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164 results on '"Garcia, M. T."'

1. Performance of the CMS High Granularity Calorimeter prototype to charged pion beams of 20$-$300 GeV/c

Author

Acar, B., Adamov, G., Adloff, C., Afanasiev, S., Akchurin, N., Akgün, B., Alhusseini, M., Alison, J., de Almeida, J. P. Figueiredo de sa Sousa, de Almeida, P. G. Dias, Alpana, A., Alyari, M., Andreev, I., Aras, U., Aspell, P., Atakisi, I. O., Bach, O., Baden, A., Bakas, G., Bakshi, A., Banerjee, S., DeBarbaro, P., Bargassa, P., Barney, D., Beaudette, F., Beaujean, F., Becheva, E., Becker, A., Behera, P., Belloni, A., Bergauer, T., Berni, M. El, Besancon, M., Bhattacharya, S., Bhowmik, D., Bilki, B., Bilokin, S., Blazey, G. C., Blekman, F., Bloch, P., Bodek, A., Bonanomi, M., Bonis, J., Bonnemaison, A., Bonomally, S., Borg, J., Bouyjou, F., Bower, N., Braga, D., Brennan, L., Brianne, E., Brondolin, E., Bryant, P., Buhmann, E., Buhmann, P., Butler-Nalin, A., Bychkova, O., Callier, S., Calvet, D., Canderan, K., Cankocak, K., Cao, X., Cappati, A., Caraway, B., Caregari, S., Carty, C., Cauchois, A., Ceard, L., Cerci, D. S., Cerci, S., Cerminara, G., Chadeeva, M., Charitonidis, N., Chatterjee, R., Chen, J. A., Chen, Y. M., Cheng, H. J., Cheng, K. Y., Cheung, H., Chokheli, D., Cipriani, M., Čoko, D., Couderc, F., Cuba, E., Danilov, M., Dannheim, D., Daoud, W., Das, I., Dauncey, P., Davies, G., Davignon, O., Day, E., Debbins, P., Defranchis, M. M., Delagnes, E., Demiragli, Z., Demirbas, U., Derylo, G., Diaz, D., Diehl, L., Dinaucourt, P., Dincer, G. G., Dittmann, J., Dragicevic, M., Dugad, S., Dulucq, F., Dumanoglu, I., Dünser, M., Dutta, S., Dutta, V., Edberg, T. K., Elias, F., Emberger, L., Eno, S. C., Ershov, Yu., Extier, S., Fahim, F., Fallon, C., Fard, K. Sarbandi, Fedi, G., Ferragina, L., Forthomme, L., Frahm, E., Franzoni, G., Freeman, J., French, T., Gadow, K., Gandhi, P., Ganjour, S., Gao, X., Garcia, M. T. Ramos, Garcia-Bellido, A., Garutti, E., Gastaldi, F., Gastler, D., Gecse, Z., Germer, A., Gerwig, H., Gevin, O., Ghosh, S., Gilbert, A., Gilbert, W., Gill, K., Gingu, C., Gninenko, S., Golunov, A., Golutvin, I., Gonultas, B., Gorbounov, N., Göttlicher, P., Gouskos, L., Graf, C., Gray, A. B., Grieco, C., Gr\"önroos, S., Gu, Y., Guilloux, F., Guler, E. Gurpinar, Guler, Y., Gülmez, E., Guo, J., Gutti, H., Hakimi, A., Hammer, M., Hartbrich, O., Hassanshahi, H. M., Hatakeyama, K., Hazen, E., Heering, A., Hegde, V., Heintz, U., Heuchel, D., Hinton, N., Hirschauer, J., Hoff, J., Hou, W. S., Hou, X., Hua, H., Huck, S., Hussain, A., Incandela, J., Irles, A., Irshad, A., Isik, C., Jain, S., Jaroslavceva, J., Jheng, H. R., Joshi, U., Kaadze, K., Kachanov, V., Kalipoliti, L., Kaminskiy, A., Kanuganti, A. R., Kao, Y. W., Kapoor, A., Kara, O., Karneyeu, A., Kałuzińska, O., Kaya, M., Kaya, O., Kazhykharim, Y., Khan, F. A., Khukhunaishvili, A., Kieseler, J., Kilpatrick, M., Kim, S., Koetz, K., Kolberg, T., Komm, M., Köseyan, O. K., Kraus, V., Krawczyk, M., Kristiansen, K., Kristić, A., Krohn, M., Kronheim, B., Krüger, K., Kulis, S., Kumar, M., Kunori, S., Kuo, C. M., Kuryatkov, V., Kvasnicka, J., Kyre, S., Lai, Y., Lamichhane, K., Landsberg, G., Lange, C., Langford, J., Laurien, S., Lee, M. Y., Lee, S. W., Leiton, A. G. Stahl, Levin, A., Li, A., Li, J. H., Li, Y. Y., Liang, Z., Liao, H., Lin, Z., Lincoln, D., Linssen, L., Lipton, R., Liu, G., Liu, Y., Lobanov, A., Lohezic, V., Lomidze, D., Lu, R. S., Lu, S., Lupi, M., Lysova, I., Magnan, A. -M., Magniette, F., Mahjoub, A., Martens, S., Matysek, M., Meier, B., Malakhov, A., Mallios, S., Mandjavize, I., Mannelli, M., Mans, J., Marchioro, A., Martelli, A., Martinez, G., Masterson, P., Matthewman, M., Mayekar, S. N., David, A., Coco, S., Meng, B., Menkel, A ., Mestvirishvili, A., Milella, G., Mirza, I., Moccia, S., Mohanty, G. B., Monti, F., Moortgat, F. W., Morrissey, I., Motta, J., Murthy, S., Musić, J., Musienko, Y., Nabili, S., Nguyen, M., Nikitenko, A., Noonan, D., Noy, M., Nurdan, K., Nursanto, M. Wulansatiti, Ochando, C., Odell, N., Okawa, H., Onel, Y., Ortez, W., Ozegović, J., Ozkorucuklu, S., Paganis, E., Palmer, C. A., Pandey, S., Pantaleo, F., Papageorgakis, C., Papakrivopoulos, I., Paranjpe, M., Parshook, J., Pastika, N., Paulini, M., Peitzmann, T., Peltola, T., Peng, N., Perraguin, A. Buchot, Petiot, P., Pierre-Emile, T., Pinto, M. Vicente Barreto, Popova, E., Pöschl, R., Prosper, H., Prvan, M., Puljak, I., Qasim, S. R., Qu, H., Quast, T., Quinn, R., Quinnan, M., Rane, A., Rao, K. K., Rapacz, K., Raux, L., Redjeb, W., Reinecke, M., Revering, M., Richard, F., Roberts, A., Sanchez, A. M., Rohlf, J., Rolph, J., Romanteau, T., Rosado, M., Rose, A., Rovere, M., Roy, A., Rubinov, P., Rusack, R., Rusinov, V., Ryjov, V., Sahin, O. M., Salerno, R., Saradhy, R., Sarkar, T., Sarkisla, M. A., Sauvan, J. B., Schmidt, I., Schmitt, M., Schuwalow, S., Scott, E., Seez, C., Sefkow, F., Selivanova, D., Sharma, S., Shelake, M., Shenai, A., Shukla, R., Sicking, E., De, M., Silva, P., Simkina, P., Simon, F., Simsek, A. E., Sirois, Y., Smirnov, V., Sobering, T. J., Spencer, E., Srimanobhas, N., Steen, A., Strait, J., Strobbe, N., Su, X. F., Sudo, Y., Suarez, C. Mantilla, Sukhov, E., Sulak, L., Sun, L., Suryadevara, P., Syal, C., de La Taille, C., Tali, B., Tan, C. L., Tao, J., Tarabini, A., Tatli, T., Thaus, R., Taylor, R. D., Tekten, S., Thiebault, A., Thienpont, D., Tiley, C., Tiras, E., Titov, M., Tlisov, D., Tok, U. G., Kayis, A., Troska, J., Tsai, L. S., Tsamalaidze, Z., Tsipolitis, G., Tsirou, A., Undleeb, S., Urbanski, D., Uslan, E., Ustinov, V., Uzunian, A., Varela, J., Velasco, M., Vernazza, E., Viazlo, O., Vichoudis, P., Virdee, T., Voirin, E., Vojinovi\c, M., Vojinovic, M., Wade, A., Wang, C., Wang, C. C., Wang, D., Wang, F., Wang, X., Wang, Z., Wayne, M., Webb, S. N., Whitbeck, A., Wickwire, R., Wilson, J. S., Wu, H. Y., Wu, L., Xiao, M., Yang, J., Yeh, C. H, Yohay, R., Yu, D., Yu, S. S., Yuan, C., Miao, Y., Yumiceva, F., Yusuff, I., Zabi, A., Zacharopoulou, A., Zamiatin, N., Zarubin, A., Zehetner, P., Zerwas, D., Zhang, H., Zhang, J., Zhang, Y., Zhang, Z., and Zhao, X.

Subjects
Physics - Instrumentation and Detectors
Abstract

The upgrade of the CMS experiment for the high luminosity operation of the LHC comprises the replacement of the current endcap calorimeter by a high granularity sampling calorimeter (HGCAL). The electromagnetic section of the HGCAL is based on silicon sensors interspersed between lead and copper (or copper tungsten) absorbers. The hadronic section uses layers of stainless steel as an absorbing medium and silicon sensors as an active medium in the regions of high radiation exposure, and scintillator tiles directly readout by silicon photomultipliers in the remaining regions. As part of the development of the detector and its readout electronic components, a section of a silicon-based HGCAL prototype detector along with a section of the CALICE AHCAL prototype was exposed to muons, electrons and charged pions in beam test experiments at the H2 beamline at the CERN SPS in October 2018. The AHCAL uses the same technology as foreseen for the HGCAL but with much finer longitudinal segmentation. The performance of the calorimeters in terms of energy response and resolution, longitudinal and transverse shower profiles is studied using negatively charged pions, and is compared to GEANT4 predictions. This is the first report summarizing results of hadronic showers measured by the HGCAL prototype using beam test data., Comment: Accepted for publication by JINST

Published
2022

2. Response of a CMS HGCAL silicon-pad electromagnetic calorimeter prototype to 20-300 GeV positrons

Author

Acar, B., Adamov, G., Adloff, C., Afanasiev, S., Akchurin, N., Akgün, B., Khan, F. Alam, Alhusseini, M., Alison, J., Alpana, A., Altopp, G., Alyari, M., An, S., Anagul, S., Andreev, I., Aspell, P., Atakisi, I. O., Bach, O., Baden, A., Bakas, G., Bakshi, A., Bannerjee, S., Bargassa, P., Barney, D., Beaudette, F., Beaujean, F., Becheva, E., Becker, A., Behera, P., Belloni, A., Bergauer, T., Besancon, M., Bhattacharya, S., Bhowmik, D., Bilki, B., Bloch, P., Bodek, A., Bonanomi, M., Bonnemaison, A., Bonomally, S., Borg, J., Bouyjou, F., Bower, N., Braga, D., Brashear, J., Brondolin, E., Bryant, P., Perraguin, A. Buchot, Bueghly, J., Burkle, B., Butler-Nalin, A., Bychkova, O., Callier, S., Calvet, D., Cao, X., Cappati, A., Caraway, B., Caregari, S., Cauchois, A., Ceard, L., Cekmecelioglu, Y. C., Cerci, S., Cerminara, G., Chadeeva, M., Charitonidis, N., Chatterjee, R., Chen, Y. M., Chen, Z., Cheng, H. J., Cheng, K. y., Chernichenko, S., Cheung, H., Chien, C. H., Choudhury, S., Čoko, D., Collura, G., Couderc, F., Danilov, M., Dannheim, D., Daoud, W., Dauncey, P., David, A., Davies, G., Davignon, O., Day, E., DeBarbaro, P., De Guio, F., de La Taille, C., De Silva, M., Debbins, P., Defranchis, M. M., Delagnes, E., Berrio, J. M. Deltoro, Derylo, G., de Almeida, P. G. Dias, Diaz, D., Dinaucourt, P., Dittmann, J., Dragicevic, M., Dugad, S., Dulucq, F., Dumanoglu, I., Dutta, V., Dutta, S., Dünser, M., Eckdahl, J., Edberg, T. K., Berni, M. El, Elias, F., Eno, S. C., Ershov, Yu., Everaerts, P., Extier, S., Fahim, F., Fallon, C., Fedi, G., Alves, B. A. Fontana Santos, Frahm, E., Franzoni, G., Freeman, J., French, T., Gandhi, P., Ganjour, S., Gao, X., Garcia-Bellido, A., Gastaldi, F., Gecse, Z., Geerebaert, Y., Gerwig, H., Gevin, O., Ghosh, S., Gilbert, A., Gilbert, W., Gill, K., Gingu, C., Gninenko, S., Golunov, A., Golutvin, I., Gonzalez, T., Gorbounov, N., Gouskos, L., Gray, A. B., Gu, Y., Guilloux, F., Guler, Y., Gülmez, E., Guo, J., Guler, E. Gurpinar, Hammer, M., Hassanshahi, H. M., Hatakeyama, K., Heering, A., Hegde, V., Heintz, U., Hinton, N., Hirschauer, J., Hoff, J., Hou, W. -S., Hou, X., Hua, H., Incandela, J., Irshad, A., Isik, C., Jain, S., Jheng, H. R., Joshi, U., Kachanov, V., Kalinin, A., Kalipoliti, L., Kaminskiy, A., Kapoor, A., Kara, O., Karneyeu, A., Kaya, M., Kaya, O., Topaksu, A. Kayis, Khukhunaishvili, A., Kiesler, J., Kilpatrick, M., Kim, S., Koetz, K., Kolberg, T., Köseyan, O. K., Kristić, A., Krohn, M., Krüger, K., Kulagin, N., Kulis, S., Kunori, S., Kuo, C. M., Kuryatkov, V., Kyre, S., Lai, Y., Lamichhane, K., Landsberg, G., Lange, C., Langford, J., Lee, M. Y., Levin, A., Li, A., Li, B., Li, J. H., Li, Y. y., Liao, H., Lincoln, D., Linssen, L., Lipton, R., Liu, Y., Lobanov, A., Lu, R. -S., Lupi, M., Lysova, I., Magnan, A. -M., Magniette, F., Mahjoub, A., Maier, A. A., Malakhov, A., Mallios, S., Mandjavize, I., Mannelli, M., Mans, J., Marchioro, A., Martelli, A., Martinez, G., Masterson, P., Meng, B., Mengke, T., Mestvirishvili, A., Mirza, I., Moccia, S., Mohanty, G. B., Monti, F., Morrissey, I., Murthy, S., Musić, J., Musienko, Y., Nabili, S., Nagar, A., Nguyen, M., Nikitenko, A., Noonan, D., Noy, M., Nurdan, K., Ochando, C., Odegard, B., Odell, N., Okawa, H., Onel, Y., Ortez, W., Ozegović, J., Ozkorucuklu, S., Paganis, E., Pagenkopf, D., Palladino, V., Pandey, S., Pantaleo, F., Papageorgakis, C., Papakrivopoulos, I., Parshook, J., Pastika, N., Paulini, M., Paulitsch, P., Peltola, T., Gomes, R. Pereira, Perkins, H., Petiot, P., Pierre-Emile, T., Pitters, F., Popova, E., Prosper, H., Prvan, M., Puljak, I., Qu, H., Quast, T., Quinn, R., Quinnan, M., Garcia, M. T. Ramos, Rao, K. K., Rapacz, K., Raux, L., Reichenbach, G., Reinecke, M., Revering, M., Roberts, A., Romanteau, T., Rose, A., Rovere, M., Roy, A., Rubinov, P., Rusack, R., Rusinov, V., Ryjov, V., Sahin, O. M., Salerno, R., Rodriguez, A. M. Sanchez, Saradhy, R., Sarkar, T., Sarkisla, M. A., Sauvan, J. B., Schmidt, I., Schmitt, M., Scott, E., Seez, C., Sefkow, F., Sharma, S., Shein, I., Shenai, A., Shukla, R., Sicking, E., Sieberer, P., Silva, P., Simsek, A. E., Sirois, Y., Smirnov, V., Sozbilir, U., Spencer, E., Steen, A., Strait, J., Strobbe, N., Su, J. W., Sukhov, E., Sun, L., Cerci, D. Sunar, Syal, C., Tali, B., Tan, C. L., Tao, J., Tastan, I., Tatli, T., Thaus, R., Tekten, S., Thienpont, D., Tiras, E., Titov, M., Tlisov, D., Tok, U. G., Troska, J., Tsai, L. -S., Tsamalaidze, Z., Tsipolitis, G., Tsirou, A., Tyurin, N., Undleeb, S., Urbanski, D., Ustinov, V., Uzunian, A., Van de Klundert, M., Varela, J., Velasco, M., Viazlo, O., Pinto, M. Vicente Barreto, Virdee, P. Vichoudis T., de Oliveira, R. Vizinho, Voelker, J., Voirin, E., Vojinovic, M., Wade, A., Wang, C., Wang, F., Wang, X., Wang, Z., Wayne, M., Webb, S. N., Whitbeck, A., White, D., Wickwire, R., Wilson, J. S., Winter, D., Wu, H. y., Wu, L., Nursanto, M. Wulansatiti, Yeh, C. H, Yohay, R., Yu, D., Yu, G. B., Yu, S. S., Yuan, C., Yumiceva, F., Yusuff, I., Zacharopoulou, A., Zamiatin, N., Zarubin, A., Zenz, S., Zghiche, A., Zhang, H., Zhang, J., Zhang, Y., and Zhang, Z.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The Compact Muon Solenoid Collaboration is designing a new high-granularity endcap calorimeter, HGCAL, to be installed later this decade. As part of this development work, a prototype system was built, with an electromagnetic section consisting of 14 double-sided structures, providing 28 sampling layers. Each sampling layer has an hexagonal module, where a multipad large-area silicon sensor is glued between an electronics circuit board and a metal baseplate. The sensor pads of approximately 1 cm$^2$ are wire-bonded to the circuit board and are readout by custom integrated circuits. The prototype was extensively tested with beams at CERN's Super Proton Synchrotron in 2018. Based on the data collected with beams of positrons, with energies ranging from 20 to 300 GeV, measurements of the energy resolution and linearity, the position and angular resolutions, and the shower shapes are presented and compared to a detailed Geant4 simulation.

Published
2021
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3. Game-Based Learning and Just-in-Time Teaching to Address Misconceptions and Improve Safety and Learning in Laboratory Activities

Author

Llanos, J., Ferna´ndez-Marchante, C. M., Garci´a-Vargas, J. M., Lacasa, E., de la Osa, A. R., Sanchez-Silva, M. L., De Lucas-Consuegra, A., Garcia, M. T., and Borreguero, A. M.

Abstract

Serious game-based learning coupled with just-in-time teaching strategies was applied by offering six different questionnaires to evaluate student knowledge about the safety issues and theoretical concepts and protocols of laboratory exercises. The questionnaires were presented with an appearance similar to that of computer games by means of the Kahoot! platform. Passing the safety questionnaire was mandatory, and high scores were achieved by all the students, ensuring they all properly knew the laboratory safety rules. We consider this point essential in chemistry and engineering education, because future professionals must be aware of the importance of safety. In addition, responses to the questionnaires regarding the theory and procedures of each laboratory session allowed us to detect the main problems students had in the acquisition of the theoretical concepts before starting the practical activities. Additionally, the satisfaction of teachers and students with this methodology was also evaluated through surveys in the Moodle platform, showing consensus about the fact that the questionnaires are a valuable tool.

Published
2021
Full Text
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7. Response of a CMS HGCAL silicon-pad electromagnetic calorimeter prototype to 20-300 GeV positrons

Author

Acar, B, Adamov, G, Adloff, C, Afanasiev, S, Akchurin, N, Akgun, B, Khan, F, Alhusseini, M, Alison, J, Alpana, A, Altopp, G, Alyari, M, An, S, Anagul, S, Andreev, I, Aspell, P, Atakisi, I, Bach, O, Baden, A, Bakas, G, Bakshi, A, Bannerjee, S, Bargassa, P, Barney, D, Beaudette, F, Beaujean, F, Becheva, E, Becker, A, Behera, P, Belloni, A, Bergauer, T, Besancon, M, Bhattacharya, S, Bhowmik, D, Bilki, B, Bloch, P, Bodek, A, Bonanomi, M, Bonnemaison, A, Bonomally, S, Borg, J, Bouyjou, F, Bower, N, Braga, D, Brashear, J, Brondolin, E, Bryant, P, Buchot Perraguin, A, Bueghly, J, Burkle, B, Butler-Nalin, A, Bychkova, O, Callier, S, Calvet, D, Cao, X, Cappati, A, Caraway, B, Caregari, S, Cauchois, A, Ceard, L, Cekmecelioglu, Y, Cerci, S, Cerminara, G, Chadeeva, M, Charitonidis, N, Chatterjee, R, Chen, Y, Chen, Z, Cheng, H, Cheng, K, Chernichenko, S, Cheung, H, Chien, C, Choudhury, S, Coko, D, Collura, G, Couderc, F, Danilov, M, Dannheim, D, Daoud, W, Dauncey, P, David, A, Davies, G, Davignon, O, Day, E, Debarbaro, P, De Guio, F, De La Taille, C, De Silva, M, Debbins, P, Defranchis, M, Delagnes, E, Deltoro Berrio, J, Derylo, G, Dias De Almeida, P, Diaz, D, Dinaucourt, P, Dittmann, J, Dragicevic, M, Dugad, S, Dulucq, F, Dumanoglu, I, Dutta, V, Dutta, S, Dunser, M, Eckdahl, J, Edberg, T, El Berni, M, Elias, F, Eno, S, Ershov, Y, Everaerts, P, Extier, S, Fahim, F, Fallon, C, Fedi, G, Fontana Santos Alves, B, Frahm, E, Franzoni, G, Freeman, J, French, T, Gandhi, P, Ganjour, S, Gao, X, Garcia-Bellido, A, Gastaldi, F, Gecse, Z, Geerebaert, Y, Gerwig, H, Gevin, O, Ghosh, S, Gilbert, A, Gilbert, W, Gill, K, Gingu, C, Gninenko, S, Golunov, A, Golutvin, I, Gonzalez, T, Gorbounov, N, Gouskos, L, Gray, A, Gu, Y, Guilloux, F, Guler, Y, Gulmez, E, Guo, J, Gurpinar Guler, E, Hammer, M, Hassanshahi, H, Hatakeyama, K, Heering, A, Hegde, V, Heintz, U, Hinton, N, Hirschauer, J, Hoff, J, Hou, W, Hou, X, Hua, H, Incandela, J, Irshad, A, Isik, C, Jain, S, Jheng, H, Joshi, U, Kachanov, V, Kalinin, A, Kalipoliti, L, Kaminskiy, A, Kapoor, A, Kara, O, Karneyeu, A, Kaya, M, Kaya, O, Kayis Topaksu, A, Khukhunaishvili, A, Kiesler, J, Kilpatrick, M, Kim, S, Koetz, K, Kolberg, T, Koseyan, O, Kristic, A, Krohn, M, Kruger, K, Kulagin, N, Kulis, S, Kunori, S, Kuo, C, Kuryatkov, V, Kyre, S, Lai, Y, Lamichhane, K, Landsberg, G, Lange, C, Langford, J, Lee, M, Levin, A, Li, A, Li, B, Li, J, Li, Y, Liao, H, Lincoln, D, Linssen, L, Lipton, R, Liu, Y, Lobanov, A, Lu, R, Lupi, M, Lysova, I, Magnan, A, Magniette, F, Mahjoub, A, Maier, A, Malakhov, A, Mallios, S, Mandjavize, I, Mannelli, M, Mans, J, Marchioro, A, Martelli, A, Martinez, G, Masterson, P, Meng, B, Mengke, T, Mestvirishvili, A, Mirza, I, Moccia, S, Mohanty, G, Monti, F, Morrissey, I, Murthy, S, Music, J, Musienko, Y, Nabili, S, Nagar, A, Nguyen, M, Nikitenko, A, Noonan, D, Noy, M, Nurdan, K, Ochando, C, Odegard, B, Odell, N, Okawa, H, Onel, Y, Ortez, W, Ozegovic, J, Ozkorucuklu, S, Paganis, E, Pagenkopf, D, Palladino, V, Pandey, S, Pantaleo, F, Papageorgakis, C, Papakrivopoulos, I, Parshook, J, Pastika, N, Paulini, M, Paulitsch, P, Peltola, T, Pereira Gomes, R, Perkins, H, Petiot, P, Pierre-Emile, T, Pitters, F, Popova, E, Prosper, H, Prvan, M, Puljak, I, Qu, H, Quast, T, Quinn, R, Quinnan, M, Ramos Garcia, M, Rao, K, Rapacz, K, Raux, L, Reichenbach, G, Reinecke, M, Revering, M, Roberts, A, Romanteau, T, Rose, A, Rovere, M, Roy, A, Rubinov, P, Rusack, R, Rusinov, V, Ryjov, V, Sahin, O, Salerno, R, Sanchez Rodriguez, A, Saradhy, R, Sarkar, T, Sarkisla, M, Sauvan, J, Schmidt, I, Schmitt, M, Scott, E, Seez, C, Sefkow, F, Sharma, S, Shein, I, Shenai, A, Shukla, R, Sicking, E, Sieberer, P, Silva, P, Simsek, A, Sirois, Y, Smirnov, V, Sozbilir, U, Spencer, E, Steen, A, Strait, J, Strobbe, N, Su, J, Sukhov, E, Sun, L, Sunar Cerci, D, Syal, C, Tali, B, Tan, C, Tao, J, Tastan, I, Tatli, T, Thaus, R, Tekten, S, Thienpont, D, Tiras, E, Titov, M, Tlisov, D, Tok, U, Troska, J, Tsai, L, Tsamalaidze, Z, Tsipolitis, G, Tsirou, A, Tyurin, N, Undleeb, S, Urbanski, D, Ustinov, V, Uzunian, A, Van De Klundert, M, Varela, J, Velasco, M, Viazlo, O, Barreto Pinto, M, Vichoudis, P, Virdee, T, Vizinho De Oliveira, R, Voelker, J, Voirin, E, Vojinovic, M, Wade, A, Wang, C, Wang, F, Wang, X, Wang, Z, Wayne, M, Webb, S, Whitbeck, A, White, D, Wickwire, R, Wilson, J, Winter, D, Wu, H, Wu, L, Wulansatiti Nursanto, M, Yeh, C, Yohay, R, Yu, D, Yu, G, Yu, S, Yuan, C, Yumiceva, F, Yusuff, I, Zacharopoulou, A, Zamiatin, N, Zarubin, A, Zenz, S, Zghiche, A, Zhang, H, Zhang, J, Zhang, Y, Zhang, Z, Acar B., Adamov G., Adloff C., Afanasiev S., Akchurin N., Akgun B., Khan F. A., Alhusseini M., Alison J., Alpana A., Altopp G., Alyari M., An S., Anagul S., Andreev I., Aspell P., Atakisi I. O., Bach O., Baden A., Bakas G., Bakshi A., Bannerjee S., Bargassa P., Barney D., Beaudette F., Beaujean F., Becheva E., Becker A., Behera P., Belloni A., Bergauer T., Besancon M., Bhattacharya S., Bhowmik D., Bilki B., Bloch P., Bodek A., Bonanomi M., Bonnemaison A., Bonomally S., Borg J., Bouyjou F., Bower N., Braga D., Brashear J., Brondolin E., Bryant P., Buchot Perraguin A., Bueghly J., Burkle B., Butler-Nalin A., Bychkova O., Callier S., Calvet D., Cao X., Cappati A., Caraway B., Caregari S., Cauchois A., Ceard L., Cekmecelioglu Y. C., Cerci S., Cerminara G., Chadeeva M., Charitonidis N., Chatterjee R., Chen Y. M., Chen Z., Cheng H. J., Cheng K. Y., Chernichenko S., Cheung H., Chien C. H., Choudhury S., Coko D., Collura G., Couderc F., Danilov M., Dannheim D., Daoud W., Dauncey P., David A., Davies G., Davignon O., Day E., Debarbaro P., De Guio F., De La Taille C., De Silva M., Debbins P., Defranchis M. M., Delagnes E., Deltoro Berrio J. M., Derylo G., Dias De Almeida P. G., Diaz D., Dinaucourt P., Dittmann J., Dragicevic M., Dugad S., Dulucq F., Dumanoglu I., Dutta V., Dutta S., Dunser M., Eckdahl J., Edberg T. K., El Berni M., Elias F., Eno S. C., Ershov Y., Everaerts P., Extier S., Fahim F., Fallon C., Fedi G., Fontana Santos Alves B. A., Frahm E., Franzoni G., Freeman J., French T., Gandhi P., Ganjour S., Gao X., Garcia-Bellido A., Gastaldi F., Gecse Z., Geerebaert Y., Gerwig H., Gevin O., Ghosh S., Gilbert A., Gilbert W., Gill K., Gingu C., Gninenko S., Golunov A., Golutvin I., Gonzalez T., Gorbounov N., Gouskos L., Gray A. B., Gu Y., Guilloux F., Guler Y., Gulmez E., Guo J., Gurpinar Guler E., Hammer M., Hassanshahi H. M., Hatakeyama K., Heering A., Hegde V., Heintz U., Hinton N., Hirschauer J., Hoff J., Hou W. -S., Hou X., Hua H., Incandela J., Irshad A., Isik C., Jain S., Jheng H. R., Joshi U., Kachanov V., Kalinin A., Kalipoliti L., Kaminskiy A., Kapoor A., Kara O., Karneyeu A., Kaya M., Kaya O., Kayis Topaksu A., Khukhunaishvili A., Kiesler J., Kilpatrick M., Kim S., Koetz K., Kolberg T., Koseyan O. K., Kristic A., Krohn M., Kruger K., Kulagin N., Kulis S., Kunori S., Kuo C. M., Kuryatkov V., Kyre S., Lai Y., Lamichhane K., Landsberg G., Lange C., Langford J., Lee M. Y., Levin A., Li A., Li B., Li J. H., Li Y. Y., Liao H., Lincoln D., Linssen L., Lipton R., Liu Y., Lobanov A., Lu R. -S., Lupi M., Lysova I., Magnan A. -M., Magniette F., Mahjoub A., Maier A. A., Malakhov A., Mallios S., Mandjavize I., Mannelli M., Mans J., Marchioro A., Martelli A., Martinez G., Masterson P., Meng B., Mengke T., Mestvirishvili A., Mirza I., Moccia S., Mohanty G. B., Monti F., Morrissey I., Murthy S., Music J., Musienko Y., Nabili S., Nagar A., Nguyen M., Nikitenko A., Noonan D., Noy M., Nurdan K., Ochando C., Odegard B., Odell N., Okawa H., Onel Y., Ortez W., Ozegovic J., Ozkorucuklu S., Paganis E., Pagenkopf D., Palladino V., Pandey S., Pantaleo F., Papageorgakis C., Papakrivopoulos I., Parshook J., Pastika N., Paulini M., Paulitsch P., Peltola T., Pereira Gomes R., Perkins H., Petiot P., Pierre-Emile T., Pitters F., Popova E., Prosper H., Prvan M., Puljak I., Qu H., Quast T., Quinn R., Quinnan M., Ramos Garcia M. T., Rao K. K., Rapacz K., Raux L., Reichenbach G., Reinecke M., Revering M., Roberts A., Romanteau T., Rose A., Rovere M., Roy A., Rubinov P., Rusack R., Rusinov V., Ryjov V., Sahin O. M., Salerno R., Sanchez Rodriguez A. M., Saradhy R., Sarkar T., Sarkisla M. A., Sauvan J. B., Schmidt I., Schmitt M., Scott E., Seez C., Sefkow F., Sharma S., Shein I., Shenai A., Shukla R., Sicking E., Sieberer P., Silva P., Simsek A. E., Sirois Y., Smirnov V., Sozbilir U., Spencer E., Steen A., Strait J., Strobbe N., Su J. W., Sukhov E., Sun L., Sunar Cerci D., Syal C., Tali B., Tan C. L., Tao J., Tastan I., Tatli T., Thaus R., Tekten S., Thienpont D., Tiras E., Titov M., Tlisov D., Tok U. G., Troska J., Tsai L. -S., Tsamalaidze Z., Tsipolitis G., Tsirou A., Tyurin N., Undleeb S., Urbanski D., Ustinov V., Uzunian A., Van De Klundert M., Varela J., Velasco M., Viazlo O., Barreto Pinto M. V., Vichoudis P., Virdee T., Vizinho De Oliveira R., Voelker J., Voirin E., Vojinovic M., Wade A., Wang C., Wang F., Wang X., Wang Z., Wayne M., Webb S. N., Whitbeck A., White D., Wickwire R., Wilson J. S., Winter D., Wu H. Y., Wu L., Wulansatiti Nursanto M., Yeh C. H., Yohay R., Yu D., Yu G. B., Yu S. S., Yuan C., Yumiceva F., Yusuff I., Zacharopoulou A., Zamiatin N., Zarubin A., Zenz S., Zghiche A., Zhang H., Zhang J., Zhang Y., Zhang Z., Acar, B, Adamov, G, Adloff, C, Afanasiev, S, Akchurin, N, Akgun, B, Khan, F, Alhusseini, M, Alison, J, Alpana, A, Altopp, G, Alyari, M, An, S, Anagul, S, Andreev, I, Aspell, P, Atakisi, I, Bach, O, Baden, A, Bakas, G, Bakshi, A, Bannerjee, S, Bargassa, P, Barney, D, Beaudette, F, Beaujean, F, Becheva, E, Becker, A, Behera, P, Belloni, A, Bergauer, T, Besancon, M, Bhattacharya, S, Bhowmik, D, Bilki, B, Bloch, P, Bodek, A, Bonanomi, M, Bonnemaison, A, Bonomally, S, Borg, J, Bouyjou, F, Bower, N, Braga, D, Brashear, J, Brondolin, E, Bryant, P, Buchot Perraguin, A, Bueghly, J, Burkle, B, Butler-Nalin, A, Bychkova, O, Callier, S, Calvet, D, Cao, X, Cappati, A, Caraway, B, Caregari, S, Cauchois, A, Ceard, L, Cekmecelioglu, Y, Cerci, S, Cerminara, G, Chadeeva, M, Charitonidis, N, Chatterjee, R, Chen, Y, Chen, Z, Cheng, H, Cheng, K, Chernichenko, S, Cheung, H, Chien, C, Choudhury, S, Coko, D, Collura, G, Couderc, F, Danilov, M, Dannheim, D, Daoud, W, Dauncey, P, David, A, Davies, G, Davignon, O, Day, E, Debarbaro, P, De Guio, F, De La Taille, C, De Silva, M, Debbins, P, Defranchis, M, Delagnes, E, Deltoro Berrio, J, Derylo, G, Dias De Almeida, P, Diaz, D, Dinaucourt, P, Dittmann, J, Dragicevic, M, Dugad, S, Dulucq, F, Dumanoglu, I, Dutta, V, Dutta, S, Dunser, M, Eckdahl, J, Edberg, T, El Berni, M, Elias, F, Eno, S, Ershov, Y, Everaerts, P, Extier, S, Fahim, F, Fallon, C, Fedi, G, Fontana Santos Alves, B, Frahm, E, Franzoni, G, Freeman, J, French, T, Gandhi, P, Ganjour, S, Gao, X, Garcia-Bellido, A, Gastaldi, F, Gecse, Z, Geerebaert, Y, Gerwig, H, Gevin, O, Ghosh, S, Gilbert, A, Gilbert, W, Gill, K, Gingu, C, Gninenko, S, Golunov, A, Golutvin, I, Gonzalez, T, Gorbounov, N, Gouskos, L, Gray, A, Gu, Y, Guilloux, F, Guler, Y, Gulmez, E, Guo, J, Gurpinar Guler, E, Hammer, M, Hassanshahi, H, Hatakeyama, K, Heering, A, Hegde, V, Heintz, U, Hinton, N, Hirschauer, J, Hoff, J, Hou, W, Hou, X, Hua, H, Incandela, J, Irshad, A, Isik, C, Jain, S, Jheng, H, Joshi, U, Kachanov, V, Kalinin, A, Kalipoliti, L, Kaminskiy, A, Kapoor, A, Kara, O, Karneyeu, A, Kaya, M, Kaya, O, Kayis Topaksu, A, Khukhunaishvili, A, Kiesler, J, Kilpatrick, M, Kim, S, Koetz, K, Kolberg, T, Koseyan, O, Kristic, A, Krohn, M, Kruger, K, Kulagin, N, Kulis, S, Kunori, S, Kuo, C, Kuryatkov, V, Kyre, S, Lai, Y, Lamichhane, K, Landsberg, G, Lange, C, Langford, J, Lee, M, Levin, A, Li, A, Li, B, Li, J, Li, Y, Liao, H, Lincoln, D, Linssen, L, Lipton, R, Liu, Y, Lobanov, A, Lu, R, Lupi, M, Lysova, I, Magnan, A, Magniette, F, Mahjoub, A, Maier, A, Malakhov, A, Mallios, S, Mandjavize, I, Mannelli, M, Mans, J, Marchioro, A, Martelli, A, Martinez, G, Masterson, P, Meng, B, Mengke, T, Mestvirishvili, A, Mirza, I, Moccia, S, Mohanty, G, Monti, F, Morrissey, I, Murthy, S, Music, J, Musienko, Y, Nabili, S, Nagar, A, Nguyen, M, Nikitenko, A, Noonan, D, Noy, M, Nurdan, K, Ochando, C, Odegard, B, Odell, N, Okawa, H, Onel, Y, Ortez, W, Ozegovic, J, Ozkorucuklu, S, Paganis, E, Pagenkopf, D, Palladino, V, Pandey, S, Pantaleo, F, Papageorgakis, C, Papakrivopoulos, I, Parshook, J, Pastika, N, Paulini, M, Paulitsch, P, Peltola, T, Pereira Gomes, R, Perkins, H, Petiot, P, Pierre-Emile, T, Pitters, F, Popova, E, Prosper, H, Prvan, M, Puljak, I, Qu, H, Quast, T, Quinn, R, Quinnan, M, Ramos Garcia, M, Rao, K, Rapacz, K, Raux, L, Reichenbach, G, Reinecke, M, Revering, M, Roberts, A, Romanteau, T, Rose, A, Rovere, M, Roy, A, Rubinov, P, Rusack, R, Rusinov, V, Ryjov, V, Sahin, O, Salerno, R, Sanchez Rodriguez, A, Saradhy, R, Sarkar, T, Sarkisla, M, Sauvan, J, Schmidt, I, Schmitt, M, Scott, E, Seez, C, Sefkow, F, Sharma, S, Shein, I, Shenai, A, Shukla, R, Sicking, E, Sieberer, P, Silva, P, Simsek, A, Sirois, Y, Smirnov, V, Sozbilir, U, Spencer, E, Steen, A, Strait, J, Strobbe, N, Su, J, Sukhov, E, Sun, L, Sunar Cerci, D, Syal, C, Tali, B, Tan, C, Tao, J, Tastan, I, Tatli, T, Thaus, R, Tekten, S, Thienpont, D, Tiras, E, Titov, M, Tlisov, D, Tok, U, Troska, J, Tsai, L, Tsamalaidze, Z, Tsipolitis, G, Tsirou, A, Tyurin, N, Undleeb, S, Urbanski, D, Ustinov, V, Uzunian, A, Van De Klundert, M, Varela, J, Velasco, M, Viazlo, O, Barreto Pinto, M, Vichoudis, P, Virdee, T, Vizinho De Oliveira, R, Voelker, J, Voirin, E, Vojinovic, M, Wade, A, Wang, C, Wang, F, Wang, X, Wang, Z, Wayne, M, Webb, S, Whitbeck, A, White, D, Wickwire, R, Wilson, J, Winter, D, Wu, H, Wu, L, Wulansatiti Nursanto, M, Yeh, C, Yohay, R, Yu, D, Yu, G, Yu, S, Yuan, C, Yumiceva, F, Yusuff, I, Zacharopoulou, A, Zamiatin, N, Zarubin, A, Zenz, S, Zghiche, A, Zhang, H, Zhang, J, Zhang, Y, Zhang, Z, Acar B., Adamov G., Adloff C., Afanasiev S., Akchurin N., Akgun B., Khan F. A., Alhusseini M., Alison J., Alpana A., Altopp G., Alyari M., An S., Anagul S., Andreev I., Aspell P., Atakisi I. O., Bach O., Baden A., Bakas G., Bakshi A., Bannerjee S., Bargassa P., Barney D., Beaudette F., Beaujean F., Becheva E., Becker A., Behera P., Belloni A., Bergauer T., Besancon M., Bhattacharya S., Bhowmik D., Bilki B., Bloch P., Bodek A., Bonanomi M., Bonnemaison A., Bonomally S., Borg J., Bouyjou F., Bower N., Braga D., Brashear J., Brondolin E., Bryant P., Buchot Perraguin A., Bueghly J., Burkle B., Butler-Nalin A., Bychkova O., Callier S., Calvet D., Cao X., Cappati A., Caraway B., Caregari S., Cauchois A., Ceard L., Cekmecelioglu Y. C., Cerci S., Cerminara G., Chadeeva M., Charitonidis N., Chatterjee R., Chen Y. M., Chen Z., Cheng H. J., Cheng K. Y., Chernichenko S., Cheung H., Chien C. H., Choudhury S., Coko D., Collura G., Couderc F., Danilov M., Dannheim D., Daoud W., Dauncey P., David A., Davies G., Davignon O., Day E., Debarbaro P., De Guio F., De La Taille C., De Silva M., Debbins P., Defranchis M. M., Delagnes E., Deltoro Berrio J. M., Derylo G., Dias De Almeida P. G., Diaz D., Dinaucourt P., Dittmann J., Dragicevic M., Dugad S., Dulucq F., Dumanoglu I., Dutta V., Dutta S., Dunser M., Eckdahl J., Edberg T. K., El Berni M., Elias F., Eno S. C., Ershov Y., Everaerts P., Extier S., Fahim F., Fallon C., Fedi G., Fontana Santos Alves B. A., Frahm E., Franzoni G., Freeman J., French T., Gandhi P., Ganjour S., Gao X., Garcia-Bellido A., Gastaldi F., Gecse Z., Geerebaert Y., Gerwig H., Gevin O., Ghosh S., Gilbert A., Gilbert W., Gill K., Gingu C., Gninenko S., Golunov A., Golutvin I., Gonzalez T., Gorbounov N., Gouskos L., Gray A. B., Gu Y., Guilloux F., Guler Y., Gulmez E., Guo J., Gurpinar Guler E., Hammer M., Hassanshahi H. M., Hatakeyama K., Heering A., Hegde V., Heintz U., Hinton N., Hirschauer J., Hoff J., Hou W. -S., Hou X., Hua H., Incandela J., Irshad A., Isik C., Jain S., Jheng H. R., Joshi U., Kachanov V., Kalinin A., Kalipoliti L., Kaminskiy A., Kapoor A., Kara O., Karneyeu A., Kaya M., Kaya O., Kayis Topaksu A., Khukhunaishvili A., Kiesler J., Kilpatrick M., Kim S., Koetz K., Kolberg T., Koseyan O. K., Kristic A., Krohn M., Kruger K., Kulagin N., Kulis S., Kunori S., Kuo C. M., Kuryatkov V., Kyre S., Lai Y., Lamichhane K., Landsberg G., Lange C., Langford J., Lee M. Y., Levin A., Li A., Li B., Li J. H., Li Y. Y., Liao H., Lincoln D., Linssen L., Lipton R., Liu Y., Lobanov A., Lu R. -S., Lupi M., Lysova I., Magnan A. -M., Magniette F., Mahjoub A., Maier A. A., Malakhov A., Mallios S., Mandjavize I., Mannelli M., Mans J., Marchioro A., Martelli A., Martinez G., Masterson P., Meng B., Mengke T., Mestvirishvili A., Mirza I., Moccia S., Mohanty G. B., Monti F., Morrissey I., Murthy S., Music J., Musienko Y., Nabili S., Nagar A., Nguyen M., Nikitenko A., Noonan D., Noy M., Nurdan K., Ochando C., Odegard B., Odell N., Okawa H., Onel Y., Ortez W., Ozegovic J., Ozkorucuklu S., Paganis E., Pagenkopf D., Palladino V., Pandey S., Pantaleo F., Papageorgakis C., Papakrivopoulos I., Parshook J., Pastika N., Paulini M., Paulitsch P., Peltola T., Pereira Gomes R., Perkins H., Petiot P., Pierre-Emile T., Pitters F., Popova E., Prosper H., Prvan M., Puljak I., Qu H., Quast T., Quinn R., Quinnan M., Ramos Garcia M. T., Rao K. K., Rapacz K., Raux L., Reichenbach G., Reinecke M., Revering M., Roberts A., Romanteau T., Rose A., Rovere M., Roy A., Rubinov P., Rusack R., Rusinov V., Ryjov V., Sahin O. M., Salerno R., Sanchez Rodriguez A. M., Saradhy R., Sarkar T., Sarkisla M. A., Sauvan J. B., Schmidt I., Schmitt M., Scott E., Seez C., Sefkow F., Sharma S., Shein I., Shenai A., Shukla R., Sicking E., Sieberer P., Silva P., Simsek A. E., Sirois Y., Smirnov V., Sozbilir U., Spencer E., Steen A., Strait J., Strobbe N., Su J. W., Sukhov E., Sun L., Sunar Cerci D., Syal C., Tali B., Tan C. L., Tao J., Tastan I., Tatli T., Thaus R., Tekten S., Thienpont D., Tiras E., Titov M., Tlisov D., Tok U. G., Troska J., Tsai L. -S., Tsamalaidze Z., Tsipolitis G., Tsirou A., Tyurin N., Undleeb S., Urbanski D., Ustinov V., Uzunian A., Van De Klundert M., Varela J., Velasco M., Viazlo O., Barreto Pinto M. V., Vichoudis P., Virdee T., Vizinho De Oliveira R., Voelker J., Voirin E., Vojinovic M., Wade A., Wang C., Wang F., Wang X., Wang Z., Wayne M., Webb S. N., Whitbeck A., White D., Wickwire R., Wilson J. S., Winter D., Wu H. Y., Wu L., Wulansatiti Nursanto M., Yeh C. H., Yohay R., Yu D., Yu G. B., Yu S. S., Yuan C., Yumiceva F., Yusuff I., Zacharopoulou A., Zamiatin N., Zarubin A., Zenz S., Zghiche A., Zhang H., Zhang J., Zhang Y., and Zhang Z.

Abstract

The Compact Muon Solenoid collaboration is designing a new high-granularity endcap calorimeter, HGCAL, to be installed later this decade. As part of this development work, a prototype system was built, with an electromagnetic section consisting of 14 double-sided structures, providing 28 sampling layers. Each sampling layer has an hexagonal module, where a multipad large-area silicon sensor is glued between an electronics circuit board and a metal baseplate. The sensor pads of approximately 1.1 cm2 are wire-bonded to the circuit board and are readout by custom integrated circuits. The prototype was extensively tested with beams at CERN's Super Proton Synchrotron in 2018. Based on the data collected with beams of positrons, with energies ranging from 20 to 300 GeV, measurements of the energy resolution and linearity, the position and angular resolutions, and the shower shapes are presented and compared to a detailed Geant4 simulation.

Published
2022

10. Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma

Author

Perez C., Botta C., Zabaleta A., Puig N., Cedena M. -T., Goicoechea I., Alameda D., Jose-Eneriz E. S., Merino J., Rodriguez-Otero P., Maia C., Alignani D., Maiso P., Manrique I., Lara-Astiaso D., Vilas-Zornoza A., Sarvide S., Riillo C., Rossi M., Rosinol L., Oriol A., Blanchard M. -J., Rios R., Sureda A., Martin J., Martinez R., Bargay J., de la Rubia J., Hernandez M. -T., Martinez-Lopez J., Orfao A., Agirre X., Prosper F., Mateos M. -V., Lahuerta J. -J., Blade J., San-Miguel J. F., Paiva B., Espinosa M. C., Zamudio J. L. G., Herranz E. R., Tamayo R. R., Sanchez J. M., Bernal L. P., Rodriguez A. P. G., Garcia M. E. G., Mayol A. S., Lleonart J. B., Suarez A., Garcia M. T. H., Gaisan C. M., Ruiz B. H., Montero F. C., de Miguel Llorente D., Ramos F. S., Garcia A. I., Manteca M. M., Martin J. M. H., Barrigon F. E., Frade J. G., de Coca A. G., Franco C. A., Gomez J. L., Perez E. C., Creixenti J. B., Balari A. M. S., Montes Y. G., Teigell L. E., Guinon A. G., Monreal E. A., Campos J. A. S., Tutusaus J. M. M., Rocafiguera A. O., Gorrochategui M. G., Mesa M. G., Silva C. C., Perez M. S. G., Loureiro A. D., Sanchez J. A. M., Irazu M. J. N., Parraga F. J. P., Palacios J. J. L., Barahona P. B., Rodriguez C. E., Rivas J. A. H., de Oteyza J. P., del Barrio R. I., de la Guia A. L., Amor A. A., Pareja E. P., Castello I. K., Rodriguez M. J. B., Martinez R. M., Grau R. R., Mesa E. G., Sainz E. R., de Arriba F., Jimenez J. M. M., Romera M., Cardoso F. P., Perez J. M. A., Pomposo M. P., Persona E. P., Casasus A. I. T., Garcia P. R., Ramos I. J., Lor M. B. V., Garcia P. L. F., Chamorro C. M., Perez C., Botta C., Zabaleta A., Puig N., Cedena M.-T., Goicoechea I., Alameda D., Jose-Eneriz E.S., Merino J., Rodriguez-Otero P., Maia C., Alignani D., Maiso P., Manrique I., Lara-Astiaso D., Vilas-Zornoza A., Sarvide S., Riillo C., Rossi M., Rosinol L., Oriol A., Blanchard M.-J., Rios R., Sureda A., Martin J., Martinez R., Bargay J., de la Rubia J., Hernandez M.-T., Martinez-Lopez J., Orfao A., Agirre X., Prosper F., Mateos M.-V., Lahuerta J.-J., Blade J., San-Miguel J.F., Paiva B., Espinosa M.C., Zamudio J.L.G., Herranz E.R., Tamayo R.R., Sanchez J.M., Bernal L.P., Rodriguez A.P.G., Garcia M.E.G., Mayol A.S., Lleonart J.B., Suarez A., Garcia M.T.H., Gaisan C.M., Ruiz B.H., Montero F.C., de Miguel Llorente D., Ramos F.S., Garcia A.I., Manteca M.M., Martin J.M.H., Barrigon F.E., Frade J.G., de Coca A.G., Franco C.A., Gomez J.L., Perez E.C., Creixenti J.B., Balari A.M.S., Montes Y.G., Teigell L.E., Guinon A.G., Monreal E.A., Campos J.A.S., Tutusaus J.M.M., Rocafiguera A.O., Gorrochategui M.G., Mesa M.G., Silva C.C., Perez M.S.G., Loureiro A.D., Sanchez J.A.M., Irazu M.J.N., Parraga F.J.P., Palacios J.J.L., Barahona P.B., Rodriguez C.E., Rivas J.A.H., de Oteyza J.P., del Barrio R.I., de la Guia A.L., Amor A.A., Pareja E.P., Castello I.K., Rodriguez M.J.B., Martinez R.M., Grau R.R., Mesa E.G., Sainz E.R., de Arriba F., Jimenez J.M.M., Romera M., Cardoso F.P., Perez J.M.A., Pomposo M.P., Persona E.P., Casasus A.I.T., Garcia P.R., Ramos I.J., Lor M.B.V., Garcia P.L.F., and Chamorro C.M.

Subjects
Male, Transcription, Genetic, Neutrophils, T-Lymphocytes, Immunology, CD33, Biology, CD16, Biochemistry, Follow-Up Studie, Flow cytometry, Antigens, CD, medicine, Humans, Cytotoxic T cell, Lymphocyte Count, Tumor microenvironment, medicine.diagnostic_test, Myeloid-Derived Suppressor Cells, Cell Biology, Hematology, Middle Aged, Cell sorting, Neoplasm Proteins, medicine.anatomical_structure, T-Lymphocyte, Cancer research, Myeloid-derived Suppressor Cell, Female, Bone marrow, Multiple Myeloma, Human, Follow-Up Studies
Abstract

Granulocytic myeloid-derived suppressor cells (G-MDSCs) promote tumor growth and immunosuppression in multiple myeloma (MM). However, their phenotype is not well established for accurate monitoring or clinical translation. We aimed to provide the phenotypic profile of G-MDSCs based on their prognostic significance in MM, immunosuppressive potential, and molecular program. The preestablished phenotype of G-MDSCs was evaluated in bone marrow samples from controls and MM patients using multidimensional flow cytometry; surprisingly, we found that CD11b+CD14−CD15+CD33+HLADR− cells overlapped with common eosinophils and neutrophils, which were not expanded in MM patients. Therefore, we relied on automated clustering to unbiasedly identify all granulocytic subsets in the tumor microenvironment: basophils, eosinophils, and immature, intermediate, and mature neutrophils. In a series of 267 newly diagnosed MM patients (GEM2012MENOS65 trial), only the frequency of mature neutrophils at diagnosis was significantly associated with patient outcome, and a high mature neutrophil/T-cell ratio resulted in inferior progression-free survival (P < .001). Upon fluorescence-activated cell sorting of each neutrophil subset, T-cell proliferation decreased in the presence of mature neutrophils (0.5-fold; P = .016), and the cytotoxic potential of T cells engaged by a BCMA×CD3-bispecific antibody increased notably with the depletion of mature neutrophils (fourfold; P = .0007). Most interestingly, RNA sequencing of the 3 subsets revealed that G-MDSC–related genes were specifically upregulated in mature neutrophils from MM patients vs controls because of differential chromatin accessibility. Taken together, our results establish a correlation between the clinical significance, immunosuppressive potential, and transcriptional network of well-defined neutrophil subsets, providing for the first time a set of optimal markers (CD11b/CD13/CD16) for accurate monitoring of G-MDSCs in MM.

Published
2020
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12. Biological Amphiphile Systems, and Relevance of Surfactants in the Biomedical Arena, Health, and the Human Body

Author

Lo Nostro, Pierandrea, Gabrielli, Gabriella, Novelli, Anne, Rico, Isabelle, Lattes, Armand, Leal, J. Sánchez, González, J. J., Kaiser, K. L. E., Comelles, F., García, M. T., Riess, J. G., Krafft, M. P., Postel, M., Rolland, J. P., Santaella, C., Vierling, P., Niven, Ralph W., Schreier, Hans, Lichtenberg, D., Meyouchas, D., Rotenberg, M., Bor, A., Rubin, M., Milov, D. E., Shireman, R. B., Chun, P. W., Vodyanoy, V., Bluestone, G. L., Longmuir, K. J., Misra, D. N., Fonteijn, T. A. A., Engberts, J. B. F. N., Hoekstra, D., Wahlgren, M., Arnebrant, T., Lohner, K., Colotto, A., Laggner, P., Smeulders, J. B. A. F., Blom, C., Mellema, J., Bouwstra, J. A., Gooris, G. S., Bras, W., Winterhalter, M., Helfrich, W., Carvajal, Teresa, Hofland, H. E. J., Talsma, H., Lin, T. L., Liu, C. C., Roberts, M. F., Chen, S. H., Urbaneja, M. A., Alonso, A., González-Mañas, J. M., Goñi, F. M., Paredes, S., Partearroyo, M. A., Tribout, M., Kang, Hak-Hee, Kim, Jin-Gu, Kim, Jong-Duk, Lee, Ok-Sup, Vater, J., Ullrich, C., Kluge, B., Baumgart, F., Ziessow, D., Spies, F., Bodde, H. E., Junginger, H. E., Pawelek, Janusz, Polanska, Maria, Maciejowska, Iwona, Kalachandra, S., Singh, D. P., Singh, Sanjay Kumar, Roy, Narendra N., Hanicka, Magdalena, Kurzawa, Ryszard, Tancréde, P., Barwicz, J., Jutras, S., Gruda, I., Speer, Melissa, Chiu, Y. C., Yu, K. M., Deniz, K. Usha, Parvathanathan, P. S., Datta, Geeta, Sumanan, Lata, Khetrapal, C. L., Ramanathan, K. V., del Rio, E., González Mañas, J. M., Disalvo, E. A., Senisterra, G. A., Viera, L. I., Long, M. A., Kaler, E. W., Lee, S. P., Dhathathreyan, A., Dhathathreyan, K. S., Chatterjee, M., Nandy, P., Bosch, P., Caelles, J., Sanchez, J., Parra, Y. J. L., Singh, Kehar, Tiwari, A. K., Shahi, V. K., Mittal, K. L., editor, and Shah, D. O., editor

Published
1991
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25. Description of the stress - strain behaviour of granular soils

Author

Mateos Garcia, M. T. and Estaire, J.

Subjects
Granular soils, Stress - strain behaviour, Critical state
Abstract

The main features of the stress - strain behaviour of granular soils are described in this paper on the basis o f the typical results of triaxial tests. The principal feature of this behaviour consists on the capability of this kind of soils to change their volume when they are suffering shear strains. The complete and genera/ behaviour of granular soils is explained through a general theory known as Critical State Theory

Published
1996

26. Modelization of the dynamic behaviour of dense granular soils. Cyclic Mobilility

Author

Mateos Garcia, M. T. and Estaire, J.

Subjects
Granular soils, Modelization, Plasticity, Stress - strain behaviour
Abstract

This paper shows the results of the mathematical simulation of the dynamic behaviour of a dense granular soil when tested in a triaxial device. Under these conditions and due to the capability of these soils to increment their volume a process, known as cyclic mobility, is developed. Although this process does not imply a total lose of the soil strengh, it is possible that the soil develops important strains. The used model is an elastopiastic one based on the Generalized Theory of Plasticity. This model was adapted in order to be able to reproduce the dynamic behavio ur of dense granular soils

Published
1996

27. Modelización del comportamiento dinámico de los suelos granulares densos. Movilidad cíclica

Author

Mateos Garcia, M. T. and Estaire, J.

Subjects
Granular soils, Modelization, Plasticity, Stress - strain behaviour
Abstract

This paper shows the results of the mathematical simulation of the dynamic behaviour of a dense granular soil when tested in a triaxial device. Under these conditions and due to the capability of these soils to increment their volume a process, known as cyclic mobility, is developed. Although this process does not imply a total lose of the soil strengh, it is possible that the soil develops important strains. The used model is an elastopiastic one based on the Generalized Theory of Plasticity. This model was adapted in order to be able to reproduce the dynamic behavio ur of dense granular soils

Published
1996

28. Descripción del comportamiento tensodeformacional de los suelos granulares. Teoría del estado crítico

Author

Mateos Garcia, M. T. and Estaire, J.

Subjects
Granular soils, Stress - strain behaviour, Critical state
Abstract

The main features of the stress - strain behaviour of granular soils are described in this paper on the basis o f the typical results of triaxial tests. The principal feature of this behaviour consists on the capability of this kind of soils to change their volume when they are suffering shear strains. The complete and genera/ behaviour of granular soils is explained through a general theory known as Critical State Theory

Published
1996

30. An experimental determination of the dilatancy function of a granular dense soil

Author

Mateos Garcia, M. T.

Subjects
Granular soils, Laboratory testing, Dilatancy function
Abstract

This paper presents an experimental method to determine the dilatancy function of a dense granular soil. The knowledge of that function is essential to modelize the geomechanical behaviour of the soil because it controls the development of plastic strains. The results obtained are compared with some theorical equations published in the technical literature

Published
1995

32. DIFFERENCES BETWEEN PREHYPERTENSIVE AND HYPERTENSIVE SUBJECTS IN THE FIRST YEAR OF FOLLOW-UP. THE PREVASTURIAS STUDY

Author

De La. Escosura Garcia, A., primary, Rubiera Alvarez, C., additional, Varela Suarez, C., additional, Bousquets Toral, L., additional, Alonso Arguelles, J., additional, Suarez Garcia, S., additional, Martin Lopez, C., additional, Arias Garcia, M. T., additional, Pizarro Lopez, M., additional, Perez Fernandez, I., additional, Florez Garcia, J., additional, Pastrana Pastrana, I., additional, Crespo Garcia, J. R., additional, Marin Iranzo, R., additional, and Prieto Diaz, M. A., additional

Published
2011
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34. Partial Reversal of the Methylation Pattern of the X-linked Gene HUMARA during Hematopoietic Differentiation of Human Embryonic Stem Cells

Author

Mitjavila-Garcia, M.-T., primary, Bonnet, M. L., additional, Yates, F., additional, Haddad, R., additional, Oudrhiri, N., additional, Feraud, O., additional, Magniez, A., additional, Makhlouf, M., additional, Vallot, C., additional, Rougeulle, C., additional, Bennaceur-Griscelli, A., additional, and Turhan, A. G., additional

Published
2010
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41. What is the influence of cyclooxygenase-2 on postmenopausal endometrial polyps?

Author

Pereira, A. K. C., Garcia, M. T., Pinheiro, W., Ejzenberg, D., Soares, J. M., and Baracat, E. C.

Subjects
*CYCLOOXYGENASE 2, *POSTMENOPAUSE, *GENETIC polymorphisms, *ENDOMETRIUM, *IMMUNOHISTOCHEMISTRY
Abstract

Background The genesis of the endometrial polyp is as yet unclear. There is evidence that the polyp is related to the inflammatory process and that it interacts with the cyclooxygenase-2 (COX-2) enzyme. Objective To review the influence of COX-2 on the postmenopausal endometrial polyp. Methods A systematic review was made of the Medline, Embase, and Cochrane databases, covering the years of 2001-2014. The inclusion criteria were: experimental studies with immunohistological analysis of COX-2 in endometrial polyps; women; hysteroscopic and surgical evaluation; and studies with comparisons between the endometrial polyp and other tissues (normal endometrium, adjacent endometrium, and other uterine diseases). The exclusion criteria were: polyps in other organs; genetic polymorphisms; endometrial cancer exclusively; abnormal uterine bleeding unrelated to polyps. The search key words (taken from the Medical Subject Headings - MeSH) were endometrial polyp and cyclooxygenase-2. Results Seven of ten articles were selected. Results showed positive COX-2 expression in the glandular epithelium of the polyps, and expression was more intense when the polyp was malignant. However, there was a study which did not find any difference between polyps and the normal endometrium, and there was another which compared polyps in menacme with postmenopausal polyps. Conclusion There is no consensus in the literature as to the participation of COX-2 in the development of benign and/or malignant endometrial polyps. In all of the studies, COX-2 was present in the postmenopausal polyps and with greater intensity in the malignant ones. [ABSTRACT FROM AUTHOR]

Published
2015
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45. PKA tightly bound to human placental mitochondria participates in steroidogenesis and is not modified by cAMP.

Author

Gomez-Chang, E., Espinosa-Garcia, M. T., Olvera-Sanchez, S., Flores-Herrera, O., and Martinez, F.

Abstract

Introduction: Protein phosphorylation plays an important role in the modulation of steroidogenesis and it depends on the activation of different signaling cascades. Previous data showed that PKA activity is related to steroidogenesis in mitochondria from syncytiotrophoblast of human placenta (HPM). PKA localization and contribution in progesterone synthesis and protein phosphorylation of HPM was assessed in this work. Methods: Placental mitochondria and submitochondrial fractions were used. Catalytic and regulatory PKA subunits were identified by Western blot. PKA activity was determined by the incorporation of 32P into proteins in the presence or absence of specific inhibitors. The effect of PKA activators and inhibitors on steroidogenesis and protein phosphorylation in HPM was tested by radioimmunoassay and autoradiography. Results: The PKAα catalytic subunit was distributed in all the submitochondrial fractions whereas βII regulatory subunit was the main isoform observed in both the outer and inner membranes of HPM. PKA located in the inner membrane showed the highest activity. Progesterone synthesis and mitochondrial protein phosphorylation are modified by inhibitors of PKA catalytic subunit but are neither sensitive to inhibitors of the regulatory subunit nor to activators of the holoenzyme. Discussion: The lack of response in the presence of PKA activators and inhibitors of the regulatory subunit suggests that the activation of intramitochondrial PKA cannot be prevented or further activated. Conclusions: The phosphorylating activity of PKA inside HPM could be an important component of the steroidogenesis transduction cascade, probably exerting its effects by direct phosphorylation of its substrates or by modulating other kinases and phosphatases. [ABSTRACT FROM AUTHOR]

Published
2014
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