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395 results on '"Ganne P"'

1. SMCHD1 genetic variants in type 2 facioscapulohumeral dystrophy and challenges in predicting pathogenicity and disease penetrance

Author

Gérard, Laurène, Delourme, Mégane, Tardy, Charlotte, Ganne, Benjamin, Perrin, Pierre, Chaix, Charlene, Trani, Jean Philippe, Eudes, Nathalie, Laberthonnière, Camille, Bertaux, Karine, Missirian, Chantal, Bassez, Guillaume, Behin, Anthony, Cintas, Pascal, Cluse, Florent, De La Cruz, Elisa, Delmont, Emilien, Evangelista, Teresinha, Fradin, Mélanie, Hadouiri, Nawale, Kouton, Ludivine, Laforêt, Pascal, Lefeuvre, Claire, Magot, Armelle, Manel, Véronique, Nectoux, Juliette, Pegat, Antoine, Sole, Guilhem, Spinazzi, Marco, Stojkovic, Tanya, Svahn, Juliette, Tard, Celine, Thauvin, Christel, Verebi, Camille, Salort Campana, Emmanuelle, Attarian, Shahram, Nguyen, Karine, Badache, Ali, Bernard, Rafaëlle, and Magdinier, Frédérique

Published
2024
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5. Tumor endothelial cell autophagy is a key vascular‐immune checkpoint in melanoma

Author

Verhoeven, Jelle, Jacobs, Kathryn A, Rizzollo, Francesca, Lodi, Francesca, Hua, Yichao, Poźniak, Joanna, Narayanan Srinivasan, Adhithya, Houbaert, Diede, Shankar, Gautam, More, Sanket, Schaaf, Marco B, Dubroja Lakic, Nikolina, Ganne, Maarten, Lamote, Jochen, Van Weyenbergh, Johan, Boon, Louis, Bechter, Oliver, Bosisio, Francesca, Uchiyama, Yasuo, Bertrand, Mathieu JM, Marine, Jean Christophe, Lambrechts, Diether, Bergers, Gabriele, Agrawal, Madhur, and Agostinis, Patrizia

Published
2023
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6. International survey among hepatologists and pulmonologists on the hepatic hydrothorax: plea for recommendations

Author

Cadranel, Jean-François David, Ollivier-Hourmand, Isabelle, Cadranel, Jacques, Thevenot, Thierry, Zougmore, Honoré, Nguyen-Khac, Eric, Bureau, Christophe, Allaire, Manon, Nousbaum, Jean-Baptiste, Loustaud-Ratti, Véronique, Causse, Xavier, Sogni, Philippe, Hanslik, Bertrand, Bourliere, Marc, Peron, Jean-Marie, Ganne-Carrie, Nathalie, Dao, Thong, Thabut, Dominique, Maitre, Bernard., Debzi, Nabil, Smadhi, Ryad, Sombie, Roger, Kpossou, Raimi, Nouel, Olivier, Bissonnette, Julien, Ruiz, Isaac, Medmoun, Mourad, Dastis, Sergio Negrin, Deltenre, Pierre, Artru, Florent, Raherison, Chantal, Elkrief, Laure, and Lemagoarou, Tristan

Published
2023
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8. Perniosis in the COVID-19 era

Author

Shah, Ishan, Stacey, Stephen K, Ganne, Nandita, and Merfeld, John

Subjects
chilblains, COVID-19, pernio, perniosis, SARS CoV-2, toe
Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) and the most common symptoms include fever, dry cough, dyspnea, fatigue, anorexia, ageusia, and anosmia. Cutaneous manifestations are less common and we share our experience with an otherwise healthy and asymptomatic young man. The patient presented with painless acrocynosis of the left toes which progressed to desquamation by day 16 of disease onset. Disease progression is documented via multiple photographs that portray progression of disease and subsequent resolution over approximately six weeks. Symptomatic treatment included non-steroidal anti-inflammatory medications, leg elevation, and warm compresses.

Published
2021

12. Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding

Author

Waldman, Zachary J., Camarillo-Rodriguez, Liliana, Chervenova, Inna, Berry, Brent, Shimamoto, Shoichi, Elahian, Bahareh, Kucewicz, Michal, Ganne, Chaitanya, He, Xiao-Song, Davis, Leon A., Stein, Joel, Das, Sandhitsu, Gorniak, Richard, Sharan, Ashwini D., Gross, Robert, Inman, Cory S., Lega, Bradley C., Zaghloul, Kareem, Jobst, Barbara C., Davis, Katheryn A., Wanda, Paul, Khadjevand, Mehraneh, Tracy, Joseph, Rizzuto, Daniel S., Worrell, Gregory, Sperling, Michael, and Weiss, Shennan A.

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

Background: We sought to determine if ripple oscillations (80-120Hz), detected in intracranial EEG (iEEG) recordings of epilepsy patients, correlate with an enhancement or disruption of verbal episodic memory encoding. Methods: We defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the relationship between the occurrence of ripple and spike events during word presentation and the odds of successful word recall following a distractor epoch, and included the seizure onset zone (SOZ) as a covariate in the LRMs. Results: We detected events during 58,312 word presentation trials from 7,630 unique electrode sites. The probability of ripple on spike (RonS) events was increased in the seizure onset zone (SOZ, p<0.04). In the left temporal neocortex RonS events during word presentation corresponded with a decrease in the odds ratio (OR) of successful recall, however this effect only met significance in the SOZ (OR of word recall 0.71, 95% CI: 0.59-0.85, n=158 events, adaptive Hochberg p<0.01). Ripple on oscillation events (RonO) that occurred in the left temporal neocortex non-SOZ also correlated with decreased odds of successful recall (OR 0.52, 95% CI: 0.34-0.80, n=140, adaptive Hochberg , p<0.01). Spikes and RonS that occurred during word presentation in the left middle temporal gyrus during word presentation correlated with the most significant decrease in the odds of successful recall, irrespective of the location of the SOZ (adaptive Hochberg, p<0.01). Conclusion: Ripples and spikes generated in left temporal neocortex are associated with impaired verbal episodic memory encoding.

Published
2018

13. High permittivity processed SrTiO3 for metamaterials applications at terahertz frequencies

Author

Dupas, Cyrielle, Guillemet-Fritsch, Sophie, Geffroy, Pierre-Marie, Chartier, Thierry, Baillergeau, Matthieu, Mangeney, Juliette, Ganne, Jean-Pierre, Marcellin, Simon, Degiron, Aloyse, and Akmansoy, Eric

Subjects
Physics - Applied Physics, Physics - Chemical Physics
Abstract

High permittivity SrTiO3 for the realization of all-dielectric metamaterials operating at terahertz frequencies was fabricated. A comparison of different processing routes evidences that Spark Plasma Sintering is the most effective sintering process to yield high density ceramic with high permittivity. We compare this sintering process with two others. The elaborated samples are characterized in the low frequency and in the terahertz frequency ranges. Their relative permittivities are compared with that a reference \sto single crystal. The permittivity of the sample elaborated by Spark Plasma Sintering is as high as that the single crystal., Comment: 13 pages with supplementary material - 4 figures

Published
2017

14. Clinical outcomes after treatment with direct antiviral agents: beyond the virological response in patients with previous HCV-related decompensated cirrhosis

Author

Pageaux, Georges-Philippe, Nzinga, Clovis Lusivika, Ganne, Nathalie, Samuel, Didier, Dorival, Céline, Zoulim, Fabien, Cagnot, Carole, Decaens, Thomas, Thabut, Dominique, Asselah, Tarik, Mathurin, Philippe, Habersetzer, François, Bronowicki, Jean-Pierre, Guyader, Dominique, Rosa, Isabelle, Leroy, Vincent, Chazouilleres, Olivier, de Ledinghen, Victor, Bourliere, Marc, Causse, Xavier, Cales, Paul, Metivier, Sophie, Loustaud-Ratti, Véronique, Riachi, Ghassan, Alric, Laurent, Gelu-Simeon, Moana, Minello, Anne, Gournay, Jérôme, Geist, Claire, Tran, Albert, Abergel, Armand, Portal, Isabelle, d’Alteroche, Louis, Raffi, François, Fontaine, Hélène, Carrat, Fabrice, and Pol, Stanislas

Published
2022
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15. Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis

Author

Meçe, Odeta, Houbaert, Diede, Sassano, Maria-Livia, Durré, Tania, Maes, Hannelore, Schaaf, Marco, More, Sanket, Ganne, Maarten, García-Caballero, Melissa, Borri, Mila, Verhoeven, Jelle, Agrawal, Madhur, Jacobs, Kathryn, Bergers, Gabriele, Blacher, Silvia, Ghesquière, Bart, Dewerchin, Mieke, Swinnen, Johan V., Vinckier, Stefan, Soengas, María S., Carmeliet, Peter, Noël, Agnès, and Agostinis, Patrizia

Published
2022
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22. Spatial solitons in a semiconductor microresonator

Author

Taranenko, V. B., Ganne, I., Kuszelewicz, R. J., and Weiss, C. O.

Subjects
Nonlinear Sciences - Pattern Formation and Solitons
Abstract

We show experimentally the existence of bright and dark spatial solitons in a passive quantum-well-semiconductor resonator of large Fresnel number. For the wavelength of observation the nonlinearity is mixed absorptive/defocusing. Bright solitons appear more stable than dark ones., Comment: 4 pages with 7 figures

Published
2000

23. Patterns and localized structures in bistable semiconductor resonators

Author

Taranenko, V. B., Ganne, I., Kuszelewicz, R. J., and Weiss, C. O.

Subjects
Nonlinear Sciences - Pattern Formation and Solitons
Abstract

We report experiments on spatial switching dynamics and steady state structures of passive nonlinear semiconductor resonators of large Fresnel number. Extended patterns and switching front dynamics are observed and investigated. Evidence of localization of structures is given., Comment: 5 pages with 9 figures

Published
2000
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25. Stereoelectroencephalography of the Deep Brain: Basal Ganglia and Thalami

Author

Pati, Sandipan, Agashe, Shruti, Kheder, Ammar, Riley, Kristen, Gavvala, Jay, McGovern, Robert, Suresh, Surya, Chaitanya, Ganne, and Thompson, Stephen

Abstract

Stereoelectroencephalography (SEEG) has emerged as a transformative tool in epilepsy surgery, shedding light on the complex network dynamics involved in focal epilepsy. This review explores the role of SEEG in elucidating the role of deep brain structures, namely the basal ganglia and thalamus, in epilepsy. SEEG advances understanding of their contribution to seizure generation, propagation, and control by permitting precise and minimally invasive sampling of these brain regions. The basal ganglia, comprising the subthalamic nucleus, globus pallidus, substantia nigra, and striatum, have gained recognition for their involvement in both focal and generalized epilepsy. Electrophysiological recordings reveal hyperexcitability and increased synchrony within these structures, reinforcing their role as critical nodes within the epileptic network. Furthermore, low-frequency and high-frequency stimulation of the basal ganglia have demonstrated potential in modulating epileptogenic networks. Concurrently, the thalamus, a key relay center, has garnered prominence in epilepsy research. Disrupted thalamocortical connectivity in focal epilepsy underscores its significance in seizure maintenance. The thalamic subnuclei, including the anterior nucleus, centromedian, and medial pulvinar, present promising neuromodulatory targets, suggesting pathways for personalized epilepsy therapies. The prospect of multithalamic SEEG and thalamic SEEG stimulation trials has the potential to revolutionize epilepsy management, offering tailored solutions for challenging cases. SEEG's ability to unveil the dynamics of deep brain structures in epilepsy promises enhanced and personalized epilepsy care in our new era of precision medicine. Until deep brain SEEG is accepted as a standard of care, a rigorous informed consent process remains paramount for patients for whom such an exploration is proposed.

Published
2024
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26. Atezolizumab and bevacizumab for non‐resectable or metastatic combined hepatocellular‐cholangiocarcinoma: A multicentric retrospective study

Author

Gigante, Elia, Bouattour, Mohamed, Bedoya, José Ursic, Regnault, Hélène, Ziol, Marianne, Assenat, Eric, Paradis, Valérie, Calderaro, Julien, Ganne‐Carrié, Nathalie, Bouhier‐Leporrier, Karine, Amaddeo, Giuliana, and Nault, Jean Charles

Abstract

The efficacy of atezolizumab/bevacizumab has never been reported in patients with metastatic/unresectable combined hepatocellular‐cholangiocarcinoma (cHCC‐CCA). We retrospectively included patients with a histological diagnosis of unresectable/metastatic cHCC‐CCA and treated with atezolizumab/bevacizumab (2020–2022) in 7 centers. Clinical and radiological features were collected at the beginning of atezolizumab/bevacizumab. We reported the radiological response using RECIST criteria, overall survival (OS) and progression‐free survival (PFS). Sixteen patients with cHCC‐CCA were included and were predominantly male (75%) with advanced fibrosis/cirrhosis (69%). Nine patients received atezolizumab/bevacizumab as a first‐line systemic treatment, 5 as a second line, 1 as a third line and 1 as a fifth line. Severe digestive bleeding occurred in 2 patients. Among the 9 patients treated in the first line, 4 experienced radiological progression, 3 partial response and 1 had stable disease. Patients treated with atezolizumab/bevacizumab in the first line had a median OS of 13 months and a median PFS of 3 months. Among the 7 patients receiving atezolizumab/bevacizumab as a second line or more, 4 patients harbored a stable disease, 2 a partial response, and 1 a progressive disease. The combination of atezolizumab and bevacizumab showed signs of anti‐tumor efficacy in patients with unresectable/metastatic cHCC‐CCA.

Published
2024
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30. Giroctocogene fitelparvovec gene therapy for severe hemophilia A: 104-week analysis of the phase 1/2 Alta study

Author

Leavitt, Andrew D., Konkle, Barbara A., Stine, Kimo C., Visweshwar, Nathan, Harrington, Thomas J., Giermasz, Adam, Arkin, Steven, Fang, Annie, Plonski, Frank, Yver, Anne, Ganne, Florence, Agathon, Delphine, Resa, Maria de los Angeles, Tseng, Li-Jung, Di Russo, Gregory, Cockroft, Bettina M., Cao, Liching, and Rupon, Jeremy

Abstract

•Giroctocogene fitelparvovec is the first gene therapy for hemophilia A that uses a recombinant AAV serotype 6–based vector.•Giroctocogene fitelparvovec was generally well tolerated with appropriate clinical management and showed efficacy at the highest dose.

Published
2024
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32. Safety and efficacy of the combination simeprevir-sofosbuvir in HCV genotype 1- and 4-mono-infected patients from the French ANRS CO22 hepather cohort

Author

Laurain, Anne, Metivier, Sophie, Haour, Georges, Larrey, Dominique, Dorival, Céline, Hezode, Christophe, Zoulim, Fabien, Marcellin, Patrick, Bourliere, Marc, Zarski, Jean-Pierre, Thabut, Dominique, Alric, Laurent, Ganne-Carrie, Nathalie, Cales, Paul, Bronowicki, Jean-Pierre, Riachi, Ghassan, Geist, Claire, Causse, Xavier, Abergel, Armand, Chazouilleres, Olivier, Mathurin, Philippe, Guyader, Dominique, Samuel, Didier, Tran, Albert, Loustaud-Ratti, Véronique, Petrov-Sanchez, Ventzislava, Diallo, Alpha, Luzivika-Nzinga, Clovis, Fontaine, Hélène, Carrat, Fabrice, Pol, Stanislas, and on behalf of the ANRS/AFEF HEPATHER study group

Published
2019
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36. SMCHD1genetic variants in type 2 facioscapulohumeral dystrophy and challenges in predicting pathogenicity and disease penetrance

Author

Gérard, Laurène, Delourme, Mégane, Tardy, Charlotte, Ganne, Benjamin, Perrin, Pierre, Chaix, Charlene, Trani, Jean Philippe, Eudes, Nathalie, Laberthonnière, Camille, Bertaux, Karine, Missirian, Chantal, Bassez, Guillaume, Behin, Anthony, Cintas, Pascal, Cluse, Florent, De La Cruz, Elisa, Delmont, Emilien, Evangelista, Teresinha, Fradin, Mélanie, Hadouiri, Nawale, Kouton, Ludivine, Laforêt, Pascal, Lefeuvre, Claire, Magot, Armelle, Manel, Véronique, Nectoux, Juliette, Pegat, Antoine, Sole, Guilhem, Spinazzi, Marco, Stojkovic, Tanya, Svahn, Juliette, Tard, Celine, Thauvin, Christel, Verebi, Camille, Salort Campana, Emmanuelle, Attarian, Shahram, Nguyen, Karine, Badache, Ali, Bernard, Rafaëlle, and Magdinier, Frédérique

Abstract

The molecular diagnosis of type 1 facioscapulohumeral muscular dystrophy (FSHD1) relies on the detection of a shortened D4Z4 array at the 4q35 locus. Until recently, the diagnosis of FSHD2 relied solely on the absence of a shortened D4Z4 allele in clinically affected patients. It is now established that most FSHD2 cases carry a heterozygous variant in the SMCHD1gene. A decrease in D4Z4 DNA methylation is observed in both FSHD1 and FSHD2 patients. To refine the molecular diagnosis of FSHD2, we performed a molecular diagnosis of SMCHD1in 54 patients with a clinical diagnosis of FSHD. All patients carry a D4Z4 array of more than 10 D4Z4 units, or a cis-duplication of the locus. Forty-eight of them carry a variant in SMCHD1and six other cases are hemizygous for the 18p32 locus encompassing SMCHD1. Genetic and epigenetic analyses were considered to assess the pathogenicity of new SMCHD1variants and of variants previously classified as likely pathogenic. In comparison to the healthy population and FSHD1 patients, we defined a threshold of 40% of methylation at the D4Z4 DR1 site as associated with SMCHD1variants or SMCHD1hemizygosity. We also showed that the number of D4Z4 on the shortest 4q allele ranges from 11 up to 35 units in these same patients. Using variant interpretation and protein structure prediction tools, we also highlight the difficulty in interpreting the impact of pathogenic variants on SMCHD1 function. Our study further emphasizes the intriguing relationship between D4Z4 methylation, SMCHD1variants with SMCHD1 protein structure-function in FSHD.

Published
2024
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39. Atezolizumab plus bevacizumab versus active surveillance in patients with resected or ablated high-risk hepatocellular carcinoma (IMbrave050): a randomised, open-label, multicentre, phase 3 trial

Author

Qin, Shukui, Chen, Minshan, Cheng, Ann-Lii, Kaseb, Ahmed O, Kudo, Masatoshi, Lee, Han Chu, Yopp, Adam C, Zhou, Jian, Wang, Lu, Wen, Xiaoyu, Heo, Jeong, Tak, Won Young, Nakamura, Shinichiro, Numata, Kazushi, Uguen, Thomas, Hsiehchen, David, Cha, Edward, Hack, Stephen P, Lian, Qinshu, Ma, Ning, Spahn, Jessica H, Wang, Yulei, Wu, Chun, Chow, Pierce K H, Thompson, Alexander, Danta, Mark, Poursoltan, Pirooz, Kiberu, Andrew, Chittajallu, Renuka, Sood, Siddarth, Stauber, Rudolf, Pinter, Matthias, Peck-Radosavljevic, Markus, Decaestecker, Jochen, Cuyle, Pieter-Jan, Verset, Gontran, Van Vlierberghe, Hans, De Azevedo, Sergio, Andrade, Livia, Cunha Júnior, Ademar, Faria, Luiza, Yen, Cheng Tzu, Colli, Leandro, Asselah, Jamil, Kavan, Petr, Marquez, Vladimir, Brahmania, Mayur, Li, Qiang, Xing, Baocai, Guo, Yabing, Chen, Zhendong, Zhao, Haitao, Peng, Tao, Wang, Liming, Wang, Lu, Liu, Hongming, Wu, Feixiang, Qin, Lunxiu, Zheng, Qichang, Ying, Jieer, Li, Haitao, Wen, Tianfu, Qin, Shukui, Wen, Xiaoyu, Liu, Yunpeng, Chen, Minshan, Wang, Boqing, Bai, Yuxian, He, Yifu, Zhao, Hong, Zhou, Dong, Dai, Chaoliu, Teng, Gaojun, Cui, Shuzhong, Gao, Yi, Zhang, Xizhi, Lu, Zheng, Yin, Tao, Ding, Youming, Jia, Weidong, Xia, Yongxiang, Sun, Beicheng, Xia, Qiang, Yuan, Yufeng, Sun, Huichuan, Shi, Xuetao, Guzmán, Adrián, Corrales, Luis, Kral, Zdenek, Priester, Peter, Kubala, Eugen, Blanc, Jean Frederic, Bourliere, Marc, Peron, Jean Marie, Borg, Christophe, Bronowicki, Jean-Pierre, Ganne, Nathalie, Decaens, Thomas, Uguen, Thomas, Heurgue, Alexandra, Trojan, Joerg, Gonzalez-Carmona, Maria Angeles, Roderburg, Christoph, Ettrich, Thomas, Schotten, Clemens, Kandulski, Arne, Yau, Thomas, Chan, Lam, Scartozzi, Mario, Masi, Gianluca, Fanello, Silvia, Battezzati, Pier Maria, Leonardi, Francesco, Ghidini, Michele, Numata, Kazushi, Morimoto, Manabu, Hidaka, Hisashi, Tsuchiya, Kaoru, Yamashita, Tatsuya, Kato, Naoya, Kudo, Masatoshi, Hagihara, Atsushi, Koga, Hironori, Arakawa, Tomohiro, Nakamura, Ikuo, Kawamura, Yusuke, Kawaoka, Tomokazu, Shimada, Mitsuo, Hasegawa, Kiyoshi, Marusawa, Hiroyuki, Nakamura, Shinchiro, Hiraoka, Atsushi, Hayashi, Hiromitsu, Takeda, Shin, Lee, Han Chu, Paik, Seung Woon, Kim, Do Young, Lee, Jung Il, Jeong, Sook-Hyang, Kim, Won, Tak, Won Young, Heo, Jeong, Kim, Hyeyeong, Chon, Hong Jae, Cheong, Jaeyoun, Yoon, Seung Kew, Yoon, Jung-Hwan, Villalobos, Ricardo, Martinez Rodriguez, Jorge Luis, Oyervides Juarez, Victor, Hernández, Carlos Alberto, Klumpen, Heinz-Josef, de Vos-Geelen, Judith, Gane, Edward, Montenegro, Paola, Torres Mattos, Cesar, Janczewska, Ewa, Kawecki, Maciej, Nowakowska-Zajdel, Ewa, Fedenko, Alexander, Granov, Dmitrii, Alyasova, Anna, Sekacheva, Marina, Ledin, Evgeny, Samol, Jens, Toh, Han Chong, Calvo Campos, Mariona, Gomez Martin, Carlos, Lopez Lopez, Carlos, Muñoz Martin, Andres Jesus, Calleja Panero, Jose Luis, Montero Alvarez, Jose Luis, Reig Monzón, Maria, Delgado Mingorance, Ignacio, Minguez Rosique, Beatriz, Cheng, Ann Lii, Huang, Yi-Hsiang, Lin, Shi-Ming, Huang, Jee-Fu, Yu, Ming-Lung, Su, Wei-Wen, Korphaisarn, Krittiya, Maneenil, Kunlatida, Samdaengpan, Chayanee, Tharavichitkul, Ekkapong, Ozguroglu, Mustafa, Kose, Fatih, Harputluoglu, Hakan, Buchschacher, Gary, Thuluvath, Paul, Xiong, Henry, Patel, Mital, Gold, Philip, Li, Daneng, Brooks, Gabriel, Masood, Ashiq, Patel, Reema, George, Ben, Salgia, Reena, Manji, Gulam, Crow, Mary, Kaseb, Ahmed, Dugan, Matthew, Kadakia, Kunal, Kardosh, Adel, Gibbs, John, Shah, Ashesh, Burris III, Howard, and Hsiehchen, David

Abstract

No adjuvant treatment has been established for patients who remain at high risk for hepatocellular carcinoma recurrence after curative-intent resection or ablation. We aimed to assess the efficacy of adjuvant atezolizumab plus bevacizumab versus active surveillance in patients with high-risk hepatocellular carcinoma.

Published
2023
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