PR, Perez, CM, Gil-Albarova, O, Estelles, JG, Aghababyan, K, Rivas, R, Rivas, F, Escartin, J, Laina, JLB, Nogues, A, Cros, B, El-Abur, IT, Egea, JG, Yanez, C, Kauppila, JH, Sarjanoja, E, Tzedakis, S, Bouche, PA, Gaujoux, S, Gossot, D, Seguin-Givelet, A, Fuks, D, Grigoroiu, M, Salas, RS, Cathelineau, X, Macek, P, Barbe, Y, Rozet, F, Barret, E, Mombet, A, Cathala, N, Brian, E, Zadegan, F, Conso, C, Baldwin, AJ, West, R, Gammeri, E, Catton, A, Kouris, SM, Pereca, J, Singh, J, Patel, P, Handa, S, Kaushal, M, Kler, A, Reghuram, V, Tezas, S, Oktseloglou, V, Mosley, F, Monroy, MFID, Bobak, P, Omar, I, Ahad, S, Langlands, F, Brown, V, Hashem, M, Williams, A, Ridgway, A, Pournaras, D, Britton, E, Lostis, E, Ambler, GK, Chu, H, Hopkins, J, Manara, J, Chan, M, Doe, M, Moon, RDC, Jichi, T, Singleton, W, Mannion, R, Ramzi, J, Mohan, M, Singh, AA, Ashcroft, J, Baker, OJ, Coughlin, P, Davies, RJ, Durst, AZED, Abood, A, Habeeb, A, Hudson, VE, Lamb, B, Luke, L, Mitrasinovic, S, Murphy, S, Ngu, AWT, O'Neill, JR, Waseem, S, Wong, K, Georgiades, F, Hutchinson, PJ, Tan, XS, Pushpa-rajah, J, Colquhoun, A, Masterson, L, Abu-Nayla, I, Walker, C, Balakrishnan, A, Rooney, S, Irune, E, Byrne, MHV, Durrani, A, Richards, T, Venkatesan, AS, Combellack, T, Williams, J, Tahhan, G, Mohammed, M, Kornaszewska, M, Valtzoglou, V, Deglurkar, I, Rahman, M, Von Oppell, U, Mehta, D, Koutentakis, M, Chek, SAHSN, Hill, G, Morris, C, Shinkwin, M, Torkington, J, Cornish, J, Houston, R, Mannan, S, Ayeni, F, Tustin, H, Bordenave, M, Robson, A, Manu, N, Eardley, N, Krishnan, E, Serevina, OL, Martin, E, Smith, C, Jones, A, Mahapatra, SR, Clifford, R, Matthews, W, Mohankumar, K, Khawaja, I, Palepa, A, Doulias, T, Premakumar, Y, Jauhari, Y, Koshnow, Z, Bowen, D, Uberai, A, Hirri, F, Stubbs, BM, McDonald, C, Manickavasagam, J, Ragupathy, K, Davison, S, Dalgleish, S, McGrath, N, Kanitkar, R, Payne, CJ, Ramsay, L, Ng, CE, Collier, T, Khan, K, Evans, R, Brennan, C, Henshall, DE, Drake, T, Zamvar, V, Tambyraja, A, Skipworth, RJE, Linder, G, McGregor, R, Brennan, P, Mayes, J, Ross, L, Smith, S, White, T, Jamjoom, AAB, Pasricha, R, Holme, T, Abbott, S, Razik, A, Thrumurthy, S, Steinke, J, Baker, M, Howden, D, Baxter, Z, Osagie, L, Bence, M, Fowler, GE, Massey, L, Rajaretnam, N, Evans, J, John, J, Goubran, A, Campain, N, McDermott, FD, McGrath, JS, Ng, M, Pascoe, J, Phillips, JRA, Daniels, IR, Raptis, DA, Pollok, JM, Machairas, N, Davidson, B, Fusai, G, Soggiu, F, Xyda, S, Salinas, CH, Tzerbinis, H, Pissanou, T, Gilliland, J, Chowdhury, S, Varcada, M, Hart, C, Mirnezami, R, Knowles, J, Angamuthu, N, Vijay, V, Shakir, T, Hasan, R, Tansey, R, Ross, E, Loubani, M, Wilkins, A, Cao, H, Capitelli-McMahon, H, Hitchman, L, Ikram, H, Andronic, A, Ibrahim, AA, Totty, J, Tayeh, S, Chase, T, Humphreys, L, Ayorinde, J, Ghanbari, A, Cuming, T, Williams, K, Chung, E, Hagger, R, Karim, A, Hainsworth, A, Flatman, M, Trompeter, A, Hing, C, Tsinaslanidis, P, Benjamin, MW, Leyte, A, Tan, C, Smelt, J, Vaughan, P, Santhirakumaran, G, Hunt, I, Raza, M, Labib, A, Luo, X, Sudarsanam, A, Rolls, A, Lyons, O, Onida, S, Shalhoub, J, Sugand, K, Park, C, Sarraf, KM, Erridge, S, Kinross, J, Denning, M, Yalamanchili, S, Abuown, A, Ibrahim, M, Martin, G, Davenport, D, Wheatstone, S, Andreani, S, Bath, MF, Sahni, A, Judkins, N, Springford, LR, Sohrabi, C, Bacarese-Hamilton, J, Taylor, FG, Patki, P, Tanabalan, C, Reynolds, J, Alexander, ME, Smart, CJ, Stylianides, N, Abdalla, M, Newton, K, Bhatia, K, Edmondson, R, Abdeh, L, Jones, D, Zeiton, M, Ismail, O, Naseem, H, Advani, R, Fell, A, Smith, A, Nikolaou, S, English, C, Kristinsson, S, Oni, T, Ilahi, N, Ballantyne, K, Woodward, Z, Merh, R, Robertson-Smith, B, Mahmoud, A, Ameerally, P, Finch, JG, Gnanachandran, C, Pop, I, Rogers, M, Yousef, Y, Woods, R, Zahid, H, Mundy, G, Dass, D, Ford, D, Khan, J, Thiruchandran, G, Toh, SKC, Ahmad, Y, Allana, A, Bellis, C, Babawale, O, Phan, YC, Lokman, U, Ismail, M, Koc, T, Witek, A, Duggleby, L, Shamoon, S, Stefan, S, Clancy, H, Singh, S, Mukherjee, S, Ferguson, D, Mansuri, A, Thakrar, A, Wickramarachchi, L, Cuthbert, R, Sivayoganathan, S, Chui, K, Karam, E, Dott, C, Singh, R, Lane, J, Colvin, HV, Badran, A, Cadersa, A, Cumpstey, A, Hamady, Z, Aftab, R, Wensley, F, Byrne, J, Morrison-Jones, V, Sekhon, GK, Shields, H, Shakoor, Z, Yener, A, Talbot, T, Alzetani, A, Cresner, R, Johnson, D, Hughes, I, Hall, J, Rooney, J, Chatterji, S, Zhang, Y, Owen, R, Rudic, M, Hunt, J, Zakai, D, Aladeojebi, A, Ali, M, Gaunt, A, Barmayehvar, B, Kitchen, M, Gowda, M, Mansour, F, Jarvis, M, Halliday, E, Lefroy, R, Nanjaiah, P, Ali, S, Lin, DJ, Rajgor, AD, Scurrah, RJ, Kang, C, Watson, LJ, Harris, G, Royle, T, Cunningham, Y, James, G, Steel, B, Luk, ACO, Stables, G, Doorgakant, A, Thiruvasagam, VG, Carter, J, Reid, S, Mohammed, R, Marlow, W, Ferguson, H, Wilkin, R, Konstantinou, C, Yershov, D, Vatish, J, Denning, A, Das, R, Powell, S, Magee, C, Agarwal, K, Mangos, E, Nambirajan, T, Flindall, I, Mahendran, V, Hanson, A, De Marchi, J, Hill, A, Farrell, T, Davis, NF, Kearney, D, Nelson, T, Picciariello, A, Papagni, V, Altomare, DF, Granieri, S, Cotsoglou, C, Cabeleira, A, Branco, C, Serralheiro, P, Alves, R, Teles, T, Lazaro, A, Canhoto, C, Simoes, J, Costa, M, Almeida, AC, Nogueira, O, Oliveira, A, Nemesio, RA, Silva, M, Lopes, C, Amaral, MJ, da Costa, AV, Andrade, R, Martins, R, Guimaraes, A, Guerreiro, P, Ruivo, A, Camacho, C, Duque, M, Santos, E, Breda, D, Oliveira, JM, Lopez, ALD, Garrido, S, Colino, M, De Barros, J, Correia, S, Rodrigues, M, Cardoso, P, Teixeira, J, Soares, AP, Morais, H, Pereira, R, Revez, T, Manso, MI, Domingues, JC, Henriques, P, Ribeiro, R, Ribeiro, VI, Cardoso, N, Sousa, S, dos Santos, SM, Miranda, P, Garrido, R, Ferreira, MP, Ascensao, J, Costeira, B, Cunha, C, Rodrigues, LR, Fernandes, MS, Azevedo, P, Ribeiro, J, Lourenco, I, Gomes, H, Mendinhos, G, Pinto, AN, dos Santos, GM, Taflin, H, Abdou, H, Diaz, J, Richmond, M, Clark, J, O'Meara, L, Hanna, N, Cooper, Z, Salim, A, Hirji, SA, Brown, A, Chung, C, Hansen, L, Okafor, BU, Roxo, V, Raut, CP, Jolissaint, JS, Mahvi, DA, Reinke, C, Ross, S, Thompson, K, Manning, D, Perkins, R, Volpe, A, Merola, S, Ssentongo, A, Ssentongo, P, Oh, JS, Hazelton, J, Maines, J, Gusani, N, Garner, M, Horvath, S, Martin, RCG, Bhutiani, N, Choron, R, Peck, G, Soliman, F, Rehman, S, Abbas, A, Soliman, A, Kim, B, Jones, C, Dauer, MDE, Renza-Stingone, E, Hernandez, E, Gokcen, E, Kropf, E, Sufrin, H, Hirsch, H, Ross, H, Engel, J, Sewards, J, Poggio, J, Sanserino, K, Rae, L, Philp, M, Metro, M, McNelis, P, Petrov, R, Pazionis, T, Quintana, M, Jackson, H, Lumenta, DB, Nischwitz, SP, Richtig, E, Pau, M, Srekl-Filzmaier, P, Eibinger, N, Michelitsch, B, Fediuk, M, Papinutti, A, Seidel, G, Kahn, J, Cohnert, TU, Kantor, E, Kahiu, J, Hossain, N, Hosny, S, Sultana, A, Taggarsi, M, Vitone, L, Lambert, J, Vaz, OP, Sarantitis, I, Shrestha, D, Timbrell, S, Shugaba, A, Jones, GP, Gardner, A, Tripathi, SS, Greenhalgh, MS, Emerson, H, Vejsbjerg, K, McCormick, W, Fisher, A, Singisetti, K, Aawsaj, Y, Barry, C, Blanco, J, Vanker, R, Ghobrial, M, Jones, G, Kanthasamy, S, Fawi, H, Awadallah, M, Chen, F, Cheung, J, Tingle, S, Abbadessa, F, Sachdeva, A, Rai, B, Chan, CD, McPherson, I, Booth, K, Ali, FM, Pandanaboyana, S, Grainger, T, Nandhra, S, Patience, A, Rogers, A, Roy, C, Williams, T, Dawe, N, McCaffer, C, Riches, J, Bhattacharya, S, Moir, J, Kalson, NS, Ahmed, HE, Mellor, C, Saleh, C, Koshy, RM, Hammond, J, Sanderson, L, Wahed, S, Phillips, AW, Ghosh, K, Rogers, LJ, Labib, PL, Miller, D, Minto, G, Hope, N, Marchbank, A, Emslie, K, Panahi, P, Ho, B, Perkins, C, Clough, E, Roy, H, Enemosah, I, Campbell, R, Natale, J, Gohil, K, Rela, M, Raza, N, Menakaya, C, Webb, JI, Antar, M, Modi, N, Sofat, R, Noel, J, Nunn, R, Adegbola, S, Eriberto, F, Sharma, V, Tanna, R, Lodhia, S, Carvalho, L, Osorio, C, Antunes, J, Lourenco, S, Balau, P, Godinho, M, Pereira, A, Keller, DS, Smart, NJ, Apollo - University of Cambridge Repository, Collaborative, COVIDSurg, and Robotics and image-guided minimally-invasive surgery (ROBOTICS)
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Male ,medicine.medical_specialty ,Multivariate analysis ,MORTALITY-RATES ,hip ,SURGERY ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MULTICENTER ,COVIDSurg Collaborative ,1117 Public Health and Health Services ,Cohort Studies ,Medicine, General & Internal ,Internal medicine ,General & Internal Medicine ,medicine ,Dementia ,Humans ,Prospective Studies ,Aged, 80 and over ,COMPLICATIONS ,Science & Technology ,HIP-FRACTURES ,business.industry ,Hip Fractures ,SARS-CoV-2 ,COVID-19 ,1103 Clinical Sciences ,General Medicine ,Femoral fracture ,Perioperative ,medicine.disease ,Heart failure ,trauma management ,Medicine ,Surgery ,business ,Life Sciences & Biomedicine ,Femoral Fractures ,Kidney disease ,Cohort study ,1199 Other Medical and Health Sciences - Abstract
ObjectivesStudies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
- Published
- 2021
4. First Report of a 16SrIII-L Phytoplasma Associated with Frogskin Disease in Cassava (Manihot esculenta Crantz) in Brazil.
- Author
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Oliveira SAS, Abreu EFM, Araújo TS, Oliveira EJ, Andrade EC, Garcia JMP, and Álvarez E
- Abstract
Cassava (Manihot esculenta Crantz) is a major staple crop in developing countries and a large source of raw material for industrial purposes as flour, starch, and ethanol. In July 2012, 24 cassava genotypes (corresponding to 1.85% of the accessions) with typical symptoms of frogskin disease (CFSD) were observed in one of the maintenance areas of the Brazilian Cassava Germplasm (located at Embrapa Cassava & Fruits, Cruz das Almas, Bahia State, Brazil). All diseased plants were asymptomatic on the aboveground parts (leaves and stem). However, for accessions BGM 880, BGM 1094, BGM 1100, BGM 1212, BGM 1218, and BGM 1526, all roots showed a woody appearance, thickened cork-like peel with opaque aspect, and coalescent lip-like slits in a honeycomb pattern. Based on literature description, two pathogens could be associated with CFSD: a dsRNA virus (belonging to family Reoviridae) and a 16SrIII-L phytoplasma (1). To investigate the presence of phytoplasma associated with the CFSD symptoms, total DNA was extracted from 0.5 g of root tissue collected from both symptomatic and asymptomatic roots by scratching the secondary vessel at the center of the cassava root with a CTAB method. The nested PCR was carried out using phytoplasma-specific primer set P1/Tint followed by R16F2n/R16R2, targeting the 16S rRNA gene sequence of 1.2 kb in length, for the final reaction (4). No phytoplasma was detected in asymptomatic cassava roots that were sampled from the same field. A posterior extraction of total RNA was made but no dsRNA was noticed on the agarose gel, and reaction of RT-PCR with specific primers (2) had no amplification. In order to characterize the strains, the 1.2-kb amplicon was digested with BamHI, MseI, MspI, KpnI, and TaqI endonucleases. The resulting patterns indicated that the symptomatic accessions were infected with a phytoplasma belonging to the 16SrIII group, sharing similarities with pseudo gel mapping from the reference strain of Peach X-Disease Phytoplasma (GenBank Accession No. L33733). Nested PCR products from accessions BGM 1526 and BGM 1212 were purified and sequenced by Macrogen, (Seoul, South Korea) in both directions, manually edited, and the consensus sequences were deposited in the NCBI database (GenBank Accession Nos. KF019184 and KF019185). Phylogenetic studies were conducted based on maximum parsimony, neighbor-joining, and maximum likelihood analysis for 16S rRNA. The phytoplasma 16S rRNA gene sequences from both strains had 99% identity (P < 0.0001) with the 16SrIII-L CFSD phytoplasma (EU346761 and AY737647), described by Alvarez et al. (1) infecting cassava in Colombia. To our knowledge, this is the first report of a phytoplasma associated with Cassava Frogskin Disease in Brazil, where only the dsRNA virus was recognized as causing this symptom (3). This is not likely to be an isolated case, and possibly more cassava plants are infected with this phytoplasma in Brazil. Due to the difficulties to observe the symptoms at the field level, this could be an emerging disease in that country. References: (1) E. Alvarez et al. Plant. Dis. 93:1139, 2009. (2) L. A. Calvert et al. J. Phytopathol. 156:647, 2008. (3) L. S. Poltroniere et al. Comun. Tec., Belem-PA. 006:2p, 1999. (4) C. D. Smart et al. Appl. Environ. Microb. 62:2988, 1996.
- Published
- 2014
- Full Text
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