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972 results on '"Gao, Fuqiang"'

5. Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke

Author

Yu, Di, Liang, Nuanyi, Zebarth, Julia, Shen, Qing, Ozzoude, Miracle, Goubran, Maged, Rabin, Jennifer S, Ramirez, Joel, Scott, Christopher JM, Gao, Fuqiang, Bartha, Robert, Symons, Sean, Haddad, Seyyed Mohammad Hassan, Berezuk, Courtney, Tan, Brian, Kwan, Donna, Hegele, Robert A, Dilliott, Allison A, Nanayakkara, Nuwan D, Binns, Malcolm A, Beaton, Derek, Arnott, Stephen R, Lawrence‐Dewar, Jane M, Hassan, Ayman, Dowlatshahi, Dar, Mandzia, Jennifer, Sahlas, Demetrios, Casaubon, Leanne, Saposnik, Gustavo, Otoki, Yurika, Lanctôt, Krista L, Masellis, Mario, Black, Sandra E, Swartz, Richard H, Taha, Ameer Y, Swardfager, Walter, Rashkovan, Natalie, Abrahao, Agessandro, Zinman, Lorne, Bonnick, Alisia, Scott, Christopher, Holmes, Melissa, Adamo, Sabrina, Freedman, Morris, Zamyadi, Mojdeh, Arnott, Stephen, Binns, Malcolm, Raamana, Pradeep, Strother, Stephen, Sunderland, Kelly, Theyers, Athena, Uthirakumaran, Abiramy, Levine, Brian, Troyer, Angela, Strong, Michael, Kleinstiver, Peter, Borrie, Michael, Finger, Elizabeth, Shoesmith, Christen, Faria, Frederico, Montero‐Odasso, Manuel, Sarquis‐Adamson, Yanina, Black, Alanna, Dilliott, Allison Ann, Hegele, Rob, Robinson, John, Farhan, Sali, Bartha, Rob, Haddad, Hassan, Nanayakkara, Nuwan, Zou, Guangyong, Pasternak, Stephen, Orange, JB, Roberts, Angela, Jog, Mandar, Seitz, Dallas, Brien, Don, Chen, Ying, Coe, Brian, Munoz, Doug, McLaughlin, Paula, Peltsch, Alicia, Bronskill, Susan, Lou, Wendy, Kumar, Sanjeev, Pollock, Bruce, Rajji, Tarek, Tang‐Wai, David, and Tartaglia, Carmela

Subjects
Biomedical Imaging, Stroke, Brain Disorders, Neurosciences, Humans, Linoleic Acid, Oxylipins, Epoxide Hydrolases, Cerebral Small Vessel Diseases, Magnetic Resonance Imaging, Atrophy, Water, lacunar stroke, oxylipin, small vessel disease, soluble epoxide hydrolase, white matter hyperintensity, ONDRI Investigators [Link], Cardiorespiratory Medicine and Haematology
Abstract

Background Cerebral small vessel disease is associated with higher ratios of soluble-epoxide hydrolase derived linoleic acid diols (12,13-dihydroxyoctadecenoic acid [DiHOME] and 9,10-DiHOME) to their parent epoxides (12(13)-epoxyoctadecenoic acid [EpOME] and 9(10)-EpOME); however, the relationship has not yet been examined in stroke. Methods and Results Participants with mild to moderate small vessel stroke or large vessel stroke were selected based on clinical and imaging criteria. Metabolites were quantified by ultra-high-performance liquid chromatography-mass spectrometry. Volumes of stroke, lacunes, white matter hyperintensities, magnetic resonance imaging visible perivascular spaces, and free water diffusion were quantified from structural and diffusion magnetic resonance imaging (3 Tesla). Adjusted linear regression models were used for analysis. Compared with participants with large vessel stroke (n=30), participants with small vessel stroke (n=50) had a higher 12,13-DiHOME/12(13)-EpOME ratio (β=0.251, P=0.023). The 12,13-DiHOME/12(13)-EpOME ratio was associated with more lacunes (β=0.266, P=0.028) but not with large vessel stroke volumes. Ratios of 12,13-DiHOME/12(13)-EpOME and 9,10-DiHOME/9(10)-EpOME were associated with greater volumes of white matter hyperintensities (β=0.364, P

Published
2023

11. White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

Author

Ozzoude, Miracle, Varriano, Brenda, Beaton, Derek, Ramirez, Joel, Adamo, Sabrina, Holmes, Melissa F., Scott, Christopher J. M., Gao, Fuqiang, Sunderland, Kelly M., McLaughlin, Paula, Goubran, Maged, Kwan, Donna, Roberts, Angela, Bartha, Robert, Symons, Sean, Tan, Brian, Swartz, Richard H., Abrahao, Agessandro, Saposnik, Gustavo, Masellis, Mario, Lang, Anthony E., Marras, Connie, Zinman, Lorne, Shoesmith, Christen, Borrie, Michael, Fischer, Corinne E., Frank, Andrew, Freedman, Morris, Montero-Odasso, Manuel, Kumar, Sanjeev, Pasternak, Stephen, Strother, Stephen C., Pollock, Bruce G., Rajji, Tarek K., Seitz, Dallas, Tang-Wai, David F., Turnbull, John, Dowlatshahi, Dar, Hassan, Ayman, Casaubon, Leanne, Mandzia, Jennifer, Sahlas, Demetrios, Breen, David P., Grimes, David, Jog, Mandar, Steeves, Thomas D. L., Arnott, Stephen R., Black, Sandra E., Finger, Elizabeth, Rabin, Jennifer, and Tartaglia, Maria Carmela

Published
2023
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17. Acoustic emission characteristics of coal rocks under different loading angles

Author

PENG Xiangyuan and GAO Fuqiang

Subjects
acoustic emission, b value, loading angle, ra and af values, degree of fragmentation, Mining engineering. Metallurgy, TN1-997
Abstract

In order to obtain the acoustic emission parameters of different bedding coal and provide reference for the analysis and determination of its fracture mechanism and fracture precursors, the uniaxial compression acoustic emission experimental study of coal samples with bedding angles of 45°, 90° and 0° was carried out, the corresponding relationship between b values of coal samples with different loading angles and stress and energy was analyzed, the variation laws of acoustic emission parameters RA and AF values were studied, and the b value and r value under loading angle of 0 ° were analyzed. The results show that: after the peak stress, a large amount of energy is released, resulting in the penetration of micro cracks into large cracks. The b values of coal samples with loading angles of 45 ° and 90 ° are close to and significantly greater than that of 0 ° coal sample, and the b value of each specimen decreases after reaching the peak stress; when the loading angle is 45 °, the failure form of coal sample is tension shear composite failure. The loading angles of 90 ° and 0 ° are mainly tensile failure; the period of sharp decrease of b value is the same as that of sharp increase of r value, and r value can be used as an index to describe the degree of coal damage.

Published
2023
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22. Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases

Author

Ozzoude, Miracle, Varriano, Brenda, Beaton, Derek, Ramirez, Joel, Holmes, Melissa F., Scott, Christopher J. M., Gao, Fuqiang, Sunderland, Kelly M., McLaughlin, Paula, Rabin, Jennifer, Goubran, Maged, Kwan, Donna, Roberts, Angela, Bartha, Robert, Symons, Sean, Tan, Brian, Swartz, Richard H., Abrahao, Agessandro, Saposnik, Gustavo, Masellis, Mario, Lang, Anthony E., Marras, Connie, Zinman, Lorne, Shoesmith, Christen, Borrie, Michael, Fischer, Corinne E., Frank, Andrew, Freedman, Morris, Montero-Odasso, Manuel, Kumar, Sanjeev, Pasternak, Stephen, Strother, Stephen C., Pollock, Bruce G., Rajji, Tarek K., Seitz, Dallas, Tang-Wai, David F., Turnbull, John, Dowlatshahi, Dar, Hassan, Ayman, Casaubon, Leanne, Mandzia, Jennifer, Sahlas, Demetrios, Breen, David P., Grimes, David, Jog, Mandar, Steeves, Thomas D. L., Arnott, Stephen R., Black, Sandra E., Finger, Elizabeth, and Tartaglia, Maria Carmela

Published
2022
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25. Soluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment

Author

Yu, Di, Hennebelle, Marie, Sahlas, Demetrios J, Ramirez, Joel, Gao, Fuqiang, Masellis, Mario, Cogo-Moreira, Hugo, Swartz, Richard H, Herrmann, Nathan, Chan, Pak Cheung, Pettersen, Jacqueline A, Stuss, Donald T, Black, Sandra E, Taha, Ameer Y, and Swardfager, Walter

Subjects
Aged, Biomarkers, Cerebral Ventricles, Cognitive Dysfunction, Cross-Sectional Studies, Epoxide Hydrolases, Female, Humans, Linoleic Acid, Male, Oxylipins, Vascular Diseases, White Matter, Small vessel disease, Vascular cognitive impairment, Soluble epoxide hydrolase, Linoleic acid, Clinical Sciences, Neurosciences, Public Health and Health Services
Abstract

White matter hyperintensities (WMH) are presumed to indicate subcortical ischemic vascular disease but their underlying pathobiology remains incompletely understood. The soluble epoxide hydrolase (sEH) enzyme converts anti-inflammatory and vasoactive cytochrome p450-derived polyunsaturated fatty acid epoxides into their less active corresponding diol species. Under the hypothesis that the activity of sEH might be associated with subcortical ischemic vascular disease and vascular cognitive impairment, this study aimed to compare the relative abundance of sEH substrates and products in peripheral blood between patients with extensive WMH (discovered due to transient ischemic attack; n = 29) and healthy elderly with minimal WMH (n = 25). The concentration of 12,13-DiHOME (a sEH-derived linoleic acid metabolite), and the ratio of 12,13-DiHOME to its sEH substrate, 12,13-EpOME, were elevated in the extensive WMH group (F1,53 = 5.9, p = 0.019), as was the 9,10-DiHOME/9,10-EpOME ratio (F1,53 = 5.4, p = 0.024). The 12,13-DiHOME/12,13-EpOME ratio was associated with poorer performance on a composite score derived from tests of psychomotor processing speed, attention, and executive function (β = - 0.473, p = 0.001, adjusted r2 = 0.213), but not with a composite verbal memory score. In a mediation model, periventricular WMH (but not deep WMH), explained 37% of the effect of the 12,13-DiHOME/12,13-EpOME ratio on the speed/attention/executive function composite score (indirect effect = - 0.50, 95% bootstrap confidence interval [- 0.99, - 0.17] Z-score units). Serum oxylipin changes consistent with higher sEH activity were markers of vascular cognitive impairment, and this association was partly explained by injury to the periventricular subcortical white matter.

Published
2019

34. Improved Segmentation of the Intracranial and Ventricular Volumes in Populations with Cerebrovascular Lesions and Atrophy Using 3D CNNs

Author

Ntiri, Emmanuel E., Holmes, Melissa F., Forooshani, Parisa M., Ramirez, Joel, Gao, Fuqiang, Ozzoude, Miracle, Adamo, Sabrina, Scott, Christopher J. M., Dowlatshahi, Dar, Lawrence-Dewar, Jane M., Kwan, Donna, Lang, Anthony E., Symons, Sean, Bartha, Robert, Strother, Stephen, Tardif, Jean-Claude, Masellis, Mario, Swartz, Richard H., Moody, Alan, Black, Sandra E., and Goubran, Maged

Published
2021
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37. MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease

Author

Strong, Michael, Kleinstiver, Peter, Rashkovan, Natalie, Bronskill, Susan, Black, Sandra E., Borrie, Michael, Finger, Elizabeth, Fischer, Corinne, Frank, Andrew, Freedman, Morris, Kumar, Sanjeev, Pasternak, Stephen, Pollock, Bruce, Rajji, Tarek, Seitz, Dallas, Tang-Wai, David, Tartaglia, Carmela, Varriano, Brenda, Abrahao, Agessandro, Chum, Marvin, Shoesmith, Christen, Turnbull, John, Zinman, Lorne, Lawrence-Dewar, Jane, Kwan, Donna, Tan, Brian, Fraser, Julia, McIlroy, Bill, Cornish, Ben, Van Ooteghem, Karen, Faria, Frederico, Montero-Odasso, Manuel, Sarquis-Adamson, Yanina, Black, Alanna, Greenberg, Barry, Hatch, Wendy, Hudson, Chris, Leontieva, Elena, Margolin, Ed, Mandelcorn, Efrem, Tayyari, Faryan, Defrawy, Sherif, Brien, Don, Chen, Ying, Coe, Brian, Munoz, Doug, Bonnick, Alisia, Casaubon, Leanne, Dowlatshahi, Dar, Hassan, Ayman, Mandzia, Jennifer, Sahlas, Demetrios, Saposnik, Gustavo, Swartz, Richard H., Breen, David, Grimes, David, Jog, Mandar, Lang, Anthony, Marras, Connie, Masellis, Mario, Steeves, Tom, Bulman, Dennis, Dilliott, Allison Ann, Ghani, Mahdi, Hegele, Rob, Robinson, John, Rogaeva, Ekaterina, Farhan, Sali, Bartha, Rob, Haddad, Hassan, Nanayakkara, Nuwan, Ramirez, Joel, Scott, Christopher, Symons, Sean, Berezuk, Courtney, Holmes, Melissa, Adamo, Sabrina, Ozzoude, Miracle, Zamyadi, Mojdeh, Arnott, Stephen, Beaton, Derek, Binns, Malcolm, Lou, Wendy, Raamana, Pradeep, Strother, Stephen, Sunderland, Kelly, Theyers, Athena, Uthirakumaran, Abiramy, Zou, Guangyong (GY), Sujanthan, Sujeevini, Munoz, David, Dixon, Roger A., Woulfe, John, Levine, Brian, McLaughlin, Paula, Orange, J.B., Peltsch, Alicia, Roberts, Angela, Troyer, Angela, Holmes, Melissa F., Scott, Christopher J.M., Gao, Fuqiang, Yu, Di, Swardfager, Walter, Boulos, Mark I., Murray, Brian J., Bartha, Robert, and Lim, Andrew

Published
2021
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42. Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases.

Author

Andriuta, Daniela, Ottoy, Julie, Ruthirakuhan, Myuri, Feliciano, Ginelle, Dilliott, Allison A., Hegele, Robert A., Gao, Fuqiang, McLaughlin, Paula M., Rabin, Jennifer S., Wood Alexander, Madeline, Scott, Christopher J. M., Yhap, Vanessa, Berezuk, Courtney, Ozzoude, Miracle, Swardfager, Walter, Zebarth, Julia, Tartaglia, M. Carmela, Rogaeva, Ekaterina, Tang‐Wai, David F., and Casaubon, Leanne

Abstract

INTRODUCTION: We investigated the effect of perivascular spaces (PVS) volume on speeded executive function (sEF), as mediated by white matter hyperintensities (WMH) volume and plasma glial fibrillary acidic protein (GFAP) in neurodegenerative diseases. METHODS: A mediation analysis was performed to assess the relationship between neuroimaging markers and plasma biomarkers on sEF in 333 participants clinically diagnosed with Alzheimer's disease/mild cognitive impairment, frontotemporal dementia, or cerebrovascular disease from the Ontario Neurodegenerative Disease Research Initiative. RESULTS: PVS was significantly associated with sEF (c = ‐0.125 ± 0.054, 95% bootstrap confidence interval [CI] [‐0.2309, ‐0.0189], p = 0.021). This effect was mediated by both GFAP and WMH. DISCUSSION: In this unique clinical cohort of neurodegenerative diseases, we demonstrated that the effect of PVS on sEF was mediated by the presence of elevated plasma GFAP and white matter disease. These findings highlight the potential utility of imaging and plasma biomarkers in the current landscape of therapeutics targeting dementia. Highlights: Perivascular spaces (PVS) and white matter hyperintensities (WMH) are imaging markers of small vessel disease.Plasma glial fibrillary protein acidic protein (GFAP) is a biomarker of astroglial injury.PVS, WMH, and GFAP are relevant in executive dysfunction from neurodegeneration.PVS's effect on executive function was mediated by GFAP and white matter disease. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Differential contributions of the hippocampal dentate gyrus and CA1 subfield to mnemonic discrimination.

Author

Mitchnick, Krista A., Marlatte, Hannah, Belchev, Zorry, Gao, Fuqiang, and Rosenbaum, R. Shayna

Subjects
DENTATE gyrus, MNEMONICS, HIPPOCAMPUS (Brain), RECOGNITION (Psychology)
Abstract

Evidence suggests that individual hippocampal subfields are preferentially involved in various memory‐related processes. Here, we demonstrated dissociations in these memory processes in two unique individuals with near‐selective bilateral damage within the hippocampus, affecting the dentate gyrus (DG) in case BL and the cornu ammonis 1 (CA1) subfield in case BR. BL was impaired in discriminating highly similar objects in memory (i.e., mnemonic discrimination) but exhibited preserved overall recognition of studied objects, regardless of similarity. Conversely, BR demonstrated impaired general recognition. These results provide evidence for the DG in discrimination processes, likely related to underlying pattern separation computations, and the CA1 in retention/retrieval. [ABSTRACT FROM AUTHOR]

Published
2024
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