621 results on '"Ganju, P."'
Search Results
2. Advancing Sustainable Aluminum Alloy Development via Comprehensive 3D Morphological and Compositional Characterization of Fe-Rich Intermetallic Particles
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Patnaik, Satyaroop, Ganju, Eshan, Yu, XiaoXiang, Kang, Minju, Park, Jaeseuck, Kang, DaeHoon, Kamat, Rajeev, Carsley, John, and Chawla, Nikhilesh
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- 2024
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3. Microstructural evolution of Ethiopian coffee beans by time-resolved X-ray microcomputed tomography
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Ganju, Eshan and Chawla, Nikhilesh
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- 2024
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4. Assessment of slip transfer criteria for prismatic-to-prismatic slip in pure Ti from 3D grain boundary data
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Nieto-Valeiras, E., Ganju, E., Chawla, N., and LLorca, J.
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Condensed Matter - Materials Science - Abstract
Slip transfer and blocking across grain boundaries was studied in a Ti foil with a strong rolling texture deformed in tension. Prior to deformation, the shape of the grains and the orientation of the grain boundaries were quantified through laboratory scale diffraction contrast tomography (LabDCT). Mechanical deformation led to the activation of prismatic slip, and slip transfer/blocking was assessed in > 300 grain boundaries by means of slip trace analysis and electron backscatter diffraction. A categorical model was employed to accurately assess slip transfer, and the "F1 score" of various slip transfer criteria proposed in the literature was evaluated for the first time from 3D grain boundary information. Remarkably, for the prismatic-dominated slip transfer in the current Ti sample, the results show that the best predictions of slip transfer/blocking are provided by the angle \k{appa}, which is directly related to the residual Burgers vector, and by the Luster-Morris parameter m'. In contrast, metrics based on the twist angle {\theta} and on the LRB criterion were not able to predict accurately slip transfer/blocking. Thus, the extensive analysis of the 3D grain boundary data and the novel application of LabDCT was able to help clarify the role of grain boundary orientation on the mechanisms of plastic deformation in polycrystals with strong prismatic-dominated slip.
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- 2023
5. A Generalization of Continuous Relaxation in Structured Pruning
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Larson, Brad, Upadhyaya, Bishal, McDermott, Luke, and Ganju, Siddha
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Deep learning harnesses massive parallel floating-point processing to train and evaluate large neural networks. Trends indicate that deeper and larger neural networks with an increasing number of parameters achieve higher accuracy than smaller neural networks. This performance improvement, which often requires heavy compute for both training and evaluation, eventually needs to translate well to resource-constrained hardware for practical value. Structured pruning asserts that while large networks enable us to find solutions to complex computer vision problems, a smaller, computationally efficient sub-network can be derived from the large neural network that retains model accuracy but significantly improves computational efficiency. We generalize structured pruning with algorithms for network augmentation, pruning, sub-network collapse and removal. In addition, we demonstrate efficient and stable convergence up to 93% sparsity and 95% FLOPs reduction without loss of inference accuracy using with continuous relaxation matching or exceeding the state of the art for all structured pruning methods. The resulting CNN executes efficiently on GPU hardware without computationally expensive sparse matrix operations. We achieve this with routine automatable operations on classification and segmentation problems using CIFAR-10, ImageNet, and CityScapes datasets with the ResNet and U-NET network architectures., Comment: 10 pages
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- 2023
6. AI-Enhanced Data Processing and Discovery Crowd Sourcing for Meteor Shower Mapping
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Ganju, Siddha, Hatua, Amartya, Jenniskens, Peter, Krishna, Sahyadri, Ren, Chicheng, and Ambardar, Surya
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Astrophysics - Earth and Planetary Astrophysics ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
The Cameras for Allsky Meteor Surveillance (CAMS) project, funded by NASA starting in 2010, aims to map our meteor showers by triangulating meteor trajectories detected in low-light video cameras from multiple locations across 16 countries in both the northern and southern hemispheres. Its mission is to validate, discover, and predict the upcoming returns of meteor showers. Our research aimed to streamline the data processing by implementing an automated cloud-based AI-enabled pipeline and improve the data visualization to improve the rate of discoveries by involving the public in monitoring the meteor detections. This article describes the process of automating the data ingestion, processing, and insight generation using an interpretable Active Learning and AI pipeline. This work also describes the development of an interactive web portal (the NASA Meteor Shower portal) to facilitate the visualization of meteor radiant maps. To date, CAMS has discovered over 200 new meteor showers and has validated dozens of previously reported showers.
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- 2023
7. Long-Term Microstructural Stability of Sn-40Bi and Sn-40Bi-10In Alloys
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Spinelli, José E., Leal, Jaderson R., Wu, John A., Luktuke, Amey, Ganju, Eshan, and Chawla, Nikhilesh
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- 2024
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8. Alterations in human health parameters during stressful ship voyage to Antarctica: effects of probiotics intervention
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Srivastava, Ashish Kumar, Bhushan, Brij, Eslavath, Malleswara Rao, Gupta, Harshita, Chanda, Sudipta, Singh, Vishwendra Vikram, Singh, Som Nath, Kumar, Bhuvnesh, Varshney, Rajeev, and Ganju, Lilly
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- 2024
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9. Curator: Creating Large-Scale Curated Labelled Datasets using Self-Supervised Learning
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Narayanan, Tarun, Krishnan, Ajay, Koul, Anirudh, and Ganju, Siddha
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Applying Machine learning to domains like Earth Sciences is impeded by the lack of labeled data, despite a large corpus of raw data available in such domains. For instance, training a wildfire classifier on satellite imagery requires curating a massive and diverse dataset, which is an expensive and time-consuming process that can span from weeks to months. Searching for relevant examples in over 40 petabytes of unlabelled data requires researchers to manually hunt for such images, much like finding a needle in a haystack. We present a no-code end-to-end pipeline, Curator, which dramatically minimizes the time taken to curate an exhaustive labeled dataset. Curator is able to search massive amounts of unlabelled data by combining self-supervision, scalable nearest neighbor search, and active learning to learn and differentiate image representations. The pipeline can also be readily applied to solve problems across different domains. Overall, the pipeline makes it practical for researchers to go from just one reference image to a comprehensive dataset in a diminutive span of time., Comment: AAAI Fall Symposium 2022
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- 2022
10. Obesity and lack of breastfeeding: a perfect storm to augment risk of breast cancer?
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Kate Ormiston, Anagh Kulkarni, Gautam Sarathy, Sara Alsammerai, Eswar Shankar, Sarmila Majumder, Kristin I. Stanford, Ramesh K. Ganju, and Bhuvaneswari Ramaswamy
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racial disparities ,triple negative breast cancer ,obesity ,involution ,breastfeeding ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with higher rates of recurrence and distant metastasis, as well as decreased 5-year survival rates. Racial disparities are evident in the incidence and mortality rates of triple negative breast cancer particularly increased in young African American women. Concurrently, young African American women have multiple risk factors for TNBC including higher rates of premenopausal abdominal obesity (higher waist-hip ratio) and lower rates of breastfeeding with higher parity, implicating these factors as potentially contributors to poor outcomes. By understanding the mechanisms of how premenopausal obesity and lack of breastfeeding may be associated with increased risk of triple negative breast cancer, we can determine the best strategies for intervention and awareness to improve outcomes in TNBC.
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- 2024
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11. Deep learning based landslide density estimation on SAR data for rapid response
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Boehm, Vanessa, Leong, Wei Ji, Mahesh, Ragini Bal, Prapas, Ioannis, Nemni, Edoardo, Kalaitzis, Freddie, Ganju, Siddha, and Ramos-Pollán, Raul
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning ,68T07 ,I.4.9 - Abstract
This work aims to produce landslide density estimates using Synthetic Aperture Radar (SAR) satellite imageries to prioritise emergency resources for rapid response. We use the United States Geological Survey (USGS) Landslide Inventory data annotated by experts after Hurricane Mar\'ia in Puerto Rico on Sept 20, 2017, and their subsequent susceptibility study which uses extensive additional information such as precipitation, soil moisture, geological terrain features, closeness to waterways and roads, etc. Since such data might not be available during other events or regions, we aimed to produce a landslide density map using only elevation and SAR data to be useful to decision-makers in rapid response scenarios. The USGS Landslide Inventory contains the coordinates of 71,431 landslide heads (not their full extent) and was obtained by manual inspection of aerial and satellite imagery. It is estimated that around 45\% of the landslides are smaller than a Sentinel-1 typical pixel which is 10m $\times$ 10m, although many are long and thin, probably leaving traces across several pixels. Our method obtains 0.814 AUC in predicting the correct density estimation class at the chip level (128$\times$128 pixels, at Sentinel-1 resolution) using only elevation data and up to three SAR acquisitions pre- and post-hurricane, thus enabling rapid assessment after a disaster. The USGS Susceptibility Study reports a 0.87 AUC, but it is measured at the landslide level and uses additional information sources (such as proximity to fluvial channels, roads, precipitation, etc.) which might not regularly be available in an rapid response emergency scenario., Comment: 7 pages, 5 figures
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- 2022
12. SAR-based landslide classification pretraining leads to better segmentation
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Böhm, Vanessa, Leong, Wei Ji, Mahesh, Ragini Bal, Prapas, Ioannis, Nemni, Edoardo, Kalaitzis, Freddie, Ganju, Siddha, and Ramos-Pollan, Raul
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Computer Science - Computer Vision and Pattern Recognition ,Electrical Engineering and Systems Science - Image and Video Processing ,Electrical Engineering and Systems Science - Signal Processing - Abstract
Rapid assessment after a natural disaster is key for prioritizing emergency resources. In the case of landslides, rapid assessment involves determining the extent of the area affected and measuring the size and location of individual landslides. Synthetic Aperture Radar (SAR) is an active remote sensing technique that is unaffected by weather conditions. Deep Learning algorithms can be applied to SAR data, but training them requires large labeled datasets. In the case of landslides, these datasets are laborious to produce for segmentation, and often they are not available for the specific region in which the event occurred. Here, we study how deep learning algorithms for landslide segmentation on SAR products can benefit from pretraining on a simpler task and from data from different regions. The method we explore consists of two training stages. First, we learn the task of identifying whether a SAR image contains any landslides or not. Then, we learn to segment in a sparsely labeled scenario where half of the data do not contain landslides. We test whether the inclusion of feature embeddings derived from stage-1 helps with landslide detection in stage-2. We find that it leads to minor improvements in the Area Under the Precision-Recall Curve, but also to a significantly lower false positive rate in areas without landslides and an improved estimate of the average number of landslide pixels in a chip. A more accurate pixel count allows to identify the most affected areas with higher confidence. This could be valuable in rapid response scenarios where prioritization of resources at a global scale is important. We make our code publicly available at https://github.com/VMBoehm/SAR-landslide-detection-pretraining., Comment: Accepted to the NeurIPS 2022 workshop Artificial Intelligence for Humanitarian Assistance and Disaster Response. This research was conducted as part of the Frontier Development Lab (FDL) 2022
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- 2022
13. Deep Learning for Rapid Landslide Detection using Synthetic Aperture Radar (SAR) Datacubes
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Boehm, Vanessa, Leong, Wei Ji, Mahesh, Ragini Bal, Prapas, Ioannis, Nemni, Edoardo, Kalaitzis, Freddie, Ganju, Siddha, and Ramos-Pollan, Raul
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Electrical Engineering and Systems Science - Signal Processing ,Computer Science - Computer Vision and Pattern Recognition ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
With climate change predicted to increase the likelihood of landslide events, there is a growing need for rapid landslide detection technologies that help inform emergency responses. Synthetic Aperture Radar (SAR) is a remote sensing technique that can provide measurements of affected areas independent of weather or lighting conditions. Usage of SAR, however, is hindered by domain knowledge that is necessary for the pre-processing steps and its interpretation requires expert knowledge. We provide simplified, pre-processed, machine-learning ready SAR datacubes for four globally located landslide events obtained from several Sentinel-1 satellite passes before and after a landslide triggering event together with segmentation maps of the landslides. From this dataset, using the Hokkaido, Japan datacube, we study the feasibility of SAR-based landslide detection with supervised deep learning (DL). Our results demonstrate that DL models can be used to detect landslides from SAR data, achieving an Area under the Precision-Recall curve exceeding 0.7. We find that additional satellite visits enhance detection performance, but that early detection is possible when SAR data is combined with terrain information from a digital elevation model. This can be especially useful for time-critical emergency interventions. Code is made publicly available at https://github.com/iprapas/landslide-sar-unet., Comment: Accepted in the NeurIPS 2022 workshop on Tackling Climate Change with Machine Learning. Authors Vanessa Boehm, Wei Ji Leong, Ragini Bal Mahesh, Ioannis Prapas contributed equally as researchers for the Frontier Development Lab (FDL) 2022
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- 2022
14. Using Geospatial Analysis to Guide Marsh Restoration in Chesapeake Bay and Beyond
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Ganju, Neil K., Ackerman, Katherine V., and Defne, Zafer
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- 2024
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15. COVID-19 Vaccine Uptake in Patients with Multiple Myeloma and AL Amyloidosis: A Cross-Sectional Observational Study from India
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Ganju, Prabhat, Kalaiyarasi, Jayachandran Perumal, Karunakaran, Parathan, Veeraiah, Surendran, and Mehra, Nikita
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- 2024
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16. Impact of capacity building and tele ECG based decision support on change in thrombolysis rate and inhospital and one year mortality in patients with STEMI, using hub and spoke model; multi-phasic intervention trial
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Prakash Chand Negi, Savio Dsouza, Arvind Kandoria, Rahul Nijhavan, Pryanka Thakur, Meena Thakur, Meenakshi Sharma, Sanjeev Asotra, Neeraj Ganju, Rajive Marwah, and Rajesh Sharma
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Acute coronary syndrome ,Hub and spoke model ,Outcomes ,Thrombolytic therapy ,Teleconsultation ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: We report the impact of capacity building and teleconsultation on change in the thrombolysis rates and one-year mortality in patients with STEMI using a hub and the spoke model of STEMI care. Methods: Twenty secondary care public hospitals were linked with a teaching hospital as a hub centre and the impact of the intervention on change in ischemic time, thrombolysis rates and all-cause in-hospital and one-year mortality was compared. Results: 29 patients with STEMI were treated during pre-intervention from April 2020 to June 2020 and 255 patients during the post-intervention period from July 2020 to Oct 2021 in spoke centres. 245 patients were reported to a hub centre during the study period. The thrombolysis rate was significantly higher in the spoke centres after intervention (65.5%vs. 27.5 % p
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- 2024
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17. Correction: Sediment Dynamics of a Divergent Bay–Marsh Complex
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Nowacki, Daniel J. and Ganju, Neil K.
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- 2024
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18. Global geomagnetic perturbation forecasting using Deep Learning
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Upendran, Vishal, Tigas, Panagiotis, Ferdousi, Banafsheh, Bloch, Teo, Cheung, Mark C. M., Ganju, Siddha, Bhatt, Asti, McGranaghan, Ryan M., and Gal, Yarin
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Physics - Space Physics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics ,Computer Science - Machine Learning - Abstract
Geomagnetically Induced Currents (GICs) arise from spatio-temporal changes to Earth's magnetic field which arise from the interaction of the solar wind with Earth's magnetosphere, and drive catastrophic destruction to our technologically dependent society. Hence, computational models to forecast GICs globally with large forecast horizon, high spatial resolution and temporal cadence are of increasing importance to perform prompt necessary mitigation. Since GIC data is proprietary, the time variability of horizontal component of the magnetic field perturbation (dB/dt) is used as a proxy for GICs. In this work, we develop a fast, global dB/dt forecasting model, which forecasts 30 minutes into the future using only solar wind measurements as input. The model summarizes 2 hours of solar wind measurement using a Gated Recurrent Unit, and generates forecasts of coefficients which are folded with a spherical harmonic basis to enable global forecasts. When deployed, our model produces results in under a second, and generates global forecasts for horizontal magnetic perturbation components at 1-minute cadence. We evaluate our model across models in literature for two specific storms of 5 August 2011 and 17 March 2015, while having a self-consistent benchmark model set. Our model outperforms, or has consistent performance with state-of-the-practice high time cadence local and low time cadence global models, while also outperforming/having comparable performance with the benchmark models. Such quick inferences at high temporal cadence and arbitrary spatial resolutions may ultimately enable accurate forewarning of dB/dt for any place on Earth, resulting in precautionary measures to be taken in an informed manner., Comment: 23 pages, 8 figures, 5 tables; accepted for publication in AGU: Spaceweather
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- 2022
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19. Learn-to-Race Challenge 2022: Benchmarking Safe Learning and Cross-domain Generalisation in Autonomous Racing
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Francis, Jonathan, Chen, Bingqing, Ganju, Siddha, Kathpal, Sidharth, Poonganam, Jyotish, Shivani, Ayush, Vyas, Vrushank, Genc, Sahika, Zhukov, Ivan, Kumskoy, Max, Koul, Anirudh, Oh, Jean, and Nyberg, Eric
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Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Systems and Control - Abstract
We present the results of our autonomous racing virtual challenge, based on the newly-released Learn-to-Race (L2R) simulation framework, which seeks to encourage interdisciplinary research in autonomous driving and to help advance the state of the art on a realistic benchmark. Analogous to racing being used to test cutting-edge vehicles, we envision autonomous racing to serve as a particularly challenging proving ground for autonomous agents as: (i) they need to make sub-second, safety-critical decisions in a complex, fast-changing environment; and (ii) both perception and control must be robust to distribution shifts, novel road features, and unseen obstacles. Thus, the main goal of the challenge is to evaluate the joint safety, performance, and generalisation capabilities of reinforcement learning agents on multi-modal perception, through a two-stage process. In the first stage of the challenge, we evaluate an autonomous agent's ability to drive as fast as possible, while adhering to safety constraints. In the second stage, we additionally require the agent to adapt to an unseen racetrack through safe exploration. In this paper, we describe the new L2R Task 2.0 benchmark, with refined metrics and baseline approaches. We also provide an overview of deployment, evaluation, and rankings for the inaugural instance of the L2R Autonomous Racing Virtual Challenge (supported by Carnegie Mellon University, Arrival Ltd., AICrowd, Amazon Web Services, and Honda Research), which officially used the new L2R Task 2.0 benchmark and received over 20,100 views, 437 active participants, 46 teams, and 733 model submissions -- from 88+ unique institutions, in 58+ different countries. Finally, we release leaderboard results from the challenge and provide description of the two top-ranking approaches in cross-domain model transfer, across multiple sensor configurations and simulated races., Comment: 20 pages, 4 figures, 2 tables
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- 2022
20. CELESTIAL: Classification Enabled via Labelless Embeddings with Self-supervised Telescope Image Analysis Learning
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Kotha, Suhas, Koul, Anirudh, Ganju, Siddha, and Kasam, Meher
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Computer Science - Computer Vision and Pattern Recognition - Abstract
A common class of problems in remote sensing is scene classification, a fundamentally important task for natural hazards identification, geographic image retrieval, and environment monitoring. Recent developments in this field rely label-dependent supervised learning techniques which is antithetical to the 35 petabytes of unlabelled satellite imagery in NASA GIBS. To solve this problem, we establish CELESTIAL-a self-supervised learning pipeline for effectively leveraging sparsely-labeled satellite imagery. This pipeline successfully adapts SimCLR, an algorithm that first learns image representations on unlabelled data and then fine-tunes this knowledge on the provided labels. Our results show CELESTIAL requires only a third of the labels that the supervised method needs to attain the same accuracy on an experimental dataset. The first unsupervised tier can enable applications such as reverse image search for NASA Worldview (i.e. searching similar atmospheric phenomenon over years of unlabelled data with minimal samples) and the second supervised tier can lower the necessity of expensive data annotation significantly. In the future, we hope we can generalize the CELESTIAL pipeline to other data types, algorithms, and applications., Comment: COSPAR 2021 Cross-Disciplinary Workshop on Machine Learning for Space Sciences, Sydney, Australia
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- 2022
21. Impact of bowel space contouring variability on radiation dose and volume assessments in treatment planning for gynaecologic cancers
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Fatjona Kraja, Kevin Kauweloa, Rohit G. Ganju, and Andrew C. Hoover
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Pelvis ,radiation oncology ,technique ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Introduction Correlations between radiation dose/volume measures and small bowel (SB) toxicity are inconsistent in the medical literature. We assessed the impact of inter‐provider variation in bowel bag contouring technique on estimates of radiation dose received by the SB during pelvic radiotherapy. Methods Ten radiation oncologists contoured rectum, bladder and bowel bags on treatment planning computed tomography (CT) scans of two patients receiving adjuvant radiation for endometrial cancer. A radiation plan was generated for each patient and used to determine the radiation dose/volume for each organ. Kappa statistics were applied to assess the inter‐provider contouring agreement, and Levene test evaluated the homogeneity of variance for radiation dose/volume metrics, including the V45Gy (cm3). Results The bowel bag showed greater variation in radiation dose/volume estimates compared to the bladder and rectum. The V45Gy ranged from 163 to 384 cm3 for data set A and 109 to 409 cm3 for dataset B. Kappa values were 0.82/0.83, 0.92/0.92 and 0.94/0.86 for the bowel bag, rectum, and bladder on data sets A/B, demonstrating lower inter‐provider agreement for bowel bag compared with bladder and rectum. Conclusion Inter‐provider contouring variability is more significant for the bowel bag than the rectum and bladder, with an associated greater variability in dose and volume estimates during radiation planning.
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- 2023
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22. 3D X-ray Tomography Analysis of Mg–Si–Zn Alloys for Biomedical Applications: Elucidating the Morphology of the MgZn Phase
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Guilherme Lisboa de Gouveia, Eshan Ganju, Danusa Moura, Swapnil K. Morankar, José Eduardo Spinelli, and Nikhilesh Chawla
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X-ray Computed Tomography ,Mg alloys ,microstructural characterization ,convex hull ,network analyses ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Temporary metal implants, made from materials like titanium (Ti) or stainless steel, can cause metabolic issues, raise toxicity levels within the body, and negatively impact the patient’s long-term health. This necessitates a subsequent operation to extract these implants once the healing process is complete or when they are outgrown by the patient. In contrast, medical devices fabricated from absorbable alloys have the advantage of being biodegradable, allowing them to be naturally absorbed by the body once they have fulfilled their role in facilitating tissue healing. Among the various absorbable alloy systems studied, magnesium (Mg) alloys stand out due to their biocompatibility, mechanical properties, and corrosion behavior. The existing literature on absorbable Mg alloys highlights the effectiveness of silicon (Si) and zinc (Zn) additions in improving mechanical properties and controlling corrosion susceptibility; however, there is a lack of comprehensive quantitative morphological analysis of the intermetallic phases within these alloy systems. The quantification of the complex morphology of intermetallic particles is a challenging task and has significant implications for the micromechanical properties of the alloys. This study, therefore, aims to introduce a robust set of morphometric parameters for evaluating the morphology of intermetallic phases within two as-cast Mg alloys with Si and Zn additions. X-ray Computed Tomography (XCT) was used to capture the 3D tomographic data of the alloys, and a novel pair of morphological parameters (ratio of convex hull to particle volume and convex hull sphericity) was applied to the 3D tomographic data to assess the MgZn phase formed in the two alloys. In addition to the impact of composition, the effect of solidification rate on the morphological parameters was also studied. Furthermore, Scanning Electron Microscopy (SEM) and Energy-Dispersive Spectroscopy (EDS) were employed to gather detailed 2D microstructural and compositional information on the intermetallics. The comprehensive characterization reveals that the morphological complexity and size distribution of the MgZn phase are influenced by both compositional changes and the solidification rate. However, the change in MgZn intermetallic particle morphology with size was found to follow a predictable trend, which was relatively agnostic of the chosen casting conditions.
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- 2024
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23. Impact of high altitude on composition and functional profiling of oral microbiome in Indian male population
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Kumari, Manisha, Bhushan, Brij, Eslavath, Malleswara Rao, Srivastava, Ashish Kumar, Meena, Ramesh Chand, Varshney, Rajeev, and Ganju, Lilly
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- 2023
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24. MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat
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Chen, Jasmine, Guanizo, Aleks C., Jakasekara, W. Samantha N., Inampudi, Chaitanya, Luong, Quinton, Garama, Daniel J., Alamgeer, Muhammad, Thakur, Nishant, DeVeer, Michael, Ganju, Vinod, Watkins, D. Neil, Cain, Jason E., and Gough, Daniel J.
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- 2023
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25. Thank You to Our 2023 Peer Reviewers
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Harihar Rajaram, Anantha Aiyyer, Suzana Camargo, Christopher D. Cappa, Andrew J. Dombard, Kathleen A. Donohue, Sarah Feakins, Lucy Flesch, Robinson Fulweiler, Neil Ganju, Alessandra Giannini, Yu Gu, Christian Huber, Valeriy Ivanov, Kristopher Karnauskas, Monika Korte, Kevin Lewis, Gang Lu, Gudrun Magnusdottir, Mathieu Morlighem, Marit Oieroset, Yuichi Otsuka, Germán A. Prieto, Bo Qiu, Lynn Russell, Hui Su, Daoyuan Sun, Guiling Wang, Kaicun Wang, Caitlin Whalen, Angelicque E. White, Quentin Williams, and Andrew Yau
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editorial ,peer review ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract On behalf of the journal, AGU, and the scientific community, the editors of Geophysical Research Letters would like to sincerely thank those who reviewed manuscripts for us in 2023. The hours reading and commenting on manuscripts not only improve the manuscripts, but also increase the scientific rigor of future research in the field. With the advent of AGU's data policy, many reviewers have also helped immensely to evaluate the accessibility and availability of data, and many have provided insightful comments that helped to improve the data presentation and quality. We greatly appreciate the assistance of the reviewers in advancing open science, which is a key objective of AGU's data policy. We particularly appreciate the timely reviews in light of the demands imposed by the rapid review process at Geophysical Research Letters. We received 4,512 submissions in 2023 and 5,112 reviewers contributed to their evaluation by providing 8,587 reviews in total. We deeply appreciate their contributions.
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- 2024
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26. Scalable Reverse Image Search Engine for NASAWorldview
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Sodani, Abhigya, Levy, Michael, Koul, Anirudh, Kasam, Meher Anand, and Ganju, Siddha
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
Researchers often spend weeks sifting through decades of unlabeled satellite imagery(on NASA Worldview) in order to develop datasets on which they can start conducting research. We developed an interactive, scalable and fast image similarity search engine (which can take one or more images as the query image) that automatically sifts through the unlabeled dataset reducing dataset generation time from weeks to minutes. In this work, we describe key components of the end to end pipeline. Our similarity search system was created to be able to identify similar images from a potentially petabyte scale database that are similar to an input image, and for this we had to break down each query image into its features, which were generated by a classification layer stripped CNN trained in a supervised manner. To store and search these features efficiently, we had to make several scalability improvements. To improve the speed, reduce the storage, and shrink memory requirements for embedding search, we add a fully connected layer to our CNN make all images into a 128 length vector before entering the classification layers. This helped us compress the size of our image features from 2048 (for ResNet, which was initially tried as our featurizer) to 128 for our new custom model. Additionally, we utilize existing approximate nearest neighbor search libraries to significantly speed up embedding search. Our system currently searches over our entire database of images at 5 seconds per query on a single virtual machine in the cloud. In the future, we would like to incorporate a SimCLR based featurizing model which could be trained without any labelling by a human (since the classification aspect of the model is irrelevant to this use case)., Comment: 7 pages, Published at COSPAR 2021, 6 figures
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- 2021
27. Flood Segmentation on Sentinel-1 SAR Imagery with Semi-Supervised Learning
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Paul, Sayak and Ganju, Siddha
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Floods wreak havoc throughout the world, causing billions of dollars in damages, and uprooting communities, ecosystems and economies. The NASA Impact Flood Detection competition tasked participants with predicting flooded pixels after training with synthetic aperture radar (SAR) images in a supervised setting. We propose a semi-supervised learning pseudo-labeling scheme that derives confidence estimates from U-Net ensembles, progressively improving accuracy. Concretely, we use a cyclical approach involving multiple stages (1) training an ensemble model of multiple U-Net architectures with the provided high confidence hand-labeled data and, generated pseudo labels or low confidence labels on the entire unlabeled test dataset, and then, (2) filter out quality generated labels and, (3) combine the generated labels with the previously available high confidence hand-labeled dataset. This assimilated dataset is used for the next round of training ensemble models and the cyclical process is repeated until the performance improvement plateaus. We post process our results with Conditional Random Fields. Our approach sets a new state-of-the-art on the Sentinel-1 dataset with 0.7654 IoU, an impressive improvement over the 0.60 IoU baseline. Our method, which we release with all the code and models, can also be used as an open science benchmark for the Sentinel-1 dataset., Comment: Equal authorship. Accepted to the Tackling Climate Change with Machine Learning workshop at NeurIPS 2021. Code and models are available at https://git.io/JW3P8
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- 2021
28. Scalable Data Balancing for Unlabeled Satellite Imagery
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Patel, Deep, Gao, Erin, Koul, Anirudh, Ganju, Siddha, and Kasam, Meher Anand
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Data imbalance is a ubiquitous problem in machine learning. In large scale collected and annotated datasets, data imbalance is either mitigated manually by undersampling frequent classes and oversampling rare classes, or planned for with imputation and augmentation techniques. In both cases balancing data requires labels. In other words, only annotated data can be balanced. Collecting fully annotated datasets is challenging, especially for large scale satellite systems such as the unlabeled NASA's 35 PB Earth Imagery dataset. Although the NASA Earth Imagery dataset is unlabeled, there are implicit properties of the data source that we can rely on to hypothesize about its imbalance, such as distribution of land and water in the case of the Earth's imagery. We present a new iterative method to balance unlabeled data. Our method utilizes image embeddings as a proxy for image labels that can be used to balance data, and ultimately when trained increases overall accuracy., Comment: Accepted to COSPAR 2021 Workshop on Machine Learning for Space Sciences. 5 pages, 9 figures
- Published
- 2021
29. Reducing Effects of Swath Gaps on Unsupervised Machine Learning Models for NASA MODIS Instruments
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Chen, Sarah, Cao, Esther, Koul, Anirudh, Ganju, Siddha, Praveen, Satyarth, and Kasam, Meher Anand
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Computer Science - Computer Vision and Pattern Recognition ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Due to the nature of their pathways, NASA Terra and NASA Aqua satellites capture imagery containing swath gaps, which are areas of no data. Swath gaps can overlap the region of interest (ROI) completely, often rendering the entire imagery unusable by Machine Learning (ML) models. This problem is further exacerbated when the ROI rarely occurs (e.g. a hurricane) and, on occurrence, is partially overlapped with a swath gap. With annotated data as supervision, a model can learn to differentiate between the area of focus and the swath gap. However, annotation is expensive and currently the vast majority of existing data is unannotated. Hence, we propose an augmentation technique that considerably removes the existence of swath gaps in order to allow CNNs to focus on the ROI, and thus successfully use data with swath gaps for training. We experiment on the UC Merced Land Use Dataset, where we add swath gaps through empty polygons (up to 20 percent areas) and then apply augmentation techniques to fill the swath gaps. We compare the model trained with our augmentation techniques on the swath gap-filled data with the model trained on the original swath gap-less data and note highly augmented performance. Additionally, we perform a qualitative analysis using activation maps that visualizes the effectiveness of our trained network in not paying attention to the swath gaps. We also evaluate our results with a human baseline and show that, in certain cases, the filled swath gaps look so realistic that even a human evaluator did not distinguish between original satellite images and swath gap-filled images. Since this method is aimed at unlabeled data, it is widely generalizable and impactful for large scale unannotated datasets from various space data domains., Comment: Accepted to COSPAR 2021 Workshop on Cloud Computing for Space Sciences
- Published
- 2021
30. Next-Gen Machine Learning Supported Diagnostic Systems for Spacecraft
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Vlontzos, Athanasios, Sutherland, Gabriel, Ganju, Siddha, and Soboczenski, Frank
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
Future short or long-term space missions require a new generation of monitoring and diagnostic systems due to communication impasses as well as limitations in specialized crew and equipment. Machine learning supported diagnostic systems present a viable solution for medical and technical applications. We discuss challenges and applicability of such systems in light of upcoming missions and outline an example use case for a next-generation medical diagnostic system for future space operations. Additionally, we present approach recommendations and constraints for the successful generation and use of machine learning models aboard a spacecraft., Comment: Accepted in the AI for Spacecraft Longevity Workshop at IJCAI2021
- Published
- 2021
31. Synthesis and Antitumor Activity of Brominated-Ormeloxifene (Br-ORM) against Cervical Cancer
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Mohammed Sikander, Shabnam Malik, John Apraku, Sonam Kumari, Parvez Khan, Hassan Mandil, Aditya Ganju, Bhavin Chauhan, Maria C. Bell, Man Mohan Singh, Sheema Khan, Murali M. Yallapu, Fathi T. Halaweish, Meena Jaggi, and Subhash C. Chauhan
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Chemistry ,QD1-999 - Published
- 2023
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32. Learn-to-Race: A Multimodal Control Environment for Autonomous Racing
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Herman, James, Francis, Jonathan, Ganju, Siddha, Chen, Bingqing, Koul, Anirudh, Gupta, Abhinav, Skabelkin, Alexey, Zhukov, Ivan, Kumskoy, Max, and Nyberg, Eric
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Computer Science - Robotics ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Existing research on autonomous driving primarily focuses on urban driving, which is insufficient for characterising the complex driving behaviour underlying high-speed racing. At the same time, existing racing simulation frameworks struggle in capturing realism, with respect to visual rendering, vehicular dynamics, and task objectives, inhibiting the transfer of learning agents to real-world contexts. We introduce a new environment, where agents Learn-to-Race (L2R) in simulated competition-style racing, using multimodal information--from virtual cameras to a comprehensive array of inertial measurement sensors. Our environment, which includes a simulator and an interfacing training framework, accurately models vehicle dynamics and racing conditions. In this paper, we release the Arrival simulator for autonomous racing. Next, we propose the L2R task with challenging metrics, inspired by learning-to-drive challenges, Formula-style racing, and multimodal trajectory prediction for autonomous driving. Additionally, we provide the L2R framework suite, facilitating simulated racing on high-precision models of real-world tracks. Finally, we provide an official L2R task dataset of expert demonstrations, as well as a series of baseline experiments and reference implementations. We make all code available: https://github.com/learn-to-race/l2r., Comment: Accepted to the International Conference on Computer Vision (ICCV 2021); equal contribution - JH and JF; 15 pages, 4 figures
- Published
- 2021
33. Global Earth Magnetic Field Modeling and Forecasting with Spherical Harmonics Decomposition
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Tigas, Panagiotis, Bloch, Téo, Upendran, Vishal, Ferdoushi, Banafsheh, Cheung, Mark C. M., Ganju, Siddha, McGranaghan, Ryan M., Gal, Yarin, and Bhatt, Asti
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Physics - Geophysics ,Astrophysics - Solar and Stellar Astrophysics ,Computer Science - Machine Learning ,Physics - Space Physics - Abstract
Modeling and forecasting the solar wind-driven global magnetic field perturbations is an open challenge. Current approaches depend on simulations of computationally demanding models like the Magnetohydrodynamics (MHD) model or sampling spatially and temporally through sparse ground-based stations (SuperMAG). In this paper, we develop a Deep Learning model that forecasts in Spherical Harmonics space 2, replacing reliance on MHD models and providing global coverage at one minute cadence, improving over the current state-of-the-art which relies on feature engineering. We evaluate the performance in SuperMAG dataset (improved by 14.53%) and MHD simulations (improved by 24.35%). Additionally, we evaluate the extrapolation performance of the spherical harmonics reconstruction based on sparse ground-based stations (SuperMAG), showing that spherical harmonics can reliably reconstruct the global magnetic field as evaluated on MHD simulation., Comment: Third Workshop on Machine Learning and the Physical Sciences (NeurIPS 2020), Vancouver, Canada
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- 2021
34. Technology Readiness Levels for Machine Learning Systems
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Lavin, Alexander, Gilligan-Lee, Ciarán M., Visnjic, Alessya, Ganju, Siddha, Newman, Dava, Baydin, Atılım Güneş, Ganguly, Sujoy, Lange, Danny, Sharma, Amit, Zheng, Stephan, Xing, Eric P., Gibson, Adam, Parr, James, Mattmann, Chris, and Gal, Yarin
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Software Engineering - Abstract
The development and deployment of machine learning (ML) systems can be executed easily with modern tools, but the process is typically rushed and means-to-an-end. The lack of diligence can lead to technical debt, scope creep and misaligned objectives, model misuse and failures, and expensive consequences. Engineering systems, on the other hand, follow well-defined processes and testing standards to streamline development for high-quality, reliable results. The extreme is spacecraft systems, where mission critical measures and robustness are ingrained in the development process. Drawing on experience in both spacecraft engineering and ML (from research through product across domain areas), we have developed a proven systems engineering approach for machine learning development and deployment. Our "Machine Learning Technology Readiness Levels" (MLTRL) framework defines a principled process to ensure robust, reliable, and responsible systems while being streamlined for ML workflows, including key distinctions from traditional software engineering. Even more, MLTRL defines a lingua franca for people across teams and organizations to work collaboratively on artificial intelligence and machine learning technologies. Here we describe the framework and elucidate it with several real world use-cases of developing ML methods from basic research through productization and deployment, in areas such as medical diagnostics, consumer computer vision, satellite imagery, and particle physics.
- Published
- 2021
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35. SpaceML: Distributed Open-source Research with Citizen Scientists for the Advancement of Space Technology for NASA
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Koul, Anirudh, Ganju, Siddha, Kasam, Meher, and Parr, James
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Computer Science - Computer Vision and Pattern Recognition ,Physics - Space Physics - Abstract
Traditionally, academic labs conduct open-ended research with the primary focus on discoveries with long-term value, rather than direct products that can be deployed in the real world. On the other hand, research in the industry is driven by its expected commercial return on investment, and hence focuses on a real world product with short-term timelines. In both cases, opportunity is selective, often available to researchers with advanced educational backgrounds. Research often happens behind closed doors and may be kept confidential until either its publication or product release, exacerbating the problem of AI reproducibility and slowing down future research by others in the field. As many research organizations tend to exclusively focus on specific areas, opportunities for interdisciplinary research reduce. Undertaking long-term bold research in unexplored fields with non-commercial yet great public value is hard due to factors including the high upfront risk, budgetary constraints, and a lack of availability of data and experts in niche fields. Only a few companies or well-funded research labs can afford to do such long-term research. With research organizations focused on an exploding array of fields and resources spread thin, opportunities for the maturation of interdisciplinary research reduce. Apart from these exigencies, there is also a need to engage citizen scientists through open-source contributors to play an active part in the research dialogue. We present a short case study of SpaceML, an extension of the Frontier Development Lab, an AI accelerator for NASA. SpaceML distributes open-source research and invites volunteer citizen scientists to partake in development and deployment of high social value products at the intersection of space and AI., Comment: Accepted to COSPAR 2021 Workshop on Cloud Computing for Space Sciences. arXiv admin note: text overlap with arXiv:2011.04776. Edit 2021/02/16: Converted Space ML to SpaceML
- Published
- 2020
36. A Retrospective Review of Patient-reported Outcomes after Postaxial Polydactyly Ligation and Surgical Excision
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Nakul Ganju, BS, Esperanza Mantilla-Rivas, MD, Paul F. Martinez, BS, Monica Manrique, MD, Joseph M. Escandón, MD, Samay Shah, BS, Ashley E. Rogers, MD, Michael J. Boyajian, MD, Albert K. Oh, MD, and Gary F. Rogers, MD, JD, LLM, MBA, MPH
- Subjects
Surgery ,RD1-811 - Abstract
Background:. Interventions for type B postaxial polydactyly include suture ligation and surgical excision, yet there is a paucity of literature comparing the outcomes of these procedures. This study sought to compare patient-reported long-term outcomes of postaxial digit excision. Methods:. A six-question survey was distributed from January 2021 to March 2022 to patients who underwent treatment for type B postaxial polydactyly at a single pediatric institution from 2010 to 2016. Patients were queried about the incidence of pain sensitivity, keloid healing, and/or persistent presence of bump (“nubbin”) at the treatment site. Results:. A total of 158 responses accounting for 258 digits were attained for a 53% response rate. The majority of digits (67.4%, n = 174) were surgically excised. Median age at procedure was 49 days: 13.0 days for ligation, 63.0 days for surgical excision. Median age at survey was 8 [IQR 5.4–10.2] years. Short-term (
- Published
- 2024
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37. Learnings from Frontier Development Lab and SpaceML -- AI Accelerators for NASA and ESA
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Ganju, Siddha, Koul, Anirudh, Lavin, Alexander, Veitch-Michaelis, Josh, Kasam, Meher, and Parr, James
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Research with AI and ML technologies lives in a variety of settings with often asynchronous goals and timelines: academic labs and government organizations pursue open-ended research focusing on discoveries with long-term value, while research in industry is driven by commercial pursuits and hence focuses on short-term timelines and return on investment. The journey from research to product is often tacit or ad hoc, resulting in technology transition failures, further exacerbated when research and development is interorganizational and interdisciplinary. Even more, much of the ability to produce results remains locked in the private repositories and know-how of the individual researcher, slowing the impact on future research by others and contributing to the ML community's challenges in reproducibility. With research organizations focused on an exploding array of fields, opportunities for the handover and maturation of interdisciplinary research reduce. With these tensions, we see an emerging need to measure the correctness, impact, and relevance of research during its development to enable better collaboration, improved reproducibility, faster progress, and more trusted outcomes. We perform a case study of the Frontier Development Lab (FDL), an AI accelerator under a public-private partnership from NASA and ESA. FDL research follows principled practices that are grounded in responsible development, conduct, and dissemination of AI research, enabling FDL to churn successful interdisciplinary and interorganizational research projects, measured through NASA's Technology Readiness Levels. We also take a look at the SpaceML Open Source Research Program, which helps accelerate and transition FDL's research to deployable projects with wide spread adoption amongst citizen scientists.
- Published
- 2020
38. Clinical characteristics, etiological profile, treatment and long term outcomes in patients with non ischemic systolic heart failure; Himachal Pradesh heart failure registry (HP–HF registry)
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Prakash Chand Negi, Ashu Gupta, Meena Rana, Sanjeev Asotra, Neeraj Ganju, Rajeev Marwah, Rajesh Sharma, and Arvind Kandoria
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Non-ischemic systolic heart failure ,Risk factors ,Outcomes ,Guideline directed treatment ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: The data on clinical characteristics, treatment practices and out comes in patients with Non- ischemic Systolic Heart Failure (NISHF) is limited. We report clinical characteristics, treatment and outcomes in patients with NISHF. Methods: 1004 patients with NISHF were prospectively enrolled and their demographics, clinical characteristics, and treatment were recorded systematically. Patients were followed annually for a median of 3 years (1 year to 8 years) for allcause death, major adverse cardiovascular events (MACE); composite of all-cause death, hospitalization of heart failure, and or for stroke. Results: Patients of NISHF were middle-aged (58.8±16.2 years) population with severely depressed left ventricular ejection fraction (29.3±7.02%) and 31.1% had symptoms of advanced Heart failure. Hypertension (43.6%), obesity and or overweight (28.0%), Diabetes (15.0%), and valvular heart disease (11.8%) were the common risk factors. The guideline directed medical treatment was prescribed in more than 80% of the study cohort. Incidence of all cause death and MACE was 7 (6.8, 8.8) per 100 person years and 11(10, 13) per 100 person years respectively. The cumulative incidence of deaths and MACE was 35% (30%, 40%) and 49% (44%, 53%) at 8 years of follow-up. Conclusions: Patients of NISHF were middle-aged population with severely depressed LV systolic function with significant incident morbidity and mortality. Early detection of risk factors and their risk management and enhancing the use of guideline directed treatment may improve the outcomes. Keywords: Non-ischemic systolic heart failure, risk factors, outcomes, guideline directed treatment.
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- 2023
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39. Slit2/Robo1 signaling inhibits small‐cell lung cancer by targeting β‐catenin signaling in tumor cells and macrophages
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Dinesh K. Ahirwar, Bo Peng, Manish Charan, Swati Misri, Sanjay Mishra, Kirti Kaul, Salha Sassi, Venkat Sundar Gadepalli, Jalal Siddiqui, Wayne O. Miles, and Ramesh K. Ganju
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MDSCs ,Robo1 ,Slit2 ,small‐cell lung cancer ,TAMs ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Small‐cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with poor patient prognosis. However, the mechanisms that regulate SCLC progression and metastasis remain undefined. Here, we show that the expression of the slit guidance ligand 2 (SLIT2) tumor suppressor gene is reduced in SCLC tumors relative to adjacent normal tissue. In addition, the expression of the SLIT2 receptor, roundabout guidance receptor 1 (ROBO1), is upregulated. We find a positive association between SLIT2 expression and the Yes1 associated transcriptional regulator (YAP1)‐expressing SCLC subtype (SCLC‐Y), which shows a better prognosis. Using genetically engineered SCLC cells, adenovirus gene therapy, and preclinical xenograft models, we show that SLIT2 overexpression or the deletion of ROBO1 restricts tumor growth in vitro and in vivo. Mechanistic studies revealed significant inhibition of myeloid‐derived suppressor cells (MDSCs) and M2‐like tumor‐associated macrophages (TAMs) in the SCLC tumors. In addition, SLIT2 enhances M1‐like and phagocytic macrophages. Molecular analysis showed that ROBO1 knockout or SLIT2 overexpression suppresses the transforming growth factor beta 1 (TGF‐β1)/β‐catenin signaling pathway in both tumor cells and macrophages. Overall, we find that SLIT2 and ROBO1 have contrasting effects on SCLC tumors. SLIT2 suppresses, whereas ROBO1 promotes, SCLC growth by regulating the Tgf‐β1/glycogen synthase kinase‐3 beta (GSK3)/β‐catenin signaling pathway in tumor cells and TAMs. These studies indicate that SLIT2 could be used as a novel therapeutic agent against aggressive SCLC.
- Published
- 2023
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40. MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat
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Jasmine Chen, Aleks C. Guanizo, W. Samantha N. Jakasekara, Chaitanya Inampudi, Quinton Luong, Daniel J. Garama, Muhammad Alamgeer, Nishant Thakur, Michael DeVeer, Vinod Ganju, D. Neil Watkins, Jason E. Cain, and Daniel J. Gough
- Subjects
Small cell lung cancer ,Platinum resistance ,Mouse models ,MYC ,Fimepinostat ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer with an appalling overall survival of less than 5% (Zimmerman et al. J Thor Oncol 14:768-83, 2019). Patients typically respond to front line platinum-based doublet chemotherapy, but almost universally relapse with drug resistant disease. Elevated MYC expression is common in SCLC and has been associated with platinum resistance. This study evaluates the capacity of MYC to drive platinum resistance and through screening identifies a drug capable of reducing MYC expression and overcoming resistance. Methods Elevated MYC expression following the acquisition of platinum resistance in vitro and in vivo was assessed. Moreover, the capacity of enforced MYC expression to drive platinum resistance was defined in SCLC cell lines and in a genetically engineered mouse model that expresses MYC specifically in lung tumors. High throughput drug screening was used to identify drugs able to kill MYC-expressing, platinum resistant cell lines. The capacity of this drug to treat SCLC was defined in vivo in both transplant models using cell lines and patient derived xenografts and in combination with platinum and etoposide chemotherapy in an autochthonous mouse model of platinum resistant SCLC. Results MYC expression is elevated following the acquisition of platinum resistance and constitutively high MYC expression drives platinum resistance in vitro and in vivo. We show that fimepinostat decreases MYC expression and that it is an effective single agent treatment for SCLC in vitro and in vivo. Indeed, fimepinostat is as effective as platinum-etoposide treatment in vivo. Importantly, when combined with platinum and etoposide, fimepinostat achieves a significant increase in survival. Conclusions MYC is a potent driver of platinum resistance in SCLC that is effectively treated with fimepinostat.
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- 2023
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41. Incidence, determinants, and outcomes of recovered left ventricular ejection fraction (LVEF) in patients with non-ischemic systolic heart failure; a hospital-based cohort study
- Author
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Prakash Chand Negi, Ashu Gupta, Pryanka Thakur, Sanjeev Asotra, Neeraj Ganju, Rajive Marwah, Rajesh Sharma, and Arvind Kandoria
- Subjects
Heart failure with reduced ejection fraction ,Non ischemic systolic heart failure ,Recovered ejection fraction ,Outcomes ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: The data on incidence of recovered Left Ventricular Ejection Fraction (LVEF) and outcome in patients with non ischemic systolic heart failure is limited. We report the incidence, determinants and mortality in patients with recovered LVEF. Methods: The 369 patients with HFrEF with LVEF of less than 40% of non ischemic etiology with available follow up echocardiography study at one year were enrolled. The baseline data of clinical characteristics and treatment was recorded prospectively and were followed up annually for mean of 3.6 years (range 2 to 5 years) to record all cause death and LVEF measured echocardiographically. The recovered, partially recovered and no recovery of LVEF was defined based on increase in LVEF to 50% and more, 41% to 49% and to persistently depressed LVEF to 40% or lower respectively. Results: The LVEF recovered in 36.5%% of the cohort at 5 years. The rate of recovery of LVEF was slower in patients with no recovery of LVEF at one year compared to cohort with partially recovered LVEF (18% vs.53%) at five year. The Baseline LVEF was significantly associated with recovered LVEF, odd ratio (95% C.I.) 1.09(1.04, 1.14). The cumulative mortality at five years was significantly lower in cohort with recovered LVEF (18.1% vs. 57.1%). Conclusions: One third of the patients had recovered LVEF and was significantly associated with baseline LVEF and lower mortality rate.
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- 2023
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42. Impact of high altitude on composition and functional profiling of oral microbiome in Indian male population
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Manisha Kumari, Brij Bhushan, Malleswara Rao Eslavath, Ashish Kumar Srivastava, Ramesh Chand Meena, Rajeev Varshney, and Lilly Ganju
- Subjects
Medicine ,Science - Abstract
Abstract The oral cavity of human contains bacteria that are critical for maintaining the homeostasis of the body. External stressors such as high altitude (HA) and low oxygen affect the human gut, skin and oral microbiome. However, compared to the human gut and skin microbiome, studies demonstrating the impact of altitude on human oral microbiota are currently scarce. Alterations in the oral microbiome have been reported to be associated with various periodontal diseases. In light of the increased occurrence of HA oral health related problems, the effect of HA on the oral salivary microbiome was investigated. We conducted a pilot study in 16 male subjects at two different heights i.e., H1 (210 m) and H2 (4420 m). Total of 31 saliva samples,16 at H1 and 15 at H2 were analyzed by utilizing the 16S rRNA high-throughput sequencing, to explore the relationship between the HA environment and salivary microbiota. The preliminary results suggesting that, the most abundant microbiome at the phylum level are: Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria. Interestingly, 11 genera were identified at the both heights with different relative abundances. In addition, the salivary microbiome was more diverse at H1 compared to H2 as demonstrated by decreased alpha diversity. Further, predicted functional results indicate that microbial metabolic profiles significantly decreased at H2 as compared to H1, including two major metabolic pathways involving carbohydrates, and amino acids. Our findings show that HA induces shifts in the composition and structure of human oral microbiota which can affect host health homeostasis.
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- 2023
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43. An omni-channel, outcomes-focused approach to scale digital health interventions in resource-limited populations: a case study
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Aditi Hazra-Ganju, Schenelle Dayna Dlima, Sonia Rebecca Menezes, Aakash Ganju, and Anjali Mer
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digital health ,mobile health ,mobile app ,behaviour change ,resource-limited settings ,scaling ,Medicine ,Public aspects of medicine ,RA1-1270 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Populations in resource-limited communities have low health awareness, low financial literacy levels, and inadequate access to primary healthcare, leading to low adoption of preventive health behaviours, low healthcare-seeking behaviours, and poor health outcomes. Healthcare providers have limited reach and insights, limiting their ability to design relevant products for resource limited settings. Our primary preventive health intervention, called the Saathealth family health interventions, is a scaled digital offering that aims to improve knowledge levels on various health topics, nudge positive behaviour changes, and drive improved health outcomes. This case study presents our learnings and best practices in scaling these digital health interventions in resource-limited settings and maximising their impact. We scaled the Saathealth interventions to cumulatively reach >10 million users across India using a multi-pronged approach: (1) ensuring localization and cultural relevance of the health content delivered through user research; (2) disseminating content using omni-channel approaches, which involved using diverse content types and multiple digital platforms; (3) using iterative product features such as gamification and artificial intelligence-based (AI-based) predictive models; (4) using real-time analytics to adapt the user's digital experience by using interactive content to drive them towards products and services and (5) experiments with sustainability models to yield some early successes. The Saathealth family health mobile app had >25,000 downloads and the intervention reached >873,000 users in India every month through the mobile app, Facebook, and Instagram combined, from the time period of February 2022 to January 2023. We repeatedly observed videos and quizzes to be the most popular content types across all digital channels being used. Our AI-based predictive models helped improve user retention and content consumption, contributing to the sustainability of the mobile apps. In addition to reaching a high number of users across India, our scaling strategies contributed to deepened engagement and improved health-seeking behaviour. We hope these strategies help guide the sustainable and impactful scaling of mobile health interventions in other resource-limited settings.
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- 2023
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44. Severe heat stress modulated nuclear factor erythroid 2-related factor 2 and macrophage migration inhibitory factor pathway in rat liver
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Gupta, Avinash, Sharma, Dolly, Gupta, Harshita, Singh, Ajeet, Chowdhury, Daipayan, Ganju, Lilly, and Meena, Ramesh Chand
- Published
- 2022
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45. 782 TransCon TLR7/8 agonist induces sustained local and systemic immune activation in patients with solid tumors
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David Bajor, Nashat Gabrail, Alain Algazi, Diwakar Davar, Douglas Laux, Morteza Aghmesheh, Joan Morris, Vinod Ganju, Vibeke Miller Breinholt, Mette Kriegbaum, Alexander I Spira, Christian Krapp, Telma Lança, Stina Singel, and Thomas Tuxen Poulsen
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2023
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46. Development and Application of Landsat-Based Wetland Vegetation Cover and UnVegetated-Vegetated Marsh Ratio (UVVR) for the Conterminous United States
- Author
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Ganju, Neil K., Couvillion, Brady R., Defne, Zafer, and Ackerman, Katherine V.
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- 2022
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47. Development of robust, indigenous ELISA for detection of IgG antibodies against CoV-2 N and S proteins: mass screening
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Srivastava, Ashish Kumar, Gupta, Avinash, Chauhan, Deepika, Meena, Ramesh Chand, Sugadev, Ragumani, Eslavath, Malleswara Rao, Gupta, Harshita, Karuna, Singh, Sayar, Singh, Yamini, Tiwari, R. P., Kohli, Veena, Varshney, Rajeev, and Ganju, Lilly
- Published
- 2022
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48. Application of CFD model for passive autocatalytic recombiners to formulate an empirical correlation for integral containment analysis
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Vikram Shukla, Bhuvaneshwar Gera, Sunil Ganju, Salil Varma, N.K. Maheshwari, P.K. Guchhait, and S. Sengupta
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Nuclear power plants ,Severe accidents ,Passive autocatalytic recombiner ,Computational fluid dynamics ,Hydrogen mitigation ,Empirical correlation ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
Hydrogen mitigation using Passive Autocatalytic Recombiners (PARs) has been widely accepted methodology inside reactor containment of accident struck Nuclear Power Plants. They reduce hydrogen concentration inside reactor containment by recombining it with oxygen from containment air on catalyst surfaces at ambient temperatures. Exothermic heat of reaction drives the product steam upwards, establishing natural convection around PAR, thus invoking homogenisation inside containment. CFD models resolving individual catalyst plate channels of PAR provide good insight about temperature and hydrogen recombination. But very thin catalyst plates compared to large dimensions of the enclosures involved result in intensive calculations. Hence, empirical correlations specific to PARs being modelled are often used in integral containment studies. In this work, an experimentally validated CFD model of PAR has been employed for developing an empirical correlation for Indian PAR. For this purpose, detailed parametric study involving different gas mixture variables at PAR inlet has been performed. For each case, respective values of gas mixture variables at recombiner outlet have been tabulated. The obtained data matrix has then been processed using regression analysis to obtain a set of correlations between inlet and outlet variables. The empirical correlation thus developed, can be easily plugged into commercially available CFD software.
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- 2022
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49. Technology readiness levels for machine learning systems
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Alexander Lavin, Ciarán M. Gilligan-Lee, Alessya Visnjic, Siddha Ganju, Dava Newman, Sujoy Ganguly, Danny Lange, Atílím Güneş Baydin, Amit Sharma, Adam Gibson, Stephan Zheng, Eric P. Xing, Chris Mattmann, James Parr, and Yarin Gal
- Subjects
Science - Abstract
The development of machine learning systems has to ensure their robustness and reliability. The authors introduce a framework that defines a principled process of machine learning system formation, from research to production, for various domains and data scenarios.
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- 2022
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50. Severity and mortality associated with COVID-19 among children hospitalised in tertiary care centres in India: a cohort studyResearch in context
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Vidushi Gupta, Amitabh Singh, Sheetal Ganju, Raghvendra Singh, Ramachandran Thiruvengadam, Uma Chandra Mouli Natchu, Nitesh Gupta, Deepali Kaushik, Surbhi Chanana, Dharmendra Sharma, Mudita Gosain, Suman PN. Rao, Narendra Pandey, Arvind Gupta, Sandeep Singh, Urmila Jhamb, Lalitha Annayappa Venkatesh, Chitra Dinakar, Anil Kumar Pandey, Rani Gera, Harish Chellani, Nitya Wadhwa, and Shinjini Bhatnagar
- Subjects
Child ,Severe COVID-19 disease ,MIS-C ,Mortality ,LMICs ,Public aspects of medicine ,RA1-1270 - Abstract
Summary: Background: It is critical to identify high-risk groups among children with COVID-19 from low-income and middle-income countries (LMICs) to facilitate the optimum use of health system resources. The study aims to describe the severity and mortality of different clinical phenotypes of COVID-19 in a large cohort of children admitted to tertiary care hospitals in India. Methods: Children aged 0–19 years with evidence of SARS-CoV-2 infection (real time polymerase chain reaction or rapid antigen test positive) or exposure (anti-SARS-CoV-2 antibody, or history of contact with SARS-CoV-2) were enrolled in the study, between January 2021 and March 2022 across five tertiary hospitals in India. All study participants enrolled prospectively and retrospectively were followed up for three months after discharge. COVID-19 was classified into severe (Multisystem Inflammatory Syndrome in Children (MIS-C), severe acute COVID-19, ‘unclassified’) or non-severe disease. The mortality rates were estimated in different phenotypes. Findings: Among 2468 eligible children enrolled, 2148 were hospitalised. Signs of illness were present in 1688 (79%) children with 1090 (65%) having severe disease. High mortality was reported in MIS-C (18.6%), severe acute COVID-19 (13.3%) and the unclassified severe COVID-19 disease (12.3%). Mortality remained high (17.5%) when modified MIS-C criteria was used. Non-severe COVID-19 disease had 14.1% mortality when associated with comorbidity. Interpretation: Our findings have important public health implications for low resource settings. The high mortality underscores the need for better preparedness for timely diagnosis and management of COVID-19. Children with associated comorbidity or coinfections are a vulnerable group and need special attention. MIS-C requires context specific diagnostic criteria for low resource settings. It is important to evaluate the clinical, epidemiological and health system-related risk factors associated with severe COVID-19 and mortality in children from LMICs. Funding: Department of Biotechnology, Govt of India and Department of Maternal, Child and Adolescent Health and Aging, WHO, Geneva, Switzerland.
- Published
- 2023
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