6 results on '"García Manrique T"'
Search Results
2. Clinical outcomes and mortality in patients with atrial fibrillation and recently diagnosed lung cancer in oncology outpatient settings.
- Author
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Piserra López-Fernández De Heredia A, Ruiz Ortiz M, Pérez Cabeza AI, Díaz Expósito A, Fernández Valenzuela MI, Carrillo Bailén M, Alarcón De La Lastra Cubiles I, Moreno Vega A, Zalabardo Aguilar M, Chaparro Muñoz M, García Manrique T, Torres Llergo J, Ortega Granados AL, Sánchez Fernández JJ, Calvete Cadenas J, and Mesa Rubio D
- Subjects
- Humans, Male, Female, Outpatients, Retrospective Studies, Hemorrhage chemically induced, Anticoagulants therapeutic use, Risk Factors, Risk Assessment, Atrial Fibrillation complications, Atrial Fibrillation diagnosis, Atrial Fibrillation epidemiology, Lung Neoplasms diagnosis, Lung Neoplasms epidemiology, Lung Neoplasms chemically induced, Stroke epidemiology
- Abstract
Introduction: Our aim was to investigate the prevalence of atrial fibrillation (AF) and recently diagnosed lung cancer in the outpatient oncology clinic and to describe the clinical profile, management and outcomes of this population., Methods: Among 6984 patients visited at the outpatient oncology clinics attending lung cancer patients in five university hospitals from 2017 to 2019, all consecutive subjects with recently diagnosed (<1 year) disease and AF were retrospectively selected and events in follow up were registered., Results: A total of 269 patients (3.9 % of all attended, 71 ± 8 years, 91 % male) were included. Charlson, CHA2DS2-VASc and HAS-BLED indexes were 6.7 ± 2.9, 2.9 ± 1.5 y 2.5 ± 1.2, respectively. Tumour stage was I, II, III and IV in 11 %, 11 %, 33 % and 45 % of them, respectively. Anticoagulants were prescribed to 226 patients (84 %): direct anticoagulants (n = 99;44 %), low molecular weight heparins (n = 69;30 %) and vitamin K antagonists (n = 58;26 %). After 46 months of maximum follow-up, 186 patients died (69 %). Cumulative incidences of events at 3 years were 3.3 ± 1.3 % for stroke/systemic embolism (n = 7); 8.9 ± 2.2 % for thrombotic events (n = 18); 9.9 ± 2.6 % for major bleeding (n = 16), and 15.9 ± 3,0 % for cardiovascular events (n = 33). In patients with early stages of cancer (I-II), 2-year mortality was significantly higher in those with cardiovascular events or major bleeding (85 % vs 25 %, p = 0.01)., Conclusion: Nearly 4 % or all outpatients in the oncology clinic attending lung cancer present recently diagnosed disease and AF. Major bleeding and cardiovascular event rates are high in this population, with an impact on mortality in early stages of cancer., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
3. Evaluation of Nutritional Interventions in the Care Plan for Cancer Patients: The NOA Project.
- Author
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García-Luna PP, Rabat Restrepo JM, Muñoz-Ayllón M, de la Calle Gil M, Remón P, Sánchez-Torralvo FJ, Pachón J, García-González JJ, García-Manrique T, Salvador-Bofill J, Vicente D, and Olveira G
- Subjects
- Humans, Nutrition Assessment, Nutritional Status, Nutritional Support methods, Malnutrition prevention & control, Malnutrition diagnosis, Neoplasms complications, Neoplasms therapy
- Abstract
The NOA (Oncological Nutrition in Andalusia) project analyses the degree of integration and areas of improvement in implementing nutritional support in the care plans of cancer patients in Andalusia. The aim was to analyse nutritional interventions for better care of cancer patients and for the improvement of the management of malnutrition in cancer. A prospective evaluation of the implementation of two areas of improvement in nutrition was conducted in three hospitals. Data were collected from each hospital over a six-month period using an online platform. A standardised care plan was designed for hospitals in Andalusia, in which proposed improvements were devised and prioritised, selecting nutritional screening in oncology services and the participation of the Nutrition Support Team (NST) on the tumour boards, as well as the assessment of the patients presented at these sessions. Our results indicated an increase in the number of medical records with nutritional evaluation results six months later, regardless of the type of tumour or hospitalisation; and there was greater participation of the NST on the tumour boards, mainly for head and neck and oesophagogastric cases. Solutions for improvement have been pinpointed and implemented that have positively impacted the nutritional care plan in the course of oncological disease.
- Published
- 2023
- Full Text
- View/download PDF
4. Deferred Locoregional Recurrence of Pleural Mesothelioma.
- Author
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García-Gómez FJ, García-Manrique T, and Castro-Montaño J
- Subjects
- Humans, Intermediate Back Muscles diagnostic imaging, Lymphatic Metastasis diagnostic imaging, Male, Mediastinal Neoplasms secondary, Middle Aged, Muscle Neoplasms secondary, Positron Emission Tomography Computed Tomography, Rectus Abdominis diagnostic imaging, Time Factors, Mediastinal Neoplasms diagnostic imaging, Mesothelioma diagnostic imaging, Mesothelioma secondary, Muscle Neoplasms diagnostic imaging, Neoplasm Recurrence, Local diagnostic imaging, Pleural Neoplasms
- Published
- 2017
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- View/download PDF
5. Primary intracranial malignant peripheral nerve sheath tumour responding to chemotherapy.
- Author
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Zambrana F, Vicente F, García-Manrique T, Pereira S, Sáinz De Zaitigui J, and De La Cruz Merino L
- Subjects
- Adult, Doxorubicin administration & dosage, Humans, Ifosfamide administration & dosage, Male, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Brain Neoplasms drug therapy, Brain Neoplasms pathology, Nerve Sheath Neoplasms drug therapy
- Abstract
Malignant peripheral nerve sheath tumours (MPNST) are a rare variety of soft tissue sarcomas (STS) arising from major peripheral nerve branches and typically located in the lower extremity, chest wall or the retroperitoneum. It is a biologically aggressive neoplasm for which the treatment of choice is surgery, but usually requires a multimodality approach, having been generally labelled as chemoresistant. We present a case of MPNST located intracranially with a good response to chemotherapy.
- Published
- 2010
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- View/download PDF
6. Role of transforming growth factor beta in cancer microenvironment.
- Author
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de la Cruz-Merino L, Henao-Carrasco F, García-Manrique T, Fernández-Salguero PM, and Codes-Manuel de Villena M
- Subjects
- Adaptive Immunity, Animals, Cell Lineage, Cytokines metabolism, Gene Expression Regulation, Neoplastic, Humans, Immunity, Innate, Immunosuppressive Agents metabolism, Models, Biological, Signal Transduction, Smad Proteins metabolism, T-Lymphocytes, Regulatory metabolism, Transforming Growth Factor beta metabolism, Neoplasms metabolism, Transforming Growth Factor beta physiology
- Abstract
Transforming growth factor Beta (TGF-Beta) family members are polypeptidic cytokines with pleiotropic physiological properties. In relation to cancer, TGF-Beta exerts a dual tumour-suppressive and oncogenic effect, which is largely dependent on microenvironment stimuli. After activation of TGF-Beta signalling, two pathways can be activated: the canonical one through the mammalian Smad family or the non-canonical one activating, among others, the cellular mitogen-activated protein kinase (MAPK) signalling downstream, which interacts with Smad signalling. During tumorigenesis, cells of many cancer types often lose their response to the tumour-suppressive effects of TGF-Beta, which, in turn, has the opposite effect, acting as an autocrine tumour-promoting factor. In this review, we summarise the current knowledge about this intriguing cytokine, with special emphasis on its immunosuppressive actions.
- Published
- 2009
- Full Text
- View/download PDF
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