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1. Electronic processes in collisions between nitrogen ions and hydrogen atoms

Author: Jia, C. C., Qi, Y. Y., Niu, J. J., Wang, Y. Wu J. G., Dubois, A., Sisourat, N., and Gao, J. W.
Subjects: Physics - Atomic Physics
Abstract: In order to interpret and predict the behavior and properties of fusion plasma, accurate cross sections for electronic processes in collisions between plasma impurities and atomic hydrogen are required. In this work, we investigate the electron capture (or charge exchange), target excitation, and ionization processes occurring in collision of ${\rm N}^{4+}$ with atomic hydrogen in a broad energy domain ranging from 0.06 to 225 keV/u. We consider ${\rm N}^{4+}$ ground state ${\rm N}^{4+} (2s)$ and also ${\rm N}^{4+} (2p)$ since the impurities in the edge plasma environment may be excited due to collisions with electrons and ions/atoms. Total and partial cross sections in both spin-averaged and spin-resolved cases are calculated using a two-active-electron semiclassical asymptotic-state close-coupling approach. For electron capture cross sections the present results show the best overall agreement with available experimental data for both total and partial cross sections, and the origins of observed discrepancies are discussed. Furthermore, we provide new data for target excitation and ionization processes, which are essential to improve our understanding of this relevant collision system.
Published: 2024

2. First joint oscillation analysis of Super-Kamiokande atmospheric and T2K accelerator neutrino data

Author: Super-Kamiokande, collaborations, T2K, Abe, S., Abe, K., Akhlaq, N., Akutsu, R., Alarakia-Charles, H., Ali, A., Hakim, Y. I. Alj, Monsalve, S. Alonso, Amanai, S., Andreopoulos, C., Anthony, L. H. V., Antonova, M., Aoki, S., Apte, K. A., Arai, T., Arihara, T., Arimoto, S., Asada, Y., Asaka, R., Ashida, Y., Atkin, E. T., Babu, N., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Bates, P., Batkiewicz-Kwasniak, M., Beauchêne, A., Berardi, V., Berns, L., Bhadra, S., Bhuiyan, N., Bian, J., Blanchet, A., Blondel, A., Bodur, B., Bolognesi, S., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bubak, A., Avanzini, M. Buizza, Burton, G. T., Caballero, J. A., Calabria, N. F., Cao, S., Carabadjac, D., Carter, A. J., Cartwright, S. L., Casado, M. P., Catanesi, M. G., Cervera, A., Chakrani, J., Chalumeau, A., Chen, S., Cherdack, D., Choi, K., Chong, P. S., Chvirova, A., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cormier, F., Cudd, A., Dalmazzone, C., Daret, T., Dasgupta, P., Davis, C., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Dharmapal, R., Di Lodovico, F., Lopez, G. Diaz, Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Duffy, K. E., Dumarchez, J., Dunne, P., Dygnarowicz, K., D'ago, D., Edwards, R., Eguchi, A., Elias, J., Emery-Schrenk, S., Erofeev, G., Ershova, A., Eurin, G., Fannon, J. E. P., Fedorova, D., Fedotov, S., Feltre, M., Feng, J., Feng, L., Ferlewicz, D., Fernandez, P., Finch, A. J., Aguirre, G. A. Fiorentini, Fiorillo, G., Fitton, M. D., Patiño, J. M. Franco, Friend, M., Fujii, Y., Fujisawa, C., Fujita, S., Fukuda, Y., Furui, Y., Gao, J., Gaur, R., Giampaolo, A., Giannessi, L., Giganti, C., Glagolev, V., Goldsack, A., Gonin, M., Rosa, J. González, Goodman, E. A. G., Gorin, A., Gorshanov, K., Gousy-Leblanc, V., Grassi, M., Griskevich, N. J., Guigue, M., Hadley, D., Haigh, J. T., Han, S., Harada, M., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hayato, Y., Heitkamp, I., Henaff, D., Hill, J., Hino, Y., Hiraide, K., Hogan, M., Holeczek, J., Holin, A., Holvey, T., Van, N. T. Hong, Honjo, T., Horiuchi, S., Hosokawa, K., Hu, Z., Hu, J., Iacob, F., Ichikawa, A. K., Ieki, K., Ikeda, M., Iovine, N., Ishida, T., Ishino, H., Ishitsuka, M., Ishizuka, T., Ito, H., Itow, Y., Izmaylov, A., Izumiyama, S., Jakkapu, M., Jamieson, B., Jang, M. C., Jang, J. S., Jenkins, S. J., Jesús-Valls, C., Ji, J. Y., Jia, M., Jiang, J., Jonsson, P., Joshi, S., Jung, C. K., Jung, S., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kanemura, Y., Kaneshima, R., Karpova, S., Kasetti, S. P., Kashiwagi, Y., Kasturi, V. S., Kataoka, Y., Katori, T., Kawamura, Y., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kim, S. B., King, S., Kiseeva, V., Kisiel, J., Kneale, L., Kobayashi, H., Kobayashi, T., Kobayashi, M., Koch, L., Kodama, S., Kolupanova, M., Konaka, A., Kormos, L. L., Koshio, Y., Koto, T., Kowalik, K., Kudenko, Y., Kudo, Y., Kuribayashi, S., Kurjata, R., Kurochka, V., Kutter, T., Kuze, M., Kwon, E., La Commara, M., Labarga, L., Lachat, M., Lachner, K., Lagoda, J., Lakshmi, S. M., LamersJames, M., Langella, A., Laporte, J. -F., Last, D., Latham, N., Laveder, M., Lavitola, L., Lawe, M., Learned, J. G., Lee, Y., Lee, S. H., Silverio, D. Leon, Levorato, S., Lewis, S., Li, X., Li, W., Lin, C., Litchfield, R. P., Liu, S. L., Liu, Y. M., Long, K. R., Longhin, A., Moreno, A. Lopez, Lu, X., Ludovici, L., Lux, T., Machado, L. N., Maekawa, Y., Magaletti, L., Mahn, K., Mahtani, K. K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Martens, K., Marti, Ll., Martin, D. G. R., Martin, J. F., Martin, D., Martini, M., Maruyama, T., Matsubara, T., Matsumoto, R., Mattiazzi, M., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., McCauley, N., McElwee, J. M., McFarland, K. S., McGrew, C., McKean, J., Mefodiev, A., Megias, G. D., Mehta, P., Mellet, L., Menjo, H., Metelko, C., Mezzetto, M., Migenda, J., Mijakowski, P., Miki, S., Miller, E., Minamino, A., Mine, S., Mineev, O., Mirabito, J., Miura, M., Bueno, L. Molina, Moon, D. H., Mori, M., Moriyama, S., Morrison, P., Muñoz, A., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, Y., Nagai, K., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, K., Nakamura, K. D., Nakamura, T., Nakanishi, F., Nakano, Y., Nakaya, T., Nakayama, S., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Nguyen, D. T., Nicholson, M., Niewczas, K., Ninomiya, K., Nishijima, K., Nishimori, S., Nishimura, Y., Noguchi, Y., Nosek, T., Nova, F., Novella, P., Nugent, J. C., Odagawa, T., Okazaki, R., Okazawa, H., Okinaga, W., Okumura, K., Okusawa, T., Ommura, Y., Onda, N., Ospina, N., Osu, L., Oyama, Y., O'Flaherty, M., O'Keeffe, H. M., O'Sullivan, L., Périssé, L., Paganini, P., Palladino, V., Paolone, V., Pari, M., Park, R. G., Parlone, J., Pasternak, J., Payne, D., Penn, G. C., de Perio, P., Pershey, D., Pfaff, M., Pickering, L., Pintaudi, G., Pistillo, C., Pointon, B. W., Popov, B., Yrey, A. Portocarrero, Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Prasad, H., Pronost, G., Prouse, N. W., Pupilli, F., Quilain, B., Quyen, P. T., Raaf, J. L., Radermacher, T., Radicioni, E., Radics, B., Ramirez, M. A., Ramsden, R. M., Ratoff, P. N., Reh, M., Riccio, C., Richards, B., Rogly, R., Rondio, E., Roth, S., Roy, N., Rubbia, A., Russo, L., Rychter, A., Saenz, W., Sakai, S., Sakashita, K., Samani, S., Santos, A. D., Sato, Y., Sato, K., Schefke, T., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Seo, J. W., Sgalaberna, D., Shaikhiev, A., Shi, W., Shiba, H., Shibayama, R., Shigeta, N., Shima, S., Shimamura, R., Shimizu, K., Shinoki, M., Shiozawa, M., Shiraishi, Y., Shvartsman, A., Skrobova, N., Skwarczynski, K., Smy, M. B., Smyczek, D., Sobczyk, J. T., Sobel, H. W., Soler, F. J. P., Sonoda, Y., Speers, A. J., Spina, R., Stroke, Y., Suslov, I. A., Suvorov, S., Suzuki, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sánchez, F., Tada, T., Tada, M., Tairafune, S., Takagi, Y., Takeda, A., Takemoto, Y., Takeuchi, Y., Takhistov, V., Takifuji, K., Tanaka, H., Tanaka, H. K., Tanigawa, H., Taniuchi, N., Tano, T., Tarrant, A., Tashiro, T., Teklu, A., Terada, K., Tereshchenko, V. V., Thamm, N., Thiesse, M. D., Thompson, L. F., Toki, W., Tomiya, T., Touramanis, C., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M. R., Vargas, D., Varghese, M., Vasseur, G., Villa, E., Vinning, W. G. S., Virginet, U., Vladisavljevic, T., Wachala, T., Wakabayashi, D., Wallace, H. T., Walsh, J. G., Walter, C. W., Wan, L., Wang, X., Wang, Y., Wark, D., Wascko, M. O., Watanabe, E., Weber, A., Wendell, R. A., Wester, T., Wilking, M. J., Wilkinson, C., Wilson, S. T., Wilson, J. R., Wood, K., Wret, C., Wu, Y., Xia, J., Xie, Z., Xu, B. D., Xu, Y. -H., Yamamoto, K., Yamamoto, T., Yamauchi, K., Yanagisawa, C., Yang, G., Yang, B. S., Yang, J. Y., Yankelevich, A., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoo, J., Yoshida, T., Yoshida, S., Yoshimoto, Y., Yoshimura, N., Yoshioka, Y., Yu, M., Yu, I., Zaki, R., Zaldivar, B., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhang, J., Zhang, A. Q., Zhang, B., Zhao, X. Y., Zhong, H., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zsoldos, S.
Subjects: High Energy Physics - Experiment
Abstract: The Super-Kamiokande and T2K collaborations present a joint measurement of neutrino oscillation parameters from their atmospheric and beam neutrino data. It uses a common interaction model for events overlapping in neutrino energy and correlated detector systematic uncertainties between the two datasets, which are found to be compatible. Using 3244.4 days of atmospheric data and a beam exposure of $19.7(16.3) \times 10^{20}$ protons on target in (anti)neutrino mode, the analysis finds a 1.9$\sigma$ exclusion of CP-conservation (defined as $J_{CP}=0$) and a preference for the normal mass ordering., Comment: 10 pages, 3 figures
Published: 2024

3. Development of a data overflow protection system for Super-Kamiokande to maximize data from nearby supernovae

Author: Mori, M., Abe, K., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Okamoto, K., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Megias, G. D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., Machado, L. N., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Edwards, R., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Kotsar, Y., Ozaki, H., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Bronner, C., Feng, J., Hu, J. R., Hu, Z., Kawaune, M., Kikawa, T., LiCheng, F., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Wilking, M. J., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Kitagawa, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Martens, K., Tsui, K. M., Vagins, M. R., Valls, C. J., Xia, J., Kuze, M., Izumiyama, S., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Yoshida, T., Martin, J. F., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Prouse, N. W., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Hadley, D., Nicholson, M., Flaherty, M. O', Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Suzuki, S., and Wada, K.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics, High Energy Physics - Experiment
Abstract: Neutrinos from very nearby supernovae, such as Betelgeuse, are expected to generate more than ten million events over 10\,s in Super-Kamokande (SK). At such large event rates, the buffers of the SK analog-to-digital conversion board (QBEE) will overflow, causing random loss of data that is critical for understanding the dynamics of the supernova explosion mechanism. In order to solve this problem, two new DAQ modules were developed to aid in the observation of very nearby supernovae. The first of these, the SN module, is designed to save only the number of hit PMTs during a supernova burst and the second, the Veto module, prescales the high rate neutrino events to prevent the QBEE from overflowing based on information from the SN module. In the event of a very nearby supernova, these modules allow SK to reconstruct the time evolution of the neutrino event rate from beginning to end using both QBEE and SN module data. This paper presents the development and testing of these modules together with an analysis of supernova-like data generated with a flashing laser diode. We demonstrate that the Veto module successfully prevents DAQ overflows for Betelgeuse-like supernovae as well as the long-term stability of the new modules. During normal running the Veto module is found to issue DAQ vetos a few times per month resulting in a total dead time less than 1\,ms, and does not influence ordinary operations. Additionally, using simulation data we find that supernovae closer than 800~pc will trigger Veto module resulting in a prescaling of the observed neutrino data., Comment: 28 pages, 18 figures. Submitted to PTEP
Published: 2024
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4. Isobaric vapor-liquid equilibria of ternary lead-tin-antimony alloy system at 2 Pa

Author: Xu J., Gao J., Kong L., Xu B., Yang B., and Liu D.
Subjects: pb-sn-sballoy, activity, vle, wilson equation, thermodynamic consistency test, Mining engineering. Metallurgy, TN1-997
Abstract: In this study, the experimental vapor–liquid equilibria data of the ternary Pb–Sn–Sb alloy system are determined using a new experimental method. The experimental VLE data passed the thermodynamic consistency test (Van Ness test), suggesting that the experimental results are reliable. The activities of the components of Pb–Sn–Sb ternary alloy and those of the corresponding three constituent binaries were calculated using the Wilson equation. The predicted values are in good agreement with the data determined from the experiments, and the average relative deviation and average standard deviation were smaller than ± 4.00% and ± 0.03 for all constituent binaries, respectively, which indicates that the Wilson equation is reliable for calculating the activity of the components of the Pb–Sn–Sb ternary alloy. The VLE data of the Pb– Sn and Sb–Sn binary alloys and Pb–Sn–Sb ternary alloy were calculated based on the VLE theory and the Wilson equation. The calculated VLE data were in good agreement with the data determined from the experiments, indicating that this method is reliable for calculating the VLE of alloy systems. The proposed study offers a valid method for analyzing the composition of products that are dependent on the distillation temperature and system pressure during vacuum distillation, which is of great significance to the experimental design of this process.
Published: 2020
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5. Antecedent cancer in Takotsubo syndrome predicts both cardiovascular and long-term mortality

Author: Thanh H. Nguyen, Jeanette Stansborough, Gao J. Ong, Sven Surikow, Timothy J. Price, and John D. Horowitz
Subjects: Takotsubo syndrome, Antecedent cancer, Cardiovascular mortality, Diseases of the circulatory (Cardiovascular) system, RC666-701, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Takotsubo syndrome (TTS), primarily an acute myocardial inflammatory condition engendered by catecholamine exposure, is associated with similar long-term mortality rates to those of patients with acute myocardial infarction. However, there is increasing evidence of a nexus between TTS and underlying malignancies:- many patients have antecedent cancer (A/Ca), while incremental risk of late cancer-related death has also been reported. Purpose To evaluate potential interactions between A/Ca among TTS patients and both early and late clinical course. Methods Three hundred forty-six consecutive TTS patients [aged 69 ± 13 (SD) years, males: 8.2%] were prospectively followed up for a median duration of 4.1 (IQR 2.2–6.4) years. Associations between A/Ca and severity of acute attacks, in-hospital complications and long-term death rates were sought utilising univariate analyses followed by multiple logistic regression analysis. Results A/Ca (present in 16.8% of patients) was associated with (i) greater elevation of hs-CRP and NT-proBNP concentrations (p = 0.01 and 0.04, respectively), (ii) more complicated in-hospital clinical course, with major adverse cardiac events (MACE) in 30.9% of patients, compared to 18.2% in non-A/Ca patients (p = 0.04). Long-term all-cause mortality rate was also greater [hazard ratio (HR) = 2.4, p = 0.0001] in A/Ca patients, with an excess cardiovascular (CVS) fatality rate (HR = 3.1, p = 0.001). On multivariate analysis, male gender, peak plasma concentrations of normetanephrine and hs-CRP, early arrhythmias and development of shock, but not A/Ca per se, were all independently associated with increased long-term mortality rate. Furthermore, patients discharged on β-adrenoceptor antagonists (βBl) or angiotensin converting enzyme inhibitors/ angiotensin receptor blockers (ACEi/ARB) had lower long-term mortality rates (β = − 0.2, p = 0.01; β = − 0.14, p = 0.05, respectively). Conclusions (1) A/Ca is associated with greater clinical severity of initial TTS attacks and substantially greater long-term CVS-related as well as all-cause mortality. (2) Post-discharge therapy with either βBl or ACEi/ARB is associated with reductions in long-term mortality rates. Overall, the current data suggest operation of substantial interactions between neoplasia and TTS, both at the level of pathogenesis and of outcomes.
Published: 2019
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6. Kinetic inductance traveling wave amplifier designs for practical microwave readout applications

Author: Giachero, A., Visser, M., Wheeler, J., Howe, L., Gao, J., Austermann, J., Hubmayr, J., Nucciotti, A., and Ullom, J.
Subjects: Quantum Physics, Condensed Matter - Superconductivity
Abstract: A Kinetic Inductance Traveling Wave amplifier (KIT) utilizes the nonlinear kinetic inductance of superconducting films, particularly Niobium Titanium Nitride (NbTiN), for parametric amplification. These amplifiers achieve remarkable performance in terms of gain, bandwidth, compression power, and frequently approach the quantum limit for noise. However, most KIT demonstrations have been isolated from practical device readout systems. Using a KIT as the first amplifier in the readout chain of an unoptimized microwave SQUID multiplexer coupled to a transition-edge sensor microcalorimeter we see an initial improvement in the flux noise. One challenge in KIT integration is the considerable microwave pump power required to drive the non-linearity. To address this, we have initiated efforts to reduce the pump power by using thinner NbTiN films and an inverted microstrip transmission line design. In this article, we present the new transmission line design, fabrication procedure, and initial device characterization -- including gain and added noise. These devices exhibit over 10 dB of gain with a 3 dB bandwidth of approximately 5.5-7.25 GHz, a maximum practical gain of 12 dB and typical gain ripple under 4 dB peak-to-peak. We observe an appreciable impedance mismatch in the NbTiN transmission line, which is likely the source of the majority of the gain ripple. Finally we perform an initial noise characterization and demonstrate system-added noise of three quanta or less over nearly the entire 3 dB bandwidth.
Published: 2024

7. Measurements of the charge ratio and polarization of cosmic-ray muons with the Super-Kamiokande detector

Author: Kitagawa, H., Tada, T., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Okamoto, K., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Megias, G. D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchêne, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Calabria, N. F., Catanesi, M. G., Radicioni, E., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Périssé, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Kotsar, Y., Ozaki, H., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Jesús-Valls, C., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Terada, K., Ishitsuka, M., Ito, H., Kinoshita, T., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Yoshida, T., Martin, J. F., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Suzuki, S., and Wada, K.
Subjects: High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present the results of the charge ratio ($R$) and polarization ($P^{\mu}_{0}$) measurements using the decay electron events collected from 2008 September to 2022 June by the Super-Kamiokande detector. Because of its underground location and long operation, we performed high precision measurements by accumulating cosmic-ray muons. We measured the muon charge ratio to be $R=1.32 \pm 0.02$ $(\mathrm{stat.}{+}\mathrm{syst.})$ at $E_{\mu}\cos \theta_{\mathrm{Zenith}}=0.7^{+0.3}_{-0.2}$ $\mathrm{TeV}$, where $E_{\mu}$ is the muon energy and $\theta_{\mathrm{Zenith}}$ is the zenith angle of incoming cosmic-ray muons. This result is consistent with the Honda flux model while this suggests a tension with the $\pi K$ model of $1.9\sigma$. We also measured the muon polarization at the production location to be $P^{\mu}_{0}=0.52 \pm 0.02$ $(\mathrm{stat.}{+}\mathrm{syst.})$ at the muon momentum of $0.9^{+0.6}_{-0.1}$ $\mathrm{TeV}/c$ at the surface of the mountain; this also suggests a tension with the Honda flux model of $1.5\sigma$. This is the most precise measurement ever to experimentally determine the cosmic-ray muon polarization near $1~\mathrm{TeV}/c$. These measurement results are useful to improve the atmospheric neutrino simulations., Comment: 29 pages, 45 figures
Published: 2024

8. Second gadolinium loading to Super-Kamiokande

Author: Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Uchida, Y., Berardi, V., Calabria, N. F., Catanesi, M. G., Radicioni, E., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Shi, W., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Jesus-Valls, C., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Terada, K., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., Suzuki, S., Scovell, P. R., Meehan, E., Bandac, I., Pena-Garay, C., Perez, J., Gileva, O., Lee, E. K., Leonard, D. S., Sakakieda, Y., Sakaguchi, A., Sueki, K., Takaku, Y., and Yamasaki, S.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The first loading of gadolinium (Gd) into Super-Kamiokande in 2020 was successful, and the neutron capture efficiency on Gd reached 50\%. To further increase the Gd neutron capture efficiency to 75\%, 26.1 tons of $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ was additionally loaded into Super-Kamiokande (SK) from May 31 to July 4, 2022. As the amount of loaded $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ was doubled compared to the first loading, the capacity of the powder dissolving system was doubled. We also developed new batches of gadolinium sulfate with even further reduced radioactive impurities. In addition, a more efficient screening method was devised and implemented to evaluate these new batches of $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$. Following the second loading, the Gd concentration in SK was measured to be $333.5\pm2.5$ ppm via an Atomic Absorption Spectrometer (AAS). From the mean neutron capture time constant of neutrons from an Am/Be calibration source, the Gd concentration was independently measured to be 332.7 $\pm$ 6.8(sys.) $\pm$ 1.1(stat.) ppm, consistent with the AAS result. Furthermore, during the loading the Gd concentration was monitored continually using the capture time constant of each spallation neutron produced by cosmic-ray muons,and the final neutron capture efficiency was shown to become 1.5 times higher than that of the first loaded phase, as expected., Comment: 34 pages, 13 figures, submitted to Nuclear Inst. and Methods in Physics Research, A
Published: 2024
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9. Performance of SK-Gd's Upgraded Real-time Supernova Monitoring System

Author: Kashiwagi, Y., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointn, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchêne, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Périssé, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarrant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Wilking, M. J., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Jesús-Valls, C., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Kuze, M., Izumiyama, S., Matsumoto, R., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., and Suzuki, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Among multi-messenger observations of the next galactic core-collapse supernova, Super-Kamiokande (SK) plays a critical role in detecting the emitted supernova neutrinos, determining the direction to the supernova (SN), and notifying the astronomical community of these observations in advance of the optical signal. On 2022, SK has increased the gadolinium dissolved in its water target (SK-Gd) and has achieved a Gd concentration of 0.033%, resulting in enhanced neutron detection capability, which in turn enables more accurate determination of the supernova direction. Accordingly, SK-Gd's real-time supernova monitoring system (Abe te al. 2016b) has been upgraded. SK_SN Notice, a warning system that works together with this monitoring system, was released on December 13, 2021, and is available through GCN Notices (Barthelmy et al. 2000). When the monitoring system detects an SN-like burst of events, SK_SN Notice will automatically distribute an alarm with the reconstructed direction to the supernova candidate within a few minutes. In this paper, we present a systematic study of SK-Gd's response to a simulated galactic SN. Assuming a supernova situated at 10 kpc, neutrino fluxes from six supernova models are used to characterize SK-Gd's pointing accuracy using the same tools as the online monitoring system. The pointing accuracy is found to vary from 3-7$^\circ$ depending on the models. However, if the supernova is closer than 10 kpc, SK_SN Notice can issue an alarm with three-degree accuracy, which will benefit follow-up observations by optical telescopes with large fields of view., Comment: 38 pages, 29 figures, 6 tables
Published: 2024

10. Developments on frequency domain multiplexing readout for large arrays of transition-edge sensor X-ray micro-calorimeters

Author: Vaccaro, D., Akamatsu, H., Gottardi, L., de Wit, M., Bruijn, M. P., van der Kuur, J., Nagayoshi, K., Taralli, E., Ravensberg, K., Gao, J. R., and Herder, J. W. A. den
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: At SRON we have been developing X-ray TES micro-calorimeters as backup technology for the X-ray Integral Field Unit (X-IFU) of the Athena mission, demonstrating excellent resolving powers both under DC and AC bias. We also developed a frequency-domain multiplexing (FDM) readout technology, where each TES is coupled to a superconducting band-pass LC resonator and AC biased at MHz frequencies through a common readout line. The TES signals are summed at the input of a superconducting quantum interference device (SQUID), which performs a first amplification at cryogenic stage. Custom analog front-end electronics and digital boards take care of further amplifying the signals at room temperature and of the modulation/demodulation of the TES signals and bias carrier, respectively. We report on the most recent developments on our FDM technology, which involves a two-channel demonstration with a total of 70 pixels with a summed energy resolution of 2.34 +/- 0.02 eV at 5.9 keV without spectral performance degradation with respect to single-channel operation. Moreover, we discuss prospects towards the scaling-up to a larger multiplexing factor up to 78 pixels per channel in a 1-6 MHz readout bandwidth., Comment: Under publication in Journal of Low Temperature Physics
Published: 2024

11. System performance of a TDM test-bed with long flex harness towards the new X-IFU FPA-DM

Author: Vaccaro, D., de Wit, M., van der Kuur, J., Gottardi, L., Ravensberg, K., Taralli, E., Adams, J., Bandler, S. R., Chervenak, J. A., Doriese, W. B., Durkin, M., Reintsema, C., Sakai, K., Smith, S. J., Wakeham, N. A., Jackson, B., Khosropanah, P., Gao, J. R., Herder, J. W. A. den, and Roelfsema, P.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: SRON (Netherlands Institute for Space Research) is developing the Focal Plane Assembly (FPA) for Athena X-IFU, whose Demonstration Model (DM) will use for the first time a time domain multiplexing (TDM)-based readout system for the on-board transition-edge sensors (TES). We report on the characterization activities on a TDM setup provided by NASA Goddard Space Flight Center (GSFC) and National Institute for Standards and Technology (NIST) and tested in SRON cryogenic test facilities. The goal of these activities is to study the impact of the longer harness, closer to X-IFU specs, in a different EMI environment and switching from a single-ended to a differential readout scheme. In this contribution we describe the advancement in the debugging of the system in the SRON cryostat, which led to the demonstration of the nominal spectral performance of 2.8 eV at 5.9~keV with 16-row multiplexing, as well as an outlook for the future endeavours for the TDM readout integration on X-IFU's FPA-DM at SRON., Comment: Under publication in Journal of Low Temperature Physics
Published: 2024

12. Characterization of NbTiN films with thicknesses below 20 nm for low power kinetic inductance amplifiers

Author: Giachero, A., Vissers, M. R., Wheeler, J. D., Malnou, M., Austermann, J. E., Hubmayr, J., Nucciotti, A., Ullom, J. N., and Gao, J.
Subjects: Condensed Matter - Superconductivity
Abstract: A quantum-limited amplification chain is a fundamental advantage for any application that may benefit from the detection of very faint signals. Reading out arrays of superconducting detectors (TESs or MKIDs), resonant cavities, or qubits, calls for large bandwidth amplifiers in addition to having the lowest possible noise. At millikelvin temperatures, Kinetic Inductance Traveling-Wave Parametric Amplifiers (KI-TWPAs) working in 3-wave-mixing (3WM) and fabricated from a 20 nm thick NbTiN film have shown promising noise performances, as they can operate close to the quantum limit. However, they still require fairly high pump power. Devices that would require lower pump power would be easier to implement in readout chains, could reach the quantum limit and they would be compatible with qubit readout. A possible solution for obtaining this optimal configuration is to use a thinner superconducting film. In this work we explore the properties of NbTiN films with a thickness less than 20 nm and we report the obtained experimental characterizations in terms of critical temperature, normal resistivity, and kinetic inductance. A new design for a 3WM KI-TWPA amplifier, based on these developed superconducting films, is introduced and discussed.
Published: 2024
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13. Adaptation of the RUSLE2 Model to Assess Soil Losses Due To Water Erosion in the Northern Part of the Great Chinese Plain (Using the Example of Beijing)

Author: Li, X., Gao, J., and Kriuchkov, N. R.
Published: 2024
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14. Effects of different mesh materials on complications after prophylactic placement for stoma formation: a systematic review and network meta-analysis

Author: Meng, C., Wei, Q., Sun, L., Zhang, X., Liu, Y., Gao, J., Wei, P., Yang, Z., Yao, H., and Zhang, Z.
Published: 2024
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15. Comparison of His–Purkinje Conduction System Pacing with Atrial–Ventricular Node Ablation and Pharmacotherapy in HFpEF Patients with Recurrent Persistent Atrial Fibrillation (HPP-AF study)

Author: Zhang, J. F., Pan, Y. W., Li, J., Kong, X. G., Wang, M., Xue, Z. M., Gao, J., and Fu, G. S.
Published: 2024
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16. Isobaric (vapour + liquid) equilibria of binary Pb-Sn and Sb-Sn system AT2Pa

Author: Gao J., Xu J., Yang B., Kong L., Xu B., and You Y.
Subjects: new experimental method, VLE, Pb-Sn, Sb-Sn alloys, MIVM, thermodynamic consistency test, Mining engineering. Metallurgy, TN1-997
Abstract: A new experimental method for determining vapor-liquid equilibrium (VLE) of binary alloys was designed in this study. The VLE data of Pb-Sn and Sb-Sn alloys were determined by using this new method. The experimental data passed the thermodynamic consistency test (Van Ness test), and the y(MAD) was 0.4066 and 0.6667, respectively, indicating that the experimental method is correct and reliable. The activity coefficient of Pb-Sn and Sb-Sn alloys was calculated by using the molecular interaction volume model (MIVM). The maximum average relative deviation Si and maximum average standard deviation Si* are ±1.34% and ±0.009, respectively, which indicates that the calculation of the activity coefficient of the Pb- Sn and Sb-Sn alloys by MIVM is reliable. The VLE data of Pb-Sn and Sb-Sn alloys were calculated based on the VLE theory and MIVM, and the calculated results agreed well with the experimental VLE data. The VLE phase diagrams of Pb-Sn and Sb-Sn alloys were also established in this study. The VLE phase diagrams offer a valid and intuitive way to analyze the product compositions’ dependence of temperature and pressure during the process of vacuum distillation. This will have immense significance in guiding the actual production of vacuum metallurgy.
Published: 2018
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17. Solar neutrino measurements using the full data period of Super-Kamiokande-IV

Author: Collaboration, Super-Kamiokande, Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Imaizumi, S., Iyogi, K., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Kato, Y., Kishimoto, Y., Miki, S., Mine, S., Miura, M., Mochizuki, T., Moriyama, S., Nagao, Y., Nakahata, M., Nakano, Y., Nakayama, S., Noguchi, Y., Okada, T., Okamoto, K., Orii, A., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, R., Wang, X., Yoshida, S., Bravo-Berguno, D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Blaszczyk, F. d. M., Kachulis, C., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Weatherly, P., Yankelevich, A., Ganezer, K. S., Hill, J., Jang, M. C., Kim, J. Y., Lee, S., Lim, I. T., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Bernard, L., Coffani, A., Drapier, O., Hedri, S. El, Giampaolo, A., Imber, J., Mueller, Th. A., Paganini, P., Rogly, R., Quilain, B., Santos, A., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Matsuno, S., Iovine, N., Choi, K., Cao, S., Anthony, L. H. V., Litchfield, R. P., Prouse, N., Marin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Intonti, R. A., Radicioni, E., Calabria, N. F., De Rosa, G., Langella, A., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Friend, M., Hasegawa, T., Ishida, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Bhuiyan, N., Burton, G. T., Gao, J., Goldsack, A., Katori, T., Di Lodovico, F., Migenda, J., Sedgwick, S. Molina, Ramsden, R. M., Taani, M., Xie, Z., Zsoldos, S., Abe, KE., Hasegawa, M., Isobe, Y., Kotsar, Y., Miyabe, H., Ozaki, H., Shiozawa, T., Sugimoto, T., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Yamamoto, S., Zhong, H., Ashida, Y., Feng, J., Feng, L., Hayashino, T., Hirota, S., Hu, J. R., Hu, Z., Jiang, M., Kawaue, M., Kikawa, T., Mori, M., Nakamura, KE., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Pritchard, A., Tarrant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Murase, M., Ninomiya, K., Niwa, T., Tsukada, M., Yoshioka, Y., Frankiewicz, K., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jiang, J., Jia, M., Jung, C. K., Palomino, J. L., Santucci, G., Shi, W., Vilela, C., Yanagisawa, C., Fukuda, D., Hagiwara, K., Harada, M., Hino, Y., Horai, T., Ishino, H., Ito, S., Kitagawa, H., Koshio, Y., Ma, W., Nakanishi, F., Piplani, N., Sakai, S., Sakuda, M., Tada, T., Tano, T., Xu, C., Yamaguchi, R., Ishizuka, T., Kuno, Y., Barr, G., Barrow, D., Cook, L., Samani, S., Simpson, C., Wark, D., Holin, A. M., Nova, F., Jung, S., Yang, B., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Choi, Y., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Tairahune, S., Nishijima, K., Eguchi, A., Iwamoto, K., Nakagiri, K., Nakajima, Y., Ogawa, N., Shima, S., Watanabe, E., Yokoyama, M., Calland, R. G., Fujita, S., Jesus-Valls, C., Junjie, X., Ming, T. K., de Perio, P., Martens, K., Murdoch, M., Vagins, M. R., Izumiyama, S., Kuze, M., Matsumoto, R., Okajima, Y., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Ohta, K., Ommura, Y., Shinoki, M., Shigeta, N., Suganuma, T., Yamaguchi, K., Martin, J. F., Nantais, C. M., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Berkman, S., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Walker, J., Amanai, S., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Sasaki, R., Suzuki, S., and Wada, K.
Subjects: High Energy Physics - Experiment
Abstract: An analysis of solar neutrino data from the fourth phase of Super-Kamiokande~(SK-IV) from October 2008 to May 2018 is performed and the results are presented. The observation time of the data set of SK-IV corresponds to $2970$~days and the total live time for all four phases is $5805$~days. For more precise solar neutrino measurements, several improvements are applied in this analysis: lowering the data acquisition threshold in May 2015, further reduction of the spallation background using neutron clustering events, precise energy reconstruction considering the time variation of the PMT gain. The observed number of solar neutrino events in $3.49$--$19.49$ MeV electron kinetic energy region during SK-IV is $65,443^{+390}_{-388}\,(\mathrm{stat.})\pm 925\,(\mathrm{syst.})$ events. Corresponding $\mathrm{^{8}B}$ solar neutrino flux is $(2.314 \pm 0.014\, \rm{(stat.)} \pm 0.040 \, \rm{(syst.)}) \times 10^{6}~\mathrm{cm^{-2}\,s^{-1}}$, assuming a pure electron-neutrino flavor component without neutrino oscillations. The flux combined with all SK phases up to SK-IV is $(2.336 \pm 0.011\, \rm{(stat.)} \pm 0.043 \, \rm{(syst.)}) \times 10^{6}~\mathrm{cm^{-2}\,s^{-1}}$. Based on the neutrino oscillation analysis from all solar experiments, including the SK $5805$~days data set, the best-fit neutrino oscillation parameters are $\rm{sin^{2} \theta_{12,\,solar}} = 0.306 \pm 0.013 $ and $\Delta m^{2}_{21,\,\mathrm{solar}} = (6.10^{+ 0.95}_{-0.81}) \times 10^{-5}~\rm{eV}^{2}$, with a deviation of about 1.5$\sigma$ from the $\Delta m^{2}_{21}$ parameter obtained by KamLAND. The best-fit neutrino oscillation parameters obtained from all solar experiments and KamLAND are $\sin^{2} \theta_{12,\,\mathrm{global}} = 0.307 \pm 0.012 $ and $\Delta m^{2}_{21,\,\mathrm{global}} = (7.50^{+ 0.19}_{-0.18}) \times 10^{-5}~\rm{eV}^{2}$., Comment: 47 pages, 61 figures
Published: 2023
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18. Validation of the $^{10}\mathrm{Be}$ Ground-State Molecular Structure Using $^{10}\mathrm{Be}(p,p\alpha)^{6}\mathrm{He}$ Triple Differential Reaction Cross-Section Measurements

Author: Li, P. J., Beaumel, D., Lee, J., Assié, M., Chen, S., Franchoo, S., Gibelin, J., Hammache, F., Harada, T., Kanada-En'yo, Y., Kubota, Y., Leblond, S., Liang, P. F., Lokotko, T., Lyu, M., Marqués, F. M., Matsuda, Y., Ogata, K., Otsu, H., Rindel, E., Stuhl, L., Suzuki, D., Togano, Y., Tomai, T., Xu, X. X., Yoshida, K., Zenihiro, J., Achouri, N. L., Aumann, T., Baba, H., Cardella, G., Ceruti, S., Stefanescu, A. I., Corsi, A., Frotscher, A., Gao, J., Gillibert, A., Inaba, K., Isobe, T., Kawabata, T., Kitamura, N., Kobayashi, T., Kondo, Y., Kurihara, A., Liu, H. N., Miki, H., Nakamura, T., Obertelli, A., Orr, N. A., Panin, V., Sasano, M., Shimada, T., Sun, Y. L., Tanaka, J., Trache, L., Tudor, D., Uesaka, T., Wang, H., Yamada, H., Yang, Z. H., and Yasuda, M.
Subjects: Nuclear Experiment, Nuclear Theory
Abstract: The cluster structure of the neutron-rich isotope $^{10}$Be has been probed via the $(p,p\alpha)$ reaction at 150 MeV/nucleon in inverse kinematics and in quasifree conditions. The populated states of $^{6}$He residues were investigated through missing mass spectroscopy. The triple differential cross-section for the ground-state transition was extracted for quasifree angle pairs ($\theta_{p}$, $\theta_{\alpha}$) and compared to distorted-wave impulse approximation reaction calculations performed in a microscopic framework using successively the Tohsaki-Horiuchi-Schuck-R\"opke product wave-function and the wave-function deduced from Antisymmetrized Molecular Dynamics calculations. The remarkable agreement between calculated and measured cross-sections in both shape and magnitude validates the molecular structure description of the $^{10}$Be ground-state, configured as an $\alpha$-$\alpha$ core with two valence neutrons occupying $\pi$-type molecular orbitals., Comment: 7 pages, 3 figures, 1 tables
Published: 2023
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19. Atmospheric neutrino oscillation analysis with neutron tagging and an expanded fiducial volume in Super-Kamiokande I-V

Author: Collaboration, Super-Kamiokande, Wester, T., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R., Xie, Z., Zsoldos, S., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarrant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Wilking, M. J., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Holin, A., Nova, F., Samani, S., Wark, D., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Koshiba, M., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., and Suzuki, S.
Subjects: High Energy Physics - Experiment
Abstract: We present a measurement of neutrino oscillation parameters with the Super-Kamiokande detector using atmospheric neutrinos from the complete pure-water SK I-V (April 1996-July 2020) data set, including events from an expanded fiducial volume. The data set corresponds to 6511.3 live days and an exposure of 484.2 kiloton-years. Measurements of the neutrino oscillation parameters $\Delta m^2_{32}$, $\sin^2\theta_{23}$, $\sin^2 \theta_{13}$, $\delta_{CP}$, and the preference for the neutrino mass ordering are presented with atmospheric neutrino data alone, and with constraints on $\sin^2 \theta_{13}$ from reactor neutrino experiments. Our analysis including constraints on $\sin^2 \theta_{13}$ favors the normal mass ordering at the 92.3% level., Comment: 24 pages, 18 figures
Published: 2023
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20. Measurement of the neutrino-oxygen neutral-current quasielastic cross section using atmospheric neutrinos in the SK-Gd experiment

Author: Sakai, S., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Calabria, N. F., Catanesi, M. G., Radicioni, E., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Suzuki, A. T., Takagi, Y., Zhong, H., Takeuchi, Y., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Wilking, M. J., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., and Suzuki, S.
Subjects: High Energy Physics - Experiment
Abstract: We report the first measurement of the atmospheric neutrino-oxygen neutral-current quasielastic (NCQE) cross section in the gadolinium-loaded Super-Kamiokande (SK) water Cherenkov detector. In June 2020, SK began a new experimental phase, named SK-Gd, by loading 0.011% by mass of gadolinium into the ultrapure water of the SK detector. The introduction of gadolinium to ultrapure water has the effect of improving the neutron-tagging efficiency. Using a 552.2 day data set from August 2020 to June 2022, we measure the NCQE cross section to be 0.74 $\pm$ 0.22(stat.) $^{+0.85}_{-0.15}$ (syst.) $\times$ 10$^{-38}$ cm$^{2}$/oxygen in the energy range from 160 MeV to 10 GeV, which is consistent with the atmospheric neutrino-flux-averaged theoretical NCQE cross section and the measurement in the SK pure-water phase within the uncertainties. Furthermore, we compare the models of the nucleon-nucleus interactions in water and find that the Binary Cascade model and the Liege Intranuclear Cascade model provide a somewhat better fit to the observed data than the Bertini Cascade model. Since the atmospheric neutrino-oxygen NCQE reactions are one of the main backgrounds in the search for diffuse supernova neutrino background (DSNB), these new results will contribute to future studies - and the potential discovery - of the DSNB in SK., Comment: 8 pages, 3 figures
Published: 2023

21. Enhanced Sensitivity of THz NbN Hot Electron Bolometer Mixers

Author: Mirzaei, B., Silva, J. R. G., Vreeling, W. J., Laauwen, W., Ren, D., and Gao, J. R.
Subjects: Physics - Instrumentation and Detectors
Abstract: We studied the effect of the NbN/Au contact on the sensitivities of a NbN hot electron bolometer (HEB) mixer by measuring the double sideband (DSB) receiver noise temperature (T_rec_DSB) at three local oscillator frequencies of 1.6, 2.5 and 5.3 THz. The HEB has cleaned contact structures with a thick Au layer. We demonstrated low mixer noise temperatures (T_mixer_DSB) of 240 K and 290 K at 1.6 and 2.5 THz, respectively. The latter reach roughly 3 times the quantum noise at their frequencies. The mixer is developed for the proposed OASIS and SALTUS (concept) missions. The enhanced T_mixer_DSB are more than 30 % better in comparison with published NbN HEB mixers. The improvement can reduce the integration time of a heterodyne instrument roughly by a factor of 2. The T_mixer^DSB of the same HEB has shown limited improvement at 5.3 THz, which is partly due to non-optimized antenna geometry. Besides, the results also help to understand device physics of a wide HEB (4 um) at high frequencies.
Published: 2023

22. Search for Periodic Time Variations of the Solar $^8$B Neutrino Flux between 1996 and 2018 in Super-Kamiokande

Author: Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Lee, S. H., Moon, D. H., Park, R. G., Jang, M. C., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Xie, Z., Ramsden, R. M., Zsoldos, S., Suzuki, A. T., Takagi, Y., Zhong, H., Takeuchi, Y., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kikawa, T., Mori, M., Kawaue, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Wilking, M. J., Yanagisawa, C., Shi, W., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Yang, B. S., Yang, J. Y., Yoo, J., Jung, S., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., Flaherty, M. O, Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., and Suzuki, S.
Subjects: High Energy Physics - Experiment
Abstract: We report a search for time variations of the solar $^8$B neutrino flux using 5804 live days of Super-Kamiokande data collected between May 31, 1996, and May 30, 2018. Super-Kamiokande measured the precise time of each solar neutrino interaction over 22 calendar years to search for solar neutrino flux modulations with unprecedented precision. Periodic modulations are searched for in a dataset comprising five-day interval solar neutrino flux measurements with a maximum likelihood method. We also applied the Lomb-Scargle method to this dataset to compare it with previous reports. The only significant modulation found is due to the elliptic orbit of the Earth around the Sun. The observed modulation is consistent with astronomical data: we measured an eccentricity of (1.53$\pm$0.35)\%, and a perihelion shift of ($-$1.5$\pm$13.5) days., Comment: 8 pages, 5 figures, 2 tables, and data file: "sksolartimevariation5804d.txt" (the data file updated with additional 3 columns -- R^2 correction, upper-error, lower-error)
Published: 2023

23. Microstructure, hardness and interfacial energy in Co-9Al-10W-xNi (x=15, 25, 35 at. %) alloys during aging

Author: Che C., Yang S., Wei M., Zhang L., Li Q., Gao J., and Du Y.
Subjects: Co-Al-W-Ni superalloys, microstructure, hardness, coarsening, interfacial energy, Mining engineering. Metallurgy, TN1-997
Abstract: In the present paper, three Co-Al-W-Ni alloys (i.e., Co-9Al-10W-xNi with x=15, 25, 35 at. %) and their heat treatment mechanisms were carefully designed on the basis of the available phase equilibrium information. The temporal evolution of the microstructure and hardness in the Co-9Al-10W-xNi (x=15, 25, 35) alloys during aging process was measured, from which the effect of additional Ni contents, aging temperature and time on microstructure and hardness in the three Co-Al- W-Ni alloys was analyzed. Considering that the alloy compositions and heat treatment are not directly related with the hardness, the relationship between hardness and microstructure was then linked. It was found that the hardness of Co-based superalloys increases as the volume fraction of γ' precipitates increases, while decreases with the increase of the radius and interval of γ' precipitates. Moreover, the interfacial energy of γ/γ' interface was also evaluated on the basis of the coarsening kinetics of γ' precipitates and the Philippe-Voorhees model in combination with the thermodynamic and atomic mobility databases. The results indicate that the interfacial energies of γ/γ' interface reduce as the increase of additional Ni content and aging temperature.
Published: 2017
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24. Search for leptoquark pair production decaying into te-t¯e+tμ-t¯μ+s=13TeV or te-t¯e+tμ-t¯μ+s=13TeV in multi-lepton final states in pp collisions at te-t¯e+tμ-t¯μ+s=13TeV with the ATLAS detector

Author: Aad, G., Abbott, B., Abbott, D. C., Abeling, K., Abidi, S. H., Aboulhorma, A., Abramowicz, H., Abreu, H., Abulaiti, Y., Hoffman, A. C. Abusleme, Acharya, B. S., Achkar, B., Bourdarios, C. Adam, Adamczyk, L., Adamek, L., Addepalli, S. V., Adelman, J., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agaras, M. N., Agarwala, J., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ahuja, S., Ai, X., Aielli, G., Aizenberg, I., Akbiyik, M., Åkesson, T. P. A., Akimov, A. V., Khoury, K. Al, Alberghi, G. L., Albert, J., Albicocco, P., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, A., Alfonsi, F., Alhroob, M., Ali, B., Ali, S., Aliev, M., Alimonti, G., Alkakhi, W., Allaire, C., Allbrooke, B. M. M., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Camelia, E. Alunno, Estevez, M. Alvarez, Alviggi, M. G., Aly, M., Coutinho, Y. Amaral, Ambler, A., Amelung, C., Amerl, M., Ames, C. G., Amidei, D., Santos, S. P. Amor Dos, Amoroso, S., Amos, K. R., Ananiev, V., Anastopoulos, C., Andeen, T., Anders, J. K., Andrean, S. Y., Andreazza, A., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Antrim, D. J. A., Anulli, F., Aoki, M., Aoki, T., Pozo, J. A. Aparisi, Aparo, M. A., Bella, L. Aperio, Appelt, C., Aranzabal, N., Ferraz, V. Araujo, Arcangeletti, C., Arce, A. T. H., Arena, E., Arguin, J-F., Argyropoulos, S., Arling, J.-H., Armbruster, A. J., Arnaez, O., Arnold, H., Tame, Z. P. Arrubarrena, Artoni, G., Asada, H., Asai, K., Asai, S., Asbah, N. A., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Atmani, H., Atmasiddha, P. A., Augsten, K., Auricchio, S., Auriol, A. D., Austrup, V. A., Avner, G., Avolio, G., Axiotis, K., Ayoub, M. K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Bachiu, A., Backman, F., Badea, A., Bagnaia, P., Bahmani, M., Bailey, A. J., Bailey, V. R., Baines, J. T., Bakalis, C., Baker, O. K., Bakker, P. J., Bakos, E., Gupta, D. Bakshi, Balaji, S., Balasubramanian, R., Baldin, E. M., Balek, P., Ballabene, E., Balli, F., Baltes, L. M., Balunas, W. K., Balz, J., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Bansal, S., Barak, L., Barberio, E. L., Barberis, D., Barbero, M., Barbour, G., Barends, K. N., Barillari, T., Barisits, M-S., Barklow, T., Barnett, R. M., Baron, P., Moreno, D. A. Baron, Baroncelli, A., Barone, G., Barr, A. J., Navarro, L. Barranco, Barreiro, F., da Costa, J. Barreiro Guimarães, Barron, U., Teixeira, M. G. Barros, Barsov, S., Bartels, F., Bartoldus, R., Barton, A. E., Bartos, P., Basalaev, A., Basan, A., Baselga, M., Bashta, I., Bassalat, A., Basso, M. J., Basson, C. R., Bates, R. L., Batlamous, S., Batley, J. R., Batool, B., Battaglia, M., Battulga, D., Bauce, M., Bauer, P., Bayirli, A., Beacham, J. B., Beau, T., Beauchemin, P. H., Becherer, F., Bechtle, P., Beck, H. P., Becker, K., Beddall, A. J., Bednyakov, V. A., Bee, C. P., Beemster, L. J., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Da Cruz E Silva, C. Beirao, Beirer, J. F., Beisiegel, F., Belfkir, M., Bella, G., Bellagamba, L., Bellerive, A., Bellos, P., Beloborodov, K., Belotskiy, K., Belyaev, N. L., Benchekroun, D., Bendebba, F., Benhammou, Y., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Kuutmann, E. Bergeaas, Berger, N., Bergmann, B., Beringer, J., Berlendis, S., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Berthold, A., Bertram, I. A., Bethke, S., Betti, A., Bevan, A. J., Bhamjee, M., Bhatta, S., Bhattacharya, D. S., Bhattarai, P., Bhopatkar, V. S., Bi, R., Bianchi, R. M., Biebel, O., Bielski, R., Biglietti, M., Billoud, T. R. V., Bindi, M., Bingul, A., Bini, C., Biondi, S., Biondini, A., Birch-sykes, C. J., Bird, G. A., Birman, M., Bisanz, T., Bisceglie, E., Biswas, D., Bitadze, A., Bjørke, K., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Blumenthal, J., Bobbink, G. J., Bobrovnikov, V. S., Boehler, M., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Bomben, M., Bona, M., Boonekamp, M., Booth, C. D., Borbély, A. G., Borecka-Bielska, H. M., Borgna, L. S., Borissov, G., Bortoletto, D., Boscherini, D., Bosman, M., Sola, J. D. Bossio, Bouaouda, K., Bouchhar, N., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Bouquet, R., Boveia, A., Boyd, J., Boye, D., Boyko, I. R., Bracinik, J., Brahimi, N., Brandt, G., Brandt, O., Braren, F., Brau, B., Brau, J. E., Brendlinger, K., Brener, R., Brenner, L., Brenner, R., Bressler, S., Brickwedde, B., Britton, D., Britzger, D., Brock, I., Brooijmans, G., Brooks, W. K., Brost, E., Bruckler, T. L., de Renstrom, P. A. 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W., Cranmer, K., Crépé-Renaudin, S., Crescioli, F., Cristinziani, M., Cristoforetti, M., Croft, V., Crosetti, G., Cueto, A., Donszelmann, T. Cuhadar, Cui, H., Cui, Z., Cukierman, A. R., Cunningham, W. R., Curcio, F., Czodrowski, P., Czurylo, M. M., Da Cunha Sargedas De Sousa, M. J., Da Fonseca Pinto, J. V., Da Via, C., Dabrowski, W., Dado, T., Dahbi, S., Dai, T., Dallapiccola, C., Dam, M., D’amen, G., D’Amico, V., Damp, J., Dandoy, J. R., Daneri, M. F., Danninger, M., Dao, V., Darbo, G., Darmora, S., Das, S. J., D’Auria, S., David, C., Davidek, T., Davis, D. R., Davis-Purcell, B., Dawson, I., De, K., De Asmundis, R., De Beurs, M., De Biase, N., De Castro, S., De Groot, N., de Jong, P., De la Torre, H., De Maria, A., De Salvo, A., De Sanctis, U., De Santo, A., De Vivie De Regie, J. B., Dedovich, D. V., Degens, J., Deiana, A. M., Corso, F. Del, Peso, J. Del, Rio, F. Del, Deliot, F., Delitzsch, C. M., Pietra, M. Della, Volpe, D. 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F., Zhang, G., Zhang, J., Zhang, J., Zhang, K., Zhang, L., Zhang, P., Zhang, R., Zhang, S., Zhang, T., Zhang, X., Zhang, X., Zhang, Y., Zhang, Z., Zhang, Z., Zhao, H., Zhao, P., Zhao, T., Zhao, Y., Zhao, Z., Zhemchugov, A., Zheng, X., Zheng, Z., Zhong, D., Zhou, B., Zhou, C., Zhou, H., Zhou, N., Zhou, Y., Zhu, C. G., Zhu, C., Zhu, H. L., Zhu, H., Zhu, J., Zhu, Y., Zhu, Y., Zhuang, X., Zhukov, K., Zhulanov, V., Zimine, N. I., Zinsser, J., Ziolkowski, M., Živković, L., Zoccoli, A., Zoch, K., Zorbas, T. G., Zormpa, O., Zou, W., and Zwalinski, L.
Published: 2024
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25. Nanoparticle-Based Drug Delivery Systems for Inflammatory Bowel Disease Treatment

Author: Gao J, Li J, Luo Z, Wang H, and Ma Z
Subjects: nanoparticles, inflammatory bowel diseases, targeted delivery, passive targeting, active targeting, drug delivery system, Therapeutics. Pharmacology, RM1-950
Abstract: Jian Gao,1 Jiannan Li,2 Zengyou Luo,1 Hongyong Wang,3 Zhiming Ma1 1Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University, Changchun, People’s Republic of China; 3Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Zhiming Ma, Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Changchun, People’s Republic of China, Email mazhiming@jlu.edu.cnAbstract: Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory condition characterized by recurring inflammation of the intestinal mucosa. However, the existing IBD treatments are ineffective and have serious side effects. The etiology of IBD is multifactorial and encompasses immune, genetic, environmental, dietary, and microbial factors. The nanoparticles (NPs) developed based on specific targeting methodologies exhibit great potential as nanotechnology advances. Nanoparticles are defined as particles between 1 and 100 nm in size. Depending on their size and surface functionality, NPs exhibit different properties. A variety of nanoparticle types have been employed as drug carriers for the treatment of inflammatory bowel disease (IBD), with encouraging outcomes observed in experimental models. They increase the bioavailability of drugs and enable targeted drug delivery, promoting localized treatment and thus enhancing efficacy. Nevertheless, numerous challenges persist in the translation from nanomedicine to clinical application, including enhanced formulations and preparation techniques, enhanced drug safety profiles, and so forth. In the future, it will be necessary for scientists and clinicians to collaborate in order to study disease mechanisms, develop new drug delivery strategies, and screen new nanomedicines. Nevertheless, numerous challenges persist in the translation from nanomedicine to clinical application, including enhanced formulations and preparation techniques, enhanced drug safety profiles, and so forth. In the future, it will be necessary for scientists and clinicians to collaborate in order to study disease mechanisms, develop new drug delivery strategies, and screen new nanomedicines.Keywords: nanoparticles, inflammatory bowel diseases, targeted delivery, passive targeting, active targeting, drug delivery system
Published: 2024

26. Molecular Landscape and Prognostic Value in the Post-Translational Ubiquitination, SUMOylation and Neddylation in Osteosarcoma: A Transcriptome Study

Author: Jia C, Yao X, Dong Z, Wang L, Zhao F, Gao J, and Cai T
Subjects: post-translational modifications, osteosarcoma, immune microenvironment, immune therapy, rad21, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Chenguang Jia,1,&ast; Xiaowei Yao,1,&ast; Zhaoliang Dong,1 Lianbo Wang,1 Fangchao Zhao,2,&ast; Jianguo Gao,1,&ast; Tao Cai3,&ast; 1Department of Orthopedics, Hebei Chest Hospital, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 3Hebei Chest Hospital, Shijiazhuang, Hebei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Tao Cai, Hebei Chest Hospital, No. 372, Shengli North Street, Shijiazhuang, Hebei, People’s Republic of China, Tel/Fax +86-311-86911080, Email caitaoxiongke@163.comBackground: Post-translational modifications (PTM) significantly influence the pathogenesis and progression of diverse neoplastic conditions. Nevertheless, there has been limited research focusing on the potential of PTM-related genes (PTMRGs) as tumor biomarkers for predicting the survival of specific patients.Methods: The datasets utilized in this research were obtained from the TARGET and GEO repositories, respectively. The gene signature was constructed through the utilization of LASSO Cox regression method. GSEA and GO was used to identify hub pathways associated with risk genes. The functionality of risk genes in osteosarcoma (OS) cell lines was verified through the implementation of the CCK-8 assay, cell cycle analysis, and immunofluorescence assay.Results: Two distinct PTM patterns and gene clusters were finally determined. Significant differences in the prognosis of patients were found among two different PTM patterns and gene clusters, so were in the function enrichment and the landscape of TME immune cell infiltration. Moreover, we examined two external immunotherapy cohorts and determining that patients in the low-risk group was more likely to profit from immunotherapy. In addition, we mapped the expression of the genes in the signature in distinct cells using single-cell analysis. Finally, CCK-8 assay, cell cycle analysis, and immunofluorescence assay were utilized to confirm that RAD21 was expressed and functioned in OS.Conclusion: In conclusion, this study elucidated the potential link between PTM and immune infiltration landscape of OS for the first time and provided a new assessment protocol for the precise selection of treatment strategies for patients with advanced OS.Keywords: post-translational modifications, osteosarcoma, immune microenvironment, immune therapy, RAD21
Published: 2024

27. Search for astrophysical electron antineutrinos in Super-Kamiokande with 0.01wt% gadolinium-loaded water

Author: Harada, M., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Okamoto, K., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Megias, G. D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., Machado, L. N., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Xie, Z., Zsoldos, S., Kotsar, Y., Ozaki, H., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarrant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Wilking, M. J., Yanagisawa, C., Hino, Y., Ishino, H., Kitagawa, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Kuze, M., Izumiyama, S., Matsumoto, R., Ishitsuka, M., Ito, H., Kinoshita, T., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Martin, J. F., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Prouse, N. W., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., Flaherty, M. O, Richards, B., Ali, A., Jamieson, B., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Suzuki, S., and Wada, K.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment, Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract: We report the first search result for the flux of astrophysical electron antineutrinos for energies O(10) MeV in the gadolinium-loaded Super-Kamiokande (SK) detector. In June 2020, gadolinium was introduced to the ultra-pure water of the SK detector in order to detect neutrons more efficiently. In this new experimental phase, SK-Gd, we can search for electron antineutrinos via inverse beta decay with efficient background rejection and higher signal efficiency thanks to the high efficiency of the neutron tagging technique. In this paper, we report the result for the initial stage of SK-Gd with a $22.5\times552$ $\rm kton\cdot day$ exposure at 0.01% Gd mass concentration. No significant excess over the expected background in the observed events is found for the neutrino energies below 31.3 MeV. Thus, the flux upper limits are placed at the 90% confidence level. The limits and sensitivities are already comparable with the previous SK result with pure-water ($22.5 \times 2970 \rm kton\cdot day$) owing to the enhanced neutron tagging.
Published: 2023
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28. Prediction of m6A and m5C at single-molecule resolution reveals a transcriptome-wide co-occurrence of RNA modifications

Author: Acera Mateos, P, J Sethi, A, Ravindran, A, Srivastava, A, Woodward, K, Mahmud, S, Kanchi, M, Guarnacci, M, Xu, J, W S Yuen, Z, Zhou, Y, Sneddon, A, Hamilton, W, Gao, J, M Starrs, L, Hayashi, R, Wickramasinghe, V, Zarnack, K, Preiss, T, Burgio, G, Dehorter, N, E Shirokikh, N, and Eyras, E
Published: 2024
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29. DPSCs regulate epithelial-T cell interactions in oral submucous fibrosis

Author: Wang, S. Y., Zhang, S. J., Meng, H. F., Xu, H. Q., Guo, Z. X., Yan, J. F., Gao, J. L., Niu, L. N., Wang, S. L., and Jiao, K.
Published: 2024
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30. Sustainable application of waste construction slurry as a planting matrix capable of water and fertilizer retention

Author: Fang, Y., He, X., Long, X., Xiang, X., and Gao, J.
Published: 2024
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31. The relative contributions of iron and aluminum oxides to ferrocyanide retention in soils: a comparative study

Author: Wei, Y., Yao, R., Chen, S., Zhou, H., Ren, T., Liu, S., Gao, J., and Li, Y.
Published: 2024
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32. STCF Conceptual Design Report: Volume 1 -- Physics & Detector

Author: Achasov, M., Ai, X. C., Aliberti, R., An, L. P., An, Q., Bai, X. Z., Bai, Y., Bakina, O., Barnyakov, A., Blinov, V., Bobrovnikov, V., Bodrov, D., Bogomyagkov, A., Bondar, A., Boyko, I., Bu, Z. H., Cai, F. M., Cai, H., Cao, J. J., Cao, Q. H., Cao, Z., Chang, Q., Chao, K. T., Chen, D. Y., Chen, H., Chen, H. X., Chen, J. F., Chen, K., Chen, L. L., Chen, P., Chen, S. L., Chen, S. M., Chen, S., Chen, S. P., Chen, W., Chen, X. F., Chen, X., Chen, Y., Chen, Y. Q., Cheng, H. Y., Cheng, J., Cheng, S., Dai, J. P., Dai, L. Y., Dai, X. C., Dedovich, D., Denig, A., Denisenko, I., Ding, D. Z., Dong, L. Y., Dong, W. H., Druzhinin, V., Du, D. S., Du, Y. J., Du, Z. G., Duan, L. M., Epifanov, D., Fan, Y. L., Fang, S. S., Fang, Z. J., Fedotovich, G., Feng, C. Q., Feng, X., Feng, Y. T., Fu, J. L., Gao, J., Ge, P. S., Geng, C. Q., Geng, L. S., Gilman, A., Gong, L., Gong, T., Gradl, W., Gu, J. L., Escalante, A. G., Gui, L. C., Guo, F. K., Guo, J. C., Guo, J., Guo, Y. P., Guo, Z. H., Guskov, A., Han, K. L., Han, L., Han, M., Hao, X. Q., He, J. B., He, S. Q., He, X. G., He, Y. L., He, Z. B., Heng, Z. X., Hou, B. L., Hou, T. J., Hou, Y. R., Hu, C. Y., Hu, H. M., Hu, K., Hu, R. J., Hu, X. H., Hu, Y. C., Hua, J., Huang, G. S., Huang, J. S., Huang, M., Huang, Q. Y., Huang, W. Q., Huang, X. T., Huang, X. J., Huang, Y. B., Huang, Y. S., Hüsken, N., Ivanov, V., Ji, Q. P., Jia, J. J., Jia, S., Jia, Z. K., Jiang, H. B., Jiang, J., Jiang, S. Z., Jiao, J. B., Jiao, Z., Jing, H. J., Kang, X. L., Kang, X. S., Ke, B. C., Kenzie, M., Khoukaz, A., Koop, I., Kravchenko, E., Kuzmin, A., Lei, Y., Levichev, E., Li, C. H., Li, C., Li, D. Y., Li, F., Li, G., Li, H. B., Li, H., Li, H. N., Li, H. J., Li, H. L., Li, J. M., Li, J., Li, L., Li, L. Y., Li, N., Li, P. R., Li, R. H., Li, S., Li, T., Li, W. J., Li, X. H., Li, X. Q., Li, Y., Li, Y. Y., Li, Z. J., Liang, H., Liang, J. H., Liao, G. R., Liao, L. Z., Liao, Y., Lin, C. X., Lin, X. S., Liu, B. J., Liu, C. W., Liu, D., Liu, F., Liu, G. M., Liu, H. B., Liu, J., Liu, J. J., Liu, J. B., Liu, K., Liu, K. Y., Liu, L., Liu, Q., Liu, S. B., Liu, T., Liu, X., Liu, Y. W., Liu, Y., Liu, Y. L., Liu, Z. Q., Liu, Z. Y., Liu, Z. W., Logashenko, I., Long, Y., Lu, C. G., Lu, N., Lü, Q. F., Lu, Y., Lv, Z., Lukin, P., Luo, F. J., Luo, T., Luo, X. F., Lyu, H. J., Lyu, X. R., Ma, J. P., Ma, P., Ma, Y., Maas, F., Malde, S., Matvienko, D., Meng, Z. X., Mitchell, R., Dias, J. M., Nefediev, A., Nefedov, Y., Olsen, S. L., Ouyang, Q., Pakhlov, P., Pakhlova, G., Pan, X., Pan, Y., Passemar, E., Pei, Y. P., Peng, H. P., Peng, L., Peng, X. Y., Peng, X. J., Peters, K., Pivovarov, S., Pyata, E., Qi, B. B., Qi, Y. Q., Qian, W. B., Qian, Y., Qiao, C. F., Qin, J. J., Qin, L. Q., Qin, X. S., Qiu, T. L., Rademacker, J., Redmer, C. F., Sang, H. Y., Saur, M., Shan, W., Shan, X. Y., Shang, L. L., Shao, M., Shekhtman, L., Shen, C. P., Shen, J. M., Shen, Z. T., Shi, H. C., Shi, X. D., Shwartz, B., Sokolov, A., Song, J. J., Song, W. M., Song, Y., Song, Y. X., Sukharev, A., Sun, J. F., Sun, L., Sun, X. M., Sun, Y. J., Sun, Z. P., Tang, J., Tang, S. S., Tang, Z. B., Tian, C. H., Tian, J. S., Tikhonov, Y., Todyshev, K., Uglov, T., Vorobyev, V., Wan, B. D., Wang, B. L., Wang, B., Wang, D. Y., Wang, G. Y., Wang, G. L., Wang, H. L., Wang, J., Wang, J. H., Wang, J. C., Wang, M. L., Wang, R., Wang, S. B., Wang, W., Wang, W. P., Wang, X. C., Wang, X. D., Wang, X. L., Wang, X. P., Wang, X. F., Wang, Y. D., Wang, Y. P., Wang, Y. Q., Wang, Y. L., Wang, Y. G., Wang, Z. Y., Wang, Z. L., Wang, Z. G., Wei, D. H., Wei, X. L., Wei, X. M., Wen, Q. G., Wen, X. J., Wilkinson, G., Wu, B., Wu, J. J., Wu, L., Wu, P. W., Wu, T. W., Wu, Y. S., Xia, L., Xiang, T., Xiao, C. W., Xiao, D., Xiao, M., Xie, Y. H., Xing, Y., Xing, Z. Z., Xiong, X. N., Xu, F. R., Xu, J., Xu, L. L., Xu, Q. N., Xu, X. C., Xu, X. P., Xu, Y. C., Xu, Y. P., Xu, Y., Xu, Z. Z., Xuan, D. W., Xue, F. F., Yan, L., Yan, M. J., Yan, W. B., Yan, W. C., Yan, X. S., Yang, B. F., Yang, C., Yang, H. J., Yang, H. R., Yang, H. T., Yang, J. F., Yang, S. L., Yang, Y. D., Yang, Y. H., Yang, Y. S., Yang, Y. L., Yang, Z. Y., Yao, D. L., Yin, H., Yin, X. H., Yokozaki, N., You, S. Y., You, Z. Y., Yu, C. X., Yu, F. S., Yu, G. L., Yu, H. L., Yu, J. S., Yu, J. Q., Yuan, L., Yuan, X. B., Yue, Y. F., Zeng, M., Zeng, S., Zhang, A. L., Zhang, B. W., Zhang, G. Y., Zhang, G. Q., Zhang, H. J., Zhang, H. B., Zhang, J. Y., Zhang, J. L., Zhang, J., Zhang, L., Zhang, L. M., Zhang, R., Zhang, S. L., Zhang, T., Zhang, X., Zhang, Y., Zhang, Y. X., Zhang, Y. T., Zhang, Y. F., Zhang, Y. C., Zhang, Y. M., Zhang, Y. L., Zhang, Z. H., Zhang, Z. Y., Zhao, H. Y., Zhao, J., Zhao, L., Zhao, M. G., Zhao, Q., Zhao, R. G., Zhao, R. P., Zhao, Z. G., Zhao, Z. X., Zhemchugov, A., Zheng, B., Zheng, L., Zheng, Q. B., Zheng, R., Zheng, Y. H., Zhong, X. H., Zhou, H. J., Zhou, H. Q., Zhou, H., Zhou, S. H., Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, Y. L., Zhou, Y., Zhou, Y. X., Zhou, Z. Y., Zhu, J. Y., Zhu, K., Zhu, R. D., Zhu, R. L., Zhu, S. H., Zhu, Y. C., Zhu, Z. A., Zhukova, V., Zhulanov, V., Zou, B. S., and Zuo, Y. B.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract: The Super $\tau$-Charm facility (STCF) is an electron-positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of $0.5\times 10^{35}{\rm cm}^{-2}{\rm s}^{-1}$ or higher. The STCF will produce a data sample about a factor of 100 larger than that by the present $\tau$-Charm factory -- the BEPCII, providing a unique platform for exploring the asymmetry of matter-antimatter (charge-parity violation), in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions, as well as searching for exotic hadrons and physics beyond the Standard Model. The STCF project in China is under development with an extensive R\&D program. This document presents the physics opportunities at the STCF, describes conceptual designs of the STCF detector system, and discusses future plans for detector R\&D and physics case studies.
Published: 2023
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33. Improved microwave SQUID multiplexer readout using a kinetic-inductance traveling-wave parametric amplifier

Author: Malnou, M., Mates, J. A. B., Vissers, M. R., Vale, L. R., Schmidt, D. R., Bennett, D. A., Gao, J., and Ullom, J. N.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Quantum Physics
Abstract: We report on the use of a kinetic-inductance traveling-wave parametric amplifier (KITWPA) as the first amplifier in the readout chain of a microwave superconducting quantum interference device (SQUID) multiplexer (umux). This umux is designed to multiplex signals from arrays of low temperature detectors such as superconducting transition-edge sensor microcalorimeters. When modulated with a periodic flux-ramp to linearize the SQUID response, the flux noise improves, on average, from $1.6$ $\mu\Phi_0/\sqrt{\mathrm{Hz}}$ with the KITWPA off, to $0.77$ $\mu\Phi_0/\sqrt{\mathrm{Hz}}$ with the KITWPA on. When statically biasing the umux to the maximally flux-sensitive point, the flux noise drops from $0.45$ $\mu\Phi_0/\sqrt{\mathrm{Hz}}$ to $0.2$ $\mu\Phi_0/\sqrt{\mathrm{Hz}}$. We validate this new readout scheme by coupling a transition-edge sensor microcalorimeter to the umux and detecting background radiation. The combination of umux and KITWPA provides a variety of new capabilities including improved detector sensitivity and more efficient bandwidth utilization.
Published: 2023
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34. G4CMP: Condensed Matter Physics Simulation Using the Geant4 Toolkit

Author: Kelsey, M. H., Agnese, R., Alam, Y. F., Langroudy, I. Ataee, Azadbakht, E., Brandt, D., Bunker, R., Cabrera, B., Chang, Y. -Y., Coombes, H., Cormier, R. M., Diamond, M. D., Edwards, E. R., Figueroa-Feliciano, E., Gao, J., Harrington, P. M., Hong, Z., Hui, M., Kurinsky, N. A., Lawrence, R. E., Loer, B., Masten, M. G., Michaud, E., Michielin, E., Miller, J., Novati, V., Oblath, N. S., Orrell, J. L., Perry, W. L., Redl, P., Reynolds, T., Saab, T., Sadoulet, B., Serniak, K., Singh, J., Speaks, Z., Stanford, C., Stevens, J. R., Strube, J., Toback, D., Ullom, J. N., VanDevender, B. A., Vissers, M. R., Wilson, M. J., Wilson, J. S., Zatschler, B., and Zatschler, S.
Subjects: High Energy Physics - Experiment, Quantum Physics
Abstract: G4CMP simulates phonon and charge transport in cryogenic semiconductor crystals using the Geant4 toolkit. The transport code is capable of simulating the propagation of acoustic phonons as well as electron and hole charge carriers. Processes for anisotropic phonon propagation, oblique charge-carrier propagation, and phonon emission by accelerated charge carriers are included. The simulation reproduces theoretical predictions and experimental observations such as phonon caustics, heat-pulse propagation times, and mean charge-carrier drift velocities. In addition to presenting the physics and features supported by G4CMP, this report outlines example applications from the dark matter and quantum information science communities. These communities are applying G4CMP to model and design devices for which the energy transported by phonons and charge carriers is germane to the performance of superconducting instruments and circuits placed on silicon and germanium substrates. The G4CMP package is available to download from GitHub: github.com/kelseymh/G4CMP., Comment: 21 pages, 11 figures, 10 tables
Published: 2023
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35. Multiple Mechanisms in Proton-Induced Nucleon Removal at $\sim$100 MeV/Nucleon

Author: Pohl, T., Sun, Y. L., Obertelli, A., Lee, J., Gomez-Ramos, M., Ogata, K., Yoshida, K., Cai, B. S., Yuan, C. X., Brown, B. A., Baba, H., Beaumel, D., Corsi, A., Gao, J., Gibelin, J., Gillibert, A., Hahn, K. I., Isobe, T., Kim, D., Kondo, Y., Kobayashi, T., Kubota, Y., Li, P., Liang, P., Liu, H. N., Liu, J., Lokotko, T., Marques, F. M., Matsuda, Y., Motobayashi, T., Nakamura, T., Orr, N. A., Otsu, H., Panin, V., Park, S. Y., Sakaguchi, S., Sasano, M., Sato, H., Sakurai, H., Shimizu, Y., Stefanescu, A. I., Stuhl, L., Suzuki, D., Togano, Y., Tudor, D., Uesaka, T., Wang, H., Xu, X., Yang, Z. H., Yoneda, K., and Zenihiro, J.
Subjects: Nuclear Experiment, Nuclear Theory
Abstract: We report on the first proton-induced single proton- and neutron-removal reactions from the neutron-deficient $^{14}$O nucleus with large Fermi-surface asymmetry $S_n-S_p$ = 18.6 MeV at $\sim$100 MeV/nucleon, a widely used energy regime for rare-isotope studies. The measured inclusive cross sections and parallel momentum distributions of the $^{13}$N and $^{13}$O residues are compared to the state-of-the-art reaction models, with nuclear structure inputs from many-body shell-model calculations. Our results provide the first quantitative contributions of multiple reaction mechanisms including the quasifree knockout, inelastic scattering and nucleon transfer processes. It is shown that the inelastic scattering and nucleon transfer, usually neglected at such energy regime, contribute about 50% and 30% to the loosely bound proton and deeply bound neutron removal, respectively. These multiple reaction mechanisms should be considered in analyses of inclusive one-nucleon removal cross sections measured at intermediate energies for quantitative investigation of single-particle strengths and correlations in atomic nuclei.
Published: 2023
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36. Identification of Biomarkers Associated with Oxidative Stress and Immune Cells in Acute Pancreatitis

Author: Xu Y, Song J, Gao J, and Zhang H
Subjects: acute pancreatitis, oxidative stress, diagnosis, immunity, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Yuan Xu,1 Jie Song,1 Jie Gao,1 Hongjing Zhang2 1Department of Gastroenterology, Dongying People’s Hospital(Dongying Hospital of Shandong Provincial Hospital Group), Dongying, Shandong, People’s Republic of China; 2Community Health Service Center in Hekou District, Dongying, Shandong, People’s Republic of ChinaCorrespondence: Yuan Xu, Department of Gastroenterology, Dongying People’s Hospital (Dongying Hospital of Shandong Provincial Hospital Group), No. 317 Nanyi Road, Dongying, Shandong, 257091, People’s Republic of China, Email jry0919@sina.comPurpose: Oxidative stress promotes disease progression by stimulating the humoral and cellular immune responses. However, the molecular mechanisms underlying oxidative stress and immune responses in acute pancreatitis (AP) have not been extensively studied.Patients and Methods: We analyzed the GSE194331 dataset and oxidative stress-related genes (OSRGs). We identified differentially expressed immune cell-associated OSRGs (DE-ICA-OSRGs) by overlapping key module genes from weighted gene co-expression network analysis, OSRGs, and DEGs between AP and normal samples. Functional enrichment analysis was performed to investigate the functions of DE-ICA-OSRGs. We then filtered diagnostic genes using receiver operating characteristic curves and investigated their molecular mechanisms using single-gene set enrichment analysis (GSEA). We also explored the correlation between diagnostic genes and differential immune cells. Finally, we constructed a transcription factor-microRNA-messenger RNA (TF-miRNA-mRNA) network of biomarkers.Results: In this study, three DE-ICA-OSRGs (ARG1, NME8 and VNN1) were filtered by overlapping key module genes, OSRGs and DEGs. Functional enrichment results revealed that DE-ICA-OSRGs were involved in the cellular response to reactive oxygen species and arginine biosynthesis. Latterly, a total of two diagnostic genes (ARG1 and VNN1) were derived and their expression was higher in the AP group than in the normal group. The single-gene GSEA enrichment results revealed that diagnostic genes were mainly enriched in macroautophagy and Toll-like receptor signaling pathways. Correlation analysis revealed that CD8 T cells, resting memory T CD4 cells, and resting NK cells were negatively correlated with ARG1, and neutrophils were positively correlated with ARG1, which was consistent with that of VNN1. The TF-miRNA-mRNA regulatory network included 11 miRNAs, 2 mRNAs, 10 transcription factors (TFs), and 26 pairs of regulatory relationships, like NFKB1-has-miR-2909-VNN1.Conclusion: In this study, two immune cell oxidative stress-related AP diagnostic genes (ARG1 and VNN1) were screened to offer a new reference for the diagnosis of patients with AP. Keywords: acute pancreatitis, oxidative stress, diagnosis, immunity
Published: 2024

37. Tumor-Targeted cRGD-Coated Liposomes Encapsulating Optimized Synergistic Cepharanthine and IR783 for Chemotherapy and Photothermal Therapy

Author: Wu Y, Zeng C, Lv J, Li H, Gao J, Liu Z, and Yuan Z
Subjects: drug delivery, liposomes, synergistic effects, phototherapy, Medicine (General), R5-920
Abstract: Yumei Wu,1– 3,&ast; Chunhua Zeng,1– 3,&ast; Jiajia Lv,1– 3 Hongyu Li,1– 3 Jie Gao,1– 3 Zhidong Liu,4 Zeli Yuan1– 3 1Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 2Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 3Guizhou International Scientific and Technological Cooperation Base for Medical Photo-Theranostics Technology and Innovative Drug Development, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 4Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhidong Liu, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Tianjin, Jinghai District, 301617, People’s Republic of China, Email lonerliuzd@163.com Zeli Yuan, Zunyi Medical University, Zunyi, 563000, People’s Republic of China, Email zlyuan@zmu.edu.cnBackground: Combination therapy offers superior therapeutic results compared to monotherapy. However, the outcomes of combination therapy often fall short of expectations, mainly because of increased toxicity from drug interactions and challenges in achieving the desired spatial and temporal distribution of drug delivery. Optimizing synergistic drug combination ratios to ensure uniform targeting and distribution across space and time, particularly in vivo, is a significant challenge. In this study, cRGD-coated liposomes encapsulating optimized synergistic cepharanthine (CEP; a chemotherapy drug) and IR783 (a phototherapy agent) were developed for combined chemotherapy and photothermal therapy in vitro and in vivo.Methods: An MTT assay was used to evaluate the combination index of CEP and IR783 in five cell lines. The cRGD-encapsulated liposomes were prepared via thin-film hydration, and unencapsulated liposomes served as controls for the loading of CEP and IR783. Fluorescence and photothermal imaging were used to assess the efficacy of CEP and IR783 encapsulated in liposomes at an optimal synergistic ratio, both in vitro and in vivo.Results: The combination indices of CEP and IR783 were determined in five cell lines. As a proof-of-concept, the optimal synergistic ratio (1:2) of CEP to IR783 in 4T1 cells was evaluated in vitro and in vivo. The average diameter of the liposomes was approximately 100 nm. The liposomes effectively retained the encapsulated CEP and IR783 in vitro at the optimal synergistic molar ratio for over 7 d. In vivo fluorescence imaging revealed that the fluorescence signal from cRGD-CEP-IR783-Lip was detectable at the tumor site at 4 h post-injection and peaked at 8 h. In vivo photothermal imaging of tumor-bearing mice indicated an increase in tumor temperature by 32°C within 200 s. Concurrently, cRGD-CEP-IR783-Lip demonstrated a significant therapeutic effect and robust biosafety in the in vivo antitumor experiments.Conclusion: The combination indices of CEP and IR783 were successfully determined in vitro in five cell lines. The cRGD-coated liposomes encapsulated CEP and IR783 at an optimal synergistic ratio, exhibiting enhanced antitumor effects and targeting upon application in vitro and in vivo. This study presents a novel concept and establishes a research framework for synergistic chemotherapy and phototherapy treatment. Keywords: drug delivery, liposomes, synergistic effects, phototherapy
Published: 2024

38. The Relationship Between Social Isolation and Cognitive Frailty Among Community-Dwelling Older Adults: The Mediating Role of Depressive Symptoms

Author: Bai Y, Chen Y, Tian M, Gao J, Song Y, Zhang X, Yin H, and Xu G
Subjects: cognitive frailty, social isolation, depression, older adults, Geriatrics, RC952-954.6
Abstract: Yamei Bai,&ast; Yuqing Chen,&ast; Meng Tian, Jiaojiao Gao, Yulei Song, Xueqing Zhang, Haiyan Yin, Guihua Xu School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Guihua Xu, School of Nursing, Nanjing University of Chinese Medicine, No. 138, Xianlin Avenue, Qixia District, Nanjing, Jiangsu Province, 210023, People’s Republic of China, Tel +86-153-6513-2927, Email 7115@njucm.edu.cnPurpose: Social isolation and depression have an impact on cognitive frailty. However, the underlying mechanisms between these variables have not been well defined. This study aims to investigate the mediating role of depressive symptoms in the association between social isolation and cognitive frailty among older adults in China.Methods: From Mar 2023 to Aug 2023, a cross-sectional study was conducted with 496 community-dwelling older adults aged ≥ 60 years in Nanjing, Jiangsu Province, China. Demographic information was collected using the General Information Questionnaire. The Lubben Social Network Scale-6 (LSNS-6), Geriatric Depression Scale 15-item (GDS-15), Montreal Cognitive Assessment (MoCA), Clinical Dementia Rating (CDR), and FRAIL scale were used for the questionnaire survey. Multiple linear regression and binary logistic regression were utilized to explore the associations among social isolation, depressive symptoms, and cognitive frailty, and Bootstrap analysis was used to explore the mediating role of depressive symptoms in social isolation and cognitive frailty.Results: Linear regression results revealed that social isolation was positively associated with depressive symptoms (β = 0.873, p < 0.001). Logistic regression analysis showed that social isolation (OR = 1.769, 95% CI = 1.018~3.075) and depressive symptoms (OR = 1.227, 95% CI = 1.108~1.357) were significantly associated with cognitive frailty. Mediation analysis demonstrated that depressive symptoms significantly mediated the relationship between social isolation and cognitive frailty, with an indirect effect of 0.027 (95% CI = 0.003~0.051), and the mediating effect accounted for 23.6% of the total effect.Conclusion: Social isolation is associated with cognitive frailty in community-dwelling older adults, and depressive symptoms partially mediate the effect between social isolation and cognitive frailty. Active promotion of social integration among older individuals is recommended to enhance their mental health, reduce the incidence of cognitive frailty, and foster active aging.Keywords: cognitive frailty, social isolation, depressive symptoms, older adults
Published: 2024

39. Prosthetic Metals: Release, Metabolism and Toxicity

Author: Zhong Q, Pan X, Chen Y, Lian Q, Gao J, Xu Y, Wang J, Shi Z, and Cheng H
Subjects: metallic joint prostheses, prosthetic metal release, potential toxicity and adverse effects, Medicine (General), R5-920
Abstract: Qiang Zhong,&ast; Xin Pan,&ast; Yuhang Chen, Qiang Lian, Jian Gao, Yixin Xu, Jian Wang, Zhanjun Shi, Hao Cheng Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhanjun Shi; Hao Cheng, Nanfang Hospital, Southern Medical University, 1838&num; Guangzhou North Avenue, Guangzhou, People’s Republic of China, Tel +86 2062787924, Email shizhanjun111@gmail.com; haocool317@gmail.comAbstract: The development of metallic joint prostheses has been ongoing for more than a century alongside advancements in hip and knee arthroplasty. Among the materials utilized, the Cobalt-Chromium-Molybdenum (Co-Cr-Mo) and Titanium-Aluminum-Vanadium (Ti-Al-V) alloys are predominant in joint prosthesis construction, predominantly due to their commendable biocompatibility, mechanical strength, and corrosion resistance. Nonetheless, over time, the physical wear, electrochemical corrosion, and inflammation induced by these alloys that occur post-implantation can cause the release of various metallic components. The released metals can then flow and metabolize in vivo, subsequently causing potential local or systemic harm. This review first details joint prosthesis development and acknowledges the release of prosthetic metals. Second, we outline the metallic concentration, biodistribution, and elimination pathways of the released prosthetic metals. Lastly, we discuss the possible organ, cellular, critical biomolecules, and significant signaling pathway toxicities and adverse effects that arise from exposure to these metals. Keywords: metallic joint prostheses, prosthetic metal release, potential toxicity and adverse effects
Published: 2024

40. Ergothioneine Protects Against UV-Induced Oxidative Stress Through the PI3K/AKT/Nrf2 Signaling Pathway

Author: Li Y, Gao J, Liu S, Chen S, Wei X, Guan Y, Li X, Huang Z, Li G, Zhao Y, Liu P, and Zhang Y
Subjects: ergothioneine, skin aging, pi3k/akt, nrf2, Dermatology, RL1-803
Abstract: Yongchao Li,1,&ast; Jinfeng Gao,2,&ast; Shuhua Liu,1 Shijian Chen,3 Xiaoyue Wei,3 Yalun Guan,1 Xuejiao Li,1 Yunfeng Li,1 Zhongqiang Huang,1 Ge Li,1 Yuhong Zhao,3 Pinghua Liu,4 Yu Zhang1 1Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, 510663, People’s Republic of China; 2Guangdong Quality Supervision and Testing Station for Medical and Health Care Appliances, Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou, 510632, People’s Republic of China; 3School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China; 4Department of Chemistry, Boston University, Boston, MA, 02215, USA&ast;These authors contributed equally to this workCorrespondence: Yu Zhang; Pinghua Liu, Email zhangyugzh@hotmail.com; pinghua@bu.eduBackground: Ergothioneine (EGT) is an antioxidant, which could be detected in human tissues, and human skin cells could utilize EGT and play an anti-oxidative role in keratinocytes. And in this study we are going to elucidate whether EGT could protect the skin from photoaging by Ultraviolet (UV) exposure in mice and its molecule pathway.Methods: Histological analysis was performed for evaluating the skin structure change. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were measured with biological assay for evaluating oxidative and antioxidative ability of skin exposed to UV light. And the level of marker molecules in mouse skin were detected by hydroxyproline (Hyp) assay, immunohistochemical analysis, Western blot, and quantitative real-time PCR (qRT-PCR). The markers of skin aging and cell death were tested by cell culture and treatment, Western blot and qRT-PCR.Results: EGT decreased the levels of inflammatory factors induced by UV exposure in mouse skin. MDA and SOD activity detection showed that EGT decreased MDA levels, increased SOD activity, and upregulated PI3K/Akt/Nrf2 signals in mouse skin exposed to UV, which further activated Nrf2 in the nucleus and enhanced the expression of Nrf2 target genes. In the cell model, we revealed that EGT could inhibit the increase in senescence-associated β-galactosidase-positive cells and p16 and γ-H2A.X positive cells induced by etoposide and activate PI3K/Akt/Nrf2 signaling. Moreover, a PI3K inhibitor blocked EGT protection against etoposide-induced cell death.Conclusion: The study showed EGT may play an important protective role against cell damage or death through the PI3K/Akt/Nrf2 signaling pathway in skin.Keywords: ergothioneine, skin aging, PI3K/Akt, Nrf2
Published: 2024

41. Preparation of Pueraria lobata Root-Derived Exosome-Like Nanovesicles and Evaluation of Their Effects on Mitigating Alcoholic Intoxication and Promoting Alcohol Metabolism in Mice

Author: Zhang W, Song Q, Bi X, Cui W, Fang C, Gao J, Li J, Wang X, Qu K, Qin X, An X, Zhang C, Zhang X, Yan F, and Wu G
Subjects: pueraria lobata root-derived exosome-like nanovesicles, acute alcoholism, loss of the righting reflex, ethanol metabolism, ferroptosis., Medicine (General), R5-920
Abstract: Wenjin Zhang,1 Qiang Song,1 Xiaofei Bi,1 Wei Cui,1 Chengmei Fang,1 Jianya Gao,1 Jinan Li,1 Xiang Wang,1 Kai Qu,1 Xian Qin,1 Xuan An,2,3 Cheng Zhang,1,3 Xianxiang Zhang,1,3 Fang Yan,4 Guicheng Wu1– 3 1Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic Diseases, Chongqing University Three Gorges Hospital, Chongqing, People’s Republic of China; 2Department of Hepatology, Chongqing University Three Gorges Hospital, Chongqing, People’s Republic of China; 3School of Medicine, Chongqing University, Chongqing, People’s Republic of China; 4Geriatric Diseases Institute of Chengdu, Department of Geriatrics, Chengdu Fifth People’s Hospital, Chengdu, People’s Republic of ChinaCorrespondence: Guicheng Wu, Chongqing University Three Gorges Hospital, Xincheng Road 165&num;, Wanzhou District, Chongqing, 404000, People’s Republic of China, Tel +(86) 58103079, Fax +86 23 581045783, Email wuguicheng@cqu.edu.cn Fang Yan, Geriatric Diseases Institute of Chengdu, Department of Geriatrics, Chengdu Fifth People’s Hospital, Mashi Street 33&num;, Wenjiang District, Chengdu, 611130, People’s Republic of China, Tel/Fax +86 28 82661127, Email fangyan@cdutcm.edu.cnPurpose: Pueraria lobata (P. lobata), a dual-purpose food and medicine, displays limited efficacy in alcohol detoxification and liver protection, with previous research primarily focused on puerarin in its dried roots. In this study, we investigated the potential effects and mechanisms of fresh P. lobata root-derived exosome-like nanovesicles (P-ELNs) for mitigating alcoholic intoxication, promoting alcohol metabolism effects and protecting the liver in C57BL/6J mice.Methods: We isolated P-ELNs from fresh P. lobata root using differential centrifugation and characterized them via transmission electron microscopy, nanoscale particle sizing, ζ potential analysis, and biochemical assays. In Acute Alcoholism (AAI) mice pre-treated with P-ELNs, we evaluated their effects on the timing and duration of the loss of the righting reflex (LORR), liver alcohol metabolism enzymes activity, liver and serum alcohol content, and ferroptosis-related markers.Results: P-ELNs, enriched in proteins, lipids, and small RNAs, exhibited an ideal size (150.7 ± 82.8 nm) and negative surface charge (− 31 mV). Pre-treatment with 10 mg/(kg.bw) P-ELNs in both male and female mice significantly prolonged ebriety time, shortened sobriety time, enhanced acetaldehyde dehydrogenase (ALDH) activity while concurrently inhibited alcohol dehydrogenase (ADH) activity, and reduced alcohol content in the liver and serum. Notably, P-ELNs demonstrated more efficacy compared to P-ELNs supernatant fluid (abundant puerarin content), suggesting alternative active components beyond puerarin. Additionally, P-ELNs prevented ferroptosis by inhibiting the reduction of glutathione peroxidase 4 (GPX4) and reduced glutathione (GSH), and suppressing acyl-CoA synthetase long-chain family member 4 (ACSL4) elevation, thereby mitigating pathological liver lipid accumulation.Conclusion: P-ELNs exhibit distinct exosomal characteristics and effectively alleviate alcoholic intoxication, improve alcohol metabolism, suppress ferroptosis, and protect the liver from alcoholic injury. Consequently, P-ELNs hold promise as a therapeutic agent for detoxification, sobriety promotion, and prevention of alcoholic liver injury.Keywords: Pueraria lobata root-derived exosome-like nanovesicles, acute alcoholism, loss of the righting reflex, ethanol metabolism, ferroptosis
Published: 2024

42. Clinical Predictors of Bacteremia Outcome After Initial Empirical Antimicrobial Therapy in Patients with Hematological Malignancies: A Retrospective Analysis

Author: Gao J, Zheng J, Zhang H, Wang J, and Jing H
Subjects: antimicrobial resistance, mortality, risk factors, initial clinical response, Infectious and parasitic diseases, RC109-216
Abstract: Jinjie Gao,1 Jiajia Zheng,2 Hua Zhang,3 Jijun Wang,1 Hongmei Jing1 1Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, 100191, People’s Republic of China; 2Department of Laboratory Medicine, Peking University Third Hospital, Beijing, 100191, People’s Republic of China; 3Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, 100191, People’s Republic of ChinaCorrespondence: Hongmei Jing, Tel +86-010-82266785, Email hongmeijing@bjmu.edu.cnObjective: We performed a retrospective analysis to investigate the clinical predictors of bacteremia outcome involving Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) after initial empirical antimicrobial therapy among hematological malignancy cases.Methods: This retrospective study was conducted between April 2018 and April 2023. All bloodstream infections (BSIs) caused by E. coli and K. pneumoniae in hospitalized hematological malignancy (HM) patients were identified. Data on patient demographics, clinical characteristics, empirical antimicrobial treatment, outcomes and the antimicrobial susceptibility were collected from medical records. Multivariate analyses were utilized to assess the risk factors for all-cause mortality within 28 days and carbapenem resistance. Optimal cutoffs for continuous predictive variables were evaluated by receiver operating characteristic (ROC) curve analysis.Results: Among 61 individuals diagnosed with bacteremia, 39 cases were caused by E. coli bacteremia, while the remaining 22 were identified as K. pneumoniae bacteremia. Out of these, there were 10 cases of carbapenem-resistant Enterobacteriaceae (CRE) and 12 cases resulted in all-cause mortality within 28 days. Analysis indicated that Pitt score was an independent risk factor for mortality and a cut-off of 2.5 was a reliable predictor with 83.3% sensitivity and 85.7% specificity, respectively. Impaired mental status and elevated body temperature exceeding 38.6°C as well as a procalcitonin (PCT) level over 8.24 ng/mL on the third day (d3) after antimicrobial treatment were identified as independent risk factors for predicting carbapenem resistance.Conclusion: We found that Pitt score with a cut-off of 2.5 was a reliable predictor for mortality within 28 days in HM bacteremia cases. Impaired mental status and elevated temperature exceeding 38.6°C as well as a procalcitonin (PCT) level over 8.24 ng/mL on d3 after antimicrobial treatment were identified as predictive risk factors to carbapenem resistance.Keywords: antimicrobial resistance, mortality, risk factors, initial clinical response
Published: 2024

43. Distributional Characteristics Analysis of Allergens in Patients with Allergic Rhinitis in Southern Fujian Province, China

Author: He J, Gao J, Zhao Y, and Chen S
Subjects: allergic rhinitis, allergen, skin prick test, southern fujian province in china, Immunologic diseases. Allergy, RC581-607
Abstract: Jingjing He,1– 3 Jing Gao,1– 3 Yan Zhao,4 Shuai Chen1,3 1Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, People’s Republic of China; 2Teaching Hospital of Fujian Medical University, Xiamen, 361003, People’s Republic of China; 3Xiamen Key Laboratory of Otolaryngology Head and Neck Surgery, Xiamen, 361003, People’s Republic of China; 4Army 73rd Group Military Hospital, Chenggong Hospital Affiliated to Xiamen University, Xiamen, 361000, People’s Republic of ChinaCorrespondence: Shuai Chen, Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Xiamen University, School of Medicine, No. 55, Zhenhai Road, Siming District, Xiamen, 361005, People’s Republic of China, Email chenshuai@xmu.edu.cn Yan Zhao, Army 73rd group military hospital, Chenggong Hospital Affiliated to Xiamen University, No. 92-96, Wenyuan Road, Siming District, Xiamen, 361000, People’s Republic of China, Email 46330926@qq.comBackground: Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa. However, few studies focus on the distributional characteristics of allergens in AR patients in Southern Fujian Province, China.Methods: A skin prick test (SPT) was performed and eight common allergens including Dermatophagoides farinae (Df), Dermatophagoides pteronyssinus (Dpt), weeds, animal dander, molds, cockroaches, and mangoes were chosen.Results: The positive reactions rate to the allergens was 65.79% in 6689 patients in Southern Fujian Province. Positive reactions to Df and Dpt had a negative association with age, whereas positive reactions to cockroach and weed had a positive association with age. A linear trend analysis demonstrated a significant positive relationship between positive reactions to various allergens from 2016 to 2019. Positive reactions to Df and Dpt were both correlated with the season. Positive reactions to Df, Dpt, cockroach and weed were related to disease duration and positive reactions to cockroach were correlated with city residence. Multivariate analysis revealed that male positive reactions gradually decreased with age (≤ 60), in contrast to female (≤ 60) positive reactions. Statistical difference was observed between the genders with regard to AR incidence from 2016 to 2019. The positive rate of skin tests was highest in summer in men, whereas in women it was lowest in summer. The gender composition ratios of positive cases in Xiamen, Zhangzhou, and Quanzhou cities differed significantly. The proportion of patients with positive reactions to the allergens in the three cities decreased with age. The highest proportions of patients with positive reactions all occurred during summer in the three cities. Furthermore, there were statistically significant differences in the age composition ratios across the seasons.Conclusion: This study analyzed the distributional characteristics of AR allergens in Southern Fujian Province, China. These findings will inform specific immunotherapy for AR patients.Keywords: allergic rhinitis, allergen, skin prick test, Southern Fujian Province in China
Published: 2024

44. Genomic Insights into the First Emergence of blaNDM-5-Carrying Carbapenem-Resistant Salmonella enterica Serovar London Strain in China

Author: Tan S, Li X, Lu B, Lin Y, Cai Y, He J, Chen S, Gao J, and Qiang X
Subjects: blandm-5, salmonella london, st155, carbapenem resistance, incfib, integron, Infectious and parasitic diseases, RC109-216
Abstract: Shaohua Tan,1,&ast; Xiangchen Li,2,&ast; Bing Lu,1,3 Yibin Lin,3 Yunxiang Cai,1 Jie He,4 Sisi Chen,2 Junli Gao,2 Junshun Gao,2 Xinhua Qiang1 1Department of Clinical Laboratory, The First People’s Hospital of Huzhou, Huzhou, Zhejiang, 313000, People’s Republic of China; 2Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou, Zhejiang, 310020, People’s Republic of China; 3School of Medicine, Huzhou University, Huzhou, Zhejiang, 313000, People’s Republic of China; 4Department of Infectious Diseases, The First People’s Hospital of Huzhou, Huzhou, Zhejiang, 313000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xinhua Qiang, Department of Clinical Laboratory, The First People’s Hospital of Huzhou, No. 158 Back Square Road, Wuxing District, Huzhou, Zhejiang, 313000, People’s Republic of China, Email qiangxinhua@zjhu.edu.cnAbstract: Carbapenem-resistant Salmonella enterica (S. enterica) pose a significant threat to public health, causing gastroenteritis and invasive infections. We report the first emergence of a carbapenem-resistant S. enterica serovar London strain, A132, carrying the blaNDM-5 gene in China. Whole-genome sequencing and bioinformatics analysis assigned A132 to be ST155, a multidrug-resistant clone frequently reported in China. The strain A132 exhibited resistance to multiple antibiotics, with 20 acquired antibiotic resistance genes (ARGs) identified, predominantly located on the IncFIB plasmid (pA132-1-NDM). Notably, the blaNDM-5 gene was located within an IS 26 flanked-class 1 integron-ISCR1 complex, comprising two genetic cassettes. One cassette is the class 1 integron, which may facilitate the transmission of the entire complex, while the other is the blaNDM-5-containing ISCR1-IS 26-flanked cassette, carrying multiple other ARGs. Genbank database search based on the blaNDM-5-carrying cassette identified a similar genetic context found in transmissible IncFIA plasmids from Escherichia coli (p91) and Enterobacter hormaechei (p388) with a shared host range, suggesting the potential for cross-species transmission of blaNDM-5. To our knowledge, this is the first reported case of Salmonella serovar London ST155 harboring blaNDM-5 gene. Phylogenetic analysis indicated a close relationship between A132 and eight S. London ST155 strains isolated from the same province. However, A132 differed by carrying the blaNDM-5 gene and four unique ARGs. Given the high transmissibility of the F-type plasmid harboring blaNDM-5 and 18 other ARGs, it is imperative to implement vigilant surveillance and adopt appropriate infection control measures to mitigate the threat to public health.Keywords: blaNDM-5, Salmonella London, ST155, carbapenem resistance, IncFIB, integron
Published: 2024

45. Efficacy and Safety of Kuoxin Formula in the Treatment of Dilated Cardiomyopathy-Related Heart Failure: Study Protocol of a Randomized, Double-Blind, Placebo-Controlled, Multi-Center Clinical Trial

Author: Wu Q, An S, Lee R, Gao D, Zhou Y, Peng L, Hu C, Yao L, Zhou C, Zhou L, Gao J, Cao M, Mao M, Li G, Deng B, Xu Y, and Wang Y
Subjects: dilated cardiomyopathy, heart failure, kuoxin formula, traditional chinese medicine, clinical trials, Medicine (General), R5-920
Abstract: Qiong Wu,1,&ast; Shiying An,1,&ast; RueyJyh Lee,1 Dongwen Gao,2 Yinyifan Zhou,1 Longping Peng,1 Chunrui Hu,1 Lei Yao,3 Chang Zhou,4 Li Zhou,5 Junjie Gao,6 Min Cao,1 Meijiao Mao,1 Guanghao Li,1 Bing Deng,1 Yingjia Xu,4 Youhua Wang1 1Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Ultrasound, Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 3Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 4Department of Cardiology, Shanghai Fifth People’s Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China; 5Department of Cardiology, Shanghai Jiading Nanxiang Hospital, Shanghai, People’s Republic of China; 6Department of Cardiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yingjia Xu, Shanghai Fifth People’s Hospital, Fudan University, Minhang District, 128 Ruili Road, Shanghai, 200240, People’s Republic of China, Tel +862164308151, Email xuyingjia@5thhospital.com Youhua Wang, Department of cardiology, Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Xunhui, 725 South Wan-Ping Road, Shanghai, 200032, People’s Republic of China, Tel +862164385700, Email doctorwyh@163.comBackground: Dilated cardiomyopathy (DCM) is a severe heterogeneous cardiomyopathy characterized by cardiac enlargement and declining heart function, often leading to refractory heart failure and life-threatening outcomes, particularly prevalent in China. The challenge lies in the scarcity of targeted therapies with substantial efficacy for DCM. Additionally, traditional anti-heart failure drugs are constrained due to hypotension propensity or limited symptom improvement. Kuoxin Formula (KXF), internally endorsed at Longhua Hospital, demonstrates clear biological evidence for enhancing cardiac function and myocardial remodeling. Previous clinical studies suggest its potential to enhance patients’ quality of life. This trial aims to further evaluate KXF’s safety and efficacy in managing DCM-related heart failure.Methods: This prospective, randomized, double-blind, placebo-controlled, multicenter trial aims to recruit 230 DCM patients from five centers. Participants will be randomly assigned to either KXF or placebo for 12 weeks, with careful monitoring of key indicators and adverse events. The primary outcome measures the proportion of patients with NT-proBNP reduction exceeding 30%. Secondary outcomes include New York Heart Association functional classification, Traditional Chinese Medicine syndrome scores, 6-minute walk test, Lee’s heart failure score, and Minnesota Heart Failure Quality of Life Scale score. Ventricular remodeling will be assessed using cardiac ultrasound and ELISA. Safety metrics and adverse events will be meticulously recorded.Discussion: This study will be the first multicentered research conducted in China that utilizes a randomized, double-blind, placebo-controlled design to investigate the use of TCM in the treatment of DCM. It seeks to develop new theoretical frameworks and provide solid clinical data to support the integration of TCM and modern medicine in treating heart failure in DCM patients.Trial Registration: China Clinical Trial Registry, ChiCTR2300068937. Registered on March 1, 2023. https://www.chictr.org.cn/bin/project/edit?pid=190926.Keywords: dilated cardiomyopathy, heart failure, Kuoxin Formula, traditional Chinese medicine, clinical trials
Published: 2024

46. Knowledge, Attitudes, and Practices Among Elderly CHD Patients Towards Self-Perceived Health Abilities

Author: Ren L, Li Z, Wu J, Duan L, and Gao J
Subjects: knowledge, attitudes, practices, cross-dimensional study, coronary heart disease, self-perceived health abilities, Medicine (General), R5-920
Abstract: Li Ren, Zhaoling Li, Ji Wu, Lian Duan, Jialiang Gao Cardiovascular Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, People’s Republic of ChinaCorrespondence: Li Ren, Cardiovascular Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Address: No. 5, Beixiange, Xicheng District, Beijing, 100053, People’s Republic of China, Tel +86 18600697916, Email renlirl7961@hotmail.comObjective: This study aimed to assess the knowledge, attitudes and practices (KAP) among elderly coronary heart disease (CHD) patients toward self-perceived health abilities.Methods: This web-based study was carried out between April 2023 and September 2023 at Guang’anmen Hospital, China Academy of Chinese Medical Sciences. A self-developed questionnaire was utilized to collect demographic information from elderly CHD patients, and evaluate their KAP towards self-perceived health abilities.Results: A total of 568 valid questionnaires were collected. Among the participants, the average age was 65.97± 5.50 years, and 298 (52.46%) were female, and the mean scores for knowledge, attitudes, and practices were 6.34± 2.29 (possible range: 0– 9), 35.24± 4.99 (possible range: 9– 45), and 27.79± 10.09 (possible range: 9– 45), respectively. The structural equation model demonstrated that elderly CHD patients’ knowledge directly affects attitudes and practices, with path coefficient of 0.93 (P< 0.001) and 0.39 (P=0.033), respectively. Moreover, attitudes play an intermediary role between knowledge and practice with path coefficient of 0.75 (P< 0.001). Furthermore, residence directly affects knowledge with path coefficient of 0.67 (P< 0.001), cardiac function directly affects knowledge with path coefficient of − 0.97 (P< 0.001) and history of interventional therapy directly affects practice with path coefficient of 4.23 (P< 0.001).Conclusion: Elderly CHD patients demonstrated sufficient knowledge, positive attitudes, and proactive practices towards self-perceived health abilities. However, educational programs and behavior modification are recommended, particularly for elderly with lower age and education, living in rural areas, lacking interventional therapy, obese, or taking multiple CHD medications.Keywords: knowledge, attitudes, practices, cross-dimensional study, coronary heart disease, self-perceived health abilities
Published: 2024

47. Clinical Value of the Diagonal Earlobe Crease in Patients with Chest Pain for Diagnosing Coronary Heart Disease

Author: Gao J, Dou J, Yang HH, Guo RL, Jiang C, Tse G, Liu T, Liu JW, and Luo DL
Subjects: coronary heart disease, diagonal earlobe crease, coronary angiography, model, Medicine (General), R5-920
Abstract: Jie Gao,1,&ast; Jie Dou,1,&ast; Hui-Hui Yang,1 Ruo-Ling Guo,1 Chao Jiang,1 Gary Tse,2– 4 Tong Liu,2 Jian-Wei Liu,5 Dong-Lei Luo6 1Chengde Medical University, Chengde, 067000, People’s Republic of China; 2Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, 300211, People’s Republic of China; 3School of Nursing and Health Studies, Hong Kong Metropolitan University, Hong Kong, 999077, People’s Republic of China; 4Epidemiology Research Unit, Cardiovascular Analytics Group, PowerHealth Limited, Hong Kong, 999077, People’s Republic of China; 5Department of Cardiothoracic Interventional Vascular Surgery, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde, Hebei, 067000, People’s Republic of China; 6Department of Cardiology, Chengde Central Hospital / Second Clinical College of Chengde Medical University, Chengde, 067000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Dong-Lei Luo, Department of Cardiology, Chengde Central Hospital / Second Clinical College of Chengde Medical University, Chengde, 067000, People’s Republic of China, Email dongleiluocn@aliyun.com Jian-Wei Liu, Department of Cardiothoracic Interventional Vascular Surgery, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde, Hebei, 067000, People’s Republic of China, Email Ljw2112@126.comPurpose: To investigate the clinical application value of diagonal earlobe crease (DELC) in patients with chest pain for the diagnosis of coronary heart disease (CHD) and to construct a risk model by multivariate logistic regression.Patients and Methods: Our trial enrolled prospectively and consecutively 706 chest pain patients with suspected CHD between January 2021 to June 2023 from Chengde Central Hospital. According to coronary angiography results, they were categorized into the CHD (n=457) and non-CHD groups (n=249).Results: The trial demonstrated a significant positive relationship between DELC and CHD. Independent risk factors were sex, age, hypertension, diabetes mellitus, LP (a), Cys C, and DELC, whilst HDL-C was a protective factor, for CHD. Patients with-DELC were older than those in the without-DELC arm (P< 0.001) and had a higher proportion of males than females (61.6% vs 50.0%, P=0.026). After multifactorial correction, independent risk factors for CHD included DELC (OR=1.660, 95% CI:1.153 to 2.388, P=0.006), age (OR=1.024, 95% CI:1.002 to 1.045, P=0.030), gender (OR=1.702, 95% CI:1.141 to 2.539, P=0.009), hypertension (OR=1.744, 95% CI:1.226 to 2.482, P=0.002), diabetes mellitus (OR=2.113, 95% CI:1.404 to 3.179, P< 0.001), LP(a) (OR=1.010, 95% CI:1.003 to 1.017, P=0.005), Cys C (OR=3.549, 95% CI:1.605 to 7.846, P=0.002). The Hosmer and Lemeshow (H-L) test (P=0.818) suggests a high goodness of fit, and the area under the ROC curve was calculated to be 0.721 (95% CI:0.682 to 0.760, P< 0.001), which demonstrates that the model has a superior diagnostic value for CHD.Conclusion: DELC is an independent risk factor for CHD after adjusting for sex, age, hypertension, diabetes mellitus, smoking index, LP (a), Cys C, and HDL-C. Our model can be used clinically for assessing the risk of CHD.Keywords: coronary heart disease, diagonal earlobe crease, coronary angiography, model
Published: 2024

48. Unveiling Intricacies of DIEP Breast Reconstruction Post Early Breast Cancer: A Deep Dive into a Case of Unforeseen Complications

Author: Xie L, Kong X, and Gao J
Subjects: breast cancer, nsm, diep, breast reconstruction, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Li Xie,1,&ast; Xiangyi Kong,1,2,&ast; Jidong Gao1,2 1Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, People’s Republic of China; 2Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jidong Gao, Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, People’s Republic of China, Email ab168@cicams.ac.cnAbstract: In the vast expanse of restorative surgical procedures, the Deep Inferior Epigastric Perforator (DIEP) flap, originating from the inferior epigastric artery, has emerged as the preferred method of breast reconstruction, attributable to its myriad advantages. The technique provides reliable vascular supply, robust tissue volume for excision, minimal invasiveness to the donor site, with direct closure and concealment of the said site. This paper embarks on an elaborate elucidation of the DIEP surgical procedure, pivoting on the analytical exploration of a particular instance where necrosis of the skin flap occurred following immediate DIEP breast reconstruction in a patient diagnosed with early-stage breast cancer. This patient had previously undergone Nipple Areola Complex Sparing Mastectomy (NSM). We endeavor to extrapolate insights from this singular case of post-NSM DIEP breast reconstruction failure and correlate our findings with current literature dedicated to similar instances of surgical failure in DIEP breast reconstruction.Keywords: breast cancer, NSM, DIEP, breast reconstruction
Published: 2024

49. High Monocyte-to-Lymphocyte Ratio is Associated with Obstructive Sleep Apnea Hypopnea Syndrome

Author: Bao W, Gao J, Fang S, Zhang S, and Wan Y
Subjects: obstructive sleep apnea hypopnea syndrome, inflammation, monocyte to lymphocyte ratio, polysomnography., Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Wenyu Bao,&ast; Junkang Gao,&ast; Siyu Fang, Shiwei Zhang, Yufeng Wan Department of Otolaryngology, Head and Neck Surgery, Chaohu Hospital Affiliated to Anhui Medical University, Hefei, 238000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yufeng Wan, Department of Otolaryngology, Head and Neck Surgery, Chaohu Hospital Affiliated to Anhui Medical University, Hefei, 238000, People’s Republic of China, Email Wanyufeng135@126.comObjective: This study aims to explore the correlation between serum monocyte-to-lymphocyte ratio (MLR) and other inflammatory parameters with the occurrence of obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients.Methods: This study included 310 patients who underwent polysomnography monitoring at our hospital between January 2021 and January 2023. Routine blood inflammatory parameters and polysomnography (PSG) results were also evaluated. The differences in inflammatory markers between the OSAHS and normal groups were compared, and OSAHS independent related factors were screened.Results: The MLR of OSAHS group was significantly higher than that of control group, and the difference was statistically significant. Multivariate logistic regression analysis suggested that MLR is an independent risk factor for OSAHS.Conclusion: High MLR was correlated with OSAHS. The diagnostic value of MLR was better than that of the other inflammatory parameters.Keywords: obstructive sleep apnea hypopnea syndrome, inflammation, monocyte to lymphocyte ratio, polysomnography
Published: 2024

50. Measurement of t-channel production of single top quarks and antiquarks in pp collisions at 13 TeV using the full ATLAS Run 2 data sample

Author: Aad, G., Abbott, B., Abeling, K., Abicht, N. J., Abidi, S. H., Aboulhorma, A., Abramowicz, H., Abreu, H., Abulaiti, Y., Abusleme Hoffman, A. C., Acharya, B. S., Adam Bourdarios, C., Adamczyk, L., Adamek, L., Addepalli, S. V., Addison, M. J., Adelman, J., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agaras, M. N., Agarwala, J., Aggarwal, A., Agheorghiesei, C., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ahuja, S., Ai, X., Aielli, G., Aikot, A., Ait Tamlihat, M., Aitbenchikh, B., Aizenberg, I., Akbiyik, M., Åkesson, T. P. A., Akimov, A. V., Akiyama, D., Akolkar, N. N., Al Khoury, K., Alberghi, G. L., Albert, J., Albicocco, P., Albouy, G. L., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, F., Algren, M., Alhroob, M., Ali, B., Ali, H. M. J., Ali, S., Alibocus, S. W., Aliev, M., Alimonti, G., Alkakhi, W., Allaire, C., Allbrooke, B. M. M., Allen, J. F., Allendes Flores, C. A., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Alvarez Estevez, M., Alvarez Fernandez, A., Alves Cardoso, M., Alviggi, M. G., Aly, M., Amaral Coutinho, Y., Ambler, A., Amelung, C., Amerl, M., Ames, C. G., Amidei, D., Amor Dos Santos, S. P., Amos, K. R., Ananiev, V., Anastopoulos, C., Andeen, T., Anders, J. K., Andrean, S. Y., Andreazza, A., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Anulli, F., Aoki, M., Aoki, T., Aparisi Pozo, J. A., Aparo, M. A., Aperio Bella, L., Appelt, C., Apyan, A., Aranzabal, N., Arcangeletti, C., Arce, A. T. H., Arena, E., Arguin, J-F., Argyropoulos, S., Arling, J.-H., Arnaez, O., Arnold, H., Artoni, G., Asada, H., Asai, K., Asai, S., Asbah, N. A., Assamagan, K., Astalos, R., Atashi, S., Atkin, R. J., Atkinson, M., Atmani, H., Atmasiddha, P. A., Augsten, K., Auricchio, S., Auriol, A. D., Austrup, V. A., Avolio, G., Axiotis, K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Bachiu, A., Backman, F., Badea, A., Bagnaia, P., Bahmani, M., Bailey, A. J., Bailey, V. R., Baines, J. T., Baines, L., Bakalis, C., Baker, O. K., Bakos, E., Bakshi Gupta, D., Balakrishnan, V., Balasubramanian, R., Baldin, E. M., Balek, P., Ballabene, E., Balli, F., Baltes, L. M., Balunas, W. K., Balz, J., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Bansal, S., Barak, L., Barakat, M., Barberio, E. L., Barberis, D., Barbero, M., Barends, K. N., Barillari, T., Barisits, M-S., Barklow, T., Baron, P., Baron Moreno, D. A., Baroncelli, A., Barone, G., Barr, A. J., Barr, J. D., Barranco Navarro, L., Barreiro, F., Barreiro Guimarães da Costa, J., Barron, U., Barros Teixeira, M. G., Barsov, S., Bartels, F., Bartoldus, R., Barton, A. E., Bartos, P., Basan, A., Baselga, M., Bassalat, A., Basso, M. J., Basson, C. R., Bates, R. L., Batlamous, S., Batley, J. R., Batool, B., Battaglia, M., Battulga, D., Bauce, M., Bauer, M., Bauer, P., Bazzano Hurrell, L. T., Beacham, J. B., Beau, T., Beauchemin, P. H., Becherer, F., Bechtle, P., Beck, H. P., Becker, K., Beddall, A. J., Bednyakov, V. A., Bee, C. P., Beemster, L. J., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Beirer, J. F., Beisiegel, F., Belfkir, M., Bella, G., Bellagamba, L., Bellerive, A., Bellos, P., Beloborodov, K., Belyaev, N. L., Benchekroun, D., Bendebba, F., Benhammou, Y., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Bergeaas Kuutmann, E., Berger, N., Bergmann, B., Beringer, J., Bernardi, G., Bernius, C., Bernlochner, F. U., Bernon, F., Berry, T., Berta, P., Berthold, A., Bertram, I. A., Bessidskaia Bylund, O., Bethke, S., Betti, A., Bevan, A. J., Bhamjee, M., Bhatta, S., Bhattacharya, D. S., Bhattarai, P., Bhopatkar, V. S., Bi, R., Bianchi, R. M., Bianco, G., Biebel, O., Bielski, R., Biglietti, M., Billoud, T. R. V., Bindi, M., Bingul, A., Bini, C., Biondini, A., Birch-sykes, C. J., Bird, G. A., Birman, M., Biros, M., Biryukov, S., Bisanz, T., Bisceglie, E., Biswal, J. P., Biswas, D., Bitadze, A., Bjørke, K., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Blumenthal, J., Bobbink, G. J., Bobrovnikov, V. S., Boehler, M., Boehm, B., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Bomben, M., Bona, M., Boonekamp, M., Booth, C. D., Borbély, A. G., Bordulev, I. S., Borecka-Bielska, H. M., Borgna, L. S., Borissov, G., Bortoletto, D., Boscherini, D., Bosman, M., Bossio Sola, J. D., Bouaouda, K., Bouchhar, N., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Bouquet, R., Boveia, A., Boyd, J., Boye, D., Boyko, I. R., Bracinik, J., Brahimi, N., Brandt, G., Brandt, O., Braren, F., Brau, B., Brau, J. E., Brener, R., Brenner, L., Brenner, R., Bressler, S., Britton, D., Britzger, D., Brock, I., Brooijmans, G., Brooks, W. K., Brost, E., Brown, L. M., Bruce, L. E., Bruckler, T. L., Bruckman de Renstrom, P. A., Brüers, B., Bruni, A., Bruni, G., Bruschi, M., Bruscino, N., Buanes, T., Buat, Q., Buchin, D., Buckley, A. G., Bulekov, O., Bullard, B. A., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burlayenko, O., Burr, J. T. P., Burton, C. D., Burzynski, J. C., Busch, E. L., Büscher, V., Bussey, P. J., Butler, J. M., Buttar, C. M., Butterworth, J. M., Buttinger, W., Buxo Vazquez, C. J., Buzykaev, A. R., Cabrera Urbán, S., Cadamuro, L., Caforio, D., Cai, H., Cai, Y., Cairo, V. M. M., Cakir, O., Calace, N., Calafiura, P., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Calvet, D., Calvet, S., Calvet, T. P., Calvetti, M., Camacho Toro, R., Camarda, S., Camarero Munoz, D., Camarri, P., Camerlingo, M. T., Cameron, D., Camincher, C., Campanelli, M., Camplani, A., Canale, V., Canesse, A., Cantero, J., Cao, Y., Capocasa, F., Capua, M., Carbone, A., Cardarelli, R., Cardenas, J. C. J., Cardillo, F., Carli, T., Carlino, G., Carlotto, J. I., Carlson, B. T., Carlson, E. M., Carminati, L., Carnelli, A., Carnesale, M., Caron, S., Carquin, E., Carrá, S., Carratta, G., Carrio Argos, F., Carter, J. W. S., Carter, T. M., Casado, M. P., Caspar, M., Castiglia, E. G., Castillo, F. L., Castillo Garcia, L., Castillo Gimenez, V., Castro, N. F., Catinaccio, A., Catmore, J. R., Cavaliere, V., Cavalli, N., Cavasinni, V., Cekmecelioglu, Y. C., Celebi, E., Celli, F., Centonze, M. S., Cepaitis, V., Cerny, K., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cervato, B., Cervelli, A., Cesarini, G., Cetin, S. A., Chadi, Z., Chakraborty, D., Chan, J., Chan, W. Y., Chapman, J. D., Chapon, E., Chargeishvili, B., Charlton, D. G., Charman, T. P., Chatterjee, M., Chauhan, C., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chen, A., Chen, B., Chen, B., Chen, H., Chen, H., Chen, J., Chen, J., Chen, M., Chen, S., Chen, S. J., Chen, X., Chen, X., Chen, Y., Cheng, C. L., Cheng, H. C., Cheong, S., Cheplakov, A., Cheremushkina, E., Cherepanova, E., Cherkaoui El Moursli, R., Cheu, E., Cheung, K., Chevalier, L., Chiarella, V., Chiarelli, G., Chiedde, N., Chiodini, G., Chisholm, A. S., Chitan, A., Chitishvili, M., Chizhov, M. V., Choi, K., Chomont, A. R., Chou, Y., Chow, E. Y. S., Chowdhury, T., Chu, K. L., Chu, M. C., Chu, X., Chudoba, J., Chwastowski, J. J., Cieri, D., Ciesla, K. M., Cindro, V., Ciocio, A., Cirotto, F., Citron, Z. H., Citterio, M., Ciubotaru, D. A., Ciungu, B. M., Clark, A., Clark, P. J., Clavijo Columbie, J. M., Clawson, S. E., Clement, C., Clercx, J., Coadou, Y., Cobal, M., Coccaro, A., Coelho Barrue, R. F., Coelho Lopes De Sa, R., Coelli, S., Cohen, H., Coimbra, A. E. C., Cole, B., Collot, J., Conde Muiño, P., Connell, M. P., Connell, S. H., Connelly, I. A., Conroy, E. I., Conventi, F., Cooke, H. G., Cooper-Sarkar, A. M., Cordeiro Oudot Choi, A., Cormier, F., Corpe, L. D., Corradi, M., Corriveau, F., Cortes-Gonzalez, A., Costa, M. J., Costanza, F., Costanzo, D., Cote, B. M., Cowan, G., Cranmer, K., Cremonini, D., Crépé-Renaudin, S., Crescioli, F., Cristinziani, M., Cristoforetti, M., Croft, V., Crosby, J. E., Crosetti, G., Cueto, A., Cuhadar Donszelmann, T., Cui, H., Cui, Z., Cunningham, W. R., Curcio, F., Czodrowski, P., Czurylo, M. M., Da Cunha Sargedas De Sousa, M. J., Da Fonseca Pinto, J. V., Da Via, C., Dabrowski, W., Dado, T., Dahbi, S., Dai, T., Dal Santo, D., Dallapiccola, C., Dam, M., D’amen, G., D’Amico, V., Damp, J., Dandoy, J. R., Daneri, M. F., Danninger, M., Dao, V., Darbo, G., Darmora, S., Das, S. J., D’Auria, S., David, C., Davidek, T., Davis-Purcell, B., Dawson, I., Day-hall, H. A., De, K., De Asmundis, R., De Biase, N., De Castro, S., De Groot, N., de Jong, P., De la Torre, H., De Maria, A., De Salvo, A., De Sanctis, U., De Santo, A., De Vivie De Regie, J. B., Dedovich, D. V., Degens, J., Deiana, A. M., Del Corso, F., Del Peso, J., Del Rio, F., Deliot, F., Delitzsch, C. M., Della Pietra, M., Della Volpe, D., Dell’Acqua, A., Dell’Asta, L., Delmastro, M., Delsart, P. A., Demers, S., Demichev, M., Denisov, S. P., D’Eramo, L., Derendarz, D., Derue, F., Dervan, P., Desch, K., Deutsch, C., Di Bello, F. A., Di Ciaccio, A., Di Ciaccio, L., Di Domenico, A., Di Donato, C., Di Girolamo, A., Di Gregorio, G., Di Luca, A., Di Micco, B., Di Nardo, R., Diaconu, C., Diamantopoulou, M., Dias, F. A., Dias Do Vale, T., Diaz, M. A., Diaz Capriles, F. G., Didenko, M., Diehl, E. B., Diehl, L., Díez Cornell, S., Diez Pardos, C., Dimitriadi, C., Dimitrievska, A., Dingfelder, J., Dinu, I-M., Dittmeier, S. J., Dittus, F., Djama, F., Djobava, T., Djuvsland, J. I., Doglioni, C., Dohnalova, A., Dolejsi, J., Dolezal, Z., Dona, K. M., Donadelli, M., Dong, B., Donini, J., D’Onofrio, A., D’Onofrio, M., Dopke, J., Doria, A., Dos Santos Fernandes, N., Dougan, P., Dova, M. T., Doyle, A. T., Draguet, M. A., Dreyer, E., Drivas-koulouris, I., Drobac, A. S., Drozdova, M., Du, D., du Pree, T. A., Dubinin, F., Dubovsky, M., Duchovni, E., Duckeck, G., Ducu, O. A., Duda, D., Dudarev, A., Duden, E. R., D’uffizi, M., Duflot, L., Dührssen, M., Dülsen, C., Dumitriu, A. E., Dunford, M., Dungs, S., Dunne, K., Duperrin, A., Duran Yildiz, H., Düren, M., Durglishvili, A., Dwyer, B. L., Dyckes, G. I., Dyndal, M., Dysch, S., Dziedzic, B. S., Earnshaw, Z. O., Eberwein, G. H., Eckerova, B., Eggebrecht, S., Egidio Purcino De Souza, E., Ehrke, L. F., Eigen, G., Einsweiler, K., Ekelof, T., Ekman, P. A., El Farkh, S., El Ghazali, Y., El Jarrari, H., El Moussaouy, A., Ellajosyula, V., Ellert, M., Ellinghaus, F., Elliot, A. A., Ellis, N., Elmsheuser, J., Elsing, M., Emeliyanov, D., Enari, Y., Ene, I., Epari, S., Erdmann, J., Erland, P. A., Errenst, M., Escalier, M., Escobar, C., Etzion, E., Evans, G., Evans, H., Evans, L. S., Evans, M. O., Ezhilov, A., Ezzarqtouni, S., Fabbri, F., Fabbri, L., Facini, G., Fadeyev, V., Fakhrutdinov, R. M., Falciano, S., Falda Ulhoa Coelho, L. F., Falke, P. J., Faltova, J., Fan, C., Fan, Y., Fang, Y., Fanti, M., Faraj, M., Farazpay, Z., Farbin, A., Farilla, A., Farooque, T., Farrington, S. M., Fassi, F., Fassouliotis, D., Faucci Giannelli, M., Fawcett, W. J., Fayard, L., Federic, P., Federicova, P., Fedin, O. L., Fedotov, G., Feickert, M., Feligioni, L., Fellers, D. E., Feng, C., Feng, M., Feng, Z., Fenton, M. J., Fenyuk, A. B., Ferencz, L., Ferguson, R. A. M., Fernandez Luengo, S. I., Fernoux, M. J. V., Ferrando, J., Ferrari, A., Ferrari, P., Ferrari, R., Ferrere, D., Ferretti, C., Fiedler, F., Filipčič, A., Filmer, E. K., Filthaut, F., Fiolhais, M. C. N., Fiorini, L., Fisher, W. C., Fitschen, T., Fitzhugh, P. M., Fleck, I., Fleischmann, P., Flick, T., Flores, M., Flores Castillo, L. R., Flores Sanz De Acedo, L., Follega, F. M., Fomin, N., Foo, J. H., Forland, B. C., Formica, A., Forti, A. C., Fortin, E., Fortman, A. W., Foti, M. G., Fountas, L., Fournier, D., Fox, H., Francavilla, P., Francescato, S., Franchellucci, S., Franchini, M., Franchino, S., Francis, D., Franco, L., Franconi, L., Franklin, M., Frattari, G., Freegard, A. C., Freund, W. S., Frid, Y. Y., Friend, J., Fritzsche, N., Froch, A., Froidevaux, D., Frost, J. A., Fu, Y., Fujimoto, M., Fullana Torregrosa, E., Fung, K. Y., Furtado De Simas Filho, E., Furukawa, M., Fuster, J., Gabrielli, A., Gabrielli, A., Gadow, P., Gagliardi, G., Gagnon, L. G., Gallas, E. J., Gallop, B. J., Gan, K. K., Ganguly, S., Gao, J., Gao, Y., Garay Walls, F. M., Garcia, B., García, C., Garcia Alonso, A., Garcia Caffaro, A. G., García Navarro, J. E., Garcia-Sciveres, M., Gardner, G. L., Gardner, R. W., Garelli, N., Garg, D., Garg, R. B., Gargan, J. M., Garner, C. A., Gasiorowski, S. J., Gaspar, P., Gaudio, G., Gautam, V., Gauzzi, P., Gavrilenko, I. L., Gavrilyuk, A., Gay, C., Gaycken, G., Gazis, E. N., Geanta, A. A., Gee, C. M., Gemme, C., Genest, M. H., Gentile, S., Gentry, A. D., George, S., George, W. F., Geralis, T., Gessinger-Befurt, P., Geyik, M. E., Ghani, M., Ghneimat, M., Ghorbanian, K., Ghosal, A., Ghosh, A., Ghosh, A., Giacobbe, B., Giagu, S., Giani, T., Giannetti, P., Giannini, A., Gibson, S. M., Gignac, M., Gil, D. T., Gilbert, A. K., Gilbert, B. J., Gillberg, D., Gilles, G., Gillwald, N. E. K., Ginabat, L., Gingrich, D. M., Giordani, M. P., Giraud, P. F., Giugliarelli, G., Giugni, D., Giuli, F., Gkialas, I., Gladilin, L. K., Glasman, C., Gledhill, G. R., Glemža, G., Glisic, M., Gnesi, I., Go, Y., Goblirsch-Kolb, M., Gocke, B., Godin, D., Gokturk, B., Goldfarb, S., Golling, T., Gololo, M. G. D., Golubkov, D., Gombas, J. P., Gomes, A., Gomes Da Silva, G., Gomez Delegido, A. J., Gonçalo, R., Gonella, G., Gonella, L., Gongadze, A., Gonnella, F., Gonski, J. L., González Andana, R. Y., González de la Hoz, S., Gonzalez Fernandez, S., Gonzalez Lopez, R., Gonzalez Renteria, C., Gonzalez Rodrigues, M. 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Published: 2024
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