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Tuberculosis （TB） and human immunodeficiency virus infection / acquired immune deficiency syndrome （HIV/AIDS） are both serious global public health threats. Early detection of infected persons and/or patients through TB/HIV bi-directional screening is crucial for prevention and control strategy in China and globally. In recent years， with the promotion and application of new TB and HIV detection technologies worldwide， TB/HIV bi-directional screening technologies and strategies have made remarkable changes. This expert consensus introduces the significance and challenges of TB/HIV bi-directional screening， summarizes important progress of research and applications， and makes recommendations on screening measures and procedures to further strengthen TB/HIV bi-directional screening in China.

IntroductionPathologists rely on whole slide images (WSIs) to diagnose cancer by identifying tumor cells and subtypes. Deep learning models, particularly weakly supervised ones, classify WSIs using image tiles but may overlook false positives and negatives due to the heterogeneous nature of tumors. Both cancerous and healthy cells can proliferate in patterns that extend beyond individual tiles, leading to errors at the tile level that result in inaccurate tumor-level classifications.MethodsTo address this limitation, we introduce NATMIL (Neighborhood Attention Transformer Multiple Instance Learning), which utilizes the Neighborhood Attention Transformer to incorporate contextual dependencies among WSI tiles. NATMIL enhances multiple instance learning by integrating a broader tissue context into the model. Our approach enhances the accuracy of tumor classification by considering the broader tissue context, thus reducing errors associated with isolated tile analysis.ResultsWe conducted a quantitative analysis to evaluate NATMIL’s performance against other weakly supervised algorithms. When applied to subtyping non-small cell lung cancer (NSCLC) and lymph node (LN) tumors, NATMIL demonstrated superior accuracy. Specifically, NATMIL achieved accuracy values of 89.6% on the Camelyon dataset and 88.1% on the TCGA-LUSC dataset, outperforming existing methods. These results underscore NATMIL’s potential as a robust tool for improving the precision of cancer diagnosis using WSIs.DiscussionOur findings demonstrate that NATMIL significantly improves tumor classification accuracy by reducing errors associated with isolated tile analysis. The integration of contextual dependencies enhances the precision of cancer diagnosis using WSIs, highlighting NATMILs´ potential as a robust tool in pathology.

Konjac (Amorphophallus konjac) is a horticultural plant with high nutritional and medicinal values. Soft rot is a severe disease in production of konjac and it is also the main factor restricting the development of the konjac industry. It has been reported that the soft rot of konjac is mainly caused by pathogenic bacteria (mainly including Pectobacterium aroidearum, P. carotovorum subsp. carotovorum, P. chrysanthemi and Enterobacter sp.), and there is rare reports on pathogenic fungi that cause konjac soft rot. In order to clarify the pathogenic types and infection characteristics of the soft rot in Qujing City, Yunnan Province, the diseased corms were collected for fungal isolation by tissue isolation methods. The isolated fungi were identified by morphological and molecular identification methods based on ITS and LSU sequence analyses, and pathogenicity was determined according to Koch's rule. The infection characteristic was analyzed by mixed inoculation using the identified pathogenic fungi and the pathogenic bacteria of konjac soft rot. The results were as follows: (1) Three species of Fusarium spp. (Fusarium concentricum, F. oxysporum and F. ambrosium), one species of Mucor sp., one species of Rhizopus sp., one species of Penicillium sp. and one species of Clonostachys sp. were identified. (2) Statistics analysis found that Fusarium concentricum had the highest relative abundance (45.45%). (3) Koch postulates tests showed that inoculation with F. concentricum caused obvious soft rot symptoms of konjac corms within three days. (4) In addition, mixed Pectobacterium aroidearum and Fusarium concentricum together inoculation promoted the disease development, and the weight of rotten tissue was significantly higher than that of single inoculation using F. concentricum or Pectobacterium aroidearum. Overall, these results indicate that konjac soft rot may be caused by a combination of fungus and bacterium infection. The results provide a theoretical reference for the prevention and management of konjac soft rot.

The purpose of this study was to investigate whether doxorubicin nanobubbles (DOX-NB) combined with diagnostic ultrasound (DUS) irradiation could downregulate the expression of carbonic anhydrase IX (CAIX) in mouse xenograft nasopharyngeal carcinoma (NPC) model. In this study, the prepared DOX-NB was round and well dispersed. The average diameter of DOX-NB was 250.9 ± 50.8 nm, with an average polydispersity of 0.321 ± 0.05. The cumulative release of DOX in the DOX-NB + DUS group was significantly higher compared with that of the DOX-NB group (p < 0.05). DOX-NB combined with DUS irradiation could significantly inhibit cell viability (p < 0.05). The expression of CAIX and microvessel density (MVD) in the xenografted tumors was the lowest in the DOX-NB + DUS group compared with that of other groups (p < 0.05). In conclusion, DOX-NB combined with DUS irradiation could improve DOX-NB drug release and synergistically inhibit NPC cell activity. DOX-NB combined with DUS irradiation can downregulate the expression of CAIX in mouse xenograft NPC model. This may be due to the synergistic effect of DUS combined with DOX-NB in reducing MVD in NPC.

[Objective] The effects of Salix psammophila sand barrier decay on the composition and diversity of fungal communities were analyzed in order to provide a theoretical basis for further research on the ecological function of fungal communities in desert ecosystems. [Methods] S. psammophila sand barriers aged 1, 3, 5,and 7 years were observed, and newly laid sand barriers were used as the control. Field in-situ sampling, laboratory index determination, and Illumina MiSeq sequencing technology were used to determine the response relationships between fungal diversity and sand barrier components, soil properties, and enzyme activities during sand barrier decay. [Results] ① The relative abundance of Phialophora, Trichoderma, Knufia, Veronaea and Coniochaeta increased over time, while Didymella and Phaeococcomyces decreased over time. Fungal diversity and richness increased over time. ② Soil organic carbon, alkaline nitrogen, and dissolved organic carbon at seven years were 2.47, 1.83, and 1.71 times higher, respectively, than observed for the control. Activities of β-1,4-glucosidase and leucine aminopeptidase significantly increased by 139.36% and 35.16%, respectively. ③ Knufia, Parasola, Veronaea, and Coniochaeta were positively correlated with soil organic carbon, alkaline nitrogen, and dissolved orgainic carbon, but negatively correlated with cellulose and hemifiber (p

The dissipative Kerr soliton combs based on microresonators have attracted wide attention due to their high coherence and on-chip integration. Meanwhile, the soliton microcombs have shown broad applications in coherent communication, on-chip low-noise microwave synthesizer, optical clock, etc. However, the performance of these applications is typically limited by their bandwidth as the precise tuning of the soliton microcombs usually relies on the thermoelectric cooler, which is slow and may increase the system’s complexity. Here, we demonstrate the observation of dissipative solitons based on the magnesium fluoride resonator with an ultrahigh-quality (Q) factor of about 927 million. The ‘power-kicking’ scheme is employed to lock and stabilize the solitons actively. Also, tuning the acousto-optical modulator allows changing the bandwidth and recoil of the solitons. This approach enables more direct and concise feedback and reduces the system’s complexity.

This study aimed to assess the correlation among the peak intensity (PI) values of quantitative parameters, microvessel density (MVD), microvessel maturity, and International Society of Urological Pathology (ISUP) grades in biopsy specimens from prostate cancer (PCa) patients. The study population included PCa patients who underwent targeted and systematic biopsy, without radiation or chemohormonal therapy before biopsy. Contrast-enhanced transrectal ultrasonography (CE-TRUS) was performed in all patients before biopsy. Contrast-enhancement patterns and PI values of quantitative parameters were observed. Tumor tissue samples were immunostained for CD31 expression. MVD, microvessel maturity, and ISUP grades were determined in prostate biopsy specimens. Based on the contrast enhancement patterns of prostate lesions, 16 patients were assigned to a low-enhancement group and 45 to a high-enhancement group. The number of mature vessels, MVD, mature vessel index, and ISUP grades were all higher in the high-enhancement group than in the low-enhancement group (all P < 0.05). The immature vessel index was lower in the high-enhancement group than in the low-enhancement group (P < 0.05). The PI value was positively correlated with the number of mature vessels (r = 0.372). In conclusion, enhancement patterns on CE-TRUS can reflect microvessel maturity in PCa. The PI value was positively correlated with the number of mature vessels.

Per- and polyfluoroalkyl substances (PFAS) are a large class of organic compounds, in which all or part of the hydrogen atoms in the alkyl-chain are replaced by fluorine, and many PFAS are used globally in chemicals, leather textile, paper, packaging and other industrial and consumer goods production fields. Many studies have shown that PFAS possesses hepatic and metabolic toxicity, reproductive and developmental toxicity, immunotoxicity, and so on. Therefore, the use of PFAS in textiles has been restricted by lots of regulations or standards world widely, such as the International Ecological Textile Standard (STANDARD 100 by OEKO-TEX®), the Restricted Substances List (RSL) of the American Apparel & Footwear Association (AAFA) and the REACH regulations of EU. However, there is still lack of simultaneous determination method for various volatile PFAS in relevant standards. In this study, a method of gas chromatography-mass spectrometry (GC-MS) was developed for the simultaneous determination of 12 volatile PFAS in infant and child textiles, including four fluorotelomer alcohols (FTOHs), three fluorotelomer acrylates (FTAs), three perfluorooctane sulfonamides (FOSAs) and two perfluorooctane sulfonamidoethanols (FOSEs). The redissolve solvent was optimized, and the extraction efficiencies for different extraction solvents, extraction volumes, extraction times, extraction temperature and time were compared. 20 mL Acetonitrile was selected as extraction solvent, and the sample was extracted twice by ultrasonic at 60 ℃ for 30 min each time, then the combined supernatants were concentrated by rotary evaporation. Finally, the targets were separated by DB-5MS column and detected at selected ion monitor (SIM) mode, and quantified by external standard method. The results showed that 4∶2 FTOH and the other 11 volatile PFAS had good linear relationship in the range of 20-5 000, 10-5 000 μg/L, respectively, and the correlation coefficients (R2) were not less than 0.998. The limits of quantification (LOQs) were 0.03-0.07 mg/kg. The recoveries of 12 PFAS were 71.9%-113.6% under the two spiked levels (levels at the LOQ and the limit content of relevant standards), and the relative standard deviations (RSDs) were 1.2%-12.8% (n=6). The method has the advantages of simple pretreatment, accurate qualitative and quantitative determination, high sensitivity, and good repeatability. The actual samples were divided into two groups and determined by this method. One group included 53 pieces of textile fabrics with certain waterproofness that were tested daily in the laboratory. Some of these textile fabrics have cartoon patterns, which may be used for making children’s clothing. The other group included 26 pieces of infant and child clothes purchased from online stores. The results showed that the positive rate of volatile PFAS in textile fabrics was high. FTOHs and FTAs were detected, and their concentrations were in the range of 0.08-276.41 mg/kg. FOSAs were not detected in the samples. The textile fibers with PFAS detected were mainly polyester. Volatile PFAS were not detected in the randomly purchased infant and child cloth products, which might be mainly because they didn’t have waterproofs. The skin exposure model proposed by the European Chemical Agency was used to assess exposure risks. The mixed exposure of various PFAS in textiles was calculated by the relative potency factor (RPF), which was converted into the equivalent of PFOA, and compared with the safety threshold given by the US Environmental Protection Agency and the European Food Safety Agency. The results showed that the risk of direct health hazards to infants and children from the exposure of detected target substances was low. The method has reference value for the control of volatile PFAS risk substances in baby textiles.

AbstractA random-effects meta-analysis was performed in English and Chinese databases since its inception to August 2020 to assess the incidence, causes and severity of acute pancreatitis (AP) at various stages of pregnancy, maternal and foetal mortality. A total of 154 articles representing 4034 patients with AP during pregnancy in China were included for the analysis. The incidence of AP during pregnancy was 0.0469 (95% confidence interval [CI], 0.0349; 0.0627) in the first trimester, whereas it was 0.2518 (95% CI, 0.2210; 0.2854) and 0.6323 (95% CI, 0.5870; 0.6753) in the second and third trimester, respectively. The major causes of AP were hypertriglyceridaemia (0.351 [95% CI, 0.3202; 0.3834]) and biliary pancreatitis (0.424 [95% CI, 0.4094; 0.5002]). The severity of AP was mild in majority of the patients. The incidence of AP at maternal mortality was 0.0184 (95% CI, 0.0126; 0.0269) and foetal mortality was 0.1018 (95% CI, 0.0867; 0.1192). Our meta-analysis revealed that hypertriglyceridaemia and biliary pancreatitis remain the major causes of AP during pregnancy. Foetal mortality requires further investigation. IMPACT STATEMENTWhat is already known on this subject? Acute pancreatitis (AP) in pregnant women is characterised by acute onset and delay in understanding the interaction of the metabolic changes with pancreatic pathophysiology, and thus becomes difficult to diagnose the disease and provide timely treatment to the patients. This poses a greater health risk among women and their foetus by increasing their chances of mortality.What the results of this study add? We performed an exhaustive, random-effects meta-analysis involving 154 articles representing 4034 patients to assess the incidence of AP at various stages of pregnancy, the causes of AP and the severity of AP during pregnancy, maternal and foetal mortality.What are the implications of these findings for clinical practice and/or further research? Our meta-analysis revealed that hypertriglyceridaemia and biliary pancreatitis remain the major causes of AP during pregnancy. Although the rates of maternal mortality have decreased in the recent years, foetal mortality still remains high and requires further investigation.

Objective To summarize the technical points and curative effects of neuroendoscopy in the removal of ventricular casting hematoma. Methods A total of 36 patients with ventricular casting who underwent neuroendoscopy hematoma evacuation in Huaihe Hospital of He'nan University from January 2019 to May 2021 were included. Among them, 12 cases were whole ventricle casting, 15 cases were third ventricle and unilateral lateral ventricle casting, and 9 cases were the third ventricle and bilateral lateral ventricle casting. A small arc⁃shaped incision was made parallel to the sagittal suture in the case of heavy whole ventricle casting, which made the incision anterior 2/3 and posterior 1/3 of the coronal suture. Compared with the conventional frontal angle puncture incision, the incision was moved back by 1-2 cm. A 10ml syringe was used to create a self⁃made endoscope working channel, precise positioning to avoid damage to brain tissue due to continuous changes in the direction and depth of the sleeve. At 3 months after surgery, the quality of daily life and prognosis of the patients were evaluated according to the Activities of Daily Living Scale (ADL) and Glasgow Outcome Scale (GOS). Results The average surgery time was 1.50 h. The hematoma clearance rate was＞90% in 32 cases and＞80%-90% in 4 cases. CT showed no residual hematoma, and the ventricular system returned to normal anatomical shape. Continuous lumbar drainage after surgery was undergone in 28 cases, while lumbar puncture and drainage was undergone in 8 cases. On the 14th day after surgery, the GCS score was 11.63±2.47, which was higher than the preoperative score of 9.82±1.68 (t=3.162, P=0.021), with significant improvement in eye opening and motor function. There were no deaths during hospitalization, and 2 patients died of pulmonary infection at 3 months after the surgery. Among the survival patients, 94.12% (32/34, 18 cases of ADL grade Ⅱ and 14 cases of grade Ⅲ, or 18 cases of GOS score 5 and 14 cases of GOS score 4) had good quality of life, 5.88% (2/34, ADL grade Ⅳ or GOS score 3) were not good. Conclusions Under the direct vision of neuroendoscopy, the ventricular casting hematoma can be quickly removed, which relieved the pressure of the ventricle, shorten the recovery period of patients, and improved the quality of life after surgery. It is worthy of clinical application.

Objective Based on the theory of biomechanics, the finite element method was used to study the injury characteristics of different parts of brain hit by fist with different force and to predict the risk of craniocerebral injury, in order to provide reference for actual medical protection and forensic identification. Methods The finite element model of fist was constructed by using DICOM data modeling method and related software, and the effective mass and speed of fist were used to represent the kinetic energy of fist, and combined with human finite element model THUMS 4.02, the characteristics of craniocerebral injury caused by frontal and lateral blows were parametrically simulated. Results The probability of direct death from a blow to the head was low, but as fist power increased, so did the risk of craniocerebral injury. The characteristics of craniocerebral injury were also significantly different with the different fist hitting head locations. When the frontal area was attacked, the maximum equivalent stress of skull was 122.40 MPa, while that of brain tissue was 4.31 kPa. When the temporal area was attacked, the maximum equivalent stress of skull was 71.53 MPa, while that of brain tissue was 7.09 kPa. Conclusion The characteristics and risks of skull fracture and brain tissue injury are different when different parts of the brain are hit by fist. When the frontal area is hit, the risk of skull fracture is significantly higher than when the temporal area is hit. The risk of brain tissue injury is the opposite. The position with the highest probability of skull fracture is generally the place where the skull is directly impacted, and with the conduction of stress waves, it will spread to other parts of the skull, while the position with the highest risk of brain tissue injury is not the place where the brain is directly impacted.

Moment tensor inversion theory is an effective method to study the rock failure mechanism. However, the inversion results are prone to large errors, which can mislead the understanding of fracture mechanism. In order to achieve a better understanding of the generation process and the mechanism of the rock macro-fracture surface, we perform a location analysis of source events based on the uniaxial compression test of a granite sample, with the help of ultrasonic testing and acoustic emission monitoring. The events near the macro-fracture with small location errors are selected for moment tensor inversion. Then, we use the network calibration method to calibrate the sensors so that more accurate moment tensors can be obtained. The results show that the source event locations are in good agreement with the locations of the specimen's macro-fracture. After the sensors having been calibrated, there are a few noticeable observations. The inversion root-mean-square (RMS) errors of moment tensors reduce significantly. The distributions of events on the T-k plot and P/T axis plot become more concentrated. The shear component and the proportion of different types of events change accordingly. The distributions of strike, dip and rake angles of the events become more concentrated, which are in general consistent with the macro-fracture of the specimen. The tensile angles of some events change from negative to positive. The above results reasonably explain the failure process and mechanism of the specimen and highlight the importance of sensor calibration for the moment tensor inversion, which can be a useful tool to provide guidance and reference for a deeper understanding of rock failure mechanism.

In China, Budd-Chiari syndrome has been transliterated into six names according to the pronunciation of the letters. To standardize and unify the Chinese names of the disease, multi-disciplinary experts suggest translating Budd-Chiari syndrome into hepatic vein inferior venal cava obstruction syndrome as its Chinese name after reaching a consensus through discussion.

Fat mass and obesity-associated (FTO) gene is an obesity susceptibility gene and its relationship with the nonalcoholic fatty liver disease (NAFLD) remains unclear. This study aims to investigate the relationships of FTO gene variations with NAFLD risk in a Chinese male population.

Along with the studies of the properties of optical microcavities, the optical nonlinear effects of the material and the interaction between light and matter are becoming important topics. For example, the chaotic effect of the optical field may appear under the strong laser pumping due to the nonlinear effects. In this study, the chaotic phenomenon of photonic superposed states is investigated in an optomagnonical cavity. Through the dynamic evolution of two-mode photons in the cavity, we found that the energy of the system could be transferred between different modes, and the chaotic behaviour can be tuned by the coupling and the dissipation.

Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) accelerated vascular diseases progression, like atherosclerosis and restenosis. MicroRNAs were reported to participate in modulating diverse cellular processes. Here, we focused on exploring the role of miR-638 in VSMCs glycolysis and underlying mechanism.

Based on the similarity simulation theory, a parallel-tunnel model test system was constructed that consists of a test bench design, a monitoring system design, a loading system design, and the construction of a rock mass model. The models were monitored in key positions of displacement, stress changes, and destruction of the tunnel walls. It is found that the experimental observation and numerical simulation results based on the Mohr-Coulomb model exhibit relatively large disparities. However, based on the Plastic-Hardening model, the yield states and variation laws of the rock and soil were obtained by numerical simulation and these results are in good agreement with the experimental results. If all aspects of research results is integrated, the Plastic-Hardening model accurately reflects real changes in the states of the rock and soil in actual engineering applications and tests and can provide an important reference for double parallel-tunnel construction and maintenance under similar geological conditions.

Objective To describe a novel workflow for the anterior dental esthetics in immediate implant and im⁃ mediate aesthetic restoration with digital technique. Methods Before the implant placement, a intra⁃oral optical scan (IOS) combined with CBCT was performed to virtually design the 3D implant position and restoration. A surgical guide and an individualized Ti abutment restoration was CAD/CAM⁃fabricated out of the PMMA⁃based in a fully digital work⁃ flow and seated at the stage of minimal invasive surgery. Results The technique achieved immediate implant and im⁃ mediate restoration after tooth extraction. Immediate restoration of temporary crown could be completed immediately in second patient visit after the operation, finally realized the aesthetic implantation with preserved soft tissue contour. Conclusion The fully digital technique changed the conventional workflow which achieves more efficiency and better aesthetic effect.

The performance of vehicle transmission system has great influence on fuel consumption of the vehicle. In order to reduce the resistance of transmission system and the fuel consumption,a research experimental about resistance for front engine front drive（ FF） transmission system is carried out on the four-drive and five-motor bench. The experimental results show,the resistance of the vehicle is positive correlated with gear level and engine speed. And the largest resistant part of vehicle transmission system is the gearbox. Then,the efficiency experiment is carried out on the lubricating oil that has influence on transmission system efficiency,and the gearbox efficiency under the condition of four different kinds of lubricating oil is compared,it is found that the optimized lubricating oil is 2#. Through the experiment,it is concluded that the comprehensive efficiency of this oil is increased by 0. 43% comparing to original oil.

To overcome the defects of the depth estimation of buried structures by the empirical method, a new method to estimate the depth based on the reflected waveform characteristics of buried targets was put forward by extracting few points from the reflected waveform. Accuracy analysis was performed in consideration of waveform distortion. The resuhs show that on ideal undistorted ground penetrating radar (GPR) data, the proposed method is accurate in estimating the depth and the horizontal position of buried targets, as well as the electromagnetic wave speed. An average error of 55.202% occurs in depth estimation based on distorted waveform data even though the estimation result of wave speed is accurate as before. So the method is corrected to confirm the depth of buried targets using the estimated wave speed and the two-way travel time of the reflected wave from the structures when facing distorted GPR data, and the accuracy of estimation satisfies the requirements of the GPR method. This method is more satisfactory and robust compared with the empirical method.

Combining the arm training practice after the Strong Army Reform, this paper put forwards using the F-ANP method for military training security risks to semi- quantitative evaluation, builds the safety risk assessment index system of military training, semi-quantitative calculation and analysis, and put forwards the opinions of the security risk prevention and control suggestions. This paper enriches the military training of security risk assessment methods, and provides the reference to the research of military training safety risk assessment.

Studies on the shape of an isolated extraction zone are the basis for investigating the flow laws of caved ore and rock and optimizing a stope's structural parameters. Based on the method of labeled markers, the shape of an isolated extraction zone and its changing law under both infinite and semi-infinite boundary conditions were analyzed, and the reliability and suitability of the ex-pectation body theory were validated through bottom and side drawing tests. On this basis, research on the rate of advance during ore breaking in side drawing was performed at the structural parameter of 18 m×20 m. The results show that the actual shape of the isola-ted extraction zone is not a standard ellipsoid, but more similar to the expectation body. Under both infinite and semi-infinite boundary conditions, the mass drawn has a power function relation with the height of the isolated extraction zone and has an exponential function relation with the radius of the isolated extraction zone. It is suggested that the non-dilution drawing mode and the 4.6-m rate of ad-vance during ore breaking should be preferentially used at the structural parameter of 18 m×20 m.

Tailing-cemented backfill is a cement-based heterogeneous composite whose uniaxial compressive strength (UCS) and ultrasonic pulse velocity (UPV) are dependent on cement dosage, solid content, sample type, etc. In this paper, uniaxial compressive test and ultrasonic pulse velocity test of three types of backfill samples (7.07 cm×7.07 cm×7.07 cm cube, Φ5 cm×10 cm cylinder and Φ7 cm×14 cm cylinder) were performed, and the effects of cement dosage, solid content and sample type on the backfill strength and ultrasonic pulse velocity were investigated by grey correlative degree analysis. The results show that cement dosage is the key to the backfill strength with a correlative degree of 0.837, while the ultrasonic pulse velocity is mostly influenced by solid content with a correlation degree of 0.712. An exponential prediction relation between UCS and UPV and a BP neural network prediction model were built, and they were validated by F-test and t-test of statistical analysis, respectively. The methods proposed can be new approaches for predicting the backfill strength.

Objective To evaluate the effects of decompression in treating large maxillary cystic lesions.Methods 25 cases of large maxillary cystic lesions were performed decompression during Oct. 2007-Oct. 2014. According to the clinical and radiological examination, morphology of maxillary sinus and cyst cavity were observed.Results 12 cases of radicular cysts, 10 cases of dentigerous cysts, and 3 cases of keratocystic odontogenic tumor were diagnosed according to pathological examination. The appearance of the maxillary sinus were completely restored and the cyst disappeared totally in 7 cases after the first 3 months, and then after the next 9-12 months, the other 18 cases had the appearance of maxillary sinus completely or basically restored with a following enucleation of cysts. All patients were followed up for 1-5 years, and no recurrence was observed. Conclusion To treat large maxillary cystic lesions by decompression is effective to conserve the morphology and function of maxillary sinus, and it is a simple surgical approach with less damage and complications.

The grain body creep of waste dumps including deceleration creep and constant creep was described by the Burgers model.Using the layered summation method,the vertical filling waste dump was sliced and the bottom part settled under the variable weight load of the overlaid part.The computational formulas of settlement in the waste dump filling dynamic process,post-construction settlement and cumulative settlement were derived from theoretical analysis though the steady and unsteady Burgers creep models.The monitoring data of Qidashan Iron Mine were used as a case of proofing.The results show that the correlation coefficients of fitting with both the unsteady and steady Burgers models are high,and the final settlement value of the former is 5.07 m,while the settlement curve of the latter is divergent,thus the unsteady Burgers model performs better in simulating the real working condition of mine subsidence.The waste dump was divided into ten layers and the settle rate of each layer was calculated by the creep simulation model in Flac3D.The post-construction settlement of the top layers is smaller than that of the middle layers and bottom layers,the settlement of the top layers decreases when getting closed to the upper surface of the waste dump.The settlement of the middle layers is larger than that of the bottom layers,and the fifth layer performs a largest settlement.

In order to analyze the form of the isolated extraction zone (IEZ) in side drawing and get optimal independent advance with large structural parameters, drawing models with the mesomechanical properties of ore granular media were constructed based on the particle flow theory and PFC3D code. The reliability of the drawing models was validated by comparative analysis between existing research conclusions and simulated results. On this basis, a study on independent advance of side drawing at different end wall angles in the structural parameters of 18 m×20 m was performed. The results show that the IEZ form is incomplete and is not a regular ellipsoid at different end wall angles. When the drawn mass is equal, the IEZ height increases with decreasing end wall angle and the IEZ form becomes more and more slender. The trend of the IEZ height at both the infinite boundary condition and the boundary condition of different end wall angles can be divided into two stages:in the first stage, the IEZ height rapidly increases in the exponential form at the initiation of side drawing and its growth rate decreases with the increasing of drawn mass, while in the second stage the IEZ height linearly increases with the increasing of drawn mass. It is suggested that the end wall angle of 85°-90° and the independent advance of 4. 8 m should be used in the structural parameters of 18 m×20 m.

The stress distribution characteristics of adjacent horizontal parallel tunnels are revealed by comprehensively utilizing the complex function theory, analytic continuation method and Schwarz alternating method. Then a mechanical model of adjacent horizontal parallel tunnels is constructed in combination with the D-P yield criterion which considers the effect of intermediate principal stress. The concept of connected radius of the tunnel plastic zone is proposed, the solving equation is established and its correctness is verified by numerical simulation. The critical distance of the plastic zone connected between tunnels is considered as a reasonable spacing, which has a better agreement with the spacing of tunnels when the displacement and settlement of surrounding rock do not basically change with the spacing of tunnels calculated by numerical simulation software FLAC3D, thus demonstrating its feasibility as the reasonable spacing of adjacent horizontal parallel tunnels.

Progressive cerebral infarctions increase mortality and functional disability through mechanisms which have yet to be completely understood. The goal of this study was to explore the dynamic changes of serum C-reactive protein (CRP), fibrinogen (FIB) and D-dimer (D-D) in order to better characterize progressive cerebral infarction.

A ubiquitous jointed rock mass(UJRM) model constructed by combining the FLAC3D software and discrete fracture network(DFN) technique,which takes the features of rock and joints into account,has a clear concept,high efficiency of modeling and calculation,and so on. Firstly,the in-situ survey results of joints were statistically analyzed to obtain their probability distribution parameters,on the basis of which the joints were considered in two scales and their DFN models were determined. Secondly,based on the determined DFN models,the jointed rock mass was modeled and the strength characteristics were researched to get the uniaxial compressive strength(UCS) of engineering rock mass,then the mechanical parameters of jointed rock mass were fitted and determined by the Hoek-Brown and Mohr-Coulomb criteria while considering the max confining stress. Finally,the determined parameters were applied to slope stability analysis,the safety factors of the two kinds of criterions solved by the limit equilibrium method(LEM) and the strength reduction method(SRM) are basically the same,indicating that using the proposed approach to determine the mechanical parameters of jointed rock mass is practicable.

The deformation and failure characteristics of total 270 consequent rock slopes under complicated working conditions are investigated by the discrete element method depending on two parameters,structural plane dip angle θ and slope angle α. Different θ and α ranges corresponding to different failure modes are obtained by the statistical method. Moreover,the relationship between the two parameters and the slope stability is attempted based on the shear strength reduction method. The failure mechanism and stability characteristics of consequent rock slopes are revealed. Four deformation and failure modes of consequent rock slopes are proposed according to different deformation and failure characteristics:toe-slip-failure along the structural plane,top-sliding-failure along the structural plane,lower edge uplift bending-shear failure,and upper edge fracturing-fold-bending-failure. Further general rules of the four modes are analyzed and summarized such as occurrences,deformation characteristics and possible failure modes. The safety factor fs of the slopes decreases and subsequently increases with the increase of θ,it reaches a minimum and then rises quickly to a high value and finally slowing down. During the changing process of θ,the safety factor fs will obtain a minimum when θ is approximately equal to α-7. 3°,which corresponds to the worst slope stability.