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Zi-Wei Yu,1,&ast; Sheng-Dan Pu,2,&ast; Xiao-Tong Sun,2 Xi-Chang Wang,1 Xin-Yuan Gao,2 Zhong-Yan Shan1 1Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhong-Yan Shan; Xin-Yuan Gao, Tel +8613804905018 ; +8613904517001, Email cmushanzhongyan@163.com; m15124768260@163.comPurpose: The prevalence of mild cognitive impairment (MCI) in patients with type 2 diabetes (T2D) is rapidly increasing. Thyroid hormones are key regulators of cognitive function in adults. The purpose of this study was to investigate the relationship between thyroid hormone sensitivity and MCI in euthyroid T2D patients.Patients and Methods: A total of 400 euthyroid T2D patients were enrolled in this cross-sectional study, including 218 patients with normal cognition and 182 MCI patients. The Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive function. The free triiodothyronine to free thyroxine (FT3/FT4) ratio was calculated as a measure of peripheral sensitivity to thyroid hormones; the thyroid-stimulating hormone index (TSHI), thyrotrophic thyroxine resistance index (TT4RI) and thyroid feedback quantile-based index (TFQI) were calculated as measures of central sensitivity to thyroid hormones. Linear regression analysis and logistic regression analysis were performed to explore the relationships between these indices of thyroid hormone sensitivity and the MoCA score and MCI, respectively.Results: Compared with the normal cognitive function group, patients in the MCI group had higher TSHI, TT4RI and TFQI but a lower FT3/FT4 ratio (P< 0.05). The MoCA score was positively correlated with the FT3/FT4 ratio but negatively correlated with TSHI, TT4RI and TFQI (P< 0.05). Multivariate logistic regression analysis showed that a low FT3/FT4 ratio and high TSHI, TT4RI and TFQI were independently associated with MCI (P< 0.05). After adjustment for confounding factors, the odds ratio (OR) for the association between MCI and the highest tertile of the FT3/FT4 was 0.455 (95% CI: 0.264– 0.785), for the highest tertile of TSHI, the OR was 2.380 (95% CI: 1.376– 4.119), for the highest tertile of TT4RI, the OR was 2.342 (95% CI:1.353– 4.054), and for the highest tertile of TFQI, the OR was 2.536 (95% CI: 1.466– 4.387) (P< 0.05).Conclusion: Impaired sensitivity to thyroid hormones is associated with MCI in euthyroid T2D patients.Keywords: type 2 diabetes, mild cognitive impairment, thyroid hormones, sensitivity to thyroid hormones

Yi-Tong Zhang,&ast; Hui-Yao Li,&ast; Xiao-Tong Sun, Xue-Wei Tong, Yong-Yan Shan, Yu-Xin Xu, Sheng-Dan Pu, Xin-Yuan Gao Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xin-Yuan Gao, Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, People’s Republic of China, Email 15124768260@163.comBackground: Diabetic retinopathy (DR) is strongly associated with cardiovascular disease, which is a risk factor for sudden cardiac death (SCD). The index of cardiac electrophysiological balance (iCEB) and the frontal QRS-T angle are recommended to predict the risk of ventricular arrhythmias more than other ECG parameters. However, the relationships between these two markers and DR have not yet been explored. The aim of this study was to investigate the variation in the iCEB, corrected iCEB (iCEBc) and frontal QRS-T angle in different stages of DR and determine whether there are associations between these markers and DR.Methods: The sample comprised 665 patients with Type 2 diabetes mellitus (T2DM) who were classified into three groups: no DR (NDR), mild to moderate non-proliferative DR (NPDR), and vision-threatening DR (VTDR). Twelve-lead ECG was performed and the QT, QTc, QRS duration, iCEB, iCEBc and frontal QRS-T angle were recorded and compared across the groups.Results: The VTDR group had a significantly higher iCEBc and frontal QRS-T angle than the NDR and NPDR groups. After controlling for confounding variables, the correlations between the iCEBc (OR=2.217, 95% CI=1.464– 3.358, P< 0.001), frontal QRS-T angle (OR=1.017, 95% CI=1.008– 1.025, P< 0.001) and DR risk remained (P< 0.05). Subjects in the fourth iCEBc quartile (adjusted OR=2.612, 95% CI=1.411– 4.834, p=0.002) had a much higher chance of developing DR compared to those in the first quartile. In comparison to the first frontal QRS-T angle quartile, subjects in the third (adjusted OR=1.998, 95% CI=1.167– 3.422, P=0.012) and fourth (adjusted OR=2.430, 95% CI=1.420– 4.160, P=0.001) frontal QRS-T angle quartiles had significantly greater risks of DR.Conclusion: With the progression of DR, the iCEBc and frontal QRS-T angle increase. An increased iCEBc and frontal QRS-T angle are associated with an increased risk of DR.Keywords: type 2 diabetes mellitus, diabetic retinopathy, index of cardiac electrophysiological balance, iCEB, frontal QRS-T angle, ventricular arrhythmia

Xue-Wei Tong, Yi-Tong Zhang, Zi-Wei Yu, Sheng-Dan Pu, Xin Li, Yu-Xin Xu, Yong-Yan Shan, Xin-Yuan Gao First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of ChinaCorrespondence: Xin-Yuan Gao, Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, People’s Republic of China, Tel +86-18846030512, Email m15124768260@163.comBackground: The triglyceride glucose (TyG) index reflects insulin resistance; the latter being associated with mild cognitive impairment (MCI).Objective: To investigate the clinical value of the TyG index to identify MCI in patients living with type 2 diabetes (T2D) using a cross-sectional study.Methods: This cross-sectional study was performed on 517 patients with T2D. The diagnosis of MCI was based on criteria established by the National Institute on Aging-Alzheimer’s Association workgroup, and patients were divided into the MCI group and the normal cognitive function (NCF) group. The logistic regression analysis determines whether the TyG index is related to MCI. Subsequently, we constructed the receiver operating characteristic curve (ROC) and calculated the area under the curve (AUC). The nomogram model of the influence factor was established and verified.Results: Compared to the type 2 diabetes-normal cognitive function (T2D-NCF) group, the MCI subjects were olderand had higher TyG indexes, lower cognitive scores, and lower education levels (p < 0.01). After adjusting for the confounders, the TyG index was associated with MCI (OR = 7.37, 95% CI = 4.72– 11.50, p < 0.01), and TyG-BMI was also associated with MCI (OR = 1.02, 95% CI = 1.01– 1.02, p< 0.01). The TyG index AUC was 0.79 (95% CI = 0.76– 0.83). The consistency index of the nomogram was 0. 83[95% CI (0. 79, 0. 86)].Conclusion: Our results indicate that the TyG index and TyG-BMI are associated with MCI in T2D patients, and the TyG index is an excellent indicator of the risk of MCI in T2D patients. The nomogram incorporating the TyG index is useful to predict MCI risk in patients with T2D.Keywords: triglyceride glucose index, TyG, mild cognitive impairment, MCI, insulin resistance, IR, type 2 diabetes, T2D

Xin Li,&ast; Hui-Yao Li,&ast; Zi-Wei Yu, Yi-Tong Zhang, Xue-Wei Tong, Xin-Yuan Gao The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xin-Yuan GaoDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of ChinaTel +86 13904517001Email 15369337970@163.comBackground and Aim: Obesity often coexists with diabetes, especially abdominal obesity, recognized as a risk factor for diabetic complications. Diabetic retinopathy (DR), as one of the most common microvascular complications of diabetes, may be associated with these indices. Lipid accumulation product (LAP) and Chinese visceral obesity index (CVAI) are novel visceral obesity indicators, which have been proven to be an influential factor predicting type 2 diabetes (T2DM). However, the correlation among LAP, CVAI, and DR still lacks systematic research in T2DM. The study aimed to explore the relationship among LAP, CVAI levels in different DR stages of T2DM patients and the diagnostic efficacy of LAP and CVAI for DR.Methods: A total of 263 participants were recruited in this cross-sectional study. We enrolled 169 patients with T2DM, divided into the non-DR group (NDR, n = 61), non-proliferative DR group (NPDR, n = 55), and proliferative DR group (PDR, n = 53). And we also enrolled 94 healthy control participants. We collected demographic, anthropometric, and biochemical data on each subject. LAP and CVAI are calculated according to different formulas for men and women.Results: Compared with the control group, LAP and CVAI were significantly higher (P < 0.05). After adjusting for confounding factors, LAP (OR: 1.029, 95CI%: 1.010– 1.049, P < 0.05), WC (OR: 1.073, 95CI%: 1.009– 1.141, P < 0.05) and CVAI (OR: 1.017, 95CI%: 1.000– 1.033, P < 0.05) were all associated with an increased risk of DR. Furthermore, increased LAP (OR: 1.020, 95% CI: 0.100– 0.290) is associated with DR severity (P < 0.001). Moreover, the LAP had the most significant area under the receiver operating characteristics (ROC) curve (AUC) (AUC = 0.728, 95% CI: 0.653– 0.804).Conclusion: A high LAP is associated with an increased risk of DR in T2DM patients, and the LAP index appears to be a good predictor of DR risk and severity in patients with T2DM, compared with BMI, WC, and CVAI.Keywords: lipid accumulation product, LAP, Chinese visceral obesity index, CVAI, diabetic retinopathy, DR, abdominal/visceral obesity

By analyzing 2.93 fb$^{-1}$ data collected at the center-of-mass energy$\sqrt s=3.773$ GeV with the BESIII detector, we measure the absolute branchingfraction of the semileptonic decay $D^+\rightarrow\bar K^0 e^{+}\nu_{e}$ to be${\mathcal B}(D^{+}\rightarrow\bar K^0 e^{+}\nu_{e})=(8.59 \pm 0.14 \pm0.21)\%$ using $\bar K^0\to K^0_S\to \pi^0\pi^0$, where the first uncertaintyis statistical and the second systematic. Our result is consistent withprevious measurements within uncertainties.

By analyzing 2.93 fb$^{-1}$ data collected at the center-of-mass energy$\sqrt s=3.773$ GeV with the BESIII detector, we measure the absolute branchingfraction of the semileptonic decay $D^+\rightarrow\bar K^0 e^{+}\nu_{e}$ to be${\mathcal B}(D^{+}\rightarrow\bar K^0 e^{+}\nu_{e})=(8.59 \pm 0.14 \pm0.21)\%$ using $\bar K^0\to K^0_S\to \pi^0\pi^0$, where the first uncertaintyis statistical and the second systematic. Our result is consistent withprevious measurements within uncertainties.

A search for radiative decays of the P-wave spin singlet charmonium resonance h_{c} is performed based on 4.48×10^{8} ψ^{'} events collected with the BESIII detector operating at the BEPCII storage ring. Events of the reaction channels h_{c}→γη^{'} and γη are observed with a statistical significance of 8.4σ and 4.0σ, respectively, for the first time. The branching fractions of h_{c}→γη^{'} and h_{c}→γη are measured to be B(h_{c}→γη^{'})=(1.52±0.27±0.29)×10^{-3} and B(h_{c}→γη)=(4.7±1.5±1.4)×10^{-4}, respectively, where the first errors are statistical and the second are systematic uncertainties.

From 2011 to 2014, the BESIII experiment collected about 5 fb-1 data at center-of-mass energies around 4 GeV for the studies of the charmonium-like and higher excited charmonium states. By analyzing the di-muon process e+e- → γISR/FSRμ+μ-, the center-of-mass energies of the data samples are measured with a precision of 0.8 MeV. The center-of-mass energy is found to be stable for most of the time during data taking.

We study the decays of the charmonium resonances J/ψ and ψ(3686) to the final states Ξ-Ξ+, Σ(1385) Σ(1385)± based on a single baryon tag method using data samples of (223.7±1.4)×106 J/ψ and (106.4±0.9)×106 ψ(3686) events collected with the BESIII detector at the BEPCII collider. The decay ψ(3686)→Σ(1385) Σ(1385)± is observed for the first time, and the measurements of the other processes, including the branching fractions and angular distributions, are in good agreement with, and much more precise than, the previously published results. Additionally, the ratios B(ψ(3686)→Ξ-Ξ+)B(J/ψ→Ξ-Ξ+), B(ψ(3686)→Σ(1385)-Σ(1385)+)B(J/ψ→Σ(1385)-Σ(1385)+) and B(ψ(3686)→Σ(1385)+Σ(1385)-)B(J/ψ→Σ(1385)+Σ(1385)-) are determined.

We present the first search for the rare decay of η′ into K±π in J/ψ→φη′, using a sample of 1.3×109 J/ψ events collected with the BESIII detector. No significant signal is observed, and the upper limit at the 90% confidence level for the ratio B(η′→K±π)B(η′→γπ+π-) is determined to be 1.3×10-4. In addition, we report the measurement of the branching fraction of J/ψ→φη′ to be [5.10±0.03(stat)±0.32(syst)]×10-4, which agrees with previous results from BESII.

Using a data sample of 1.31×109 J/ψ events accumulated with the BESIII detector, the decay J/ψ→ppφ is studied via two decay modes, φ→KS0KL0 and φ→K+K-. The branching fraction of J/ψ→pp φ is measured to be B(J/ψ→pp φ)=[5.23±0.06(stat)±0.33(syst)]×10-5, which agrees well with a previously published measurement, but with a significantly improved precision. No evident enhancement near the pp-mass threshold, denoted as X(pp ), is observed, and the upper limit on the branching fraction of J/ψ→X(pp )φ→pp φ is determined to be B(J/ψ→X(pp )φ→pp φ)

Xin-Yi Gao,1– 3,* Yi-Da Wang,4,* Shi-Man Wu,5,* Wen-Ting Rui,5 De-Ning Ma,1 Yi Duan,4 An-Ni Zhang,1– 3 Zhen-Wei Yao,5 Guang Yang,4 Yan-Ping Yu1– 3 1Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, People’s Republic of China; 2Department of Radiology, Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, People’s Republic of China; 3Department of Radiology, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of China; 4Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, Shanghai, People’s Republic of China; 5Department of Radiology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan-Ping YuDepartment of Radiology, Cancer Hospital of the University of Chinese Academy of Sciences, East Banshan Road, 1#, Hangzhou City, Zhejiang Province, People’s Republic of ChinaTel/Fax +86-571-88122222Email yuyanpingdoc@163.comGuang YangDepartment of Physics, Shanghai Key Laboratory of Magnetic Resonance, North Zhongshan Road, 3663#, Shanghai, People’s Republic of ChinaTel/Fax +86-21-62233873Email gyang@phy.ecnu.edu.cnPurpose: We propose three support vector machine (SVM) classifiers, using pre-and post-contrast T2 fluid-attenuated inversion recovery (FLAIR) subtraction and/or pre-and post-contrast T1WI subtraction, to differentiate treatment-related effects (TRE) from glioma recurrence.Materials and Methods: Fifty-six postoperative high-grade glioma patients with suspicious progression after radiotherapy and chemotherapy from two centers were studied. Pre-and post-contrast T1WI and T2 FLAIR were collected. Each pre-contrast image was voxel-wise subtracted from the co-registered post-contrast image. Dataset was randomly split into training, and testing on a 7:3 ratio, accordingly subjected to a five fold cross validation. Best feature subsets were selected by Pearson correlation coefficient and recursive feature elimination, whereupon a radiomics classifier was built with SVM. The discriminating performance was assessed with the area under receiver-operating characteristic curve (AUC), accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV).Results: In all, 186 features were extracted on each subtraction map. Top nine T1WI subtraction features, top thirteen T2 FLAIR subtraction features and top thirteen combination features were selected to build optimal SVM classifiers accordingly. The accuracies/AUCs/sensitivity/specificity/PPV/NPV of SVM based on sole T1WI subtraction were 80.00%/80.00% (CI: 0.5370– 1.0000)/100%/70.00%/62.50%/100%. Those results of SVM based on sole T2 FLAIR subtraction were 86.67%/84.00% (CI: 0.5962– 1.0000)/100%/80%/71.43%/100%. Those results of SVM based on both T1WI subtraction and T2 FLAIR subtraction were 93.33%/94.00% (CI: 0.7778– 1.0000)/100%/90%/83.33%/100%, respectively.Conclusion: Pre- and post-contrast T2 FLAIR subtraction provided added value for diagnosis between recurrence and TRE. SVM based on a combination of T1WI and T2 FLAIR subtraction maps was superior to the sole use of T1WI or T2 FLAIR for differentiating TRE from recurrence. The SVM classifier based on combination of pre-and post-contrast subtraction T2 FLAIR and T1WI imaging allowed for the accurate differential diagnosis of TRE from recurrence, which is of paramount importance for treatment management of postoperative glioma patients after radiation therapy.Keywords: glioma recurrence, treatment-related effects, T2 FLAIR enhancement, image subtraction, support vector machines

Zi-Wei Yu,* Rong Liu,* Xin Li, Ying Wang, Yu-Hong Fu, Hui-Yao Li, Yue Yuan, Xin-Yuan Gao Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin-Yuan Gao Tel +86 13904517001 Email 15369337970@163.comPurpose: Diabetic retinopathy (DR) can increase the risk of mild cognitive impairment (MCI), which has been confirmed by previous researches. With the frequent occurrence of MCI in patients with DR, the early detection of MCI has become a research hot-spot. The aim of this study was to investigate the relationship between neuron-specific enolase (NSE) and MCI in patients with DR.Patients and Methods: A total of 124 patients with DR, including 56 MCI patients and 68 normal cognition patients, were recruited in this cross-sectional study. The demographic and clinical data of patients were collected through questionnaires. Serum NSE was measured using electrochemiluminescence immunoassay. The Minimum Mental State Examination (MMSE) scale was used to evaluate the cognitive function of the participants.Results: Compared with the normal cognition group, serum NSE levels and HbA1c levels in the MCI group were higher, while MMSE scores and educational level were lower (P< 0.05). Serum NSE levels were significantly negatively correlated with MMSE total score, attention and calculation score, and language score (P< 0.05). After adjusting for confounding factors, serum NSE still increased the MCI risk in DR patients (OR:1.606, 95CI%:1.264– 2.041, P< 0.001). The areas under the receiver operating characteristics (ROC) curves (AUC) of the crude model and the adjusted model were 0.75 and 0.73, respectively.Conclusion: A high serum NSE level is an independent risk factor for MCI in DR patients. In addition, serum NSE is expected to be a potential biomarker in DR patients with MCI.Keywords: neuron-specific enolase, mild cognitive impairment, type 2 diabetes mellitus, diabetic retinopathy

Based on 2.93  fb^{-1} e^{+}e^{-} collision data taken at center-of-mass energy of 3.773 GeV by the BESIII detector, we report searches for the singly Cabibbo-suppressed decays D^{+}→ωπ^{+} and D^{0}→ωπ^{0}. A double tag technique is used to measure the absolute branching fractions B(D^{+}→ωπ^{+})=(2.79±0.57±0.16)×10^{-4} and B(D^{0}→ωπ^{0})=(1.17±0.34±0.07)×10^{-4}, with statistical significances of 5.5σ and 4.1σ, where the first and second uncertainties are statistical and systematic, respectively.

By analyzing a data set of 2.92 fb$^{-1}$ of $e^+e^-$ collision data taken at$\sqrt s= 3.773~\rm GeV$ and 106.41$\times 10^{6}$ $\psi(3686)$ decays taken at$\sqrt s= 3.686~\rm GeV$ with the BESIII detector at the BEPCII collider, wemeasure the branching fraction and the partial decay width for$\psi(3770)\to\gamma\chi_{c0}$ to be ${\mathcalB}(\psi(3770)\to\gamma\chi_{c0})=(6.88\pm0.28\pm0.67)\times 10^{-3}$ and$\Gamma[\psi(3770)\to\gamma\chi_{c0}]=(187\pm8\pm19)~\rm keV$, respectively.These are the most precise measurements to date.

We report the first measurement of absolute hadronic branching fractions of Λ_{c}^{+} baryon at the Λ_{c}^{+}Λ[over ¯]_{c}^{-} production threshold, in the 30 years since the Λ_{c}^{+} discovery. In total, 12 Cabibbo-favored Λ_{c}^{+} hadronic decay modes are analyzed with a double-tag technique, based on a sample of 567  pb^{-1} of e^{+}e^{-} collisions at sqrt[s]=4.599  GeV recorded with the BESIII detector. A global least-squares fitter is utilized to improve the measured precision. Among the measurements for twelve Λ_{c}^{+} decay modes, the branching fraction for Λ_{c}^{+}→pK^{-}π^{+} is determined to be (5.84±0.27±0.23)%, where the first uncertainty is statistical and the second is systematic. In addition, the measurements of the branching fractions of the other 11 Cabibbo-favored hadronic decay modes are significantly improved.

We extract the e+e-→π+π- cross section in the energy range between 600 and 900 MeV, exploiting the method of initial state radiation. A data set with an integrated luminosity of 2.93 fb-1 taken at a center-of-mass energy of 3.773 GeV with the BESIII detector at the BEPCII collider is used. The cross section is measured with a systematic uncertainty of 0.9%. We extract the pion form factor |Fπ|2 as well as the contribution of the measured cross section to the leading-order hadronic vacuum polarization contribution to (g-2)μ. We find this value to be aμππ,LO(600-900MeV)=(368.2±2.5stat±3.3sys)10-10, which is between the corresponding values using the BaBar or KLOE data.

By analyzing a data set of 2.92 fb$^{-1}$ of $e^+e^-$ collision data taken at$\sqrt s= 3.773~\rm GeV$ and 106.41$\times 10^{6}$ $\psi(3686)$ decays taken at$\sqrt s= 3.686~\rm GeV$ with the BESIII detector at the BEPCII collider, wemeasure the branching fraction and the partial decay width for$\psi(3770)\to\gamma\chi_{c0}$ to be ${\mathcalB}(\psi(3770)\to\gamma\chi_{c0})=(6.88\pm0.28\pm0.67)\times 10^{-3}$ and$\Gamma[\psi(3770)\to\gamma\chi_{c0}]=(187\pm8\pm19)~\rm keV$, respectively.These are the most precise measurements to date.

We present a measurement of the azimuthal asymmetries of two charged pions in the inclusive process e^{+}e^{-}→ππX, based on a data set of 62  pb^{-1} at the center-of-mass energy of 3.65 GeV collected with the BESIII detector. These asymmetries can be attributed to the Collins fragmentation function. We observe a nonzero asymmetry, which increases with increasing pion momentum. As our energy scale is close to that of the existing semi-inclusive deep inelastic scattering experimental data, the measured asymmetries are important inputs for the global analysis of extracting the quark transversity distribution inside the nucleon and are valuable to explore the energy evolution of the spin-dependent fragmentation function.

Based on data samples collected with the BESIII detector operating at the BEPCII storage ring at center-of-mass energies s>4.4 GeV, the processes e+e-→ωχc1,2 are observed for the first time. With an integrated luminosity of 1074 pb-1 near s=4.42 GeV, a significant ωχc2 signal is found, and the cross section is measured to be (20.9±3.2±2.5) pb. With 567 pb-1 near s=4.6 GeV, a clear ωχc1 signal is seen, and the cross section is measured to be (9.5±2.1±1.3) pb, while evidence is found for an ωχc2 signal. The first errors are statistical, and the second are systematic. Due to low luminosity or low cross section at other energies, no significant signals are observed. In the ωχc2 cross section, an enhancement is seen around s=4.42 GeV. Fitting the cross section with a coherent sum of the ψ(4415) Breit-Wigner function and a phase-space term, the branching fraction B(ψ(4415)→ωχc2) is obtained to be of the order of 10-3.

Using 2.92 fb-1 of electron-positron annihilation data collected at s=3.773 GeV with the BESIII detector, we obtain the first measurements of the absolute branching fraction B(D+→KL0e+νe)=(4.481±0.027(stat)±0.103(sys))% and the CP asymmetry ACPD+→KL0e+νe=(-0.59±0.60(stat)±1.48(sys))%. From the D+→KL0e+νe differential decay rate distribution, the product of the hadronic form factor and the magnitude of the Cabibbo-Kobayashi-Maskawa matrix element, f+K(0)|Vcs|, is determined to be 0.728±0.006(stat)±0.011(sys). Using |Vcs| from the SM constrained fit with the measured f+K(0)|Vcs|, f+K(0)=0.748±0.007(stat)±0.012(sys) is obtained, and utilizing the unquenched Lattice QCD (LQCD) calculation for f+K(0), |Vcs|=0.975±0.008(stat)±0.015(sys)±0.025(LQCD).

A neutral structure in the DD[over ¯]^{*} system around the DD[over ¯]^{*} mass threshold is observed with a statistical significance greater than 10σ in the processes e^{+}e^{-}→D^{+}D^{*-}π^{0}+c.c. and e^{+}e^{-}→D^{0}D[over ¯]^{*0}π^{0}+c.c. at sqrt[s]=4.226 and 4.257 GeV in the BESIII experiment. The structure is denoted as Z_{c}(3885)^{0}. Assuming the presence of a resonance, its pole mass and width are determined to be [3885.7_{-5.7}^{+4.3}(stat)±8.4(syst)]  MeV/c^{2} and [35_{-12}^{+11}(stat)±15(syst)]  MeV, respectively. The Born cross sections are measured to be σ[e^{+}e^{-}→Z_{c}(3885)^{0}π^{0},Z_{c}(3885)^{0}→DD[over ¯]^{*}]=[77±13(stat)±17(syst)]  pb at 4.226 GeV and [47±9(stat)±10(syst)]  pb at 4.257 GeV. The ratio of decay rates B[Z_{c}(3885)^{0}→D^{+}D^{*-}+c.c.]/B[Z_{c}(3885)^{0}→D^{0}D[over ¯]^{*0}+c.c.] is determined to be 0.96±0.18(stat)±0.12(syst), consistent with no isospin violation in the process, Z_{c}(3885)^{0}→DD[over ¯]^{*}.

We study $D_{s}^{+}$ decays to final states involving the $\eta'$ with a482$\,$pb$^{-1}$ data sample collected at $\sqrt{s}$ = 4.009$\,$GeV with the\mbox{BESIII} detector at the BEPCII collider. We measure the branchingfractions $\mathcal{B}(D^+_{s}\rightarrow \eta'X)$ = (8.8$\pm$1.8$\pm$0.5)$\%$and $\mathcal{B}(D_{s}^{+}\rightarrow \eta'\rho^{+})$ = ($5.8\pm1.4\pm0.4$)$\%$where the first uncertainty is statistical and the second is systematic. Inaddition, we estimate an upper limit on the non-resonant branching ratio$\mathcal{B}(D_{s}^{+}\rightarrow \eta'\pi^+\pi^0)

We present a study of the process e+e-→π±(DD¯∗)∓ using data samples of 1092 pb-1 at s=4.23 GeV and 826 pb-1 at s=4.26 GeV collected with the BESIII detector at the BEPCII storage ring. With full reconstruction of the D meson pair and the bachelor π± in the final state, we confirm the existence of the charged structure Zc(3885)∓ in the (DD¯∗)∓ system in the two isospin processes e+e-→π+D0D∗- and e+e-→π+D-D∗0. By performing a simultaneous fit, the statistical significance of Zc(3885)∓ signal is determined to be greater than 10σ, and its pole mass and width are measured to be Mpole=(3881.7±1.6(stat)±1.6(syst)) MeV/c2 and Γpole=(26.6±2.0(stat)±2.1(syst)) MeV, respectively. The Born cross section times the (DD¯∗)∓ branching fraction (σ(e+e-→π±Zc(3885)∓)×Br(Zc(3885)∓→(DD¯∗)∓)) is measured to be (141.6±7.9(stat)±12.3(syst)) pb at s=4.23 GeV and (108.4±6.9(stat)±8.8(syst)) pb at s=4.26 GeV. The polar angular distribution of the π±-Zc(3885)∓ system is consistent with the expectation of a quantum number assignment of JP=1+ for Zc(3885)∓.

We study $D_{s}^{+}$ decays to final states involving the $\eta'$ with a482$\,$pb$^{-1}$ data sample collected at $\sqrt{s}$ = 4.009$\,$GeV with the\mbox{BESIII} detector at the BEPCII collider. We measure the branchingfractions $\mathcal{B}(D^+_{s}\rightarrow \eta'X)$ = (8.8$\pm$1.8$\pm$0.5)$\%$and $\mathcal{B}(D_{s}^{+}\rightarrow \eta'\rho^{+})$ = ($5.8\pm1.4\pm0.4$)$\%$where the first uncertainty is statistical and the second is systematic. Inaddition, we estimate an upper limit on the non-resonant branching ratio$\mathcal{B}(D_{s}^{+}\rightarrow \eta'\pi^+\pi^0)

We report a study of the process e^{+}e^{-}→(D^{*}D[over ¯]^{*})^{0}π^{0} using e^{+}e^{-} collision data samples with integrated luminosities of 1092 pb^{-1} at sqrt[s]=4.23 GeV and 826 pb^{-1} at sqrt[s]=4.26 GeV collected with the BESIII detector at the BEPCII storage ring. We observe a new neutral structure near the (D^{*}D[over ¯]^{*})^{0} mass threshold in the π^{0} recoil mass spectrum, which we denote as Z_{c}(4025)^{0}. Assuming a Breit-Wigner line shape, its pole mass and pole width are determined to be (4025.5_{-4.7}^{+2.0}±3.1) MeV/c^{2} and (23.0±6.0±1.0) MeV, respectively. The Born cross sections of e^{+}e^{-}→Z_{c}(4025)^{0}π^{0}→(D^{*}D[over ¯]^{*})^{0}π^{0} are measured to be (61.6±8.2±9.0) pb at sqrt[s]=4.23 GeV and (43.4±8.0±5.4) pb at sqrt[s]=4.26 GeV. The first uncertainties are statistical and the second are systematic.

Using the data sets taken at center-of-mass energies above 4 GeV by the BESIII detector at the BEPCII storage ring, we search for the reaction e+e-→γISRX(3872)→γISRπ+π-J/ψ via the Initial State Radiation technique. The production of a resonance with quantum numbers JPC=1++ such as the X(3872) via single photon e+e- annihilation is forbidden, but is allowed by a next-to-leading order box diagram. We do not observe a significant signal of X(3872), and therefore give an upper limit for the electronic width times the branching fraction ΓeeX(3872)B(X(3872)→π+π-J/ψ)

In an analysis of a 2.92 fb-1 data sample taken at 3.773 GeV with the BESIII detector operated at the BEPCII collider, we measure the absolute decay branching fractions B(D0→K-e+νe)=(3.505±0.014±0.033)% and B(D0→π-e+νe)=(0.295±0.004±0.003)%. From a study of the differential decay rates we obtain the products of hadronic form factor and the magnitude of the Cabibbo-Kobayashi- Maskawa (CKM) matrix element f+K(0)|Vcs|=0.7172±0.0025±0.0035 and f+π(0)|Vcd|=0.1435±0.0018±0.0009. Combining these products with the values of |Vcs(d)| from the SM constraint fit, we extract the hadronic form factors f+K(0)=0.7368±0.0026±0.0036 and f+π(0)=0.6372±0.0080±0.0044, and their ratio f+π(0)/f+K(0)=0.8649±0.0112±0.0073. These form factors and their ratio are used to test unquenched lattice QCD calculations of the form factors and a light cone sum rule (LCSR) calculation of their ratio. The measured value of f+K(π)(0)|Vcs(d)| and the lattice QCD value for f+K(π)(0) are used to extract values of the CKM matrix elements of |Vcs|=0.9601±0.0033±0.0047±0.0239 and |Vcd|=0.2155±0.0027±0.0014±0.0094, where the third errors are due to the uncertainties in lattice QCD calculations of the form factors. Using the LCSR value for f+π(0)/f+K(0), we determine the ratio |Vcd|/|Vcs|=0.238±0.004±0.002±0.011, where the third error is from the uncertainty in the LCSR normalization. In addition, we measure form factor parameters for three different theoretical models that describe the weak hadronic charged currents for these two semileptonic decays. All of these measurements are the most precise to date.

© 2015 American Physical Society. Based on a sample of η′ mesons produced in the radiative decay J/ψ→γη′ in 1.31×109J/ψ events collected with the BESIII detector, the decay η′→ωe+e- is observed for the first time, with a statistical significance of 8σ. The branching fraction is measured to be B(η′→ωe+e-)=(1.97±0.34(stat)±0.17(syst))×10-4, which is in agreement with theoretical predictions. The branching fraction of η′→ωγ is also measured to be (2.55±0.03(stat)±0.16(syst))×10-2, which is the most precise measurement to date, and the relative branching fraction B(η′→ωe+e-)B(η′→ωγ) is determined to be (7.71±1.34(stat)±0.54(syst))×10-3.

We report an observation of the process J/ψ→γX(1835)→γK_{S}^{0}K_{S}^{0}η at low K_{S}^{0}K_{S}^{0} mass with a statistical significance larger than 12.9σ using a data sample of 1.31×10^{9} J/ψ events collected with the BESIII detector. In this region of phase space the K_{S}^{0}K_{S}^{0} system is dominantly produced through the f_{0}(980). By performing a partial wave analysis, we determine the spin parity of the X(1835) to be J^{PC}=0^{-+}. The mass and width of the observed X(1835) are 1844±9(stat)_{-25}^{+16}(syst)  MeV/c^{2} and 192_{-17}^{+20}(stat)_{-43}^{+62}(syst)  MeV, respectively, which are consistent with the results obtained by BESIII in the channel J/ψ→γπ^{+}π^{-}η^{'}.

Using data samples collected at center-of-mass energies of √s= 4.009, 4.226, 4.257, 4.358, 4.416, and 4.599 GeV with the BESIII detector operating at the BEPCII storage ring, we search for the isospin violating decay Y(4260) → J/ψηπ0. No signal is observed, and upper limits on the cross section σ(e+e− → J/ψηπ0) at the 90% confidence level are determined to be 3.6, 1.7, 2.4, 1.4, 0.9, and 1.9 pb, respectively.

We report the first observation of the Dalitz decay η’→γe+e−, based on a data sample of 1.31 billion J/ψ events collected with the BESIII detector. The η’ mesons are produced via the J/ψ→γη’ decay process. The ratio Γ(η’→γe+e−)/Γ(η’→γγ) is measured to be (2.13±0.09(stat)±0.07(sys))×10−2. This corresponds to a branching fraction B(η’→γe+e−)=(4.69±0.20(stat)±0.23(sys))×10−4. The transition form factor is extracted and different expressions are compared to the measured dependence on the e+e− invariant mass. The results are consistent with the prediction of the vector meson dominance model.

Using a sample of 1.31×109 J/ψ events collected with the BESIII detector at the BEPCII collider, the decays J/ψ→φπ+π-π0 and J/ψ→φπ0π0π0 are investigated. The isospin-violating decay J/ψ→φπ0f0(980) with f0(980)→ππ is observed for the first time. The width of the f0(980) obtained from the dipion mass spectrum is found to be much smaller than the world average value. In the π0f0(980) mass spectrum, there is evidence of f1(1285) production. By studying the decay J/ψ→φη′, the branching fractions of η′→π+π-π0 and η′→π0π0π0, as well as their ratio, are also measured.

Based on a sample of 1.31×109 J/ψ events collected with the BESIII detector at the BEPCII collider, Dalitz plot analyses of selected 79,625 η→π+π-π0 events, 33,908 η→π0π0π0 events, and 1,888 η′→π0π0π0 events are performed. The measured matrix elements of η→π+π-π0 are in reasonable agreement with previous measurements. The Dalitz plot slope parameters of η→π0π0π0 and η′→π0π0π0 are determined to be -0.055±0.014±0.004 and -0.640±0.046±0.047, respectively, where the first uncertainties are statistical and the second systematic. Both values are consistent with previous measurements, while the precision of the latter one is improved by a factor of 3. Final state interactions are found to have an important role in those decays.

Using a sample of 1.31 billion J/ψ events accumulated with the BESIII detector at the BEPCII collider, we report the observation of the decay J/ψ→φπ0, which is the first evidence for a doubly Okubo-Zweig-Iizuka suppressed electromagnetic J/ψ decay. A clear structure is observed in the K+K- mass spectrum around 1.02 GeV/c2, which can be attributed to interference between J/ψ→φπ0 and J/ψ→K+K-π0 decays. Due to this interference, two possible solutions are found. The corresponding measured values of the branching fraction of J/ψ→φπ0 are [2.94±0.16(stat)±0.16(syst)]×10-6 and [1.24±0.33(stat)±0.30(syst)]×10-7.

Using 2.92 fb-1 of electron-positron annihilation data collected at √s = 3.773 GeV with the BESIII detector, we report the results of a search for the flavor-changing neutral current process D0 →γγ using a double-tag technique. We find no signal and set an upper limit at 90% confidence level for the branching fraction of B(D0 →γγ)< 3.8 × 10-6. We also investigate D0-meson decay into two neutral pions, obtaining a branching fraction of B(D0 →π0π0)= (8.24 ± 0.21(stat) ± 0.30(syst)) × 10-4, the most precise measurement to date and consistent with the current world average.

Using a sample of 1.06×108ψ(3686) events produced in e+e- collisions at s=3.686 GeV and collected with the BESIII detector at the BEPCII collider, we present studies of the decays ψ(3686)→K-ΛΞ¯++c.c. and ψ(3686)→γK-ΛΞ¯++c.c.. We observe two hyperons, Ξ(1690)- and Ξ(1820)-, in the K-Λ invariant mass distribution in the decay ψ(3686)→K-ΛΞ¯++c.c. with significances of 4.9σ and 6.2σ, respectively. The branching fractions of ψ(3686)→K-ΛΞ¯++c.c., ψ(3686)→K-Σ0Ξ¯++c.c., ψ(3686)→γχcJ→γK-ΛΞ¯++c.c. (J=0, 1, 2), and ψ(3686)→Ξ(1690/1820)-Ξ¯++c.c. with subsequent decay Ξ(1690/1820)-→K-Λ are measured for the first time.

We report a measurement of the branching fraction for ψ(3770)→γχc1 and search for the transition ψ(3770)→γχc2 based on 2.92 fb-1 of e+e- data accumulated at s=3.773 GeV with the BESIII detector at the BEPCII collider. We measure B(ψ(3770)→γχc1)=(2.48±0.15±0.23)×10-3, which is the most precise measurement to date. The upper limit on the branching fraction of ψ(3770)→γχc2 at a 90% confidence level is B(ψ(3770)→γχc2)

Pan Wang,1 Xiao-Yan Gao,1 Si-Qian Yang,1 Zhi-Xin Sun,2,3 Lu-Lu Dian,1 Muhammad Qasim,1,4 Aung Thu Phyo,1,5 Zong-Suo Liang,1 Yan-Fang Sun11College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, People’s Republic of China; 2College of Life Sciences, Wenzhou Medical University, Wenzhou 325035, People’s Republic of China; 3Department of Life Sciences, Zaozhuang No.1 Middle School, Zaozhuang, 277100, People’s Republic of China; 4Institute of Sustainable Halophyte Utilization, University of Karachi, Karachi 75270, Pakistan; 5Department of Biotechnology, Mandalay Technological University, Mandalay 05072, MyanmarPurpose: Jatrorrhizine (JAT) is a natural protoberberine alkaloid, possesses detoxification, bactericidal and hypoglycemic activities. However, its anti-cancer mechanism is not clear. This study aimed to investigate the mechanism of JAT through which inhibits colorectal cancer in HCT-116 and HT-29 cells.Methods: MTT assay and colony formation assay were used to check the cell proliferation ability. Cell apoptosis and cell cycle were measured by Hoechst 33342 staining and flow cytometry, respectively. Cell migration and invasion were detected by scratch wound healing assay and trans-well assay, respectively. Further, expression of related proteins was examined via Western blotting and the in vivo anti-cancer effect of JAT was confirmed by nude mice xenograft model.Results: The research showed that JAT inhibited the proliferation of HCT-116 and HT-29 cells with IC50 values of 6.75±0.29 μM and 5.29±0.13 μM, respectively, for 72 hrs. It has also showed a time dependently, cell cycle arrested in S phase, promoted cell apoptosis and suppressed cell migration and invasion. In addition, JAT inhibited Wnt signaling pathway by reducing β-catenin and increasing GSK-3β expressions. Increased expression of E-cadherin, while decreased N-cadherin, indicating that JAT treatment suppressed the process of cell epithelial–mesenchymal transition (EMT). In HCT-116 nude mice xenograft model, JAT inhibited tumor growth and metastasis, and induced apoptosis of tumor cells.Conclusion: This study demonstrated that JAT efficiently inhibited colorectal cancer cells growth and metastasis, which provides a new point for clinical treatment of colorectal cancer.Keywords: jatrorrhizine (JAT), colorectal cancer (CRC), Wnt/β-catenin signaling, epithelial-mesenchymal transition (EMT), xenograft model

Si-Yu Lin,1,2 Shi-Zhong Zhang,1 Jian-Xiong An,1,2 Xiao-Yan Qian,2 Xin-You Gao,2 Yong Wang,2 Wen-Xing Zhao,2 Derek Eastwood,3 Doris K Cope,4 John P Williams4 1China Three Gorges, University School of Medicine, Yichang, China; 2Department of Anesthesiology, Pain Medicine and Critical Care Medicine, Aviation General Hospital of China Medical University and Beijing Institute of Translational Medicine, Chinese Academy of Sciences, Beijing, China; 3Department of Pain Services, Wirral University Teaching Hospital, Wirral, Merseyside, UK; 4Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Objective: This study was to evaluate the effectiveness of ultrasound-guided percutaneous ozone injections around the cervical dorsal root ganglions of zoster-associated pain (ZAP) patients.Study design: Retrospective comparative study.Settings: The study was conducted at a pain center of a university hospital.Patients and methods: From June 2016 to July 2017, a total number of 30 patients with ZAP were treated with ultrasound-guided percutaneous ozone injection around the cervical dorsal root ganglion (DRG) at the injured nerve level (C2-C8). A volume of 3 mL ozone-oxygen mixture at a concentration of 30 µg/mL was injected into the area around the DRG. Patients were divided into two groups according to their disease duration: group A (at or 3 months). The pain severity was assessed according to a visual analog scale, and imaging changes were evaluated by ultrasound. Patient improvements in pain and neurologic function were evaluated during a follow-up period from 1 to 3 months.Results: The data showed that ozone injections reduced pain in patients with ZAP. However, the success rate of group A was higher than group B. After the injection, the von Frey data demonstrated decreases in both groups, but, there were no significant differences between the groups. Moreover, univariate logistic regression analysis and multivariate regression analysis showed a history of diabetes mellitus had a significant effect on the treatment results.Conclusions: Percutaneous ozone injection around the DRG might be a useful method for treatment-resistant cases of ZAP at the cervical level. Institutional Review Board (IRB) approval number: HK2017-1130. Keywords: herpes zoster, neuropathic pain, post-herpetic neuralgia, ozone injection

Mu-Jun Zhi,1,2,* Kun Liu,1,* Zhou-Li Zheng,1,3 Xun He,1 Tie Li,2 Guang Sun,1,2 Meng Zhang,4 Fu-Chun Wang,2 Xin-Yan Gao,1 Bing Zhu1 1Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2College of Acupuncture and Moxibustion, Changchun University of Chinese Medicine, Changchun, People’s Republic of China; 3College of Acupuncture and Moxibution, Shaanxi University of Chinese Medicine, People’s Republic of China; 4Department of Chinese Medicine, Dongli Hospital of Traditional Chinese Medicine, Tianjin, People’s Republic of China *These authors contributed equally to this work Purpose: To validate and explore the application of a rat model of chronic constriction injury to the partial sciatic nerve in investigation of acupuncture analgesia.Methods: Chronic constriction injury of the sciatic nerve (CCI) and chronic constriction injury of the partial sciatic nerve (CCIp) models were generated by ligating either the sciatic nerve trunk or its branches in rats. Both models were evaluated via paw mechanical withdrawal latency (PMWL), paw mechanical withdrawal threshold (PMWT), nociceptive reflex-induced electromyogram (C-fiber reflex EMG), and dorsal root ganglion immunohistochemistry. Electroacupuncture (EA) was performed at GB30 to study the analgesic effects on neuropathic pain and the underlying mechanisms.Results: Following ligation of the common peroneal and tibial nerves, CCIp rats exhibited hindlimb dysfunction, hind paw shrinkage and lameness, mirroring those of CCI rats (generated by ligating the sciatic nerve trunk). Compared to presurgery measurements, CCIp and CCI modeling significantly decreased the PMWL and PMWT. EA at GB30 increased the PMWL and PMWT in both CCI and CCIp rats. Calcitonin gene-related polypeptide and substance P expressions were apparently increased in both CCI and CCIp groups, but were not different from each other. The C-fiber reflex EMG of the biceps femoris was preserved in CCIp rats, but it could not be recorded in CCI rats on the 5th day after nerve ligation. The C-fiber reflex EMG was reduced at 0, 1, and 2 minutes after EA in CCIp rats, but only at 0 and 1 minute after EA in normal rats.Conclusion: The CCIp model is better than the CCI model for studying acupuncture analgesia on chronic neuropathic pain and the underlying mechanisms. Keywords: neuropathic pain, chronic constriction injury, acupuncture, analgesia, C-fiber reflex