1. [New aspects of diabetes]
- Author
-
Potier, P., Sasaki, A., Bakala, J., García-Alvarez, M.-C., Franck, G., Nhiri, N., Wang, Q., Ermolenko, L., Nguefeu, Y., Calvo, F., Gautier, J-Fr, Institut de Chimie des Substances Naturelles (ICSN), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
- Subjects
MESH: Glucose ,Glucose ,MESH: Diabetes Mellitus ,MESH: Humans ,MESH: Pyruvaldehyde ,Diabetes Mellitus, Type 2 ,Diabetes Mellitus ,Animals ,Humans ,MESH: Animals ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,Pyruvaldehyde ,MESH: Diabetes Mellitus, Type 2 - Abstract
International audience; Type II diabetes is a serious, insidious disease which is growing at an impressive rate, with 200 million diabetics worldwide and as many who ignore their state. Having been seriously studied over more than a century and a half, an enormous quantity of knowledge regarding this disease has been accumulated. The research we are conducting has allowed us to identify the most important actors responsible for diabetes. These are glucose which leads to glyoxal and to methylglyoxal which in turn reacts with innumerable targets in the organism (including insulin) unless prevented from doing so by detoxifying mechanisms (e.g., glyoxalases). The role of microorganisms in the occurrence and development of diabetes has also to be seriously examined.
- Published
- 2005