1. [Disregulation of collateral blood flow and lipid peroxidation abnormalities as a cause of negative influence of emotional stress on the course of cerebral ischemia].
- Author
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Ganushkina IV, Koplik EV, Konorova IL, Antelava AL, and Pirogova GV
- Subjects
- Animals, Brain Ischemia metabolism, Disease Models, Animal, Environment, Free Radicals metabolism, Male, Rats, Rats, Wistar, Brain blood supply, Brain physiopathology, Brain Ischemia etiology, Brain Ischemia physiopathology, Collateral Circulation physiology, Lipid Peroxidation physiology, Stress, Psychological physiopathology
- Abstract
Under normal conditions, local brain blood flow in young rats determined their individual resistance to ischemia and emotional stress. In low-activity rats predisposed to emotional stress, a level of blood flow was significantly (p<0.05) higher, comparing to high-active animals resistant to emotional stress. An exposure of rats to aggressive- and conflict situation for 18 h was followed by pronounced emotional stress accompanied by the reduction of local cerebral blood flow by 10-15% and abolished individual differences in resistance to cerebral ischemia. Collateral blood flow did not develop in pre-stressed rats during the acute period of cerebral ischemia. The mortality rate reached 90% independently of the animal emotional resistance. In ischemia after 2 h exposure to stress, differences were revealed in the intensity of lipid peroxidation in the brain of animals with divergent emotional resistance. Comparing to stress-resistant rats, in stress-predisposed animals, a level of malonic dialdehyde in the amygdale basal nuclei was 2-fold lower. The results suggest the differences in stress response in animals with various resistance to the effect of adverse factors.
- Published
- 2004