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Objectives: To identify the dermatological system drugs that may be prescribed by Chinese dermatological nurses through expert consensus.

To evaluate the effects of calcium supplementation on bone mineral density in children.

Aim: To assess the effectiveness of decision aids in the treatment, prevention and screening of breast cancer patients. Design: A systematic review and meta‐analysis. Methods: The review protocol was registered in the CRD Prospero database(CRD42020173028). A literature search was carried out in five databases: PubMed, Cochrane, EMBASE, Scopus and Web of science data in January 2020. We used The Cochrane risk bias assessment tool to evaluate the literature quality of included trials and the Review Manager 5.2 software to analyse data. Results: We included 22 studies. Compared with the conventional methods, decision aids reduced treatment decision conflicts and had no significant effect on screening decision conflicts (WMD=−2.25, 95% CI = ‐ 2.64,‐1.87, p <.0001; WMD=−1.37, 95% CI = ‐ 3.57,0.83, p =.22). Three were no statistical differences in participants' anxiety, decision regret, knowledge, informed choice and decision‐making satisfaction between the two groups. [ABSTRACT FROM AUTHOR]

Density functional theory calculations combined with the energy and building-block decomposition analyses have been carried out to investigate the structures, stability orders, redox potentials and proton binding of the six Baker–Figgis isomers (α, β, γ, α*, β* and γ*) of [(SbO6)W18O54(OH)2]9− {H2SbW18} and [(NaF6)W18O54(OH)2]7− {H2NaW18} anions at the level of PBEsol-D3/TZP. Both bonding energy and Gibbs free energy analyses exhibit that the two non-classical Wells–Dawson (WD) species behave quite differently from each other. The pyroanimonate {H2SbW18}, with a stability order of γ* ＞ β* ＞ α ＞ α* ＞ β ＞ γ, is a non-classical WD species, while the hexafluoride {H2NaW18} (α ＞ β ＞ γ ＞ γ* ＞ β* ＞ α*) is a transition intermediate between classical and non-classical WD types, possessing both non-classical ([XW18O60(OH)2]n−, X = I, Te and W) and classical [Si2W18O62]8− properties. Energy decomposition analyses (EDA) reveal that spatial arrangement (Ehost), host–guest fragment interaction energy (FIE), and structural distortion energy (DE) are three key factors governing the relative stability of isomers; among these, DE is always dominant, while FIE and Ehost are subordinated but are still important. Building-block decomposition analyses (BDA) disclose that the octahedral {MO6} units of the equatorial belt, particularly the staggered belt, are always more distorted than those of the two polar caps inside each structure. The theoretical redox potentials demonstrate that the oxidizing power increases with a trend of α ＜ β ＜ γ and α* ＜ β* ＜ γ* for both species, and the first redox potential is closely related to the energy level of the LUMO of each anion. Evaluation of the proton inclusion energies suggests that {H2NaW18} can only embed two protons, while {H2SbW18} may encapsulate four; the number of embedded protons is controlled by both the charge of the heteroatom X and the volume of the tetrahedral {O4}/{OF3} cavity. [ABSTRACT FROM AUTHOR]

As the most important document, the validity of the security target is mostly dependent on the accuracy of security problem definition. However there Is no necessary model and method in the security problem definition process. To reduce the subjectivity, taking IC card international terminal production applied in the online payment as the research object, a method of the threat definition was proposed based on the threat modeling method of the security development lifecycle (SDL) and threat tree analyzing. Furthermore, the definition method and considerations of other contents in security problem definition were illustrated. This paper will lay a foundation for the proposal of accurate security counter-measures in security target. [ABSTRACT FROM AUTHOR]

Dermatomyositis ( DM) is a polygenic disorder characterized by inflammation of skeletal muscle and skin. To date, the exact etiopathogenesis of DM remains elusive. To explore the genetic basis of DM, we conducted genome-wide genotyping analysis of 127 patients and 1566 healthy controls by Illumina Human OmniZhongHua-8 BeadChips in the Chinese Han population. We investigated whether the three SNP (, and ) at 6p21.32 in the HLA- DPB1 gene were significantly associated with DM ( P < 5 × 10−8) and identified two susceptibility loci at 7q34 ( PIP, , P = 7.45 × 10−7, odds ratio [ OR] = 2.71) and 10q24.2 ( CPN1, , P = 9.04 × 10−7, OR = 4.39) with suggestive evidence. We imputed 6674 classical human leukocyte antigen ( HLA) alleles, amino acids and SNP from the discovery dataset, and stepwise analysis revealed that HLA- DPB1*17 in class II HLA genes were significantly associated with DM susceptibility. This study represents the first genome-wide association study ( GWAS) of DM in the Chinese Han population. For the first time, HLA- DPB1 was found to be associated with DM in this population. Moreover, we identified two novel suggestive susceptibility loci ( PIP and CPN1) and confirmed four previously reported genes ( DMB, DQA1, DQB1 and DRB1) having potential associations with DM in the Chinese Han population. Our GWAS results in this population should provide important information regarding the genetic etiopathogenesis of DM and facilitate the development of new therapies for the treatment of DM and the prevention of DM progression. [ABSTRACT FROM AUTHOR]

Based on the features of the forest products trading information, a compound keywords vector space model was utilized to represent the user interest model of the forest products trading information website. Every compound keyword in the vector space consists of three keywords, which are supply and demand classification, the name of the forest product and the production place, and some information about the specifications, price and the company name of the forest products. Every compound keyword has a user interest value. The learning and updating of the user interest model were reaiized through the browsing, registering and releasing behaviors of the users and introducing the forgetting factors for the interest values, respectively. The perssstent interests and the temporary interests of the users were distinguished by introducing a temporary interests group. Finally, the recommendation algorithms based on the contents itering were proposed based on our user interest model, and its advantage was demonstrated by comparison experiments [ABSTRACT FROM AUTHOR]

Psoriasis is a chronic inflammatory disease with a complex genetic architecture. To further advance gene discovery, we extended our genome-wide association study data set of 1,139 cases and 2,234 controls and replicated two independent cohorts of 7,200 cases and 10,491 controls. We identified the missense variant rs2303138 (p.Ala763Thr) within the LNPEP gene associated with psoriasis (Pcombined=1.83 × 10−13, odds ratio=1.16) and validated four previously reported genes: IL28RA, NFKBIA, TRAF3IP2, and CARD14 (9.74 × 10−11P9.37 × 10−5), which confirmed the involvement of the nuclear factor-κB signaling pathway in psoriasis pathogenesis. LNPEP, also named insulin-responsive aminopeptidase, was identified as an angiotensin IV receptor. Protein function prediction suggested that this missense variant of LNPEP was most likely deleterious. Expression analysis showed that LNPEP was significantly downregulated in psoriatic lesions compared with the control skin (P=1.44 × 10−6) and uninvolved patient skin (P=2.95 × 10−4). Pathway analysis indicated that LNPEP was involved in the renin-angiotensin system, which also has a key role in cardiovascular disease and diabetes. These results provided genetic evidence that psoriasis might share common mechanisms with hypertension and diabetes, which was consistent with clinical observations. Our study identified a genetic susceptibility factor and provided genetic evidence of insight into psoriasis pathogenesis with the involvement of the renin-angiotensin system pathway. [ABSTRACT FROM AUTHOR]

A polyoxometalate-templated thiolate-protected silver nanocluster, [Cu 3 (Mo 4 O 16 ) 2 @Ag 55 (CyhS) 43 (CH 3 O)(COOCF 3 )]·3H 2 O, has been isolated under solvothermal conditions. In situ insertion of three Cu 2+ ions into two polymolybdate anions generated a new, sandwich-type D 3h -symmetric [Cu 3 (Mo 4 O 16 ) 2 ] 10- polyoxoanion template encapsulated into an Ag 55 (CyhS) 43 shell. The structure and composition of this Ag nanocluster have been fully characterized. This work has provided a new way to develop high-nuclearity metal nanoclusters with various structures.