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1. Post-operative morbidity and mortality of a cohort of steroid refractory acute severe ulcerative colitis: Nationwide multicenter study of the GETECCU ENEIDA Registry

Author

Ordás, I, Domènech, E, Mañosa, M, García-Sánchez, V, Iglesias-Flores, E, Rodríguez-Moranta, F, Márquez, L, Merino, O, Fernández-Bañares, F, Gomollón, F, Vera, M, Gutiérrez, A, LLaó, J, Gisbert, JP, Aguas, M, Arias, L, Rodríguez-Lago, I, Muñoz, C, Alcaide, N, Calvet, X, Rodríguez, C, Montoro, MA, García, S, De Castro, ML, Piqueras, M, Pareja, L, Ribes, J, Panés, J, Esteve, M, and on behalf of the ENEIDA registry of GETECCU

Published
2018
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2. OP37 Is the withdrawal of anti-tumour necrosis factor in inflammatory bowel disease patients in remission feasible without increasing the risk of relapse? Results from the randomised clinical trial of GETECCU (EXIT)

Author

Chaparro, M, primary, García Donday, M, additional, Riestra, S, additional, Lucendo, A J, additional, Benítez, J M, additional, Navarro-Llavat, M, additional, Barrio, J, additional, Morales-Alvarado, V J, additional, Rivero, M, additional, Busquets, D, additional, Leo Carnerero, E, additional, Merino Ochoa, O, additional, Nantes Castillejo, O, additional, Navarro, P, additional, Van Domselaar, M, additional, Gutiérrez Casbas, A, additional, Alonso-Abreu, I, additional, Mejuto, R, additional, Fernández Salazar, L, additional, Iborra, M, additional, Martín-Arranz, M D, additional, Pineda, J R, additional, Sampedro, M J, additional, Serra Nilsson, K, additional, Bouhmidi Assakali, A, additional, Batista, L, additional, Muñoz Villafranca, C, additional, Rodríguez-Lago, I, additional, Ceballos Santos, D S, additional, Guerra, I, additional, Mañosa, M, additional, Marín Jimenez, I, additional, Vera Mendoza, I, additional, Barreiro-de Acosta, M, additional, Domènech, E, additional, Esteve, M, additional, García-Sánchez, V, additional, Nos, P, additional, Panés, J, additional, and Gisbert, J P, additional

Published
2023
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3. OP034 The initiation of thiopurines in elderly patients with inflammatory bowel disease is associated with an increased risk of adverse effects: a case–control study of the ENEIDA registry

Author

Calafat, M, Mañosa, M, Cañete, F, Panés, J, García Sánchez, V, Calvo, M, Rodríguez-Moranta, F, Taxonera, C, Nos, P, López Sanromán, A, Martín Arranz, M D, Mínguez, M, Gisbert, J P, García-López, S, de Francisco, R, Gomollón, F, Calvet, X, Garcia-Planella, E, Rivero, M, Martínez-Cadilla, J, Argüelles, F, Arias García, L, Cimavilla, M, Zabana, Y, Márquez, L, Gutiérrez, A, Alcaín, G, Martínez Montiel, P, Lázaro, J, Busquets, D, García Sepulcre, M F, Verdejo, C, Bermejo, F, Mora, M, Monfort, D, Romero, P, Velayos, B, Rodríguez, C, Rodríguez, A, Merino, O, Rodríguez-Pescador, A, Bujanda, L, Ber, Y, Vela, M, Roncero, O, Huguet, J M, García-Bosch, O, Barreiro-de-Acosta, M, Madrigal, R E, Ramos, L, Van Domselaar, M, Almela, P, Llaó, J, Lucendo, A J, Muñoz Vilafranca, C, Abad, À, Charro, M, Legido, J, Riera, J, Khorrami, S, Sesé, E, Trapero, A M, and Domènech, E

Published
2018
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4. P607 Post-operative mortality and predictive factors in a cohort of severe refractory ulcerative colitis patients from the ENEIDA Registry (1989–2013): a multicenter nationwide study

Author

Ordas, I., Domenech, E., Aguas, M., Fernandez-Bañares, F., García, S., Peñalva, M., Muñoz, C., García-Sánchez, V., Lla, J., Jiménez, C.E., Merino, O., Gomolln, F., Piqueras, M., Vera, M., Márquez, L., De Castro, M., Gutiérrez, A., Cabriada, J.L., Alcaide, N., Calvet, X., Montoro, M.A., Arias, L., Panés, J., and Esteve, M.

Published
2017
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6. P327 Evolution after a “de-intensification” strategy with anti-TNF therapy in patients with inflammatory bowel disease in clinical remission: multicenter study

Author

Benítez, J.M., Barreiro-de Acosta, M., Chaparro, M., Vázquez, J.M., Iglesias-Flores, E., Tosca, J., García-Planella, E., García-Lpez, S., Taxonera, C., Muñoz-Villafranca, M., Pajares, R., Barrio, J., Arias, L., Nantes, O., Fernández-Salazar, L., Hervías, D., Martín-Arranz, M., Mesonero, F., Moraleja-Yudejo, I., Pineda, J., Argüelles-Arias, F., Huguet, J., Hernández-Martínez, A., Pérez-Calle, J., Leo, E., Merino, O., Van Domselaar, M., Gutiérrez, A., Lorente, R., Castro, M., Algaba, A., Castro, E., Robles-Alonso, V., Ceballos, D., Gmez-García, R., Domínguez, J., Fernández, E., Vega-Lpez, A., Trapero, A., Talavera, A., Royo, V., Gisbert, J.P., and García-Sánchez, V.

Published
2017
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7. Characteristics and Treatment of Pyoderma Gangrenosum in Inflammatory Bowel Disease

Author

Argüelles-Arias, F., Castro-Laria, L., Lobatón, T., Aguas-Peris, M., Rojas-Feria, M., Barreiro-de Acosta, M., Soto-Escribano, P., Calvo-Moya, M., Ginard-Vicens, D., Chaparro-Sánchez, M., Hernández-Durán, M., Castro-Senosiain, B., Fernández-Villaverde, A., García-Sánchez, V., Domínguez-Muñoz, E., Caunedo-Álvarez, A., and Herrerías-Gutiérrez, J. M.

Published
2013
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9. Short and long-term effectiveness and safety of vedolizumab in inflammatory bowel disease: results from the ENEIDA registry

Author

Chaparro M, Garre A, Ricart E, Iborra M, Mesonero F, Vera I, Riestra S, García-Sánchez V, Luisa De Castro M, Martin-Cardona A, Aldeguer X, Mínguez M, de-Acosta MB, Rivero M, Muñoz F, Andreu M, Bargalló A, González-Muñoza C, Pérez Calle JL, García-Sepulcre MF, Bermejo F, Huguet JM, Cabriada JL, Gutiérrez A, Mañosa M, Villoria A, Carbajo AY, Lorente R, García-López S, Piqueras M, Hinojosa E, Arajol C, Sicilia B, Conesa AM, Sainz E, Almela P, Llaó J, Roncero O, Camo P, Taxonera C, Domselaar MV, Pajares R, Legido J, Madrigal R, Lucendo AJ, Alcaín G, Doménech E, Gisbert JP, and GETECCU study group

Subjects
Adult, Male, medicine.medical_specialty, Antibodies, Monoclonal, Humanized, Communicable Diseases, Inflammatory bowel disease, Vedolizumab, 03 medical and health sciences, 0302 clinical medicine, Crohn Disease, Gastrointestinal Agents, Interquartile range, Internal medicine, medicine, Humans, Pharmacology (medical), Prospective Studies, Registries, Adverse effect, Prospective cohort study, Hepatology, business.industry, Proportional hazards model, Remission Induction, Gastroenterology, Middle Aged, Inflammatory Bowel Diseases, medicine.disease, Ulcerative colitis, Discontinuation, Treatment Outcome, Spain, 030220 oncology & carcinogenesis, Colitis, Ulcerative, Female, 030211 gastroenterology & hepatology, business, Follow-Up Studies, medicine.drug
Abstract

Background: Effectiveness of vedolizumab in real world clinical practice is unknown. Aim: To evaluate the short and long-term effectiveness of vedolizumab in patients with inflammatory bowel disease (IBD). Methods: Patients who received at least 1 induction dose of vedolizumab were included. Effectiveness was defined based on Harvey-Bradshaw index (HBI) in Crohn's disease (CD) and Partial Mayo Score (PMS) in ulcerative colitis (UC). Short-term response was assessed at week 14. Variables associated with short-term remission were identified by logistic regression analysis. The Kaplan-Meier method was used to evaluate the long-term durability of vedolizumab treatment. Cox model was used to identify factors associated with discontinuation of treatment and loss of response. Results: 521 patients were included (median follow-up 10 months [interquartile range 5-18 months]). At week 14, 46.8% had remission and 15.7% clinical response. CD (vs UC), previous surgery, higher CRP concentration and disease severity at baseline were significantly associated with impaired response. The rate of vedolizumab discontinuation was 37% per patient-year of follow-up (27.6% in UC and 45.3% in CD, P < 0.01). CD (vs UC), anaemia at baseline, steroids during induction and CRP concentration were associated with lower durability of treatment. Seven per cent of patients developed adverse events, infections being the most frequent. Conclusions: Over 60% of IBD patients respond to vedolizumab. Many patients discontinue treatment over time. CD and disease burden impair both short- and long-term response. Vedolizumab seems to be safe in clinical practice.

Published
2018

11. Smoking does influence disease behaviour and impacts the need for therapy in Crohn′s disease in the biologic era

Author

Nunes, T., Etchevers, M. J., Domènech, E., García-Sánchez, V., Ber, Y., Peñalva, M., Merino, O., Nos, P., Garcia-Planella, E., Casbas, A. G., Esteve, M., Samsó, Taxonera C., Huguet, Montoro M., Gisbert, J. P., Arranz, M. D.Martín, García-Sepulcre, M. F., de Acosta, Barreiro- M., Beltrán, B., Suárez, Alcaide N., Gismera, Saro C., Cabriada, J. L., Cañas-Ventura, A., Gomollón, F., and Panés, J.

Published
2013
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12. El registro ENEIDA (Estudio Nacional en Enfermedad Inflamatoria intestinal sobre Determinantes genéticos y Ambientales) de GETECCU: diseño, monitorización y funciones

Author

Zabana, Y., Panés, J., Nos, P., Gomollón, Fernando, Esteve, M., García-Sánchez, V., Gisbert, J.P., Barreiro-de-Acosta, M., Domènech, E., en representacion de GETECCU, UAM. Departamento de Medicina, and Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)

Subjects
Hepatology, business.industry, Medicina, Gastroenterology, Inflammatory bowel diseases, Malalties inflamatòries intestinals, 03 medical and health sciences, Crohn's disease, 0302 clinical medicine, ENEIDA, Malaltia de Crohn, Ulcerative colitis, Colitis ulcerosa, Enfermedad inflamatoria intestinal, 030220 oncology & carcinogenesis, GETECCU, Medicine, 030211 gastroenterology & hepatology, Registro, business, Humanities
Abstract

El registro ENEIDA, promovido por el Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU), fue creado en 2005 por un grupo de gastroenterólogos interesados en mejorar el manejo de los pacientes con enfermedad inflamatoria intestinal. Los objetivos principales del registro fueron facilitar la recogida de datos clínicos de interés para la práctica clínica asistencial, así como la elaboración de estudios colaborativos a partir de datos clínicos y muestras biológicas. En sus 15 años de existencia, ENEIDA ha evolucionado en múltiples aspectos, desde su contenido o su soporte tecnológico hasta el número de centros participantes, para convertirse en uno de los registros de referencia para el estudio y cuidado de los pacientes con enfermedad inflamatoria intestinal, con una producción científica continua y de alta calidad que lo ha situado como ejemplo de explotación científica colaborativa en el ámbito internacional. En este artículo se revisan los objetivos, el diseño, las características estructurales, la monitorización y la explotación científica del registro ENEIDA, The ENEIDA registry, promoted by the Spanish Working Group on Crohn’s Disease andUlcerative Colitis (GETECCU), was created in 2005 by a group of gastroenterologists interested inimproving the management of patients with inflammatory bowel disease. The main objectives ofthe registry were to facilitate the collection of clinical data of interest for clinical care practice,as well as to carry out collaborative studies using clinical data and biological samples. In its15 years of existence, ENEIDA has evolved in many aspects, from its content or technologicalsupport to the number of participating centres, to become one of the reference registries forthe study and care of patients with inflammatory bowel disease, with a continuous and highquality scientific production that has positioned it as an example of collaborative scientificexploitation at an international level. This article reviews the objectives, design, structuralcharacteristics, monitoring and scientific exploitation of the ENEIDA registry.

Published
2020

13. Índice de autores

Author

Montero Pérez, F. Javier, Jiménez Murillo, Luis, Agustín Romero, I., Agustín Varas, A., Alamillos Granados, F.J., Alcalá Partera, J.A., Alcolea Santiago, J., Aldeanueva Escribano, M., Álvarez Rivas, M.A., Anglada Curado, F.J., Anguita Sánchez, M., Antón Aguilar, L., Aparicio Pérez, C., Aranda Mora, A., Arévalo Frutos, P.J., Arjona Berral, J.E., Baena Delgado, E., Bajo Fernández, I., Baleato Gómez, B., Barbudo Merino, J., Barcones Gómez, C., Barneto Aranda, I., Benítez Cantero, J.M., Benítez Laguna, A.M., Berdud Godoy, I., Berenguer López, M.M., Berlango Jiménez, A., Blancas Sánchez, I., Bravo Aguilera, C., Bravo Rodríguez, F., Bretones Baena, S., Briceño Delgado, J., Cáceres Redondo, M.T., Calañas Continente, A., Calderón Caro, M., Calderón de la Barca Gázquez, J.M., Calvo Rodríguez, R., Campos Hernández, P., Cancelliere Fernández, N., Cano Castiñeira, R., Caracuel Ruiz, M.A., Castañeda Mendieta, R., Castilla Camacho, S., Cerezo Madueño, F., Clemente Millán, M.J., Cobos Ceballos, M.J., Cobos Requena, A.M., Comino Monroy, M.J., Concha Jarava, J.M., Conesa Pedrosa, I., Constenla Ramos, S., Cortázar Rocandio, G., Cruz Alcaide, A.B., de Burgos Marín, J., de Dios Ruiz, A.M., de la Mata García, M., de la Torre Castillo, O.M., de la Torre Cisneros, J., de la Torre González, A., de Prado López, M.F., Deán Ferrer, A., Degayón Rojo, H., Delgado Acosta, F., Díaz Rueda, L., Domínguez Grande, M.L., Dueñas Jurado, J.M., Durán Serantes, M., Duro Gómez, J., Entrenas Castillo, M., Entrenas Costa, L.M., Escuder Egea, R., Espejo Pérez, S., Espejo Rodríguez, E., Esquivias de Motta, E., Expósito Ordóñez, A., Fernández Camacho, I., Fernández de la Puebla Lechuga, E., Fernández Martínez, N.F., Fernández Sánchez de Mora, M.C., Fernández Valverde, F., Franco Jiménez, A., Gallardo Valverde, J.M., Gálvez Moreno, M.A., García Díaz, L., García Lázaro, M., García Martínez, E., García Quintana, J.M., García Rubio, J.H., García Sánchez, V., García Vázquez, A.M., García-Arévalo Arellano, R., Gavilán Guirao, F., Gil Hernández, S., Giménez Ruiz, J.J., Gimeno Gimeno, M.J., Gómez Gómez, E., Gómez Panzuela, N., González Campillo, M.T., González de Caldas Marchal, R., González Galilea, A., González García, F.M., González Requero, A.I., González Romero, M.D., González Teomiro, C., Gracia García, F., Guerra Vilches, V., Guerrero-León, M.A., Herrero González, Y., Hinojosa Marín, B., Iglesias Flores, E., Jiménez Aguilar, A.M., Jiménez Gallardo, J., Jiménez Murillo, L., Jiménez Puya, M.C., Jiménez Villalta, M.T., Jurado Gámez, B., Jurado García, J., Ladehesa Pineda, L., Lama Martínez, R., Larrasa Soriano, S., Leal Reyes, G., León López, R., Llamas Fuentes, R., Llamas Quiñones, L., Llergo Muñoz, A., López Granados, A., López Hurtado, F., López Malo de Molina, D., López Miranda, J., López Ruiz, D., Lorente González, J., Lorenzo Montero, M.J., Lozano Jiménez, M.J., Lucchini Leiva, R., Lucena Aguilera, C., Luna Morales, S., Machuca Sánchez, I.M., Marín Martín, E., Marín Pedrosa, S., Martín de León, R., Martín Malo, A., Martín Sosa, M.M., Martínez Acevedo, E., Martínez García, A.I., Martínez Grueiro, M., Martínez Losada, C., Martínez Mesones, L., Martínez Virto, A.M., Martos Órpez, M.C., Mateo Mateo, F., Medinilla Montenegro, M.C., Mellado Castillero, A., Menchero Sánchez-Migallón, C., Mesa Rubio, M.D., Mifsut Gallardo, M.J., Molina Nieto, T., Monserrat Barbudo, O., Monserrat Jordán, J.A., Montero Pérez, F.J., Mora Sánchez, A., Moreno Herrera, C.M., Moreno Montero, I., Moreno Navas, A., Moreno Sorribas, S., Moreno Velasco, I., Moya González, J., Moyano Pulido, M.J., Muñoz Carvajal, I., Muñoz del Castillo, F., Muñoz Triano, E., Natera Kindelán, C., Nieto Pascual, L., Nogué Bou, R., Pacheco Capote, C., Padilla Rico, M., Padillo Cuenca, J.C., Palacios Eito, A., Palenzuela Martín, S., Palomar Alguacil, V., Palomar Muñoz, M.C., Palomares Ortega, R., Pan Álvarez-Osorio, M., Pascual Martínez, N., Peláez Viña, N., Pérez Montilla, M.E., Pérez Rodríguez, E., Postigo Arrabal, S., Pugnet, G., Quero Espinosa, F.B., Quintana Díaz, M., Ramos Gómez, M., Recio Bermejo, M., Redel Montero, J., Reyes Vallejo, R., Ríos Jiménez, D., Rivero Román, A., Robles Arista, J.C., Rodríguez Alonso, B., Rodríguez Alonso, R., Rodríguez Benot, A., Rodríguez Cano, M.E., Rodríguez Cantalejo, F., Rodríguez Fuertes, P., Rodríguez Marín, A.B., Rodríguez Perálvarez, M., Rodríguez Salas, M., Roig Rodríguez, J.J., Roka Nchaso, L.A., Roldán Romero, E., Romero Bravo, A., Romero Moreno, M.A., Rueda García, R.L., Ruiz García, J., Ruiz Ortiz, M., Ruiz Ruiz, E., Ruiz Sáez, B., Rumbao Aguirre, J.M., Sainz de la Cuesta Alonso, S., Salamanca Bustos, J.J., Salas Hernández, F., Salcedo Leal, I., Salvatierra Velázquez, A., Sánchez Alcántara, M.B., Sánchez del Solar, M.L., Santos Luna, F., Seguí Azpilcueta, P., Segura Saint-Gerons, J., Serrano Blanch, R., Serrano Moreno, E., Serrano Ortiz, A., Solivera Vera, J., Tirado Valencia, C., Toledano Delgado, A., Torres Degayón, E., Torres Degayón, S., Torres Degayón, V., Torres Murillo, J.M., Triviño Tarradas, F., Valero Rosa, J., Vallejo Casas, J.A., Valverde Moyano, R., Vaquero Barrios, J.M., Vega Reyes, J.A., Velázquez Navarrete, M.C., Vélez García-Nieto, A.J., Vicente Rueda, J., Vicho González, C., Vida Pérez, L., Vida Pérez, M., Vidal Verdú, E., Vignote Alguacil, M.L., Villalba Calvente, M., Villalba Montoro, R., Villar García, J., Yagüe Martín, M., and Yébenes Ramírez, M.

Published
2023
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15. Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients

Author

González-Lama, Y., Bermejo, F., López-Sanromán, A., García-Sánchez, V., Esteve, M., Cabriada, J. L., McNicholl, A. G., Pajares, R., Casellas, F., Merino, O., Carpio, D., Vera, M. I., Muñoz, C., Benito, L. M., Bujanda, L., García-Fernández, F. J., Ricart, E., Ginard, D., Velasco, M., Carneros, J. A., Manceñido, N., Calvo, M., Algaba, A., Froilan, C., Cara, C., Maté, J., Abreu, L., and Gisbert, J. P.

Published
2011
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19. Prevalence and Factors Associated With Fatigue in Patients With Inflammatory Bowel Disease: A Multicentre Study

Author

Chavarría, C, primary, Casanova, M J, additional, Chaparro, M, additional, Barreiro-de Acosta, M, additional, Ezquiaga, E, additional, Bujanda, L, additional, Rivero, M, additional, Argüelles-Arias, F, additional, Martín-Arranz, M D, additional, Martínez-Montiel, M P, additional, Valls, M, additional, Ferreiro-Iglesias, R, additional, Llaó, J, additional, Moraleja-Yudego, I, additional, Casellas, F, additional, Antolín-Melero, B, additional, Cortés, X, additional, Plaza, R, additional, Pineda, J R, additional, Navarro-Llavat, M, additional, García-López, S, additional, Robledo-Andrés, P, additional, Marín-Jiménez, I, additional, García-Sánchez, V, additional, Merino, O, additional, Algaba, A, additional, Arribas-López, M R, additional, Banales, J M, additional, Castro, B, additional, Castro-Laria, L, additional, Honrubia, R, additional, Almela, P, additional, and Gisbert, J P, additional

Published
2019
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20. P816 Functional rare variants influence the clinical response to anti-TNF therapy in Crohn’s disease

Author

Chaparro, M, primary, Aterido, A, additional, Guerra, I, additional, Iborra, M, additional, Cabriada, J, additional, Bujanda, L, additional, Taxonera, C, additional, García-Sánchez, V, additional, Marín-Jiménez, I, additional, Barreiro-de Acosta, M, additional, Vera, I, additional, Martín-Arranz, M, additional, Hernández-Breijo, B, additional, Mesonero, F, additional, Sempere, L, additional, Gomollón, F, additional, Hinojosa, J, additional, Algaba, A, additional, Beltrán, B, additional, Rodríguez Pescador, A, additional, Banales, J, additional, Olivares, D, additional, Aguilar-Melero, P, additional, Menchén, L, additional, Ferreiro-Iglesias, R, additional, Blázquez Gómez, I, additional, Benitez García, B, additional, Guijarro, L, additional, C Marín, A, additional, Bernardo, D, additional, Marsal, S, additional, Julia, A, additional, and Gisbert, J P, additional

Published
2019
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21. P008 Proteomic markers of response to anti-TNF drugs in patients with Crohn's disease

Author

Medina-Medina, R, primary, Iglesias-Flores, E, additional, Benítez, J M, additional, Marín-Pedrosa, S, additional, Salgueiro, I, additional, Ferrín, G, additional, Linares, C I, additional, González-Rubio, S, additional, Soto, P, additional, Gros, B, additional, Moral, C, additional, Alvarez, F, additional, Rodríguez-Perálvarez, M, additional, Chicano-Gálvez, E, additional, Ortea, I, additional, García-Sánchez, V, additional, and Aguilar-Melero, P, additional

Published
2019
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22. Evolution After Anti-TNF Discontinuation in Patients With Inflammatory Bowel Disease: A Multicenter Long-Term Follow-Up Study

Author

Casanova MJ, Chaparro M, García-Sánchez V, Nantes O, Leo E, Rojas-Feria M, Jauregui-Amezaga A, García-López S, Huguet JM, Arguelles-Arias F, Aicart M, Marín-Jiménez I, Gómez-García M, Muñoz F, Esteve M, Bujanda L, Cortés X, Tosca J, Pineda JR, Mañosa M, Llaó J, Guardiola J, Pérez-Martínez I, Muñoz C, González-Lama Y, Hinojosa J, Vázquez JM, Martinez-Montiel MP, Rodríguez GE, Pajares R, García-Sepulcre MF, Hernández-Martínez A, Pérez-Calle JL, Beltrán B, Busquets D, Ramos L, Bermejo F, Barrio J, Barreiro-de Acosta M, Roncedo O, Calvet X, Hervías D, Gomollón F, Domínguez-Antonaya M, Alcaín G, Sicilia B, Dueñas C, Gutiérrez A, Lorente-Poyatos R, Domínguez M, Khorrami S, Taxonera C, Rodríguez-Pérez A, Ponferrada A, Van Domselaar M, Arias-Rivera ML, Merino O, Castro E, Marrero JM, Martín-Arranz M, Botella B, Fernández-Salazar L, Monfort D, Opio V, García-Herola A, Menacho M, Ramírez-de la Piscina P, Ceballos D, Almela P, Navarro-Llavat M, Robles-Alonso V, Vega-López AB, Moraleja I, Novella MT, Castaño-Milla C, Sánchez-Torres A, Benítez JM, Rodríguez C, Castro L, Garrido E, Domènech E, García-Planella E, and Gisbert JP

Subjects
Male, Constriction, Pathologic, Inflammatory bowel disease, Gastroenterology, Deprescriptions, 0302 clinical medicine, Crohn Disease, Recurrence, Risk Factors, Medicine, Young adult, Mesalamine, Aged, 80 and over, Incidence, Incidence (epidemiology), Remission Induction, Age Factors, Middle Aged, Antirheumatic Agents, 030220 oncology & carcinogenesis, Retreatment, Disease Progression, Female, 030211 gastroenterology & hepatology, Tumor necrosis factor alpha, Adult, medicine.medical_specialty, Adolescent, Drug-Related Side Effects and Adverse Reactions, Colon, Young Adult, 03 medical and health sciences, Ileum, Internal medicine, Humans, Immunologic Factors, Colitis, Aged, Proportional Hazards Models, Retrospective Studies, Hepatology, Tumor Necrosis Factor-alpha, business.industry, Proportional hazards model, Adalimumab, Retrospective cohort study, Protective Factors, Inflammatory Bowel Diseases, medicine.disease, Infliximab, Discontinuation, Methotrexate, Colitis, Ulcerative, business, Follow-Up Studies
Abstract

OBJECTIVES: The aims of this study were to assess the risk of relapse after discontinuation of anti-tumor necrosis factor (anti-TNF) drugs in patients with inflammatory bowel disease (IBD), to identify the factors associated with relapse, and to evaluate the overcome after retreatment with the same anti-TNF in those who relapsed. METHODS: This was a retrospective, observational, multicenter study. IBD patients who had been treated with anti-TNFs and in whom these drugs were discontinued after clinical remission was achieved were included. RESULTS: A total of 1,055 patients were included. The incidence rate of relapse was 19% and 17% per patient-year in Crohn's disease and ulcerative colitis patients, respectively. In both Crohn's disease and ulcerative colitis patients in deep remission, the incidence rate of relapse was 19% per patient-year. The treatment with adalimumab vs. infliximab (hazard ratio (HR)=1.29; 95% confi dence interval (CI)= 1.01-1.66), elective discontinuation of anti-TNFs (HR=1.90; 95% CI= 1.07-3.37) or discontinuation because of adverse events (HR= 2.33; 95% CI= 1.27-2.02) vs. a top-down strategy, colonic localization (HR= 1.51; 95% CI= 1.13-2.02) vs. ileal, and stricturing behavior (HR= 1.5; 95% CI= 1.09-2.05) vs. inflammatory were associated with a higher risk of relapse in Crohn's disease patients, whereas treatment with immunomodulators after discontinuation (HR= 0.67; 95% CI= 0.51-0.87) and age (HR= 0.98; 95% CI= 0.97-0.99) were protective factors. None of the factors were predictive in ulcerative colitis patients. Retreatment of relapse with the same anti-TNF was effective (80% responded) and safe. CONCLUSIONS: The incidence rate of infl ammatory bowel disease relapse after anti-TNF discontinuation is relevant. Some predictive factors of relapse after anti-TNF withdrawal have been identifi ed. Retreatment with the same anti-TNF drug was effective and safe.

Published
2017

23. Índice de autores

Author

Jiménez Murillo, L., Montero Pérez, F.J., Aguilar Humanes, F., Agustín Varas, A., Alamillos Granados, F.J., Aldeanueva Escribano, M., Altamirano Cifuentes, M., Álvarez Gil, D., Amor Trucios, J., Antón Aguilar, L., Aranda Mora, A., Arjona Berral, J.E., Baena Delgado, E., Bajo Fernández, I., Barbudo Merino, J., Barcones Gómez, C., Barneto Aranda, I., Bello Luque, A.M., Benítez Cantero, J.M., Benítez Laguna, A.M., Berdud Godoy, I., Berlango Jiménez, A., Bravo Aguilera, C., Briceño Delgado, F.J., Calañas Continente, A., Calderón de la Barca Anchústegui, C., Calderón de la Barca Gázquez, J.M., Calvo Rodríguez, R., Campos Hernández, P., Cano Castiñeira, R., Cano Sánchez, A., Cantillo Baños, E., Caracuel Ruiz, M.A., Carazo Carazo, J.L., Carrasco Valiente, J., Casais Juanena, L., Castilla Camacho, S., Castro Giménez, J.A., Cerezo Madueño, F., Clemente Millán, M.J., Cobos Ceballos, M.J., Concha Jarava, J.M., Constenla Ramos, S., Cosano Santiago, J.M., Cruz Alcaide, A.B., de Burgos Marín, J., de Dios Ruiz, A.M., de la Mata García, M., de la Torre Castillo, O.M., de la Torre González, A., de Prado López, M.F., Dean Ferrer, A., Degayón Rojo, H., del Campo Vázquez, P., Dueñas Jurado, J.M., Durán Martínez, M., Entrenas Castillo, M., Entrenas Costa, L.M., Esquivias de Motta, E., Expósito Ordóñez, A., Extremera Martínez, M.A., Fernández Ramos, J., Fernández Sánchez de Mora, M.C., Gallardo Valverde, J.M., Gálvez Moreno, M.A., García Martínez, L., García Olid, A., García Quintana, J.M., García Rubio, J.H., García Sánchez, V., García Torres, E., García Vázquez, A.M., Gascón Jiménez, F.J., Gavilán Guirao, F., Gil Hernández, S., Giménez Ruiz, J., Gimeno Gimeno, J., Gómez Gómez, E., Gómez Luque, I., Gómez Panzuela, N., González Alfaro, A., González Galilea, A., González Requero, A.I., González Romero, M.D., Gracia García, F., Herrero González, Y., Iglesias Flores, E., Jiménez Aguilar, A.M., Jiménez Puya, M.C., Jurado Cobos, C.M., Jurado Gámez, B., Jurado García, J., Ladehesa Pineda, L., Lama Martínez, R., Leal Reyes, G., León López, R., Llamas Fuentes, R., Llamas Quiñones, L., Llergo Muñoz, A., López Granados, A., López Malo de Molina, D., López Miranda, J., Lorente González, J., Lucchini Leiva, R., Lucena Aguilera, C., Marín Martín, E., Martín Malo, A., Martínez Acevedo, M.E., Martínez García, A.I., Martínez Grueiro, M., Martínez Guillén, M.R., Martínez López, M.A., Martínez Losada, C., Martos Órpez, M.C., Medina Fernández, F.J., Medinilla Montenegro, M.C., Mesa Rubio, M.D., Mifsut Gallardo, M.J., Molina Jurado, A., Molina Nieto, T., Monserrat Jordán, J.A., Mora Sánchez, A., Moreno González, F., Moreno Herrera, C., Moya González, J., Moyano García, R., Moyano Pulido, M.J., Muñoz Ávila, J., Muñoz Carvajal, I., Muñoz del Castillo, F., Muñoz Triano, E., Natera Kindelán, C., Nieto Pascual, L., Núñez Adán, A., Ocaña Martínez, R., Ochoa Sepúlveda, J.J., Padial Aguado, A., Padillo Cuenca, J.C., Padillo Ruiz, F.J., Palacios Eito, A., Palenzuela Martín, S., Palomar Alguacil, V., Palomar Muñoz, M.C., Palomares Ortega, R., Pan Álvarez-Osorio, M., Pascual Martínez, N., Paulovic, D., Peláez Viña, N., Pérez Rodríguez, E., Pino Gálvez, M.A., Poyato González, A., Quero Espinosa, F.B., Quesada Gómez, M., Redel Montero, J., Requena Tapia, M.J., Reyes Aguilar, C., Robles Arista, J.C., Rodríguez Alonso, R., Rodríguez Benot, A., Rodríguez Perálvarez, M., Roig García, J.J., Roig Rodríguez, J.J., Romero Bravo, A., Romero Moreno, M.A., Rubio Pérez, M.J., Ruiz García, J., Ruiz Ortiz, M., Ruiz Requena, I., Rumbao Aguirre, J., Salcedo Leal, I., Salvatierra Velázquez, A., Santos Luna, F., Segura Saint-Gerons, J., Serrano Blanch, R., Serrano López, J., Simarro Bravo, M.D., Solivera Vera, J., Tabares Carrasco, S., Tirado Valencia, C., Toledano Delgado, A., Torre-Cisneros, J., Torres Borrego, J., Torres Degayón, E., Torres Degayón, V., Torres Murillo, J.M., Valero Rosa, J., Valverde Moyano, R., Vaquero Barrios, J.M., Vázquez Rueda, F., Vega Reyes, J.A., Velázquez Navarrete, M.C., Vélez García-Nieto, A.J., Vidal Verdú, E., Vignote Alguacil, M.L., Villalba Calvente, M., Villalba Montoro, R., and Yébenes Ramírez, M.

Published
2021
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24. P156 Differential characteristics of patients with inflammatory bowel disease onset in paediatric age compared with patients diagnosed in adulthood: Results from the CAROUSEL study of GETECCU

Author

Chaparro, M, primary, Garre, A, additional, Ricart, E, additional, García-Sánchez, V, additional, Taxonera, C, additional, Mañosa, M, additional, Vera Mendoza, I, additional, Mínguez, M, additional, Argüelles, F, additional, De Castro Parga, L, additional, Arroyo, M, additional, López-San Román, A, additional, Rivero Tirado, M, additional, Guardiola, J, additional, Martín Arranz, M D, additional, Beltrán, B, additional, Barrio, J, additional, Riestra, S, additional, García-Planella, E, additional, Calvet, X, additional, Alcaín, G, additional, Sicilia, B, additional, García, S, additional, Esteve, M, additional, Márquez, L, additional, Fernández Salazar, L, additional, Gutiérrez Casbas, A, additional, Piqueras, M, additional, Guerra, I, additional, Pérez Calle, J L, additional, Hinojosa, J, additional, Rodríguez, A, additional, Aldeguer, X, additional, García-Sepulcre, M, additional, Bujanda, L, additional, Martínez Montiel, P, additional, Llorente Poyatos, R, additional, Rodríguez Gutiérrez, C, additional, Merino, O, additional, Cabriada, J L, additional, Roncero, O, additional, Romero Cara, P, additional, Navarro-Llavat, M, additional, Ber, Y, additional, Madrigal, R, additional, Van Domselaar, M, additional, Barreiro-de Acosta, M, additional, Llao, J, additional, Ramos, L, additional, Riera, J, additional, Lucendo Villarín, A J, additional, Rodríguez González, E, additional, Huguet Malavés, J M, additional, Muñoz Villafranca, C, additional, Almela, P, additional, Charro, M, additional, Ramírez de la Piscina, P, additional, Sese, E, additional, Abad Lacruz, Á, additional, Khorrami, S, additional, Morales Alvarado, V J, additional, Legido Gil, J, additional, Trapero Martínez, A M, additional, Pajares, R, additional, Acevedo, J, additional, García Herola, A, additional, Hernández Villalba, L, additional, Muñoz, E, additional, Novella Durán, M T, additional, Menacho, M, additional, Navas López, V M, additional, Retamero, M D, additional, Domènech, E, additional, and Gisbert, J P, additional

Published
2018
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27. P391 The availability of anti-TNF agents is associated with reduced early surgical requirements in Crohn’s disease but not in ulcerative colitis. A nationwide study from the Eneida registry

Author

Guasch, M, primary, Clos, A, additional, Ordás, I, additional, García-Sánchez, V, additional, Gisbert, J P, additional, Taxonera, C, additional, Vera, I, additional, Mínguez, M, additional, Guardiola, J, additional, López-Sanromán, A, additional, Rivero-Tirado, M, additional, Nos, P, additional, Gomollón, F, additional, Carbajo, A Y, additional, de Francisco, R, additional, Martín-Arranz, M D, additional, Garcia-Planella, E, additional, García-López, S, additional, de Castro, L, additional, Calvet, X, additional, Camargo, R, additional, Esteve, M, additional, Sicilia, B, additional, Andreu, M, additional, Macho, A, additional, Piqueras, M, additional, Bermejo, F, additional, Gutiérrez, A, additional, Busquets, D, additional, Martínez-Montiel, P, additional, Hinojosa, J, additional, Pérez-Calle, J L, additional, Bujanda, L, additional, Rodríguez-Pérez, A, additional, Lorente, R, additional, Jiménez, N, additional, Navarro-Llavat, M, additional, Cabriada, J L, additional, Camo, P, additional, Van Domselaar, M, additional, Rodríguez-González, E, additional, Rodríguez-Gutiérrez, C, additional, Huguet, J M, additional, Lucendo, A J, additional, Argüelles, F, additional, Almela, P, additional, Merino, O, additional, Calafat, M, additional, Ogueta, M, additional, Charro, M, additional, Llaó, J, additional, Muñoz, C, additional, Ramos, L, additional, Abad, Á, additional, Roncero, Ó, additional, Barreiro-de-Acosta, M, additional, Sesé, E, additional, Mañosa, M, additional, and Domènech, E, additional

Published
2018
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28. Long-Term Efficacy and Safety of Cyclosporine in a Cohort of Steroid-Refractory Acute Severe Ulcerative Colitis Patients from the ENEIDA Registry (1989–2013): A Nationwide Multicenter Study

Author

Ordás, I, primary, Domènech, E, additional, Mañosa, M, additional, García-Sánchez, V, additional, Iglesias-Flores, E, additional, Peñalva, M, additional, Cañas-Ventura, A, additional, Merino, O, additional, Fernández-Bañares, F, additional, Gomollón, F, additional, Vera, M, additional, Gutiérrez, A, additional, Garcia-Planella, E, additional, Chaparro, M, additional, Aguas, M, additional, Gento, E, additional, Muñoz, F, additional, Aguirresarobe, M, additional, Muñoz, C, additional, Fernández, L, additional, Calvet, X, additional, Jiménez, C E, additional, Montoro, M A, additional, Mir, A, additional, De Castro, M L, additional, García-Sepulcre, M F, additional, Bermejo, F, additional, Panés, J, additional, and Esteve, M, additional

Published
2017
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30. Extracolonic Cancer in Inflammatory Bowel Disease: Data from the GETECCU Eneida Registry

Author

Chaparro, María, primary, Ramas, M, additional, Benítez, J M, additional, López-García, A, additional, Juan, A, additional, Guardiola, J, additional, Mínguez, M, additional, Calvet, X, additional, Márquez, L, additional, Salazar, L I Fernández, additional, Bujanda, L, additional, García, C, additional, Zabana, Y, additional, Lorente, R, additional, Barrio, J, additional, Hinojosa, E, additional, Iborra, M, additional, Cajal, Domínguez M, additional, Van Domselaar, M, additional, García-Sepulcre, M F, additional, Gomollón, F, additional, Piqueras, M, additional, Alcaín, G, additional, García-Sánchez, V, additional, Panés, J, additional, Domènech, E, additional, García-Esquinas, E, additional, Rodríguez-Artalejo, F, additional, and Gisbert, J P, additional

Published
2017
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31. Standardization of the homogeneous mobility shift assay protocol for evaluation of anti-infliximab antibodies. Application of the method to Crohn’s disease patients treated with infliximab

Author

Hernández-Breijo, B., primary, Chaparro, M., additional, Cano-Martínez, D., additional, Guerra, I., additional, Iborra, M., additional, Cabriada, J.L., additional, Bujanda, L., additional, Taxonera, C., additional, García-Sánchez, V., additional, Marín-Jiménez, I., additional, Barreiro-de Acosta, M., additional, Vera, I., additional, Martín-Arranz, M.D., additional, Mesonero, F., additional, Sempere, L., additional, Gomollón, F., additional, Hinojosa, J., additional, Gisbert, J.P., additional, and Guijarro, L.G., additional

Published
2016
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35. Influencia del método de preparación de catalizadores Pt-Al2O3 en la eliminación de COV

Author

Portela, Raquel, García-Sánchez, V. E., Rasmussen, Soren B., Villarroel, Mirza, Gil-Llambías, F. J., Homs, N., Ramírez de la Piscina, P., Ávila García, Pedro, Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Ministerio de Ciencia e Innovación (España), and Bionatur Biotechnologies

Abstract

Trabajo presentado en el Congreso de la Sociedad Española de Catálisis SECAT 13, celebrado en Sevilla (España) del 26 al 28 de junio de 2013., En este trabajo se comparan los resultados obtenidos en la eliminación de mezclas HCHO/CH3OH usando catalizadores con la misma concentración de platino preparados por diferentes métodos, tratando de relacionar las diferencias de comportamiento observadas con las características físico-químicas de los catalizadores determinadas por diferentes técnicas de caracterización, Los autores agradecen a la empresa licenciataria de la patente BIONATUR BIOTECHNOLOGIES SL, a Fondecyt: 1095120 y al Plan Nacional I+D+i: CTM2008- 06876-C02-02 la financiación recibida.

Published
2013

36. Preparation of Pt-TiO2 catalysts for VOC abatement. Influence of the method of preparation

Author

Ávila García, Pedro, Rasmussen, Soren B., Portela, Raquel, Martín, M. P., García-Sánchez, V. E., Villarroel, Mirza, and Gil-Llambías, F. J.

Abstract

Trabajo presentado en el Symposium in honour of Ramôa Ribeiro (Catalysis: From the Active Site to the Process), celebrado en Lisboa el 8 y 9 de octubre de 2012., Industrially applied catalysts for decontamination processes are usually formed by supported noble metals, and their activities are related to the metal dispersion on the surface of the porous support and to the accessibility of the gases to the active phase which is related with its porosity. The optimization of these parameters is a goal of industrial catalysis in order to improve the activity of the system while taking into account that the cost of the catalyst is minimized. In this work the performance in the catalytic combustion of formaldehyde of a series of supported Pt catalysts with the same composition and prepared by different methods are studied and their behavior are related with their textural properties and the dispersion of the active phase.

Published
2012

38. P372 Prospective, randomized clinical trial comparing the efficacy of two vaccines against hepatitis B virus (HBV) in inflammatory bowel disease (IBD) patients

Author

Chaparro, M., primary, Gordillo, J., additional, Domènech, E., additional, Esteve, M., additional, Barreiro-de Acosta, M., additional, Villoria, A., additional, Iglesias-Flores, E., additional, Huelín, P., additional, Naves, J., additional, Benítez, O., additional, Nieto, L., additional, Calvet, X., additional, García-Sánchez, V., additional, Villagrasa, J., additional, Marín, A.C., additional, Ramas, M., additional, Moreno, I., additional, Maté, J., additional, and Gisbert, J.P., additional

Published
2014
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39. DOP051 Usefulness of a faecal calprotectin rapid semiquantitative test in predicting relapse in patients with ulcerative colitis in remission

Author

Garcia-Planella, E., primary, Manyosa, M., additional, Chaparro, M., additional, Barreiro-de-Acosta, M., additional, Beltrán, B., additional, Ricart, E., additional, García-Sánchez, V., additional, Esteve, M., additional, Piqueras, M., additional, Bermejo, F., additional, López-Sanromán, A., additional, Taxonera, C., additional, Llao, J., additional, Gisbert, J.P., additional, Cabré, E., additional, and Domènech, E., additional

Published
2014
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40. P396 Outcomes of surgical treatment of entero-urinary fistulas in Crohn's disease

Author

Fernández-Blanco, I., primary, Taxonera, C., additional, Bastida, G., additional, García-Sánchez, V., additional, Gómez-García, M., additional, Marín-Jiménez, I., additional, Iglesias, E., additional, Gisbert, J.P., additional, Barreiro-de Acosta, M., additional, Bermejo, F., additional, Casanova, M.J., additional, Saro, C., additional, López-Serrano, P., additional, Plaza, R., additional, Algaba, A., additional, Olivares, D., additional, and Mendoza, J.L., additional

Published
2014
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42. P665 A genome-wide association study identifies DSE-FAM26F as a risk locus for ulcerative colitis

Author

Domènech, E., primary, Juliá, A., additional, Chaparro, M., additional, García-Sánchez, V., additional, Gomollón, F., additional, Panés, J., additional, Mañosa, M., additional, Barreiro-de Acosta, M., additional, Gutiérrez, A., additional, García-Planella, E., additional, Nos, P., additional, Muñoz, F., additional, Esteve, M., additional, Mendoza, J.L., additional, Vera, M., additional, Marquez, L., additional, Tortosa, R., additional, López-Lasanta, M., additional, Alonso, A., additional, Gelpí, J.L., additional, García-Montero, A., additional, Bertanpetit, J., additional, Absher, D., additional, Myers, R., additional, Marsal, S., additional, and Gisbert, J.P., additional

Published
2014
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44. Safety of Thiopurines and Anti-TNF-α Drugs During Pregnancy in Patients With Inflammatory Bowel Disease

Author

Casanova, M J, primary, Chaparro, M, additional, Domènech, E, additional, Barreiro-de Acosta, M, additional, Bermejo, F, additional, Iglesias, E, additional, Gomollón, F, additional, Rodrigo, L, additional, Calvet, X, additional, Esteve, M, additional, García-Planella, E, additional, García-López, S, additional, Taxonera, C, additional, Calvo, M, additional, López, M, additional, Ginard, D, additional, Gómez-García, M, additional, Garrido, E, additional, Pérez-Calle, J L, additional, Beltrán, B, additional, Piqueras, M, additional, Saro, C, additional, Botella, B, additional, Dueñas, C, additional, Ponferrada, A, additional, Mañosa, M, additional, García-Sánchez, V, additional, Maté, J, additional, and Gisbert, J P, additional

Published
2013
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45. P425 One-year outcomes of ustekinumab therapy in a multi-drug refractory Crohn's disease cohort

Author

Ginard, D., primary, Khorrami, S., additional, Marín, I., additional, Chaparro, M., additional, Aguas, M., additional, Martínez-González, J., additional, Cabriada, J.L., additional, García-Sánchez, V., additional, Villoria, A., additional, Gelabert, J., additional, Casellas, F., additional, Sansó, A., additional, Riera, J., additional, Hervías, D., additional, García, S., additional, García-Planella, E., additional, and Gisbert, J.P., additional

Published
2013
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46. P531 Effectiveness of anti-TNF agents in the treatment of entero-urinary fistulas in Crohn's disease

Author

Taxonera, C., primary, Fernández-Blanco, I., additional, Barreiro-de Acosta, M., additional, Bastida, G., additional, López-San Román, A., additional, Merino, O., additional, García-Sánchez, V., additional, Gisbert, J.P., additional, Marín-Jiménez, I., additional, López-Serrano, P., additional, Iglesias, E., additional, Martínez-González, J., additional, Chaparro, M., additional, Saro, C., additional, Bermejo, F., additional, Pérez-Carazo, L., additional, Plaza, R., additional, Olivares, D., additional, Mendoza, J.L., additional, and Rey, E., additional

Published
2013
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47. P650 Entero-urinary fistulas in Crohn's disease: prevalence and clinical manifestations

Author

Taxonera, C., primary, Fernández-Blanco, I., additional, Barreiro-de Acosta, M., additional, Bastida, G., additional, López-San Román, A., additional, Merino, O., additional, García-Sánchez, V., additional, Gisbert, J.P., additional, Marín-Jiménez, I., additional, López-Serrano, P., additional, Iglesias, E., additional, Martínez-González, J., additional, Chaparro, M., additional, Bermejo, F., additional, Saro, C., additional, Pérez-Carazo, L., additional, Plaza, R., additional, Olivares, D., additional, Cañas, M., additional, and Mendoza, J.L., additional

Published
2013
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48. P407 Phenotypic concordance in familial inflammatory bowel disease (IBD)

Author

Cabré, E., primary, García-Sánchez, V., additional, Gutiérrez, A., additional, Panés, J., additional, Esteve, M., additional, Peñalva, M., additional, Nos, P., additional, Merino, O., additional, Ponferrada, A., additional, Gisbert, J.P., additional, García-Planella, E., additional, Ceña, G., additional, Cabriada, J.L., additional, and Montoro, M., additional

Published
2012
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49. P408 Safety of immunomodulators and anti-TNF drugs for the treatment of inflammatory bowel disease (IBD) during pregnancy

Author

Casanova, M.J., primary, Chaparro, M., additional, Doménech, E., additional, Barreiro-de Acosta, M., additional, Bermejo, F., additional, Iglesias, E., additional, Gomollón, F., additional, Rodrigo, L., additional, Calvet, X., additional, Esteve, M., additional, García-Planella, E., additional, García, S., additional, Taxonera, C., additional, Calvo, M., additional, López, M., additional, Ginard, D., additional, Gómez, M., additional, Garrido, E., additional, Pérez-Calle, J., additional, Beltrán, B., additional, Piqueras, M., additional, Saro, C., additional, Botella, B., additional, Dueñas, C., additional, Ponferrada, A., additional, Mañosa, M., additional, Iglesias, M., additional, Algaba, A., additional, García-Sánchez, V., additional, Maté, J., additional, and Gisbert, J.P., additional

Published
2012
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