1. Taenia taeniaeformis: inactivation of metacestodes by gossypol in vitro.
- Author
-
Rikihisa Y, Lin YC, Garber PL, and Gu Y
- Subjects
- Animals, L-Lactate Dehydrogenase antagonists & inhibitors, Microscopy, Electron, Microscopy, Electron, Scanning, Taenia enzymology, Taenia growth & development, Taenia ultrastructure, Gossypol pharmacology, Taenia drug effects
- Abstract
Gossypol, a natural biphenyl compound inhibits Taenia taeniaeformis metacestode development in vivo. In this paper, the direct effect of gossypol on metacestodes was examined. Within 24 hr of incubation at 37 degrees C in greater than or equal to 10(-5) M gossypol, shedding of the tegument from the surface of the metacestodes was observed. There was a significant decrease in [3H]thymidine uptake by T. taeniaeformis in greater than or equal to 10(-5)M gossypol. In addition, NADH lactate dehydrogenase activity of metacestodes was significantly inhibited in greater than or equal to 10(-5) M gossypol. Thus, gossypol has a direct inhibitory effect on T. taeniaeformis metacestodes in vitro.
- Published
- 1990
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