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27 results on '"García-López, Mireia"'

1. Viral and immune factors associated with successful treatment withdrawal in HBeAg-negative chronic hepatitis B patients

Author

García-López, Mireia, Lens, Sabela, Pallett, Laura J., Testoni, Barbara, Rodríguez-Tajes, Sergio, Mariño, Zoe, Bartres, Concepción, García-Pras, Ester, Leonel, Thais, Perpiñán, Elena, Lozano, Juan José, Rodríguez-Frías, Francisco, Koutsoudakis, George, Zoulim, Fabien, Maini, Mala K., Forns, Xavier, and Pérez-del-Pulgar, Sofía

Published
2021
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2. Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents

Author

Torrens, Laura, primary, Puigvehí, Marc, primary, Torres-Martín, Miguel, primary, Wang, Huan, primary, Maeda, Miho, primary, Haber, Philipp K., primary, Leonel, Thais, primary, García-López, Mireia, primary, Esteban-Fabró, Roger, primary, Leow, Wei Qiang, primary, Montironi, Carla, primary, Torrecilla, Sara, primary, Varadarajan, Ajay Ramakrishnan, primary, Taik, Patricia, primary, Campreciós, Genís, primary, Enkhbold, Chinbold, primary, Taivanbaatar, Erdenebileg, primary, Yerbolat, Amankyeldi, primary, Villanueva, Augusto, primary, Pérez-del-Pulgar, Sofía, primary, Thung, Swan, primary, Chinburen, Jigjidsuren, primary, Letouzé, Eric, primary, Zucman-Rossi, Jessica, primary, Uzilov, Andrew, primary, Neely, Jaclyn, primary, Forns, Xavier, primary, Roayaie, Sasan, primary, Sia, Daniela, primary, and Llovet, Josep M., primary

Published
2023
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3. Supplementary Data from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents

Author

Torrens, Laura, primary, Puigvehí, Marc, primary, Torres-Martín, Miguel, primary, Wang, Huan, primary, Maeda, Miho, primary, Haber, Philipp K., primary, Leonel, Thais, primary, García-López, Mireia, primary, Esteban-Fabró, Roger, primary, Leow, Wei Qiang, primary, Montironi, Carla, primary, Torrecilla, Sara, primary, Varadarajan, Ajay Ramakrishnan, primary, Taik, Patricia, primary, Campreciós, Genís, primary, Enkhbold, Chinbold, primary, Taivanbaatar, Erdenebileg, primary, Yerbolat, Amankyeldi, primary, Villanueva, Augusto, primary, Pérez-del-Pulgar, Sofía, primary, Thung, Swan, primary, Chinburen, Jigjidsuren, primary, Letouzé, Eric, primary, Zucman-Rossi, Jessica, primary, Uzilov, Andrew, primary, Neely, Jaclyn, primary, Forns, Xavier, primary, Roayaie, Sasan, primary, Sia, Daniela, primary, and Llovet, Josep M., primary

Published
2023
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4. Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents

Author

Torrens, Laura, primary, Puigvehí, Marc, additional, Torres-Martín, Miguel, additional, Wang, Huan, additional, Maeda, Miho, additional, Haber, Philipp K., additional, Leonel, Thais, additional, García-López, Mireia, additional, Esteban-Fabró, Roger, additional, Leow, Wei Qiang, additional, Montironi, Carla, additional, Torrecilla, Sara, additional, Varadarajan, Ajay Ramakrishnan, additional, Taik, Patricia, additional, Campreciós, Genís, additional, Enkhbold, Chinbold, additional, Taivanbaatar, Erdenebileg, additional, Yerbolat, Amankyeldi, additional, Villanueva, Augusto, additional, Pérez-del-Pulgar, Sofía, additional, Thung, Swan, additional, Chinburen, Jigjidsuren, additional, Letouzé, Eric, additional, Zucman-Rossi, Jessica, additional, Uzilov, Andrew, additional, Neely, Jaclyn, additional, Forns, Xavier, additional, Roayaie, Sasan, additional, Sia, Daniela, additional, and Llovet, Josep M., additional

Published
2022
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6. Differential changes in global and antigen-specific B cell frequencies and function associate with the outcome of HBV nucleos (t)ide analog treatment withdrawal

Author

Lens, Sabela, primary, Burton, Alice, additional, Davies, Jessica, additional, García-López, Mireia, additional, Jeffery-Smith, Anna, additional, Novikov, Nikolai, additional, Fletcher, Simon, additional, Pérez-del-Pulgar, Sofía, additional, Forns, Xavier, additional, and Maini, Mala, additional

Published
2022
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7. Liver-resident T cell PD-1 correlates with intrahepatic HBV-DNA and is reduced following prolonged antiviral therapy

Author

García-López, Mireia, primary, Pallett, Laura J., additional, Rodriguez-Tajes, Sergio, additional, Belmonte, Ernest, additional, Leonel, Thais, additional, García-Pras, Ester, additional, Lens, Sabela, additional, Mariño, Zoe, additional, Bartres, Concepció, additional, Rando-Segura, Ariadna, additional, Rodríguez-Frías, Francisco, additional, Forns, Xavier, additional, Maini, Mala, additional, and Pérez-del-Pulgar, Sofía, additional

Published
2022
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9. FRI462 - Molecular characterization of hepatocellular carcinoma in Mongolia delineates unique genomic features

Author

Puigvehí, Marc, Sia, Daniela, Torres-Martin, Miguel, Maeda, Miho, Leonel, Thais, Wang, Huan, Orlando, Vincenzo, Garciá-López, Mireia, Leow, Wei Qiang, Montironi, Carla, Torrecilla, Sara, Enkhbold, Chinbold, Taivanbaatar, Erdenebileg, Yerbolat, Amankyeldi, Campreciós, Geniś, Pérez-del-Pulgar, Sofiá, Villanueva, Augusto, Thung, Swan N, Chinburen, Jigjidsuren, Uzilov, Andrew, Forns, Xavier, Roayaie, Sasan, and Llovet, Josep M.

Published
2020
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10. Chronic genotype 1 hepatitis C along with cirrhosis drives a persistent imprint in virus‐specific CD8 + T cells after direct‐acting antiviral therapies

Author

Perpiñán, Elena, primary, Pérez‐Del‐Pulgar, Sofía, additional, Londoño, María‐Carlota, additional, Mariño, Zoe, additional, Lens, Sabela, additional, Leonel, Thais, additional, Bartres, Concepción, additional, García‐López, Mireia, additional, Rodriguez‐Tajes, Sergio, additional, Forns, Xavier, additional, and Koutsoudakis, George, additional

Published
2020
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11. Silencing HBV expression using LNA gapmers: preliminary data of a new promising strategy

Author

Cortese, Maria Francesca, primary, Casillas, Rosario, additional, García-Pras, Ester, additional, García-López, Mireia, additional, Lopez-Martinez, Rosa, additional, Cruz, Cristina Godoy, additional, Tabernero, David, additional, Sopena, Sara, additional, Yll, Marçal, additional, Rando, Ariadna, additional, Barciela, Mar Riveiro, additional, Pérez-del-Pulgar, Sofía, additional, Buti, Maria, additional, and Rodríguez-Frías, Francisco, additional

Published
2020
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12. Serum and intrahepatic HBV markers and HBV-specific CD8 T cell responses after nucleos(t)ide analog therapy discontinuation in HBeAg-negative chronic hepatitis B patients

Author

García-López, Mireia, primary, Lens, Sabela, additional, Pallett, Laura J., additional, Testoni, Barbara, additional, Mariño, Zoe, additional, Rodriguez-Tajes, Sergio, additional, Bartres, Concepció, additional, García-Pras, Ester, additional, Leonel, Thais, additional, Perpiñan, Elena, additional, Lozano, Juanjo, additional, Rodríguez-Frías, Francisco, additional, Koutsoudakis, George, additional, Zoulim, Fabien, additional, Maini, Mala, additional, Forns, Xavier, additional, and Pérez-del-Pulgar, Sofía, additional

Published
2020
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14. Cirrhosis Hampers Early and Rapid Normalization of Natural Killer Cell Phenotype and Function in Hepatitis C Patients Undergoing Interferon-Free Therapy

Author

Perpiñán, Elena, primary, Pérez-Del-Pulgar, Sofía, additional, Londoño, María-Carlota, additional, Mariño, Zoe, additional, Bartres, Concepción, additional, González, Patricia, additional, García-López, Mireia, additional, Pose, Elisa, additional, Lens, Sabela, additional, Maini, Mala K., additional, Forns, Xavier, additional, and Koutsoudakis, George, additional

Published
2020
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20. FRI-147-Gradual restoration of HCV-specific CD8+ T cell frequency but persistence of altered phenotype in cirrhotic HCV-infected patients after successful direct-acting antiviral therapy

Author

Perpiñan, Elena, primary, Pérez-del-Pulgar, Sofía, additional, Londoño, Maria Carlota, additional, González, Patricia, additional, Mariño, Zoe, additional, Lens, Sabela, additional, Bartres, Concepció, additional, García-López, Mireia, additional, Forns, Xavier, additional, and Koutsoudakis, Georgios, additional

Published
2019
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21. Chronic genotype 1 hepatitis C along with cirrhosis drives a persistent imprint in virus‐specific CD8+ T cells after direct‐acting antiviral therapies.

Author

Perpiñán, Elena, Pérez‐Del‐Pulgar, Sofía, Londoño, María‐Carlota, Mariño, Zoe, Lens, Sabela, Leonel, Thais, Bartres, Concepción, García‐López, Mireia, Rodriguez‐Tajes, Sergio, Forns, Xavier, and Koutsoudakis, George

Subjects
HEPATITIS C, CHRONIC hepatitis C, HEPATITIS C virus, CIRRHOSIS of the liver, VIROLOGY, INFLUENZA, GENOTYPES, T cells
Abstract

Chronic hepatitis C virus (HCV) infection impairs HCV CD8+ T‐cell responses, while it could influence immune responses towards unrelated viruses/vaccines (e.g. cytomegalovirus, CMV, and influenza, Flu). The aim of our study was to delineate whether restoration of these virus‐specific CD8+ T cells occurs after direct‐acting antiviral (DAA) therapies and particularly in patients with cirrhosis. We performed longitudinal analysis (baseline, week 4, follow‐up [FU] 12 and FU48) of virus‐specific CD8+ T cells by multicolour flow cytometry in HCV‐cirrhotic patients undergoing DAA therapy (n = 26) after in vitro expansion with immunodominant HCV, CMV and Flu epitopes restricted by HLA‐A*02. HCV noncirrhotic patients (n = 9) and healthy individuals (n = 10) served as controls. We found that the proliferative capacity of HCV‐specific CD8+ T cells increased from baseline up to FU48 in a significant proportion of cirrhotic and noncirrhotic patients. Nevertheless, these cells remained poor cytokine producers in both patient groups, regardless of the down‐regulation of inhibitory co‐regulatory receptors in HCV‐cirrhotic patients at FU48. Likewise, high expression levels of these exhaustion markers were detected in CMV‐/Flu‐specific CD8+ T cells in HCV‐cirrhotic patients at all time points, albeit without affecting their proliferative capacity or cytokine production. We conclude that DAA therapies induce restoration of the proliferative capacity of HCV‐specific CD8+ T cells. However, these cells remain phenotypically and functionally impaired. Contrarily, the 'exhausted' phenotype in CMV‐/Flu‐specific CD8+ T cells in HCV‐cirrhotic patients did not associate with their functions. Larger studier with longer follow‐up may elucidate whether this complex interplay influences the outcome of cirrhotic patients. [ABSTRACT FROM AUTHOR]

Published
2020
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22. Low seroprevalence and zero incidence rate of hepatitis E in men who have sex with men during a hepatitis A outbreak.

Author

Rodríguez‐Tajes, Sergio, Perpiñán, Elena, Leonel, Thais, Lens, Sabela, Mariño, Zoe, Pérez‐del‐Pulgar, Sofía, García‐López, Mireia, Pocurull, Anna, Koutsoudakis, George, and Forns, Xavier

Subjects
HEPATITIS E, HEPATITIS E virus, SEXUALLY transmitted diseases, HEPATITIS, HEPATITIS viruses
Abstract

Hepatitis E virus (HEV) and hepatitis A virus (HAV) are both secreted in feces. Despite HEV transmission in Europe is mainly zoonotic, person‐to‐person transmission has not been completely excluded. Men who have sex with men (MSM) constitute a high‐risk group for HAV mostly due to oral sex. We investigated the potential transmission of HEV during an acute hepatitis A (AHA) outbreak mainly affecting MSM. One hundred and two patients were diagnosed with AHA. Sixty‐nine (68%) self‐reported to be MSM, 75% of whom had high‐risk sexual behaviors and 46% had suffered previous sexually transmitted diseases. We collected serum from 85 (83%) patients during AHA. HEV‐IgG seroprevalence was not different among MSM (7%) compared with non‐MSM (8%) patients. Two patients had positive anti‐HEV‐IgM, but all samples tested negative for HEV‐RNA. These results suggest that HEV does not spread by sexual contact or person‐to‐person in our area. [ABSTRACT FROM AUTHOR]

Published
2020
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25. AS003 - Serum and intrahepatic HBV markers and HBV-specific CD8 T cell responses after nucleos(t)ide analog therapy discontinuation in HBeAg-negative chronic hepatitis B patients

Author

García-López, Mireia, Lens, Sabela, Pallett, Laura J., Testoni, Barbara, Mariño, Zoe, Rodriguez-Tajes, Sergio, Bartres, Concepció, García-Pras, Ester, Leonel, Thais, Perpiñan, Elena, Lozano, Juanjo, Rodríguez-Frías, Francisco, Koutsoudakis, George, Zoulim, Fabien, Maini, Mala, Forns, Xavier, and Pérez-del-Pulgar, Sofía

Published
2020
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27. Optimized Ex Vivo Fluorospot Assay to Measure Multifunctional HBV-Specific T Cell Frequencies in Chronic Hepatitis B Patients.

Author

Chua C, García-López M, and Gehring AJ

Subjects
Humans, Interferon-gamma metabolism, Interferon-gamma immunology, Leukocytes, Mononuclear immunology, Leukocytes, Mononuclear virology, Leukocytes, Mononuclear metabolism, Hepatitis B, Chronic immunology, Hepatitis B, Chronic virology, Hepatitis B virus immunology, Enzyme-Linked Immunospot Assay methods, T-Lymphocytes immunology
Abstract

Virus-specific T cells are critical to mediating viral control; however, Hepatitis B virus (HBV)-specific T cells among chronic Hepatitis B (CHB) patients are functionally exhausted. The inability to consistently measure the ex vivo functionality of HBV-specific T cells has prevented meaningful analysis during antiviral events such as HBeAg seroconversion, hepatic flares, and HBsAg loss. We optimized the traditional IFN-γ ELISpot assay to measure total ex vivo HBV-specific T cell frequencies using CHB PBMCs stimulated with HBV overlapping peptide (OLP) pools. This was then further adapted to assess individual antigen specificity (core, envelop, polymerase, X) and multifunctional HBV-specific T cells using a 3-analyte FluoroSpot assay. This protocol encompasses two major components: (1) PBMC handling/stimulation and (2) assay plate preparation and spot development. By performing this assay, ex vivo CHB patient T cell responses could be assessed longitudinally during immunotherapy or other important clinical events., (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2024
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