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Your search keyword '"Gao, Jun-Bo"' showing total 24 results
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24 results on '"Gao, Jun-Bo"'

7. Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19)

Author

Du, Bao-Wen, primary, Zhang, Xing-Jie, additional, Shi, Nan, additional, Peng, Ting, additional, Gao, Jun-Bo, additional, Azimova, Bahtigul, additional, Zhang, Ruihan, additional, Pu, De-Bing, additional, Wang, Chun, additional, Abduvaliev, Anvar, additional, Rakhmanov, Alisher, additional, Zhang, Guo-Lin, additional, Xiao, Wei-Lie, additional, and Wang, Fei, additional

Published
2020
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9. Spiroarborin, an ent-Clerodane Homodimer from Callicarpa arboreaas an Inhibitor of the Eleven-Nineteen Leukemia (ENL) Protein by Targeting the YEATS Domain

Author

Pu, De-Bing, Guo, Si-Qi, Ni, Dong-Xuan, Lin, Jing, Gao, Jun-Bo, Li, Xiao-Ning, Zhang, Rui-Han, Li, Xiao-Li, Luo, Cheng, Chen, Shi-Jie, and Xiao, Wei-Lie

Abstract

A spiro ent-clerodane homodimer with a rare 6/6/6/6/6-fused pentacyclic scaffold, spiroarborin (1), together with four new monomeric analogues (2–5), were isolated from Callicarpa arborea. Their structures were elucidated by comprehensive spectroscopic data analysis, quantum-chemical calculations, and X-ray diffraction. A plausible biosynthetic pathway of 1was proposed, and a biomimetic synthesis of its derivative was accomplished. Compound 1showed a potent inhibitory effect by directly binding to the YEATS domain of the 11-19 leukemia (ENL) protein with an IC50value of 7.3 μM. This gave a KDvalue of 5.0 μM, as recorded by a surface plasmon resonance binding assay.

Published
2022
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12. Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva

Author

Pu, De-Bing, primary, Du, Bao-Wen, additional, Chen, Wen, additional, Gao, Jun-Bo, additional, Hu, Kun, additional, Shi, Nan, additional, Li, Yi-Ming, additional, Zhang, Xing-Jie, additional, Zhang, Rui-Han, additional, Li, Xiao-Nian, additional, Zhang, Hong-Bin, additional, Wang, Fei, additional, and Xiao, Wei-Lie, additional

Published
2018
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18. Callicarpins, Two Classes of Rearranged ent-Clerodane Diterpenoids from CallicarpaPlants Blocking NLRP3 Inflammasome-Induced Pyroptosis

Author

Pu, De-Bing, Zhang, Xing-Jie, Bi, De-Wen, Gao, Jun-Bo, Yang, Yan, Li, Xiao-Li, Lin, Jing, Li, Xiao-Nian, Zhang, Rui-Han, and Xiao, Wei-Lie

Abstract

Callicarpins A–D (1–4), possessing an unprecedented A-homoent-clerodane scaffold with a bicyclo[5.4.0]undecane ring system, and callicarpins E–G (5–7), with 5/6-fused ent-clerodane diterpenoid skeletons, were isolated from Callicarpaarboreaand C. integerrim. Their structures were elucidated by comprehensive spectroscopic data, X-ray crystal diffraction, chemical derivatization, and electronic circular dichroism (ECD) data. Putative biosynthetic pathways for these callicarpins are proposed. Compounds 2, 3b, and 6–8showed potent inhibitory effects against the NLRP3 inflammasome with IC50values from 1.4 to 5.3 μM, and 2significantly blocked NLRP3 inflammasome-induced pyroptosis by inhibiting Casp-1 activation and IL-1β secretion in J774A.1 cells.

Published
2020
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19. Two new phenolic compounds from the seeds of Machilus yunnanensis

Author

Long, Hui, primary, Luo, Dan, additional, Yang, Yan, additional, Zhang, Ling, additional, Pu, De-Bing, additional, Li, Jie, additional, Chen, Xue-Jiao, additional, Zhu, Xu, additional, Liu, Shuang, additional, Gao, Jun-Bo, additional, Wang, Yong-Mei, additional, Ji, Xu, additional, and Xiao, Wei-Lie, additional

Published
2016
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20. Isolation, Characterization, and Structure–Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinierias Spleen Tyrosine Kinase Inhibitors

Author

Gao, Jun-Bo, Yang, Shuang-Jing, Yan, Zi-Ru, Zhang, Xing-Jie, Pu, De-Bing, Wang, Li-Xia, Li, Xiao-Li, Zhang, Rui-Han, and Xiao, Wei-Lie

Abstract

Species belonging to the genus Callicarpaare used traditionally in Chinese medicine for the treatment of inflammation, rheumatism, and pain. Investigation of the leaves and twigs of Callicarpa bodinieriresulted in the isolation of nine new abietane diterpenoids, bodinieric acids A–I (1–9), along with six known compounds (10–15). The structures of 1–9were elucidated on the basis of the interpretation of their HRESIMS and NMR data and by ECD calculations. To explore the potential therapeutic target of this plant for immune-mediated disease, the inhibitory activities of the isolates obtained were determined against 13 kinase enzymes. Eight compounds exhibited moderate inhibitory effects on spleen tyrosine kinase (SYK), and the IC50values of compounds 2and 6were 7.2 and 10.7 μM, respectively. In addition, a preliminary structure–activity relationship of this scaffold was analyzed with both molecular docking and a 3D-QSAR pharmacophore model.

Published
2018
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24. Distribution characteristics, occurrence modes and controlling factors of trace elements in Late Permian coal from Bijie City, Guizhou Province.

Author

CHENG Wei, YANG Rui-dong, ZHANG Qin, CUI Yu-chao, and GAO Jun-bo

Subjects
*SULFUR, *COAL, *TRACE elements, *COAL mining, *COAL industry
Abstract

Based on thirteen exploratory reports for coal mines form Bijie City, Guizhou Province, data about basic coal features such as sulphur content, ash yield, ash composition and concentration of eleven trace elements as Ge, Ga, U, Th, V, Cl, As, F, Pb, Cu and Zn was systematically analyzed and modeled, and the distribution characteristics, occurrence modes and controlling factors of those trace elements in Bijie coal were investigated. In order to obtain a relative accurate content level of those eleven trace elements in Bijie coal, a parameter called "Reserves Weight Coefficient" was applied. Results show that in Bijie coal Pb, Cu, Zn, U and V are abnormally enriched, Ga is relatively enriched, F and Th are slightly enriched while Ge and Cl are both lower than the Clarke Value, concentration of As in Bijie coal is higher than the common Chinese coal but markedly lower than the USA coal. Correlativity analysis reveals that F may occurs in carbonate minerals, Pb and Cu are probably hosted in sulphide minerals and Cu shows a certain degree of organic affinity. Evidence suggests that on the one hand enrichment of Cu, Zn and V in Bijie coal can be attributed to Emeishan basalt in terrigenous province whose content of those three elements are relatively high; on the other hand trace elements enrichment in coal are controlled by sedimentary environment, specifically some elements that migrate easily in continental sedimentation process such as Ge, Ga and Th tend to be of higher content in coal when the seawater influence is weakening. V is enriched in coal when the influence is strong. In addition, some elements' abnormal enrichment in Bijie coal is believed to be linked with the tectonic movement especially hydrothermal fluid. [ABSTRACT FROM AUTHOR]

Published
2013

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