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2. A Qualitative Approach to the Analysis of Digital Leisure of the University Student Population

Author

Sánchez-Gómez, María Cruz, Cabanillas-García, Juan Luis, Martín-Cilleros, María Victoria, del Brío-Alonso, Irene, Verdugo-Castro, Sonia, Sánchez-Vicente, M. Inmaculada, Lorenzo-Sánchez, Oscar, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Ribeiro, Jaime, editor, Brandão, Catarina, editor, Ntsobi, Mfanelo, editor, Kasperiuniene, Judita, editor, and Costa, António Pedro, editor

Published
2024
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3. Real-World Retrospective Analysis of Alemtuzumab Outcomes in Relapsing-Remitting Multiple Sclerosis: The LEMCAM Study

Author

Costa-Frossard França, Lucienne, Meca Lallana, Virginia, Labiano-Fontcuberta, Andrés, Blasco, Rosario, Monreal, Enric, Martínez Ginés, María Luisa, Aguirre, Clara, Sabin Muñoz, Julia, Sainz de la Maza, Susana, Cuello, Juan Pablo, Díaz-Pérez, Carolina, Chico García, Juan Luis, Lozano Ros, Alberto, Rodríguez Jorge, Fernando, Martínez Martínez, Susana, and García Domínguez, José Manuel

Published
2024
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4. Resolving the paradox of conflicting glacial chronologies: Reconstructing the pattern of deglaciation of the Magellan cordilleran ice dome (53–54°S) during the last glacial – interglacial transition

Author

McCulloch, Robert D., Bentley, Michael J., Fabel, Derek, Fernández-Navarro, Hans, García, Juan-Luis, Hein, Andrew S., Huynh, Carla, Jamieson, Stewart S.R., Lira, María-Paz, Lüthgens, Christopher, Nield, Grace A., San Román, Manuel, and Tisdall, Eileen W.

Published
2024
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8. Mixed Study on the use of Flipped Classroom Methodology in the Subject of Community Mental Health Care

Author

del Brío-Alonso, Irene, Cabanillas-García, Juan Luis, Sánchez-Gómez, Mari Cruz, Franco-Martín, Manuel, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Milrad, Marcelo, editor, Otero, Nuno, editor, Sánchez‑Gómez, María Cruz, editor, Mena, Juan José, editor, Durães, Dalila, editor, Sciarrone, Filippo, editor, Alvarez-Gómez, Claudio, editor, Rodrigues, Manuel, editor, Vittorini, Pierpaolo, editor, Gennari, Rosella, editor, Di Mascio, Tania, editor, Temperini, Marco, editor, and De la Prieta, Fernando, editor

Published
2023
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9. Analysis of the Digital Competence of the Students of Mathematics Sciences of the Francisco de Morazán National Pedagogical University

Author

Cabanillas-García, Juan Luis, Sánchez-Gómez, Mari Cruz, del Brío-Alonso, Irene, Eguigure, Yenny, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Milrad, Marcelo, editor, Otero, Nuno, editor, Sánchez‑Gómez, María Cruz, editor, Mena, Juan José, editor, Durães, Dalila, editor, Sciarrone, Filippo, editor, Alvarez-Gómez, Claudio, editor, Rodrigues, Manuel, editor, Vittorini, Pierpaolo, editor, Gennari, Rosella, editor, Di Mascio, Tania, editor, Temperini, Marco, editor, and De la Prieta, Fernando, editor

Published
2023
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10. Use of Exergames with Elderly Adults, a Qualitative Study

Author

Gutiérrez-Pérez, Bárbara Mariana, Martín-García, Antonio Víctor, García, Juan Luis Cabanillas, Gómez-Sánchez, María Cruz, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Milrad, Marcelo, editor, Otero, Nuno, editor, Sánchez‑Gómez, María Cruz, editor, Mena, Juan José, editor, Durães, Dalila, editor, Sciarrone, Filippo, editor, Alvarez-Gómez, Claudio, editor, Rodrigues, Manuel, editor, Vittorini, Pierpaolo, editor, Gennari, Rosella, editor, Di Mascio, Tania, editor, Temperini, Marco, editor, and De la Prieta, Fernando, editor

Published
2023
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11. Observational Study of Experiential Activities Linked to Astronomy with CAQDAS NVivo

Author

Cabanillas-García, Juan Luis, Rodríguez-Jiménez, Carlos Javier, Sánchez-Gómez, María Cruz, Losada-Vázquez, Ángel, Losada-Moncada, María, Corrales-Vázquez, José María, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Costa, António Pedro, editor, Moreira, António, editor, Freitas, Fábio, editor, Costa, King, editor, and Bryda, Grzegorz, editor

Published
2023
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19. Analysis of the Use, Knowledge and Problems of E-learning in a Distance Learning Master’s Programme

Author

Cabanillas-García, Juan Luis, Luengo-González, Ricardo, Carvalho, José Luis, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Costa, António Pedro, editor, Moreira, António, editor, Sánchez‑Gómez, Maria Cruz, editor, and Wa-Mbaleka, Safary, editor

Published
2022
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20. A Qualitative Study and Analysis on the Use, Utility, and Emotions of Technology by the Elderly in Spain

Author

García, Juan Luis Cabanillas, Martín-Sevillano, Rocío, Sánchez-Gómez, Mª Cruz, Martín-Cilleros, Mª Victoria, Verdugo-Castro, Sonia, Mena, Juanjo, Pinto-Llorente, Ana María, Álvarez, Vanessa Izquierdo, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Costa, António Pedro, editor, Moreira, António, editor, Sánchez‑Gómez, Maria Cruz, editor, and Wa-Mbaleka, Safary, editor

Published
2022
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25. Phosphorylation of cytosolic hPGK1 affects protein stability and ligand binding: implications for its subcellular targeting in cancer.

Author

Pacheco‐García, Juan Luis, Cano‐Muñoz, Mario, Loginov, Dmitry S., Vankova, Pavla, Man, Petr, and Pey, Angel L.

Subjects
*PHOSPHOGLYCERATE kinase, *BINDING sites, *STRUCTURAL dynamics, *PROTEIN kinases, *MOLECULAR dynamics, *PROTEIN stability, *LIGAND binding (Biochemistry)
Abstract

Human phosphoglycerate kinase 1(hPGK1) is a key glycolytic enzyme that regulates the balance between ADP and ATP concentrations inside the cell. Phosphorylation of hPGK1 at S203 and S256 has been associated with enzyme import from the cytosol to the mitochondria and the nucleus respectively. These changes in subcellular locations drive tumorigenesis and are likely associated with site‐specific changes in protein stability. In this work, we investigate the effects of site‐specific phosphorylation on thermal and kinetic stability and protein structural dynamics by hydrogen–deuterium exchange (HDX) and molecular dynamics (MD) simulations. We also investigate the binding of 3‐phosphoglycerate and Mg‐ADP using these approaches. We show that the phosphomimetic mutation S256D reduces hPGK1 kinetic stability by 50‐fold, with no effect of the mutation S203D. Calorimetric studies of ligand binding show a large decrease in affinity for Mg‐ADP in the S256D variant, whereas Mg‐ADP binding to the WT and S203D can be accurately investigated using protein kinetic stability and binding thermodynamic models. HDX and MD simulations confirmed the destabilization caused by the mutation S256D (with some long‐range effects on stability) and its reduced affinity for Mg‐ADP due to the strong destabilization of its binding site (particularly in the apo‐state). Our research provides evidence suggesting that modifications in protein stability could potentially enhance the translocation of hPGK1 to the nucleus in cancer. While the structural and energetic basis of its mitochondrial import remain unknown. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Muerte súbita de jóvenes: rendimiento diagnóstico de un programa autonómico de autopsia molecular con secuenciación masiva

Author

Ripoll-Vera, Tomás, Pérez Luengo, Consuelo, Borondo Alcázar, Juan Carlos, García Ruiz, Ana Belén, Sánchez Del Valle, Nieves, Barceló Martín, Bernardino, Poncela García, Juan Luis, Gutiérrez Buitrago, Gloria, Dasi Martínez, Concepción, Canós Villena, Juan Carlos, Moyano Corvillo, Susana, Esgueva Pallarés, Raquel, Sancho Sancho, Juan Ramón, Guitart Pinedo, Gemma, Hernández Marín, Elena, García García, Estela, Vingut López, Albert, Álvarez Rubio, Jorge, Govea Callizo, Nancy, Gómez Pérez, Yolanda, Melià Mesquida, Catalina, Heine, Damián, Rosell Andreo, Jordi, and Socías Crespí, Lorenzo

Published
2021
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38. Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14

Author

Rodríguez, Ana Eugenia, Hernández, Jose Ángel, Benito, Rocío, Gutiérrez, Norma C., García, Juan Luis, Hernández Sánchez, María, Risueño, Alberto, Sarasquete, M. Eugenia, Fermiñán, Encarna, Fisac, Rosa, García de Coca, Alfonso, Martín-Núñez, Guillermo, Heras, Natalia de las, Recio, Isabel, Gutiérrez, Oliver, Rivas, Javier De Las, González, Marcos, Hernández-Rivas, Jesús M., Rodríguez, Ana Eugenia, Hernández, Jose Ángel, Benito, Rocío, Gutiérrez, Norma C., García, Juan Luis, Hernández Sánchez, María, Risueño, Alberto, Sarasquete, M. Eugenia, Fermiñán, Encarna, Fisac, Rosa, García de Coca, Alfonso, Martín-Núñez, Guillermo, Heras, Natalia de las, Recio, Isabel, Gutiérrez, Oliver, Rivas, Javier De Las, González, Marcos, and Hernández-Rivas, Jesús M.

Abstract

Background Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. Design and Methods: A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors. Results Chronic lymphocytic leukemia patients with higher percentages of 13q- cells (>80%) showed a different level of gene expression as compared to patients with lower percentages (<80%, 13q-L). This deregulation affected genes involved in apoptosis and proliferation (BCR and NFkB signaling), leading to increased proliferation and decreased apoptosis in 13q-H patients. Deregulation of several microRNAs, such as miR-15a, miR-155, miR-29a and miR-223, was also observed in these patients. In addition, our study also suggests that the gene expression pattern of 13q-H cases could be similar to the patients with 11q- or 17p-. Conclusions This study provides new evidence regarding the heterogeneity of 13q deletion in chronic lymphocytic leukemia patients, showing that apoptosis, proliferation as well as miRNA regulation are involved in cases with higher percentages of 13q- cells., Spanish Fondo de Investigaciones Sanitarias, Caja de Burgos-Banca Cívica, Gerencia Regional de Salud de Castilla y León, Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation, Cancer Research Foundation of Salamanca University, Redes de Investigación, Depto. de Bioquímica y Biología Molecular, Fac. de Farmacia, TRUE, pub

Published
2024

40. Effect of alemtuzumab over sNfL and sGFAP levels in multiple sclerosis.

Author

Sainz-Amo, Raquel, Romero, Alexander Rodero, Monreal, Enric, Chico García, Juan Luis, Fernández Velasco, José Ignacio, Villarrubia, Noelia, Veiga González, Jose Luis, de la Maza, Susana Sainz, Jorge, Fernando Rodríguez, Masjuan, Jaime, Costa-Frossard, Lucienne, and Villar, Luisa María

Subjects
GLIAL fibrillary acidic protein, DEMOGRAPHIC characteristics, SINGLE molecules, DISEASE duration, MULTIPLE sclerosis
Abstract

Introduction: Alemtuzumab is a highly effective pulsed immune reconstitution therapy for multiple sclerosis (MS). Aim: To evaluate serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) in patients with relapsing-remitting MS who have been treated with Alemtuzumab over the course of 2 years. Methods: This prospective study involved MS patients treated with Alemtuzumab at a referral MS center. Both sNfL and sGFAP were analyzed at baseline and then again at 6, 12, and 24 months post-treatment using the single molecule array (SiMoA) technique. We also recruited matched healthy controls (HCs) for comparison. Results: The study included 46 patients (with a median age of 34.2 [Interquartile range (IQR), 28.7–42.3] years, 27 of which were women [58%]) and 76 HCs. No differences in demographic characteristics were observed between patients and HC. The median disease duration was 6.22 (IQR, 1.56–10.13) years. The median annualized relapse rate before treatment was 2 (IQR, 1–3). At baseline, sNfL and sGFAP levels were higher in MS patients (median of 18.8 [IQR, 10.7–52.7] pg/ml and 158.9 [IQR, 126.9–255.5] pg/ml, respectively) when compared to HC (6.11 [IQR, 2.03–8.54] pg/ml and 91.0 [72.6–109] pg/ml, respectively) (p<0.001 for both comparisons). The data indicates that 80% of patients had high (≥10 pg/ml) sNfL values at baseline. We observed a significant decrease in sNfL levels at 6 (65%, p = 0.02), 12 (70.8%, p<0.001), and 24 (78.1%, p<0.001) months. sNfL reached similar levels to HC only after 24 months of Alemtuzumab treatment. During the follow-up period, no changes were identified in the sGFAP values. Conclusion: Alemtuzumab leads to the normalization of sNfL values in MS patients after 2 years of treatment, with no apparent effect on sGFAP values. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Accelerating Glacier Area Loss Across the Andes Since the Little Ice Age.

Author

Carrivick, Jonathan L., Davies, Morwenna, Wilson, Ryan, Davies, Bethan J., Gribbin, Tom, King, Owen, Rabatel, Antoine, García, Juan‐Luis, and Ely, Jeremy C.

Subjects
LITTLE Ice Age, GLACIERS, ALPINE glaciers, ENVIRONMENTAL engineering, ENVIRONMENTAL protection, AQUATIC ecology, ENVIRONMENTAL management
Abstract

Andean glaciers are losing mass rapidly but a centennial‐scale context to those rates is lacking. Here we show the extent of >5,500 glaciers during the Little Ice Age chronozone (LIA; c. 1,400 to c. 1,850) and compute an overall area change of −25% from then to year 2000 at an average rate of −36.5 km2 yr−1 or −0.11% yr−1. Glaciers in the Tropical Andes (Peru, Bolivia) have depleted the most; median −56% of LIA area, and the fastest; median −0.16% yr−1. Up to 10 × acceleration in glacier area loss has occurred in Tropical mountain sub‐regions comparing LIA to 2,000 rates to post‐2000 rates. Regional climate controls inter‐regional variability, whereas local factors affect intra‐region glacier response time. Analyzing glacier area change by river basins and by protected areas leads us to suggest that conservation and environmental management strategies should be re‐visited as proglacial areas expand. Plain Language Summary: Andean glaciers are melting fast but how that rate compares in a longer‐term context is unknown. In this study we mapped the extent of >5,500 glaciers during the Little Ice Age, which was the last major glacial advance culminating about c. 150 years ago. We analyzed the change in glacier size and computed overall area change of −25% from the LIA to year 2000 at a rate of −36.5 km2 per year or −0.11% per year. Glaciers within Peru and Bolivia have shrunk the most by median −56% of LIA area, and the fastest by median −0.16% per year. We discuss that these glaciers are depleting and retreating due to climate change but that response is compounded by glacier size, shape and terminus environment effects. As glaciers melt they reveal proglacial landscapes that tend to be highly unstable, impacting water resources, natural hazards and terrestrial and aquatic ecology. Key Points: Little Ice Age (LIA) chronozone extent of >5,500 glaciers mapped from geomorphological evidenceOverall glacier area change of −25% to year 2000 at a rate of −36.5 km2 yr−1 or −0.11% yr−1Up to 10 × acceleration in glacier area loss for Tropical sub‐regions comparing LIA to 2,000 with post‐2000 rates [ABSTRACT FROM AUTHOR]

Published
2024
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42. Per cepción y experiencias de los estudiantes de la Universidad de Salamanca sobre el ocio y el tiempo libre.

Author

SÁNCHEZ-GÓMEZ, María Cruz, CABANILLAS-GARCÍA, Juan Luis, and VERDUGO-CASTRO, Sonia

Subjects
YOUNG adults, SOCIAL development, CULTURAL activities, SOCIALIZATION, TEAM sports, HABIT
Abstract

Copyright of Pedagogía Social is the property of Pedagogia Social and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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44. The evolution of the Patagonian Ice Sheet from 35 ka to the present day (PATICE)

Author

Davies, Bethan J., Darvill, Christopher M., Lovell, Harold, Bendle, Jacob M., Dowdeswell, Julian A., Fabel, Derek, García, Juan-Luis, Geiger, Alessa, Glasser, Neil F., Gheorghiu, Delia M., Harrison, Stephan, Hein, Andrew S., Kaplan, Michael R., Martin, Julian R.V., Mendelova, Monika, Palmer, Adrian, Pelto, Mauri, Rodés, Ángel, Sagredo, Esteban A., Smedley, Rachel K., Smellie, John L., and Thorndycraft, Varyl R.

Published
2020
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48. CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition

Author

Quijada-Álamo, Miguel, Hernández-Sánchez, María, Alonso-Pérez, Verónica, Rodríguez-Vicente, Ana E., García-Tuñón, Ignacio, Martín-Izquierdo, Marta, Hernández-Sánchez, Jesús María, Herrero, Ana B., Bastida, José María, San Segundo, Laura, Gruber, Michaela, García, Juan Luis, Yin, Shanye, ten Hacken, Elisa, Benito, Rocío, Ordóñez, José Luis, Wu, Catherine J., and Hernández-Rivas, Jesús María

Published
2020
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