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Novel temperature-sensitive poly( N-isopropylacrylamide) hydrogels containing water-soluble β-cyclodextrin polymer were prepared by forming semi-interpenetrating polymeric networks. Compared to the conventional poly( N-isopropylacrylamide) gel, the β-cyclodextrin-incorporated hydrogels showed the same lower critical solution temperature due to the independence of the β-cyclodextrin polymer in the networks. The release time of ibuprofen from the novel gel was significantly prolonged, which was presumably attributed to the formation of the inclusion complexes between the cyclodextrin groups and the drug molecules.