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6. Long COVID Through a Public Health Lens: An Umbrella Review

Author

Nittas, Vasileios, Gao, Manqi, West, Erin A, Ballouz, Tala, Menges, Dominik, Wulf Hanson, Sarah, Puhan, Milo Alan, Nittas, Vasileios, Gao, Manqi, West, Erin A, Ballouz, Tala, Menges, Dominik, Wulf Hanson, Sarah, and Puhan, Milo Alan

Abstract

Objectives: To synthesize existing evidence on prevalence as well as clinical and socio-economic aspects of Long COVID. Methods: An umbrella review of reviews and a targeted evidence synthesis of their primary studies, including searches in four electronic databases, reference lists of included reviews, as well as related article lists of relevant publications. Results: Synthesis included 23 reviews and 102 primary studies. Prevalence estimates ranged from 7.5% to 41% in non-hospitalized adults, 2.3%-53% in mixed adult samples, 37.6% in hospitalized adults, and 2%-3.5% in primarily non-hospitalized children. Preliminary evidence suggests that female sex, age, comorbidities, the severity of acute disease, and obesity are associated with Long COVID. Almost 50% of primary studies reported some degree of Long COVID-related social and family-life impairment, long absence periods off work, adjusted workloads, and loss of employment. Conclusion: Long COVID will likely have a substantial public health impact. Current evidence is still heterogeneous and incomplete. To fully understand Long COVID, well-designed prospective studies with representative samples will be essential. Keywords: COVID-19; long COVID; post COVID-19; prevalence; public healh; review

Published
2022

9. Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR

Author

He, Mingyu, primary, Yan, Gege, additional, Wang, Yang, additional, Gong, Rui, additional, Lei, Hong, additional, Yu, Shuting, additional, He, Xiaoqi, additional, Li, Guanghui, additional, Du, Weijie, additional, Ma, Tianshuai, additional, Gao, Manqi, additional, Yu, Meixi, additional, Liu, Shenzhen, additional, Xu, Zihang, additional, Idiiatullina, Elina, additional, Zagidullin, Naufal, additional, Pavlov, Valentin, additional, Cai, Benzhi, additional, Yuan, Ye, additional, and Yang, Lei, additional

Published
2021
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10. ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1

Author

Han, Zhenbo, primary, Wang, Xiuxiu, additional, Xu, Zihang, additional, Cao, Yang, additional, Gong, Rui, additional, Yu, Yang, additional, Yu, Ying, additional, Guo, Xiaofei, additional, Liu, Shenzhen, additional, Yu, Meixi, additional, Ma, Wenya, additional, Zhao, Yiming, additional, Xu, Juan, additional, Li, Xingda, additional, Li, Shuainan, additional, Xu, Yan, additional, Song, Ruijie, additional, Xu, Binbin, additional, Yang, Fan, additional, Bamba, Djibril, additional, Sukhareva, Natalia, additional, Lei, Hong, additional, Gao, Manqi, additional, Zhang, Wenwen, additional, Zagidullin, Naufal, additional, Zhang, Ying, additional, Yang, Baofeng, additional, Pan, Zhenwei, additional, and Cai, Benzhi, additional

Published
2021
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11. MicroRNA‐92b‐5p modulates melatonin‐mediated osteogenic differentiation of bone marrow mesenchymal stem cells by targeting ICAM‐1

Author

Li, Yuan, primary, Feng, Chao, additional, Gao, Manqi, additional, Jin, Mengyu, additional, Liu, Tianyi, additional, Yuan, Ye, additional, Yan, Gege, additional, Gong, Rui, additional, Sun, Yi, additional, He, Mingyu, additional, Fu, Yutuo, additional, Zhang, Lai, additional, Huang, Qi, additional, Ding, Fengzhi, additional, Ma, Wenya, additional, Bi, Zhenggang, additional, Xu, Chaoqian, additional, Sukhareva, Natalia, additional, Bamba, Djibril, additional, Reiters, Russel, additional, Yang, Fan, additional, Cai, Benzhi, additional, and Yang, Lei, additional

Published
2019
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13. The Long Non-coding RNA-ORLNC1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Fate

Author

Yang, Lei, primary, Li, Yuan, additional, Gong, Rui, additional, Gao, Manqi, additional, Feng, Chao, additional, Liu, Tianyi, additional, Sun, Yi, additional, Jin, Mengyu, additional, Wang, Dawei, additional, Yuan, Ye, additional, Yan, Gege, additional, He, Mingyu, additional, Idiiatullina, Elina, additional, Ma, Wenya, additional, Han, Zhenbo, additional, Zhang, Lai, additional, Huang, Qi, additional, Ding, Fengzhi, additional, Cai, Benzhi, additional, and Yang, Fan, additional

Published
2019
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14. Synergistic anti-tumor effects of arsenic trioxide and blue LED irradiation on human osteosarcoma

Author

Feng, Chao, primary, Gong, Rui, additional, Zheng, Qiuyan, additional, Yan, Gege, additional, He, Mingyu, additional, Lei, Hong, additional, Li, Xingda, additional, Zhang, Lai, additional, Xu, Zihang, additional, Liu, Shenzhen, additional, Yu, Meixi, additional, Ma, Tianshuai, additional, Gao, Manqi, additional, Bamba, Djibril, additional, Idiiatullina, Elina, additional, Zagidullin, Naufal, additional, Pavlov, Valentin, additional, Xu, Chaoqian, additional, Yuan, Ye, additional, and Yang, Lei, additional

Published
2019
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15. MiR-149-3p Regulates the Switch Between Adipogenic and Osteogenic Differentiation of BMSCs by Targeting FTO

Author

Li, Yuan, primary, Gong, Rui, additional, Gao, Manqi, additional, Jin, Mengyu, additional, Liu, Tianyi, additional, Sun, Yi, additional, Fu, Yutuo, additional, Huang, Qi, additional, Zhang, Wenwen, additional, Liu, Shenzhen, additional, Yu, Meixi, additional, Yan, Gege, additional, Feng, Chao, additional, He, Mingyu, additional, Zhang, Lai, additional, Ding, Fengzhi, additional, Ma, Wenya, additional, Bi, Zhenggang, additional, Xu, Chaoqian, additional, Yuan, Ye, additional, Yang, Fan, additional, Cai, Benzhi, additional, and Yang, Lei, additional

Published
2019
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16. The Long Non-coding RNA-ORLNC1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Fate

Author

Yang, Lei, Li, Yuan, Gong, Rui, Gao, Manqi, Feng, Chao, Liu, Tianyi, Sun, Yi, Jin, Mengyu, Wang, Dawei, Yuan, Ye, Yan, Gege, He, Mingyu, Idiiatullina, Elina, Ma, Wenya, Han, Zhenbo, Zhang, Lai, Huang, Qi, Ding, Fengzhi, Cai, Benzhi, and Yang, Fan

Abstract

Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to differentiate into osteoblasts or adipocytes, and the shift between osteogenic and adipogenic differentiation determines bone mass. The aim of this study was to identify whether lncRNAs are involved in the differentiation commitment of BMSCs during osteoporosis. Here, we found ORLNC1, a functionally undefined lncRNA that is highly conserved, which exhibited markedly higher expression levels in BMSCs, bone tissue, and the serum of OVX-induced osteoporotic mice than sham-operated counterparts. Notably, a similar higher abundance of lncRNA-ORLNC1 expression was also observed in the bone tissue of osteoporotic patients. The transgenic mice overexpressing lncRNA-ORLNC1 showed a substantial increase in the osteoporosis-associated bone loss and decline in the osteogenesis of BMSCs. The BMSCs pretreated with lncRNA-ORLNC1-overexpressing lentivirus vector exhibited the suppressed capacity of osteogenic differentiation and oppositely enhanced adipogenic differentiation. We then established that lncRNA-ORLNC1 acted as a competitive endogenous RNA (ceRNA) for miR-296. Moreover, miR-296 was found markedly upregulated during osteoblast differentiation, and it accelerated osteogenic differentiation by targeting Pten. Taken together, our results indicated that the lncRNA-ORLNC1-miR-296-Pten axis may be a critical regulator of the osteoporosis-related switch between osteogenesis and adipogenesis of BMSCs and might represent a plausible therapeutic target for improving osteoporotic bone loss.

Published
2024
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