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Bet-hedging is a phenotype diversification strategy that combines a fast-growing vulnerable phenotype with a slow-growing resistant phenotype. In environments switching between favorable and unfavorable conditions, bet-hedging optimizes growth and reduces fluctuations over a long time, which is expected to reduce extinction risk. Here, we address directly how bet-hedging can reduce extinction probability in an agent-based model. An agent-based model is appropriate for studying extinction due to the low number of individuals close to extinction. We also show that the agent-based model converges to the collective model behavior for populations of $100$ individuals or more. However, the collective model provides relevant qualitative insight even for low populations. The collective model provides expressions for extinction that stress the relevance of the population number, showing that a factor four increase in the total population has a greater effect than a change of strategy from maximum growth to minimal extinction. This work provides further insight into the impact of finite population effects on the bet-hedging strategy's success., Comment: revtex 4,15 pages, 10 figures. Submitted to PRE

Different types of ligands compete in binding to polymers with different consequences for the physical and chemical properties of the resulting complex. Here, we derive a general kinetic model for the competitive binding kinetics of different types of ligands to a linear polymer, using the McGhee and von Hippel detailed binding site counting procedure. The derived model allows the description of the competitive binding process in terms of the size of the ligand, binding and release rates, and cooperativity parameters. We illustrate the implications of the general theory showing the equations for the competitive binding of two ligands. The size of the ligand, given by the number of monomers occluded, is shown to have a great impact in competitive binding. Ligands requiring a large available gap for binding are strongly inhibited by smaller ligands. Ligand size then has a leading role compared to binding affinity or cooperativity. For ligands that can bind in different modes (i.e., different number of monomers), this implies that they are more effective in covering or passivating the polymer in lower modes, if the different modes have similar binding energies., Comment: 28 pages, 3 figures

Friction is one of the cruxes of hydrodynamic modeling; flood conditions are highly sensitive to the Friction Factors (FFs) used to calculate momentum losses. However, empirical FFs are challenging to measure because they require laboratory experiments. Flood models often rely on surrogate observations (such as land use) to estimate FFs, introducing uncertainty. This research presents a laboratory-trained Deep Neural Network (DNN), trained using flume experiments with data augmentation techniques, to measure Manning's n based on Point Cloud data. The DNN was deployed on real-world lidar Point Clouds to directly measure Manning's n under regulatory and extreme storm events, showing improved prediction capabilities in both 1D and 2D hydrodynamic models. For 1D models, the lidar values decreased differences with regulatory models for in-channel water depth when compared to land cover values. For 1D/2D coupled models, the lidar values produced better agreement with flood extents measured from airborne imagery, while better matching flood insurance claim data for Hurricane Harvey. In both 1D and 1D/2D coupled models, lidar resulted in better agreement with validation gauges. For these reasons, the lidar measurements of Manning's n were found to improve both regulatory models and forecasts for extreme storm events, while simultaneously providing a pathway to standardize the measurement of FFs. Changing FFs significantly affected fluvial and pluvial flood models, while surge flooding was generally unaffected. Downstream flow conditions were found to change the importance of FFs to fluvial models, advancing the literature of friction in flood models. This research introduces a reliable, repeatable, and readily-accessible avenue to measure high-resolution FFs based on 3D point clouds, improving flood prediction, and removing uncertainty from hydrodynamic modeling., Comment: 25 pages, 15 figures, 2 tables. Implementation code available at https://github.com/f-haces/LidarManning

Hydrodynamic flood modeling improves hydrologic and hydraulic prediction of storm events. However, the computationally intensive numerical solutions required for high-resolution hydrodynamics have historically prevented their implementation in near-real-time flood forecasting. This study examines whether several Deep Neural Network (DNN) architectures are suitable for optimizing hydrodynamic flood models. Several pluvial flooding events were simulated in a low-relief high-resolution urban environment using a 2D HEC-RAS hydrodynamic model. These simulations were assembled into a training set for the DNNs, which were then used to forecast flooding depths and velocities. The DNNs' forecasts were compared to the hydrodynamic flood models, and showed good agreement, with a median RMSE of around 2 mm for cell flooding depths in the study area. The DNNs also improved forecast computation time significantly, with the DNNs providing forecasts between 34.2 and 72.4 times faster than conventional hydrodynamic models. The study area showed little change between HEC-RAS' Full Momentum Equations and Diffusion Equations, however, important numerical stability considerations were discovered that impact equation selection and DNN architecture configuration. Overall, the results from this study show that DNNs can greatly optimize hydrodynamic flood modeling, and enable near-real-time hydrodynamic flood forecasting., Comment: 21 pages, 8 figures

The PICOSEC Micromegas precise timing detector is based on a Cherenkov radiator coupled to a semi-transparent photocathode and a Micromegas amplification structure. The first proof of concept single-channel small area prototype was able to achieve time resolution below 25 ps. One of the crucial aspects in the development of the precise timing gaseous detectors applicable in high-energy physics experiments is a modular design that enables large area coverage. The first 19-channel multi-pad prototype with an active area of approximately 10 cm$^2$ suffered from degraded timing resolution due to the non-uniformity of the preamplification gap. A new 100 cm$^2$ detector module with 100 channels based on a rigid hybrid ceramic/FR4 Micromegas board for improved drift gap uniformity was developed. Initial measurements with 80 GeV/c muons showed improvements in timing response over measured pads and a time resolution below 25 ps. More recent measurements with a new thinner drift gap detector module and newly developed RF pulse amplifiers show that the resolution can be enhanced to a level of 17~ps. This work will present the development of the detector from structural simulations, design, and beam test commissioning with a focus on the timing performance of a thinner drift gap detector module in combination with new electronics using an automated timing scan method.

The PICOSEC Micromegas (MM) detector is a precise timing gaseous detector consisting of a Cherenkov radiator combined with a photocathode and a MM amplifying structure. A 100-channel non-resistive PICOSEC MM prototype with 10x10 cm^2 active area equipped with a Cesium Iodide (CsI) photocathode demonstrated a time resolution below 18 ps. The objective of this work is to improve the PICOSEC MM detector robustness aspects; i.e. integration of resistive MM and carbon-based photocathodes; while maintaining good time resolution. The PICOSEC MM prototypes have been tested in laboratory conditions and successfully characterised with 150 GeV/c muon beams at the CERN SPS H4 beam line. The excellent timing performance below 20 ps for an individual pad obtained with the 10x10 cm^2 area resistive PICOSEC MM of 20 MOhm/sq showed no significant time resolution degradation as a result of adding a resistive layer. A single-pad prototype equipped with a 12 nm thick Boron Carbide (B4C) photocathode presented a time resolution below 35 ps; opening up new possibilities for detectors with robust photocathodes. The results made the concept more suitable for the experiments in need of robust detectors with good time resolution.

Feedback control uses the state information of the system to actuate on it. The information used implies an effective entropy reduction of the controlled system, potentially increasing its performance. How to compute this entropy reduction has been formally shown for a general system, and has been explicitly computed for spatially discrete systems. Here, we address a relevant example of how to compute the entropy reduction by information in a spatially continuous feedback-controlled system. Specifically, we consider a feedback flashing ratchet, which constitutes a paradigmatic example for the role of information and feedback in the dynamics and thermodynamics of transport induced by the rectification of Brownian motion. A Brownian particle moves in a periodic potential that is switched on and off by a controller, with the latter performing the switching depending on the system state. We show how the entropy reduction can be computed from the entropy of a sequence of control actions, and also discuss the required sampling effort for its accurate computation. Moreover, the output power developed by the particle against an external force is investigated, which -- for some values of the system parameters -- is shown to become larger than the input power due to the switching of the potential: the apparent efficiency of the ratchet thus becomes higher than one, if the entropy reduction contribution is not considered. This result highlights the relevance of including the entropy reduction by information in the thermodynamic balance of feedback controlled devices, specifically when writing the second principle: the inclusion of the entropy reduction by information leads to a well-behaved efficiency over all the range of parameters investigated., Comment: 17 pages, 13 figures

There are many scales at which to quantify stability in spatial and ecological networks. Local-scale analyses focus on specific nodes of the spatial network, while regional-scale analyses consider the whole network. Similarly, species- and community-level analyses either account for single species or for the whole community. Furthermore, stability itself can be defined in multiple ways, including resistance (the inverse of the relative displacement caused by a perturbation), initial resilience (the rate of return after a perturbation), and invariability (the inverse of the relative amplitude of the population fluctuations). Here, we analyze the scale-dependence of these stability properties. More specifically, we ask how spatial scale (local vs regional) and ecological scale (species vs community) influence these stability properties. We find that regional initial resilience is the weighted arithmetic mean of the local initial resiliences. The regional resistance is the harmonic mean of local resistances, which makes regional resistance particularly vulnerable to nodes with low stability, unlike regional initial resilience. Analogous results hold for the relationship between community- and species-level initial resilience and resistance. Both resistance and initial resilience are ``scale-free'' properties: regional and community values are simply the biomass-weighted means of the local and species values, respectively. Thus, one can easily estimate both stability metrics of whole networks from partial sampling. In contrast, invariability generally is greater at the regional and community-level than at the local and species-level, respectively. Hence, estimating the invariability of spatial or ecological networks from measurements at the local or species level is more complicated, requiring an unbiased estimate of the network (i.e. region or community) size.

Environmental fluctuations can create population-depleted areas and even extinct areas for the population. This effect is more severe in the presence of the Allee effect (decreasing growth rate at low population densities). Dispersal inside the habitat provides a rescue effect on population-depleted areas, enhancing the population resilience to environmental fluctuations. Habitat reduction decreases the effectiveness of the dispersal rescue mechanism. We report here how the population resilience to environmental fluctuations decreases when the dispersal length or the habitat size are reduced. The resilience reduction is characterized by a decrease of the extinction threshold for environmental fluctuations. The extinction threshold is shown to scale with the ratio between the dispersal length and the scale of environmental synchrony, i.e., it is the dispersal connection between non-environmentally-correlated regions that provides resilience to environmental fluctuations. Habitat reduction also decreases the resilience to environmental fluctuations, when the habitat size is similar to or smaller than the characteristic dispersal distances. The power laws of these scaling behaviors are characterized here. Alternative scaling functions with spatial scales of population synchrony are found to fit the simulations worse. These results support the dispersal length as the critical scale for extinction induced by habitat reduction., Comment: 24 pages

The Institute of Materials and Processes, IMP, of the University of Applied Sciences in Karlsruhe, Germany in cooperation with VDI Verein Deutscher Ingenieure e.V, AEN Automotive Engineering Network and their cooperation partners present their competences of AI-based solution approaches in the production engineering field. The online congress KI 4 Industry on November 12 and 13, 2020, showed what opportunities the use of artificial intelligence offers for medium-sized manufacturing companies, SMEs, and where potential fields of application lie. The main purpose of KI 4 Industry is to increase the transfer of knowledge, research and technology from universities to small and medium-sized enterprises, to demystify the term AI and to encourage companies to use AI-based solutions in their own value chain or in their products., Comment: Editors: Matthias Feiner and Manuel Schoellhorn, 72 pages, 48 figures, in German, Conference proceedings KI 4 Industry, 79 pages in total

Several research studies have shown that future sustainable electricity systems, mostly based on renewable generation and storage, are feasible with current technologies and costs. However, recent episodes of extreme weather conditions, probably associated with climate change, cast shades of doubt on whether the resulting generation portfolios are sufficiently robust to assure, at all times, a suitable balance between generation and demand, when adverse conditions are faced. To address this issue, this work elaborates a methodology intended to determine a sustainable electricity system that can endure extreme weather conditions, which are likely to occur. First, using hourly production and demand data from the last decade, along with estimates of new uses of electricity, a worst-case scenario is constructed, including the storage capacity and additional photovoltaic power which are needed to serve the demand on an hourly basis. Next, several key parameters which may have a significant influence on the LCOE are considered, and a sensitivity analysis is carried out to determine their real impact, significance and potential trends. The proposed methodology is then applied to the Spanish system. The results show that, under the hypotheses and conditions considered in this paper, it is possible to design a decarbonized electricity system that, taking advantage of existing sustainable assets, satisfies the long-term needs by providing a reliable supply at an average cost significantly lower than current market prices., Comment: 33 pages, 13 figures, 10 tables