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322 results on '"García-Castro, Javier"'

3. Neural cue-reactivity in pathological gambling as evidence for behavioral addiction: a systematic review

Author

García-Castro, Javier, Cancela, Ana, and Cárdaba, Miguel A. M.

Subjects
Psychological aspects, Research, Psychological research, Neural circuitry -- Psychological aspects, Compulsive gambling -- Research
Abstract

Author(s): Javier García-Castro [sup.1] , Ana Cancela [sup.1] , Miguel A. M. Cárdaba [sup.1] Author Affiliations: (1) https://ror.org/02fn69884, 0000 0004 0547 1127, Universidad Villanueva, C/Costa Brava, , 6 28034, Madrid, [...], Increasing incidence of problem gambling has led to prioritizing the problem from the point of view of public health. Additionally, gambling disorder has been recently classified as a behavioral addiction, with implications for both its diagnosis and treatment. However, the shared neural substrate of addictions, to substances and behavioral, is still discussed. Thus, this systematic review aims to provide up-to-date knowledge from the past five years (2017-2022) concerning the neural correlates of gambling related stimuli (cue-reactivity) on the basis of a previous review (Brevers et al., Cognitive, Affective and Behavioral Neuroscience 18:718-729, 2019 (See CR14)). A total of five studies were included in the review. Activation of brain areas related to memory, reward and executive functions could be the underlying mechanism of this behavioral addiction. Specifically, nucleus accumbens and striatum (ventral and dorsal), parahippocampal regions, the right amygdala and several prefrontal cortex regions have systematically been found more active in those subjects exposed to gambling-related cues. Also, the insula could play a pivotal role connecting these three systems in a highly integrated neural network with several implications for reward processing modulation, associative learning and top-down attentional regulation to improve saliency of addiction-related cues. These results are consistent with previous findings on other substance addictions, such as alcohol, tobacco, marijuana or cocaine. The study of neural reactivity to stimuli related to addiction could be useful as a biomarker of the severity of the disorder, the efficacy of the treatment, the risk of relapse, in addition to being an objective criterion to measure the effectiveness of prevention campaigns.

Published
2023
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9. Papel de los macrófagos en la funcionalidad de las terapias celulares adoptivas basadas en CAR T (linfocitos T con receptor de antígeno quimérico) en osteosarcoma

Author

García Castro, Javier, Miedes Vicente, Eva, Zubizarreta Ruiz, Marta, García Castro, Javier, Miedes Vicente, Eva, and Zubizarreta Ruiz, Marta

Abstract

Osteosarcoma is a rare disease that mainly affects children, adolescents, and young people. It can develop in any bone, but the most common ones affected are the proximal humerus and the knees. Nowadays, treatment consists of chemotherapy and surgery. Despite the improvement in the patient’s survival, the 5-year event-free survival remains less than 20% in those with aggressive osteosarcoma. The lack of response in metastatic tumours is the reason why new strategies are needed. In this context, the use of T cells expressing chimeric antigen receptors (CAR T) has shown positive results in the treatment of haematological cancers, such as leukaemia or lymphomas. Nonetheless, the application of this therapy in the treatment of solid tumours, like osteosarcoma, must face some challenges due to the nature of this tumours: the homing of CAR T cells to the tumour, the antigen heterogeneity of solid tumours and the tumour microenvironment. In order to improve the outcome of patients, we need to solve the problems that these obstacles pose to us. The tumour microenvironment is mainly composed of tumour associated macrophages (TAMs), which are involved in numerous immunosuppressive pathways. This tumoral microenvironment (TME) decreases the efficacy of CAR T cell therapy. It was, therefore, the main aim of this work to study the role that macrophages have in the functionality of the CAR T cell therapy by developing an in vitro model. To achieve this goal, peripheral blood-derived human monocytes were isolated and differentiated to M1 and M2 macrophages. They were then cocultured with osteosarcoma cells and CAR T to study their interactions. A successful polarization of the macrophages was achieved. It has been found that M2 macrophages inhibit CAR T’s cytotoxic activity in the short term and M1 macrophages improve their functionality. However, as coculture time progresses, the expression of M1 markers increases in M2 macrophages losing their immunosuppressive potential. This i

Published
2024

11. Prospects of Pluripotent and Adult Stem Cells for Rare Diseases

Author

García-Castro, Javier, Singeç, Ilyas, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, REZAEI, NIMA, Series editor, Posada de la Paz, Manuel, editor, Taruscio, Domenica, editor, and Groft, Stephen C., editor

Published
2017
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14. Immunotherapy with CAR-T cells in paediatric haematology-oncology

Author

Mirones, Isabel, Sisinni, Luisa, García-Morín, Marina, Anguita, Javier, Ramírez, Manuel, Moreno, Lucas, Alonso, Laura, Rives, Susana, Alonso, Marta M., Patiño-García, Ana, Palomo, Pilar, Verdú-Amorós, Jaime, Martínez, Isabel, Lizeaga, Garbiñe, Guerra-García, Pilar, Luis Fuster, José, Moraleda, José M., Sánchez-Salinas, Andrés, Blanquer, Miguel, García-Castro, Javier, Santen, María Luisa Toribio e Hisse M. van, Menéndez, Pablo, Pérez-Martínez, Antonio, and Toribio, María Luisa

Published
2020
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15. Inmunoterapia con células CAR-T en hematooncología pediátrica

Author

Mirones, Isabel, Sisinni, Luisa, García-Morín, Marina, Anguita, Javier, Ramírez, Manuel, Díaz, Miguel Ángel, González, Marta, Moreno, Lucas, Alonso, Laura, Rives, Susana, Alonso, Marta M., Patiño-García, Ana, Palomo, Pilar, Verdú-Amorós, Jaime, Martínez, Isabel, Lizeaga, Garbiñe, Guerra-García, Pilar, Fuster, José Luis, Moraleda, José M., Sánchez-Salinas, Andrés, Blanquer, Miguel, García-Castro, Javier, Toribio, María Luisa, van Santen, Hisse M., Menéndez, Pablo, and Pérez-Martínez, Antonio

Published
2020
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16. Future Anxiety in Young Spanish Adults: Psychometric Properties of the Dark Future Scale.

Author

Torrado, Macarena, García-Castro, Javier, and Blanca, María J.

Subjects
*YOUNG adults, *PSYCHOMETRICS, *ANXIETY, *PERSONALITY, *SPANIARDS, *TIME perspective
Abstract

Background/Objective: The Dark Future Scale (DFS) is a selfreport instrument which assesses the tendency to think about the future with anxiety, fear, and uncertainty. Although it has been applied in different populations, instrumental studies are scarce, and there is no validated Spanish version. The aim was therefore to develop a Spanish version of the scale (DFS-S) and to analyze its psychometric properties in a sample of young adults. Method: Participants were 1,019 individuals aged from 18 to 24 years. They completed the DFS-S and the IPIP-BFM-20. Validity evidence based on the internal structure, including measurement invariance across gender, as well as on relationships with personality traits was obtained. Reliability and gender differences in DFS-S scores were also examined. Results: Results supported a single-factor structure, χ2(5) = 10.79, CFI = .999, RMSEA = .034, SRMR = .016, that was invariant across gender. Reliability of test scores was satisfactory (ω = .92). In the correlation analysis, future anxiety showed a strong positive correlation with neuroticism (.42) and a moderate negative correlation with extraversion (-.25). Females scored higher than males on future anxiety. Conclusions: The DFS-S has satisfactory psychometric properties and it is an adequate tool for measuring future anxiety among young adults. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Supplementary Figures S1-S2 from Enhanced Antitumor Efficacy of Oncolytic Adenovirus–loaded Menstrual Blood–derived Mesenchymal Stem Cells in Combination with Peripheral Blood Mononuclear Cells

Author

Moreno, Rafael, primary, Fajardo, Carlos Alberto, primary, Farrera-Sal, Marti, primary, Perisé-Barrios, Ana Judith, primary, Morales-Molina, Alvaro, primary, Al-Zaher, Ahmed Abdullah, primary, García-Castro, Javier, primary, and Alemany, Ramon, primary

Published
2023
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22. Supplementary Material and Methods from Enhanced Antitumor Efficacy of Oncolytic Adenovirus–loaded Menstrual Blood–derived Mesenchymal Stem Cells in Combination with Peripheral Blood Mononuclear Cells

Author

Moreno, Rafael, primary, Fajardo, Carlos Alberto, primary, Farrera-Sal, Marti, primary, Perisé-Barrios, Ana Judith, primary, Morales-Molina, Alvaro, primary, Al-Zaher, Ahmed Abdullah, primary, García-Castro, Javier, primary, and Alemany, Ramon, primary

Published
2023
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23. Legends from Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy

Author

Cejalvo, Teresa, primary, Perisé-Barrios, Ana Judith, primary, del Portillo, Isabel, primary, Laborda, Eduardo, primary, Rodriguez-Milla, Miguel A., primary, Cubillo, Isabel, primary, Vázquez, Fernando, primary, Sardón, David, primary, Ramirez, Manuel, primary, Alemany, Ramon, primary, del Castillo, Noemí, primary, and García-Castro, Javier, primary

Published
2023
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24. Table S1 from Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy

Author

Cejalvo, Teresa, primary, Perisé-Barrios, Ana Judith, primary, del Portillo, Isabel, primary, Laborda, Eduardo, primary, Rodriguez-Milla, Miguel A., primary, Cubillo, Isabel, primary, Vázquez, Fernando, primary, Sardón, David, primary, Ramirez, Manuel, primary, Alemany, Ramon, primary, del Castillo, Noemí, primary, and García-Castro, Javier, primary

Published
2023
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25. Data from Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy

Author

Cejalvo, Teresa, primary, Perisé-Barrios, Ana Judith, primary, del Portillo, Isabel, primary, Laborda, Eduardo, primary, Rodriguez-Milla, Miguel A., primary, Cubillo, Isabel, primary, Vázquez, Fernando, primary, Sardón, David, primary, Ramirez, Manuel, primary, Alemany, Ramon, primary, del Castillo, Noemí, primary, and García-Castro, Javier, primary

Published
2023
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26. Figure S4 from Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy

Author

Cejalvo, Teresa, primary, Perisé-Barrios, Ana Judith, primary, del Portillo, Isabel, primary, Laborda, Eduardo, primary, Rodriguez-Milla, Miguel A., primary, Cubillo, Isabel, primary, Vázquez, Fernando, primary, Sardón, David, primary, Ramirez, Manuel, primary, Alemany, Ramon, primary, del Castillo, Noemí, primary, and García-Castro, Javier, primary

Published
2023
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50. Additional file 2 of Humoral responses to SARS-CoV-2 by healthy and sick dogs during the COVID-19 pandemic in Spain

Author

Perisé-Barrios, Ana Judith, Tomeo-Martín, Beatriz Davinia, Gómez-Ochoa, Pablo, Delgado-Bonet, Pablo, Plaza, Pedro, Palau-Concejo, Paula, González, Jorge, Ortiz-Díez, Gustavo, Meléndez-Lazo, Antonio, Gentil, Michaela, García-Castro, Javier, and Barbero-Fernández, Alicia

Subjects
animal diseases, bacteria, chemical and pharmacologic phenomena, biochemical phenomena, metabolism, and nutrition
Abstract

Additional file 2. Immune response of sick and healthy dogs.

Published
2021
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