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3. T23. ASSOCIATION OF CHILDHOOD TRAUMA EXPOSURE WITH DDR1 PROMOTER METHYLATION IN BIPOLAR DISORDER

Author

García-Ruiz, Beatriz, primary, Montoro, Irene, additional, Aranda, Selena, additional, Varo, Cristina, additional, Bonnin, C. Mar, additional, Jiménez, Esther, additional, Vieta, Eduard, additional, Alonso-Lana, Silvia, additional, Verdolini, Norma, additional, Fatjó-Vilas, Mar, additional, Pomarol-Clotet, Edith, additional, and Vilella, Elisabet, additional

Published
2022
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4. DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes

Author

García- Ruiz, Beatriz [0000-0001-9552-949X], Castro de Moura, Manuel [0000-0002-8488-5306], Muntané, Gerard [0000-0003-1541-8365], Martorell, Lourdes [0000-0003-4999-2197], Bosch, Elena [0000-0003-2848-103X], Esteller, Manel [0000-0003-4490-6093], Canales-Rodríguez, Erick Jorge [0000-0001-6421-2633], Pomarol-Clotet, Edith [0000-0002-8159-8563], Jiménez, Esther [0000-0001-6929-6207], Vieta, Eduard [0000-0002-0548-0053], Vilella, Elisabet [0000-0002-1887-5919], García-Ruiz, Beatriz, Castro de Moura, Manuel, Muntané, Gerard, Martorell, Lourdes, Bosch, Elena, Esteller, Manel, Canales-Rodríguez, Erick Jorge, Pomarol-Clotet, Edith, Jiménez, Esther, Vieta, Eduard, Vilella, Elisabet, García- Ruiz, Beatriz [0000-0001-9552-949X], Castro de Moura, Manuel [0000-0002-8488-5306], Muntané, Gerard [0000-0003-1541-8365], Martorell, Lourdes [0000-0003-4999-2197], Bosch, Elena [0000-0003-2848-103X], Esteller, Manel [0000-0003-4490-6093], Canales-Rodríguez, Erick Jorge [0000-0001-6421-2633], Pomarol-Clotet, Edith [0000-0002-8159-8563], Jiménez, Esther [0000-0001-6929-6207], Vieta, Eduard [0000-0002-0548-0053], Vilella, Elisabet [0000-0002-1887-5919], García-Ruiz, Beatriz, Castro de Moura, Manuel, Muntané, Gerard, Martorell, Lourdes, Bosch, Elena, Esteller, Manel, Canales-Rodríguez, Erick Jorge, Pomarol-Clotet, Edith, Jiménez, Esther, Vieta, Eduard, and Vilella, Elisabet

Abstract

[Aim] To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes., [Materials & methods] Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted., [Results] DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes., [Conclusion] DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.

Published
2021

6. DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes

Author

Edith Pomarol-Clotet, Elisabet Vilella, Gerard Muntané, Elena Bosch, Beatriz Garcia-Ruiz, Erick J. Canales-Rodríguez, Manel Esteller, Lourdes Martorell, Manuel Castro de Moura, Eduard Vieta, Esther Jiménez, García- Ruiz, Beatriz, Castro de Moura, Manuel, Muntané, Gerard, Martorell, Lourdes, Bosch, Elena, Esteller, Manel, Canales-Rodríguez, Erick Jorge, Pomarol-Clotet, Edith, Jiménez, Esther, Vieta, Eduard, Vilella, Elisabet, García- Ruiz, Beatriz [0000-0001-9552-949X], Castro de Moura, Manuel [0000-0002-8488-5306], Muntané, Gerard [0000-0003-1541-8365], Martorell, Lourdes [0000-0003-4999-2197], Bosch, Elena [0000-0003-2848-103X], Esteller, Manel [0000-0003-4490-6093], Canales-Rodríguez, Erick Jorge [0000-0001-6421-2633], Pomarol-Clotet, Edith [0000-0002-8159-8563], Jiménez, Esther [0000-0001-6929-6207], Vieta, Eduard [0000-0002-0548-0053], and Vilella, Elisabet [0000-0002-1887-5919]

Subjects
Gene isoform, Cancer Research, Bipolar disorder, Human brain, Biology, Methylation, Myelin genes, Myelin, Gene expression, Genetics, medicine, human brain, Gene, bipolar disorder, DDR1, Discoidin domain receptor 1, Molecular biology, discoidin domain receptor 1, medicine.anatomical_structure, DNA methylation, gene expression, methylation, myelin genes
Abstract

[Aim] To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes., [Materials & methods] Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted., [Results] DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes., [Conclusion] DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.

Published
2021

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