1. Children with Chronic Hepatitis B in the United States and Canada
- Author
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Schwarz, Kathleen B, Cloonan, Yona Keich, Ling, Simon C, Murray, Karen F, Rodriguez-Baez, Norberto, Schwarzenberg, Sarah Jane, Teckman, Jeffrey, Ganova-Raeva, Lilia, Rosenthal, Philip, Schwarz, Kathleen, Murray, Karen, Belle, Steven, Janssen, Harry, Ling, Simon, Terrault, Norah, Roberts, Lewis R, Di Bisceglie, Adrian, Teckman, Jeffery, Ganova-Raeva, Lilia Milkova, Li, Hongxia, Mogul, Douglas, Anders, Robert, Kafka, Kim, Riggs, Shannon M, Nagy, Rosemary, Cerkoski, Jacki, Yuan, Caitlin, Swan, Rosemary, O'Connor, Constance, Rodgers-Augustyniak, Laurie A, Montanye, Shirley, Fleck, Shannon, Langlois, Camille, Cooper, Kara L, Danielson, Michelle, Haller, Tamara, Johnson, Geoffrey, Kelley, Stephanie, Lawlor, Sharon, Li, Ruosha, Lombardero, Manuel, MacGregor, Joan M, Pelesko, Andrew, Stoliker, Donna, Walters, Barbara, and Zadorozny, Ella
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Hepatitis - B ,Hepatitis ,Liver Disease ,Digestive Diseases ,Chronic Liver Disease and Cirrhosis ,Genetics ,Infectious Diseases ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Adolescent ,Canada ,Child ,Child ,Preschool ,Cross-Sectional Studies ,Female ,Genotype ,Hepatitis B virus ,Hepatitis B ,Chronic ,Humans ,Infant ,Male ,United States ,Hepatitis B Research Network ,Human Movement and Sports Sciences ,Paediatrics and Reproductive Medicine ,Pediatrics ,Paediatrics - Abstract
ObjectivesTo test the hypothesis that children with chronic hepatitis B living in the US and Canada would have international origins and characteristic hepatitis B virus (HBV) genotypes and laboratory profiles.Study designClinical characteristics of children enrolled in the Hepatitis B Research Network were collected from 7 US and Canadian centers.ResultsChildren (n = 343) with an age range of 1.0-17.8 years were enrolled; 78% of the children were Asian, 55% were adopted, and 97% had international origins with either the child or a parent born in 1 of 31 countries. The majority had HBV genotype B (43%) or C (32%), and the remainder had genotype A (5%), D (16%), E (4%), or multiple (
- Published
- 2015