45 results on '"Garaix F"'
Search Results
2. Exercise capacity in pediatric heart transplant recipient
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Louali, F. El, primary, Huang, H., additional, Soulatges, C., additional, Garaix, F., additional, Fouilloux, V., additional, and Ovaert, C., additional
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- 2022
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3. Renforcement de la collaboration entre pharmacie clinique, pharmacologie et service de soins par un poste d’interne partagé : retour d’expérience en transplantation pédiatrique
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Caunois, L., Sampol, E., Garaix, F., Arcani, V., Hanafia, O., and Honoré, S.
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- 2024
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4. Association Between Donor Age and Posttransplant Mortality in Pediatric Lung Recipients: A 10-Year Nationwide Cohort Study
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Cantrelle, C., primary, Legeai, C., additional, Garaix, F., additional, Feuillet, S., additional, Sermet-Gaudelus, I., additional, Jougon, J., additional, Le Pavec, J., additional, Demant, X., additional, Kerbaul, F., additional, and Dorent, R., additional
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- 2022
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5. Pediatric Lung Transplantation: A 10-Year Nationwide Cohort Study
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Cantrelle, C., primary, Pavec, J. Le, additional, Legeai, C., additional, Boussaut, V., additional, Sermet-Gaudelus, I., additional, Jougon, J., additional, Feuillet, S., additional, Demant, X., additional, Garaix, F., additional, Kerbaul, F., additional, and Dorent, R., additional
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- 2022
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6. The New French Heart Allocation System Has Improved Access to Transplantation in Adolescents
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Cantrelle, C., primary, Jasseron, C., additional, Legeai, C., additional, Henaine, R., additional, Garaix, F., additional, Houyel, L., additional, Filippo, S. Di, additional, Kerbaul, F., additional, and Dorent, R., additional
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- 2022
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7. Côlon hyperéchogène et cystinurie. Intérêt du diagnostic prénatal
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Gnisci, A., Heckenroth, H., Garaix, F., Gorincour, G., Leclaire, M., and Cravello, L.
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- 2010
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8. Chapitre 94 - Complications de la transplantation rénale
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Garaix, F.
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- 2020
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9. Dynamic prediction models for graft failure in paediatric kidney transplantation
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Kabore, Remi, Ferrer, Loic, Couchoud, C., Hogan, J., Cochat, P., Dehoux, L., Roussey-Kesler, G., Novo, R., GARAIX, F., BROCHARD, K., Fila, M., Parmentier, C., FOURNIER, M. C., Macher, M. A., HARAMBAT, Jerome, Leffondre, Karen, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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surgical procedures, operative ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie - Abstract
BACKGROUND: Several models have been proposed to predict kidney graft failure in adult recipients but none in younger recipients. Our objective was to propose a dynamic prediction model for graft failure in young kidney transplant recipients. METHODS: We included 793 kidney transplant recipients waitlisted before the age of 18 years who received a first kidney transplantation before the age of 21 years in France in 2002-13 and survived >90 days with a functioning graft. We used a Cox model including baseline predictors only (sex, age at transplant, primary kidney disease, dialysis duration, donor type and age, human leucocyte antigen matching, cytomegalovirus serostatus, cold ischaemia time and delayed graft function) and two joint models also accounting for post-transplant estimated glomerular filtration rate (eGFR) trajectory. Predictive performances were evaluated using a cross-validated area under the curve (AUC) and R2 curves. RESULTS: When predicting the risk of graft failure from any time within the first 7 years after paediatric kidney transplantation, the predictions for the following 3 or 5 years were accurate and much better with the joint models than with the Cox model (AUC ranged from 0.83 to 0.91 for the joint models versus 0.56 to 0.64 for the Cox model). CONCLUSION: Accounting for post-transplant eGFR trajectory strongly increased the accuracy of graft failure prediction in young kidney transplant recipients.
- Published
- 2020
10. Evaluation of a cardiac transplanted children cohort: Long term pediatric follow-up and transiant to adulthood, twenty years of monocentric experience
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Wanert, C., primary, El Louali, F., additional, Ovaert, C., additional, Schouvey, S., additional, Lenoir, M., additional, Fouilloux, V., additional, Tsimaratos, M., additional, and Garaix, F., additional
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- 2021
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11. Population Pharmacokinetics and Pharmacogenetics of Tacrolimus in De Novo Pediatric Kidney Transplant Recipients
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Zhao, W, Elie, V, Roussey, G, Brochard, K, Niaudet, P, Leroy, V, Loirat, C, Cochat, P, Cloarec, S, André, J L, Garaix, F, Bensman, A, Fakhoury, M, and Jacqz-Aigrain, E
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- 2009
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12. Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis
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Cailliez, M., Garaix, F., Rousset-Rouvière, C., Bruno, D., Kone-Paut, I., Sarles, J., Chabrol, B., and Tsimaratos, M.
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- 2006
13. Pre-emptive kidney transplantation is associated with improved graft survival in children: Data from the French renal replacement therapy registry
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Reydit, M., primary, Salomon, R., additional, Macher, M.-A., additional, Ranchin, B., additional, Roussey, G., additional, Garaix, F., additional, Lahoche, A., additional, Decramer, S., additional, Fila, M., additional, Dunand, O., additional, Cloarec, S., additional, Vrillon, I., additional, Zaloszyc, A., additional, Ulinski, T., additional, Bérard, E., additional, Couchoud, C., additional, Leffondré, K., additional, and Harambat, J., additional
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- 2017
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14. Résultats de la transplantation rénale chez les jeunes enfants : une étude appariée sur 32 enfants de moins de trois ans
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Loiseau, Y., primary, Bacchetta, J., additional, Roy, P., additional, Nobili, F., additional, Garaix, F., additional, Laurent, A., additional, and Cochat, P., additional
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- 2016
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15. La greffe rénale DVA-ABO incompatible est une solution chez des enfants hyperimmunisés sans accès à la greffe
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Garaix, F., primary, Rousset-Rouviere, C., additional, Cailliez, M., additional, Bruno, D., additional, Basire, A., additional, Dettori, I., additional, Hery, G., additional, Daniel, L., additional, and Tsimarartos, M., additional
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- 2016
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16. Laparoscopic nephrectomy of a cross-fused ectopic kidney in a child with hypertension
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Negre, T., Haddad, M., Garaix, F., Fernandez, C., Guys, J.M., and de Lagausie, P.
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- 2010
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17. Rapid access to renal transplant waiting list in children: impact of patient and centre characteristics in France
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Hogan, J., primary, Savoye, E., additional, Macher, M.-A., additional, Bachetta, J., additional, Garaix, F., additional, Lahoche, A., additional, Ulinski, T., additional, Harambat, J., additional, and Couchoud, C., additional
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- 2014
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18. Peut-on ralentir la progression des lésions liées à la réduction néphronique ?
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Garaix, F., primary, Rousset Rouvière, C., additional, Cailliez, M., additional, Bruno, D., additional, and Tsimaratos, M., additional
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- 2009
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19. Rein et vascularite chez l’enfant
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Rousset-Rouvière, C., primary, Garaix, F., additional, Cailliez, M., additional, Bruno, D., additional, Coulibaly, B., additional, Daniel, L., additional, and Tsimaratos, M., additional
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- 2009
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20. First report of rapidly progressive glomerulonephritis in tumor necrosis factor receptor-associated periodic syndrome.
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Harambat J, Desjonqueres M, Garaix F, Cochat P, Ranchin B, Cimaz R, Dodé C, and Bouvier R
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- 2008
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21. Quality of life of chronically ill children and adolescents: a cross-sectional study.
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Perreard P, Castets S, Aouchiche K, Bernoux D, Bruno D, Cailliez M, Clave S, Coste ME, De Leusse C, Duvant P, Garaix F, Gauche L, Marquant E, Roman C, Roquelaure B, Rouvière CR, Vergier J, Tsimaratos M, Berbis J, Fabre A, and Reynaud R
- Abstract
Objective: The aim of this study was to describe the quality of life (QoL) of children with a chronic illness treated in a tertiary multidisciplinary pediatric department in comparison with the general population., Study Design: A cross-sectional study was conducted in the tertiary multidisciplinary (nephrology, hepatogastroenterology, endocrinology, diabetology, transplantation) pediatric department of Timone Hospital in Marseille, France. Patients 8-17 years of age with a chronic disease were included during regular follow-up appointments. Medical and sociodemographic variables were obtained from medical records. Self-reported QoL was assessed using the VSPA (Vécu et Santé Perçu de l'Adolescent) questionnaire and parent-reported QoL was assessed using the VSPA questionnaire for parents., Results: A total of 244 patients were included. Overall QoL did not differ significantly from that of the general population. Adolescent patients' self-reported QoL scores were lower than those of the general population in the domains of physical health and leisure, and parents reported QoL scores for adolescent patients lower than those of the general population for self-esteem and physical health. Adolescents' self-reported QoL scores were higher than in the general population for relationships with parents, healthcare professionals, and teachers as well as for school achievement. Parents also reported higher QoL scores in these areas for their children., Conclusion: Children and adolescents with a variety of chronic diseases had similar overall QoL scores to the general population but with different QoL profiles; their scores in some domains were higher than those of the general population., Competing Interests: Declaration of competing interest No involvement in study design; the collection, analysis, and interpretation of data; the writing of the report; and the decision to submit the paper for publication., (Copyright © 2024. Published by Elsevier Masson SAS.)
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- 2024
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22. National survey of prevention and management of CMV infection in pediatric kidney transplantation in comparison to clinical practice guidelines.
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Madden I, Baudouin V, Charbit M, Ranchin B, Roussey G, Novo R, Garaix F, Decramer S, Fila M, Merieau E, Vrillon I, Zaloszyc A, Hogan J, and Harambat J
- Abstract
Background: Cytomegalovirus (CMV) is one of the most frequent opportunistic infections in kidney transplant (KT) recipients and is a risk factor for patient and graft survival after KT. Center-to-center variation, optimal prevention and treatment strategies in pediatric KT are currently unknown. This survey aimed to assess current CMV prevention and treatment strategies used among French pediatric KT centers., Methods: A web-based survey was sent to all 13 French pediatric kidney transplantation centers., Results: Twelve (92%) centers responded to the survey. All centers used prophylaxis for the donor-positive/recipient-negative (D+/R-) group. For R + patients, 54% used prophylaxis, 37% used a pre-emptive strategy. In the low-risk group, D-/R-, 50% used a pre-emptive approach and 50% had no specific prevention strategy. The antiviral used by all centers for prophylaxis was valganciclovir (VGCV). The duration of prophylaxis varied from 3 to 7 months and the duration of viral load monitoring varied from 6 months to indefinitely. No center used a hybrid/sequential approach. For the treatment of CMV DNAemia, VGCV or intravenous GCV were used. Therapeutic drug monitoring of VGCV was performed in 5 centers (42%). Five centers reported drug resistance. Eight centers (67%) administered VGCV during the treatment of acute graft rejection., Conclusions: There is uniformity in CMV management in some areas among pediatric KT centers in France but not in others which remain diverse and are not up to date with current guidelines, suggesting unnecessary variation which could be reduced with better evidence to inform practice., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2022 Madden, Baudouin, Charbit, Ranchin, Roussey, Novo, Garaix, Decramer, Fila, Merieau, Vrillon, Zaloszyc, Hogan and Harambat.)
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- 2022
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23. Atypical severe early-onset nephrotic syndrome: Answers.
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Berthaud R, Heidet L, Oualha M, Brat R, Talmud D, Garaix F, Rabant M, Frémeaux-Bacchi V, Antignac C, Boyer O, and Dorval G
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- Humans, Mutation, WT1 Proteins genetics, Denys-Drash Syndrome, Nephrotic Syndrome diagnosis
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- 2022
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24. Atypical severe early-onset nephrotic syndrome: Questions.
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Berthaud R, Heidet L, Oualha M, Brat R, Talmud D, Garaix F, Rabant M, Frémeaux-Bacchi V, Antignac C, Boyer O, and Dorval G
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- Humans, Kidney, Proteinuria, Nephrotic Syndrome diagnosis
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- 2022
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25. A second case of multisystem inflammatory syndrome associated with SARS-CoV-2 in a liver-transplanted child.
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Duvant P, Roquelaure B, Morand A, Bosdure E, Garaix F, Zandotti C, and Fabre A
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- Child, Humans, Intensive Care Units, Pediatric, Liver, Systemic Inflammatory Response Syndrome, COVID-19 complications, SARS-CoV-2
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- 2022
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26. Preemptive Kidney Transplantation Is Associated With Transplantation Outcomes in Children: Results From the French Kidney Replacement Therapy Registry.
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Prezelin-Reydit M, Madden I, Macher MA, Salomon R, Sellier-Leclerc AL, Roussey G, Lahoche A, Garaix F, Decramer S, Ulinski T, Fila M, Dunand O, Merieau E, Pongas M, Zaloszyc A, Baudouin V, Bérard E, Couchoud C, Leffondré K, and Harambat J
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- Child, Graft Survival, Humans, Registries, Renal Dialysis methods, Renal Replacement Therapy, Treatment Outcome, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic surgery, Kidney Transplantation methods
- Abstract
Background: Kidney transplantation (KT) is the optimal treatment for children with end-stage kidney disease. The aim of this study was to evaluate the impact of preemptive kidney transplantation (PKT) and of pretransplant dialysis duration on graft survival among French pediatric kidney transplant recipients., Methods: We analyzed all first pediatric kidney-only transplantations performed in France between 1993 and 2012. A Cox multivariable model was used to investigate the association of PKT and pretransplant dialysis time with the hazard of graft failure defined as death, return to dialysis, or retransplant, whichever occurred first., Results: Patients (n = 1911) were included, of which 380 (19.8%) received a PKT. Median time of follow-up was 7.0 y. PKT was associated with a 55% reduction of the hazard of graft failure at any time after KT compared with patients transplanted after dialysis (hazard ratio, 0.45; 95% confidence interval, 0.33-0.62), after adjustment for recipient sex and age, primary kidney disease, donor age and type (living or deceased donor), number of HLA mismatches, cold ischemia time, and year of transplantation. A reduction of the hazard of graft failure was found in PKT whatever the compared duration of dialysis, even when <6 mo and whatever the dialysis modality. Results were similar in multiple sensitivity analyses., Conclusions: In France, PKT among pediatric patients is associated with a better graft survival when compared with KT after dialysis, even when <6 mo. Based on these findings, we suggest that PKT should be considered as the treatment of choice for children with end-stage kidney disease., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2022
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27. Technical feasibility and correlations between shear-wave elastography and histology in kidney fibrosis in children.
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Desvignes C, Dabadie A, Aschero A, Ruocco A, Garaix F, Daniel L, Ferlicot S, Villes V, Loundou AD, Gorincour G, and Petit P
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- Adolescent, Child, Feasibility Studies, Fibrosis, Humans, Kidney diagnostic imaging, Kidney pathology, Reproducibility of Results, Elasticity Imaging Techniques, Kidney Diseases diagnostic imaging, Kidney Diseases pathology
- Abstract
Background: Ultrasound elastography has been suggested for assessing organ fibrosis., Objective: To study the feasibility of shear-wave elastography in children with kidney disease and the correlation between elasticity and kidney fibrosis in order to reduce the indications for kidney biopsy and its complications., Materials and Methods: Four operators measured kidney elasticity in children with kidney diseases or transplants, all of whom also had a renal biopsy. We assessed the feasibility and the intraobserver variability of the elasticity measurements for each probe used and each kidney explored. Then we tested the correlation between elasticity measurements and the presence of fibrosis., Results: Overall, we analyzed 95 children and adolescents, 31 of whom had renal transplant. Measurements with the convex probe were possible in 100% of cases. Linear probe analysis was only possible for 20% of native kidneys and 50% of transplants. Intraobserver variabilities ranged from moderate to high, depending on the probe and kidney studied. Elasticity was higher with the linear probe than with the convex probe (P<0.001 for left kidney and P=0.03 for right kidney). Measurements did not differ from one kidney to another in the same child. Elasticity and fibrosis were both higher in transplant patients (P=0.02 with convex probe; P=0.01 with linear probe; P=0.04 overall). There was no correlation between elasticity and fibrosis., Conclusion: Of the devices used in this work, kidney elastography was more accurately analyzed with a convex probe. Our study did not identify any correlation between elasticity and kidney fibrosis., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2021
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28. Quality of life of transplanted children and their parents: a cross-sectional study.
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Duvant P, Fillat M, Garaix F, Roquelaure B, Ovaert C, Fouilloux V, Tsimaratos M, Auquier P, Fabre A, and Baumstarck K
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- Adolescent, Child, Cross-Sectional Studies, France, Humans, Surveys and Questionnaires, Parents, Quality of Life
- Abstract
Background: Transplantation is a saving therapeutic that has heavy consequences. The quality of life (QoL) of transplanted children and their parents has been little studied and should help physicians better manage these patients. The objectives of the study were to assess: (1) the QoL of transplanted children and parents and compare it with that of children with other chronic conditions associated with long-term consequences, and (2) potential variables modulating the QoL., Methods: This cross-sectional study was performed in a multidisciplinary paediatric unit (Timone Hospital, Marseille, France). Children were less than 18 years old; had a liver, kidney or heart transplant; and had a time since transplantation of 1-10 years. Socio-demographics and clinical data were recorded from medical forms. The QoL was assessed using the VSP-A (Vécu et Santé Perçue de l'Adolescent et de l'Enfant) and the WhoQoL self-reported questionnaires., Results: Forty-five families were included (response rate: 76%). The transplanted organs were the liver for 20 children, the kidney for 15 children, and the heart for 10 children. The QoL of transplanted children reported by their parents was better than that of children with inborn errors of metabolism and similar to that of childhood leukaemia survivors. The QoL of parents of transplanted children was better than that of parents of children with inborn errors of metabolism and did not differ from French norms. The QoL did not differ according to the nature of the transplanted organ, sex or the main sociodemographic data. The main modulators decreasing QoL were residual treatment level, medications switch and the presence of another regular treatment., Conclusion: Transplanted children and their families reported a fairly preserved QoL compared to children with other chronic health conditions. Special attention should be given to QoL modulators related to therapeutic management (medication switches, regular treatments) that might be amenable to improve the QoL. Trial registration Ethics committee of Aix-Marseille University, France (reference number: 2014-08-04-03, 24/4/2015; https://www.univ-amu.fr/fr/public/comite-dethique )., (© 2021. The Author(s).)
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- 2021
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29. Dilatation of the aorta in children with advanced chronic kidney disease.
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Quennelle S, Ovaert C, Cailliez M, Garaix F, Tsimaratos M, and El Louali F
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- Aorta, Child, Chronic Disease, Dilatation, Humans, Hypertrophy, Left Ventricular diagnostic imaging, Hypertrophy, Left Ventricular epidemiology, Hypertrophy, Left Ventricular etiology, Renal Dialysis adverse effects, Risk Factors, Hypertension, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic epidemiology, Renal Insufficiency, Chronic therapy
- Abstract
Background: The peculiarity of the cardiovascular risk profile with increased arterial vulnerability is well known in adults with chronic kidney disease (CKD). It is explained by an increased incidence of traditional cardiovascular risk factors together with other comorbidities related to the uremic condition and cardiorenal syndrome (CRS). The present study aimed to determine the cardiovascular impact of the uremic condition in a pediatric population with advanced CKD., Methods: From 2016 to 2018, 39 consecutive patients with advanced CKD who underwent echocardiographic evaluation were included. All echocardiographic examinations were performed by the same operator (FE). Demographic, clinical, biological, and echocardiographic data were collected., Results: The mean age at echocardiographic exam was 9.7 ± 4.6 years. Twenty-four (61.5%) patients were on hemodialysis; 17 (43.6%) patients were in a peritoneal dialysis program of whom 11 switched at a later stage to hemodialysis. Eight (20.5%) patients had an arteriovenous fistula (AVF). Hypertension was present in 30 (76.9%) patients while left ventricular hypertrophy (LVH) was described in 13 (33.3%) patients. Dilatation of the ascending aorta (Z-score > 2) was found in 15 (38.4%) patients and was statistically (in univariate analysis) related to gender, hypertension, the presence of an AVF, and the use of hemodialysis after peritoneal dialysis (p = 0.024, p = 0.016, p = 0.006, p = 0.009, respectively)., Conclusion: In addition to classical and predictable abnormalities related to CKD, we found a high prevalence of dilatation of the ascending aorta in children with advanced CKD. Hypertension, AVF, and hemodialysis were associated factors.
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- 2021
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30. Covid-19 in liver transplant recipients: the French SOT COVID registry.
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Dumortier J, Duvoux C, Roux O, Altieri M, Barraud H, Besch C, Caillard S, Coilly A, Conti F, Dharancy S, Durand F, Francoz C, Garaix F, Houssel-Debry P, Kounis I, Lassailly G, Laverdure N, Leroy V, Mallet M, Mazzola A, Meunier L, Radenne S, Richardet JP, Vanlemmens C, Hazzan M, and Saliba F
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- Adolescent, Aged, COVID-19 diagnosis, COVID-19 mortality, COVID-19 therapy, COVID-19 Nucleic Acid Testing, Child, Comorbidity, Female, France epidemiology, Hospitalization statistics & numerical data, Humans, Immunosuppression Therapy, Intensive Care Units, Liver Transplantation mortality, Male, Middle Aged, Respiration, Artificial statistics & numerical data, Risk Factors, COVID-19 epidemiology, Liver Transplantation statistics & numerical data, Pandemics, Registries statistics & numerical data, Transplant Recipients statistics & numerical data
- Abstract
Background: Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in organ transplant recipients remains limited. The aim of this registry-based observational study was to report the characteristics and clinical outcomes of liver transplant (LT) recipients included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19., Methods: COVID-19 was diagnosed in patients who had a positive PCR assay for SARS-CoV-2 or in presence of typical lung lesions on imaging or specific SARS-CoV-2 antibodies. Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded., Results: Of the 104 patients, 67 were admitted to hospital and 37 were managed at home (including all 13 children). Hospitalized patients had a median age of 65.2 years (IQR: 58.1 - 73.2 years) and two thirds were men. Most common comorbidities included overweight (67.3%), hypertension (61.2%), diabetes (50.7%), cardiovascular disease (20.9%) and respiratory disease (16.4%). SARS-CoV-2 infection was identified after a median of 92.8 months (IQR: 40.1 - 194.7 months) from LT. During hospitalization, antimetabolites, mTOR inhibitor, and CNIs were withdrawn in 41.9%, 30.0% and 12.5% of patients, respectively. The composite endpoint of severe Covid-19 within 30 days after diagnosis was reached by 33.0% of the adult patients. The 30-day mortality rate was 20.0%, and 28.1% for hospitalized patients. Multivariate analysis identified that age was independently associated with mortality., Conclusion: In our large nationwide study, Covid-19 in LT recipients was associated with a high mortality rate., (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)
- Published
- 2021
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31. Dynamic prediction models for graft failure in paediatric kidney transplantation.
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Kaboré R, Ferrer L, Couchoud C, Hogan J, Cochat P, Dehoux L, Roussey-Kesler G, Novo R, Garaix F, Brochard K, Fila M, Parmentier C, Fournier MC, Macher MA, Harambat J, and Leffondré K
- Subjects
- Adolescent, Adult, Area Under Curve, Child, France, Glomerular Filtration Rate, Graft Rejection, Graft Survival, Humans, Kidney, Kidney Diseases, Male, Middle Aged, Postoperative Complications, Proportional Hazards Models, Renal Dialysis, Risk Factors, Tissue Donors, Transplant Recipients, Young Adult, Kidney Transplantation
- Abstract
Background: Several models have been proposed to predict kidney graft failure in adult recipients but none in younger recipients. Our objective was to propose a dynamic prediction model for graft failure in young kidney transplant recipients., Methods: We included 793 kidney transplant recipients waitlisted before the age of 18 years who received a first kidney transplantation before the age of 21 years in France in 2002-13 and survived >90 days with a functioning graft. We used a Cox model including baseline predictors only (sex, age at transplant, primary kidney disease, dialysis duration, donor type and age, human leucocyte antigen matching, cytomegalovirus serostatus, cold ischaemia time and delayed graft function) and two joint models also accounting for post-transplant estimated glomerular filtration rate (eGFR) trajectory. Predictive performances were evaluated using a cross-validated area under the curve (AUC) and R2 curves., Results: When predicting the risk of graft failure from any time within the first 7 years after paediatric kidney transplantation, the predictions for the following 3 or 5 years were accurate and much better with the joint models than with the Cox model (AUC ranged from 0.83 to 0.91 for the joint models versus 0.56 to 0.64 for the Cox model)., Conclusion: Accounting for post-transplant eGFR trajectory strongly increased the accuracy of graft failure prediction in young kidney transplant recipients., (© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.)
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- 2021
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32. COQ6 mutation in patients with nephrotic syndrome, sensorineural deafness, and optic atrophy.
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Justine Perrin R, Rousset-Rouvière C, Garaix F, Cano A, Conrath J, Boyer O, and Tsimaratos M
- Abstract
Introduction: Primary coenzyme Q10 (CoQ10) deficiencies are a group of mitochondrial disorders that has proven responsiveness to replacement therapy. Mutations in enzymes involved in the biosynthesis of CoQ10 genes are associated with these deficits. The clinical presentation of this rare autosomal recessive disorder is heterogeneous and depends on the gene involved. Mutations in the COQ2, COQ6, PDSS2 , and ADCK4 genes are responsible for steroid-resistant nephrotic syndrome (SRNS), which is associated with extra-renal symptoms. Previous studies have reported COQ6 mutations in 11 patients from five different families presenting with SRNS and sensorineural deafness., Case Reports: Our study reports the cases of two brothers of Turkish origin with renal failure and sensorineural deafness associated with COQ6 mutations responsible of CoQ10 deficiency. Optical symptoms were present in the eldest, that improved with Idebenone., Conclusion/discussion: For the first time, COQ6 mutation with optical involvement is associated with renal and hearing impairment. Although the response to replacement CoQ10 therapy was difficult to evaluate, we think that this treatment was able to stop the disease progression in both patients, and even to prevent the occurrence/development of optical and neurological impairment in the younger brother. Mitochondrial dysfunction secondary to CoQ10 deficiency should always be suspected in patients with SRNS and extra-renal symptoms. Early recognition of this genetic SRNS is mandatory since SRNS can be avoided by adequate treatment based on CoQ10 supplement or an analogue. All cases of primary CoQ10 deficiency should be treated at an early stage to limit the progression of lesions and prevent the emergence of new symptoms., Competing Interests: The authors have no conflict of interest to disclose., (© 2019 The Authors. Journal of Inherited Metabolic Disease published by John Wiley & Sons Ltd on behalf of SSIEM.)
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- 2020
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33. Bernard-Soulier syndrome: first human case due to a homozygous deletion of GP9 gene.
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Ghalloussi D, Rousset-Rouvière C, Popovici C, Garaix F, Saut N, Saultier P, Tsimaratos M, Chambost H, Alessi MC, and Baccini V
- Subjects
- Bernard-Soulier Syndrome pathology, Bone Marrow pathology, Humans, Infant, Newborn, Male, Pedigree, Platelet Glycoprotein GPIb-IX Complex genetics, Sequence Deletion, Bernard-Soulier Syndrome genetics
- Published
- 2020
- Full Text
- View/download PDF
34. Social deprivation is associated with poor kidney transplantation outcome in children.
- Author
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Driollet B, Bayer F, Chatelet V, Macher MA, Salomon R, Ranchin B, Roussey G, Lahoche A, Garaix F, Decramer S, Mérieau E, Fila M, Zaloszyc A, Deschênes G, Valeri L, Launay L, Couchoud C, Leffondré K, and Harambat J
- Subjects
- Adolescent, Child, Female, Follow-Up Studies, France epidemiology, Graft Rejection etiology, Graft Survival, Humans, Male, Registries statistics & numerical data, Time Factors, Graft Rejection epidemiology, Health Status Disparities, Kidney Failure, Chronic surgery, Kidney Transplantation adverse effects, Social Class
- Abstract
Socioeconomic status is an important determinant of health. Its impact on kidney transplantation outcome has been studied among adults but data in children are scarce, especially in Europe. Here, we investigate the association between the level of social deprivation (determined by the continuous score European Deprivation Index) and graft failure risk in pediatric kidney transplant recipients. All patients listed under 18 years of age who received a first kidney transplant between 2002 and 2014 in France were included. Of 1050 kidney transplant recipients (males 59%, median age at transplantation 13.2 years, preemptive transplantation 23%), 211 graft failures occurred within a median followup of 5.9 years. Thirty-seven percent of these patients belong to the most deprived quintile, suggesting that deprivation is more frequent in pediatric patients with end-stage kidney disease (ESKD) than in the general population. Five- and ten-year graft survival were 85% and 69%, respectively, in the most deprived quintile vs. 90% and 83%, respectively, in the least deprived quintile. At any time after transplantation, patients in the most deprived quintile had almost a two-fold higher hazard of graft failure compared with the least deprived quintile, after adjustment for age at renal replacement therapy, duration of dialysis, primary kidney disease, and rural/urban living environment (hazard ratio 1.99; 95% confidence interval 1.20-3.28). The hazard of graft failure did not differ significantly between girls and boys. Thus, our findings suggest a lower socioeconomic status is independently associated with poor graft outcome in pediatric kidney transplantation., (Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
35. Human papillomavirus type 7-associated anal condyloma after renal transplantation in a child.
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Garaix F, Hery G, Tsimaratos M, Colson P, and Tamalet C
- Subjects
- Anus Diseases genetics, Anus Diseases immunology, Child, Condylomata Acuminata genetics, Condylomata Acuminata immunology, Humans, Immunosuppression Therapy methods, Male, Papillomavirus Infections genetics, Papillomavirus Infections immunology, Anus Diseases virology, Condylomata Acuminata virology, Kidney Transplantation, Papillomavirus Infections virology
- Abstract
The prevalence, clinical significance, and spectrum of many HPV genotypes are currently largely untapped. We report a case of anal condyloma associated with a rare HPV genotype in a 11-year-old kidney transplant recipient. Eleven months post-graft, rectal bleeding revealed a 5-cm-large anal condyloma for which immuno-histopathology revealed typical papillomatosis. HPV genotyping performed on anal biopsy identified a HPV type 7, for which a single sequence was found in the GenBank sequence database. HPV7 is classically found in hand cutaneous warts, but HPV7-associated condyloma was only described in two patients. Total resection of the anal lesion was performed by electrocoagulation with no recurrence after 6 years. Post-transplant immunosuppression may promote anal condyloma with uncommon HPV types. HPV genotyping in such lesions is useful to get a better understanding of the epidemiology and clinical significance of such unusual HPV types as HPV7., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
- Full Text
- View/download PDF
36. Cladribine-related immunosuppression may have fostered graft-versus-host disease after lung transplant for pulmonary Langerhans cell histiocytosis.
- Author
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Galambrun C, Garaix F, Ughetto F, Picard C, Petit P, Bosdure E, Poullin P, Stremler N, Mace L, and Donadieu J
- Subjects
- Child, Preschool, Fatal Outcome, Female, Graft vs Host Disease pathology, Histiocytosis, Langerhans-Cell immunology, Humans, Immunosuppression Therapy adverse effects, Immunosuppressive Agents adverse effects, Lung Diseases immunology, Cladribine adverse effects, Graft vs Host Disease etiology, Histiocytosis, Langerhans-Cell drug therapy, Histiocytosis, Langerhans-Cell surgery, Lung Diseases drug therapy, Lung Diseases surgery, Lung Transplantation adverse effects
- Published
- 2019
- Full Text
- View/download PDF
37. Tacrolimus Granules for Oral Suspension as Post-Transplant Immunosuppression in Routine Medical Practice in France: The OPTIMOD Study.
- Author
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Garaix F, Stern M, Lamy FX, Dubel L, and Kamar N
- Subjects
- Administration, Oral, Adolescent, Adult, Child, Child, Preschool, Female, France, Humans, Immunosuppressive Agents administration & dosage, Male, Middle Aged, Prospective Studies, Tacrolimus administration & dosage, Treatment Outcome, Immunosuppression Therapy methods, Immunosuppressive Agents therapeutic use, Kidney Transplantation methods, Liver Transplantation methods, Lung Transplantation methods, Tacrolimus therapeutic use
- Abstract
BACKGROUND Different pharmaceutical forms of oral tacrolimus allow tailored administration. The granular formulation facilitates accurate dose adjustment of tacrolimus according to patient characteristics, such as weight, or potential concomitant drug interactions. Currently, there are no data describing the use of tacrolimus granules in transplant recipients in France. MATERIAL AND METHODS OPTIMOD was a 6-month prospective, observational multicenter study that aimed to describe patient characteristics and conditions of use of tacrolimus granules. The 25 participating centers enrolled patients at time of tacrolimus granules initiation and were to collect patient and treatment data at initiation and after 6 months of follow-up. All analyses were descriptive. RESULTS Of 61 patients included, 55.7% were children (mainly kidney graft recipients) and 44.3% were adults (mostly lung graft recipients). Overall, 24.6% of patients (all children) initiated tacrolimus granules immediately post-transplant; the remaining 75.4% converted to tacrolimus granules from ciclosporin or immediate-release tacrolimus hard capsules. The main reasons for initiating tacrolimus granules, irrespective of whether first- or second-line therapy, were to offset potential drug-drug interactions in adults by adjusting dose, and to adapt to the particular needs of children as patients. Most patients (78.7%) underwent ≥1 dose modification during follow-up. Eleven rejection episodes occurred during follow-up, of which none led to graft loss. The adverse-event profile of the tacrolimus granules was similar to that of other tacrolimus formulations and 7 treatment-related adverse events were recorded. CONCLUSIONS Results suggest that tacrolimus granules are well tolerated and effective in preventing transplant rejection when administered in routine practice in France.
- Published
- 2018
- Full Text
- View/download PDF
38. Pharmacogenetics of post-transplant diabetes mellitus in children with renal transplantation treated with tacrolimus.
- Author
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Lancia P, Adam de Beaumais T, Elie V, Garaix F, Fila M, Nobili F, Ranchin B, Testevuide P, Ulinski T, Zhao W, Deschênes G, and Jacqz-Aigrain E
- Subjects
- ATP Binding Cassette Transporter, Subfamily B genetics, Adolescent, Child, Cytochrome P-450 CYP3A genetics, Cytochrome P-450 Enzyme System genetics, Diabetes Mellitus genetics, Female, France, Genetic Predisposition to Disease, Genotype, Humans, Immunosuppressive Agents therapeutic use, Male, PPAR alpha genetics, Pharmacogenetics, Postoperative Complications etiology, Postoperative Complications genetics, Receptors, Calcitriol genetics, Retrospective Studies, Risk Factors, Tacrolimus therapeutic use, Diabetes Mellitus etiology, Immunosuppressive Agents adverse effects, Kidney Transplantation adverse effects, Tacrolimus adverse effects
- Abstract
Background: Post-transplant diabetes mellitus (PTDM) is a major complication of immunosuppressive therapy, with many risk factors reported in adults with renal transplantation. The objective of this study was to investigate potential non-genetic and genetic risk factors of PTDM in children with renal transplantation treated with tacrolimus., Methods: A national database was screened for patients developing PTDM within 4 years following tacrolimus introduction. PTDM was defined as glucose disorder requiring anti-diabetic treatment. PTDM patients were matched to "non-PTDM" control transplanted children according to age, gender, and duration of post-transplant follow-up. Patients were genotyped for six selected genetic variants in POR*28 (rs1057868), PPARa (rs4253728), CYP3A5 (rs776746), VDR (rs2228570 and rs731236), and ABCB1 (rs1045642) genes, implicated in glucose homeostasis and tacrolimus disposition., Results: Among the 98 children with renal transplantation enrolled in this multicentre study, 18 developed PTDM. None of the clinical and biological parameters was significant between PTDM and control patients. Homozygous carriers of POR*28 or wild-type ABCB1 (rs1045642) gene variants were more frequent in PTDM than in control patients with differences close to significance (p = 0.114 and p = 0.066 respectively). A genetic score based on these variants demonstrated that POR*28/*28 and ABCB1 CC or CT genotype carriers were at a significantly higher risk of developing PTDM after renal transplantation., Conclusion: Identification of PTDM risk factors should allow clinicians to allocate the best immunosuppressant for each patient with renal transplantation, and improve care for patients who are at a higher risk.
- Published
- 2018
- Full Text
- View/download PDF
39. Renal transplantation in children under 3 years of age: Experience from a single-center study.
- Author
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Loiseau Y, Bacchetta J, Klich A, Ranchin B, Demede D, Laurent A, Baudin F, Garaix F, Roy P, and Cochat P
- Subjects
- Adolescent, Age Factors, Child, Child, Preschool, Female, Graft Rejection epidemiology, Humans, Infant, Infant, Newborn, Kaplan-Meier Estimate, Linear Models, Longitudinal Studies, Male, Outcome Assessment, Health Care, Postoperative Complications epidemiology, Proportional Hazards Models, Quality of Life, Retrospective Studies, Risk Assessment, Risk Factors, Graft Rejection etiology, Graft Survival, Kidney Transplantation mortality, Postoperative Complications etiology
- Abstract
RTx remains challenging in children under 3 years of age. This single-center study reviewed the medical records of children <3 years transplanted since 1987 (N = 32, Group 1). They were matched for donor type and RTx period with children aged 3-13 years (N = 32, Group 2) and 13-18 years (N = 32, Group 3). There were no between-group significant differences regarding distributions of gender, primary renal disease, proportion of dialysis before RTx, and growth (SDS). Compared to Groups 2 and 3, Group 1 had more peritoneal dialyses (P < .001), more EBV mismatches (P = .04), and longer warm ischemia times (P < .001). The risk of graft loss was not significantly different among age groups (hazard ratio, 2.4 in Group 2 and 2.0 in Group 3 vs Group 1; P = .2). Death occurred in four patients (3 in Group 1 and 1 in Group 2) and graft loss occurred in 28 patients, mainly due to chronic allograft nephropathy. In recipients <3 years of age, the outcomes of RTx are close to those obtained in older pediatric age groups. Thus, young patients may be transplanted in experienced multidisciplinary teams without additional risks provided that particular attention is paid to donor selection and prevention/early diagnosis of comorbidities and complications., (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2018
- Full Text
- View/download PDF
40. Age-Dependent Risk of Graft Failure in Young Kidney Transplant Recipients.
- Author
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Kaboré R, Couchoud C, Macher MA, Salomon R, Ranchin B, Lahoche A, Roussey-Kesler G, Garaix F, Decramer S, Pietrement C, Lassalle M, Baudouin V, Cochat P, Niaudet P, Joly P, Leffondré K, and Harambat J
- Subjects
- Adolescent, Adult, Age Factors, Child, Child, Preschool, Female, France, Humans, Infant, Infant, Newborn, Kidney Failure, Chronic diagnosis, Kidney Transplantation methods, Male, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Registries, Risk Assessment, Risk Factors, Time Factors, Treatment Failure, Young Adult, Graft Survival, Kidney Failure, Chronic surgery, Kidney Transplantation adverse effects
- Abstract
Background: The risk of graft failure in young kidney transplant recipients has been found to increase during adolescence and early adulthood. However, this question has not been addressed outside the United States so far. Our objective was to investigate whether the hazard of graft failure also increases during this age period in France irrespective of age at transplantation., Methods: Data of all first kidney transplantation performed before 30 years of age between 1993 and 2012 were extracted from the French kidney transplant database. The hazard of graft failure was estimated at each current age using a 2-stage modelling approach that accounted for both age at transplantation and time since transplantation. Hazard ratios comparing the risk of graft failure during adolescence or early adulthood to other periods were estimated from time-dependent Cox models., Results: A total of 5983 renal transplant recipients were included. The risk of graft failure was found to increase around the age of 13 years until the age of 21 years, and decrease thereafter. Results from the Cox model indicated that the hazard of graft failure during the age period 13 to 23 years was almost twice as high as than during the age period 0 to 12 years, and 25% higher than after 23 years., Conclusions: Among first kidney transplant recipients younger than 30 years in France, those currently in adolescence or early adulthood have the highest risk of graft failure.
- Published
- 2017
- Full Text
- View/download PDF
41. Rituximab fails where eculizumab restores renal function in C3nef-related DDD.
- Author
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Rousset-Rouvière C, Cailliez M, Garaix F, Bruno D, Laurent D, and Tsimaratos M
- Subjects
- Antibodies, Monoclonal, Murine-Derived therapeutic use, Child, Complement C3 Nephritic Factor analysis, Complement C3 Nephritic Factor immunology, Glomerulonephritis, Membranoproliferative immunology, Glomerulonephritis, Membranoproliferative pathology, Humans, Male, Rituximab, Antibodies, Monoclonal, Humanized therapeutic use, Glomerulonephritis, Membranoproliferative drug therapy
- Abstract
Background: Dense deposit disease (DDD), a C3 glomerulopathy (C3G), is a rare disease with unfavorable progression towards end-stage kidney disease. The pathogenesis of DDD is due to cytotoxic effects related to acquired or genetic dysregulation of the complement alternative pathway, which is at times accompanied by the production of C3 nephritic factor (C3NeF), an auto-antibody directed against the alternative C3 convertase. Available treatments include plasma exchange, CD20-targeted antibodies, and a terminal complement blockade via the anti-C5 monoclonal antibody eculizumab., Case-Diagnosis/treatment: We report here the case of an 8-year-old child with C3NeF and refractory DDD who presented with a nephritic syndrome. She tested positive for C3NeF activity; C3 was undetectable. Genetic analyses of the alternative complement pathway were normal. Methylprednisolone pulses and mycophenolate mofetil treatment resulted in complete recovery of renal function and a reduction in proteinuria. Corticosteroids were tapered and then withdrawn. Four months after corticosteroid discontinuation, hematuria and proteinuria recurred, and a renal biopsy confirmed an active DDD with a majority of extracapillary crescents. Despite an increase in immunosuppressive drugs, including methylprednisolone pulses and rituximab therapy, the patient suffered acute renal failure within 3 weeks, requiring dialysis. Eculizumab treatment resulted in a quick and impressive response. Hematuria very quickly resolved, kidney function improved, and no further dialysis was required. The patient received bimonthly eculizumab injections of 600 mg, allowing for normalization of renal function and reduction of proteinuria to <0.5 g per day. Since then, she continues to receive eculizumab., Conclusion: Complement regulation pathway-targeted therapy may be a specific and useful treatment for rapidly progressing DDD prior to the development of glomerulosclerosis. Our data provide evidence supporting the pivotal role of complement alternative pathway abnormalities in C3G with DDD.
- Published
- 2014
- Full Text
- View/download PDF
42. [Characteristics of the pediatric patient before transplantation].
- Author
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Garaix F
- Subjects
- Adolescent, Child, Child, Preschool, France epidemiology, Humans, Infant, Infant, Newborn, Kidney Failure, Chronic surgery, Preoperative Care, Prevalence, Prognosis, Risk Factors, Treatment Outcome, Kidney Failure, Chronic epidemiology, Kidney Transplantation statistics & numerical data, Living Donors statistics & numerical data, Patient Selection
- Abstract
Renal transplantation is the treatment of choice for end-stage renal disease during childhood. In France, access to transplantation is good and even better for children than for adults. Few contraindications, mostly temporary, might delay the transplantation. The different pathologies leading to end-stage renal disease in children require a specific pre-transplantation examination and a careful choice of the type of donor. Prevalence of disease recurrence is greater in children than in adults. It is one of the most frequent post-transplantation complications and contributes to the increase in patient morbidity and graft failure in our pediatrics cohorts. Kidney donations in North America are for the most part live-donation, which is not the case in France. However, thanks to parent's commitment, the ratio of living donor is currently increasing in France., (Copyright © 2011. Published by Elsevier SAS.)
- Published
- 2011
- Full Text
- View/download PDF
43. [Kidney and vaculitis in children].
- Author
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Rousset-Rouvière C, Garaix F, Cailliez M, Bruno D, Coulibaly B, Daniel L, and Tsimaratos M
- Subjects
- Child, Humans, Kidney Diseases etiology, Vasculitis complications
- Published
- 2009
- Full Text
- View/download PDF
44. [How to delay progression of chronic renal failure?].
- Author
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Garaix F, Rousset Rouvière C, Cailliez M, Bruno D, and Tsimaratos M
- Subjects
- Child, Disease Progression, Humans, Kidney Failure, Chronic complications, Time Factors, Kidney Failure, Chronic prevention & control
- Published
- 2009
- Full Text
- View/download PDF
45. Crescentic glomerulonephritis is part of hyperimmunoglobulinemia D syndrome.
- Author
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Cailliez M, Garaix F, Rousset-Rouvière C, Bruno D, Daniel L, Chabrol B, Sarles J, and Tsimaratos M
- Subjects
- Glomerulonephritis physiopathology, Humans, Hypergammaglobulinemia blood, Hypergammaglobulinemia physiopathology, Syndrome, Glomerulonephritis immunology, Hypergammaglobulinemia immunology, Immunoglobulin D blood
- Published
- 2006
- Full Text
- View/download PDF
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