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Your search keyword '"García Cano, A. M."' showing total 22 results
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22 results on '"García Cano, A. M."'

4. Prevalence, risk factors and evolution of diabetes mellitus after treatment in primary aldosteronism. Results from the SPAIN-ALDO registry

Author

Araujo-Castro, M., Paja Fano, M., Pla Peris, B., González Boillos, M., Pascual-Corrales, E., García Cano, A. M., Parra Ramírez, P., Martín Rojas-Marcos, P., Ruiz-Sanchez, J. G., Vicente Delgado, A., Gómez Hoyos, E., Ferreira, R., García Sanz, I., Recasens Sala, M., Barahona San Millan, R., Picón César, M. J., Díaz Guardiola, P., Perdomo, C. M., Manjón Miguélez, L., García Centeno, R., Percovich, J. C., Rebollo Román, Á., Gracia Gimeno, P., Robles Lázaro, C., Morales-Ruiz, M., Calatayud Gutiérrez, M., Furio Collao, S. A., Meneses, D., Sampedro Nuñez, M. A., Escudero Quesada, V., Mena Ribas, E., Sanmartín Sánchez, A., Gonzalvo Diaz, C., Lamas, C., Guerrero-Vázquez, R., del Castillo Tous, M., Serrano Gotarredona, J., Michalopoulou Alevras, T., Moya Mateo, E. M., and Hanzu, F. A.

Published
2023
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16. Characterisation of the urinary steroid profile of patients with nonfunctioning adrenal incidentalomas: A matched controlled cross‐sectional study

Author

Araujo‐Castro, Marta, primary, Casals, Gregori, additional, Hanzu, Felicia A., additional, Pascual‐Corrales, Eider, additional, García Cano, Ana M., additional, Lanza, Val F., additional, Luis del Rey Mejías, Ángel, additional, Marchan, Marta, additional, Escobar‐Morreale, Héctor F., additional, and Valderrabano, Pablo, additional

Published
2022
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17. Characterisation of the urinary steroid profile of patients with nonfunctioning adrenal incidentalomas: A matched controlled cross‐sectional study.

Author

Araujo‐Castro, Marta, Casals, Gregori, Hanzu, Felicia A., Pascual‐Corrales, Eider, García Cano, Ana M., Lanza, Val F., Luis del Rey Mejías, Ángel, Marchan, Marta, Escobar‐Morreale, Héctor F., and Valderrabano, Pablo

Subjects
CROSS-sectional method, BODY mass index, STEROIDS, MASS spectrometry
Abstract

Aim: To identify alterations in steroid metabolism in patients with nonfunctioning adrenal incidentalomas (NFAIs) through the analysis of their urinary steroid profile (USP). Methods: Cross‐sectional study with one study group (NFAIs, cortisol post dexamethasone suppression test [DST] ≤ 1.8 µg/dl [49.7 nmol/L]) and 2 control groups: patients with autonomous cortisol secretion (ACS group, cortisol post‐DST > 1.8 µg/dl (49.7 nmol/L) and patients without adrenal tumours (healthy‐adrenal group). Twenty‐four‐hour urine collections for USP measurement (total and free fraction of 51 24 h‐urine specimens) were obtained from 73 participants (24 with NFAIs, 24 without AIs, and 25 with ACS). USP was determined by gas chromatography coupled to mass spectrometry. Patients of the three groups were matched according to sex, age (±5 years‐old) and body mass index (±5 kg/m2). Results: Compared to healthy‐adrenal controls, patients with NFAIs had a lower excretion of androgen metabolites (230.5 ± 190.12 vs. 388.7 ± 328.58 µg/24 h, p =.046) and a higher excretion of urinary free cortisol (UFC) (54.3 ± 66.07 vs. 25.4 ± 11.16 µg/24 h, p =.038). UFC was above the reference range in 20.8% of patients in the NFAI, compared to 0% in the healthy‐adrenal group (p =.018). Patients with ACS had a higher prevalence of hypertension, dyslipidemia, and diabetes than patients with NFAIs or the control group. A lower excretion of androgen metabolites (218.4 ± 204.24 vs. 231 ± 190 µg/24 h, p =.041) and a nonsignificant higher excretion of glucocorticoid metabolites (2129.6 ± 1195.96 vs. 1550.8 ± 810.03 µg/24 h, p =.180) was found in patients with ACS compared to patients with NFAIs. Conclusion: NFAIs seem to secrete a subtle, yet clinically relevant, excess of glucocorticoids. Future studies are needed to confirm our findings; and to identify metabolic alterations associated with an increased cardiometabolic risk. [ABSTRACT FROM AUTHOR]

Published
2023
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