1. Serum Collagen Type II Cleavage Epitope and Serum Hyaluronic Acid as Biomarkers for Treatment Monitoring of Dogs with Hip Osteoarthritis
- Author
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Ramón Cugat, Joaquin Sopena, Montserrat García-Balletbó, José M. Carrillo, M.M. Granados, Belén Cuervo, Giuseppe Spinella, Mónica Rubio, Juan M. Domínguez, José J. Cerón, Asta Tvarijonaviciute, Jos M. Vilar, UCH. Departamento de Medicina y Cirugía Animal, Vilar, Jos M., Rubio, Mnica, Spinella, Giuseppe, Cuervo, Beln, Sopena, Joaqun, Cugat, Ramn, Garcia Balletb, Montserrat, Dominguez, Juan M., Granados, Maria, Tvarijonaviciute, Asta, Ceron, Jos J., and Carrillo, Jos M.
- Subjects
Hyaluronic acid - Therapeutic use ,Pathology ,Physiology ,Biopsy ,lcsh:Medicine ,Adipose tissue ,Osteoarthritis ,Ácido hialurónico - Uso terapéutico ,Serum Hyaluronic Acid ,Biochemistry ,Osteoarthritis, Hip ,Epitope ,0403 veterinary science ,Epitopes ,chemistry.chemical_compound ,0302 clinical medicine ,Hyaluronic acid ,Medicine and Health Sciences ,Medicine ,Crecimiento - Factores - Uso terapéutico ,Hyaluronic Acid ,lcsh:Science ,Musculoskeletal System ,Mammals ,Growth factors - Therapeutic use ,Multidisciplinary ,medicine.diagnostic_test ,Medicine (all) ,Hematology ,04 agricultural and veterinary sciences ,Biomechanical Phenomena ,Body Fluids ,Blood ,Veterinary Diseases ,Connective Tissue ,Vertebrates ,Anatomy ,Research Article ,medicine.medical_specialty ,040301 veterinary sciences ,Células madre - Uso terapéutico ,Type II collagen ,Surgical and Invasive Medical Procedures ,Osteoartritis en los perros - Tratamiento ,Pelvis ,Stem cells - Therapeutic use ,Clinical study ,03 medical and health sciences ,Dogs ,Internal medicine ,Animals ,Perros - Locomoción ,Collagen Type II ,030203 arthritis & rheumatology ,Biochemistry, Genetics and Molecular Biology (all) ,Hip ,Dogs - Locomotion ,Osteoarthritis in dogs - Treatment ,business.industry ,lcsh:R ,Mesenchymal stem cell ,Organisms ,Biology and Life Sciences ,Proteins ,Articulaciones - Enfermedades - Tratamiento ,Joints - Diseases - Treatment ,medicine.disease ,Biological Tissue ,Cartilage ,Endocrinology ,Agricultural and Biological Sciences (all) ,chemistry ,lcsh:Q ,Veterinary Science ,business ,Collagens ,Biomarkers ,Follow-Up Studies ,Articular Cartilage - Abstract
Este artículo se encuentra disponible en la siguiente URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149472 The aim of this study was to evaluate the use of serum type II collagen cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring in osteoarthritic dogs. For this purpose, a treatment model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich in growth factors was used. This clinical study included 10 dogs with hip osteoarthritis. Both analytes were measured in serum at baseline, just before applying the treatment, and 1, 3, and 6 months after treatment. These results were compared with those obtained from force plate analysis using the same animals during the same study period. Levels of type II collagen cleavage epitope decreased and those of hyaluronic acid increased with clinical improvement objectively verified via force plate analysis, suggesting these two biomarkers could be effective as indicators of clinical development of joint disease in dogs.
- Published
- 2016
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