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9 results on '"Ganiem, Ahmad R."'

2. Neurological Disease Associated with Chikungunya in Indonesia

Author

Myint, Khin S. A., primary, Mawuntu, Arthur H. P., additional, Haryanto, Sotianingsih, additional, Imran, Darma, additional, Dian, Sofiati, additional, Dewi, Yora P., additional, Ganiem, Ahmad R., additional, Anggreani, Riane, additional, Iskandar, Mirna M., additional, Bernadus, Janno B. B., additional, Maharani, Kartika, additional, Susanto, David, additional, Estiasari, Riwanti, additional, Dewi, Hasna, additional, Kristiani, Amanda, additional, Gaghiwu, Lidia, additional, Johar, Edison, additional, Yudhaputri, Frilasita A., additional, Antonjaya, Ungke, additional, Ledermann, Jeremy P., additional, van Crevel, Reinout, additional, Hamers, Raph L., additional, and Powers, Ann M., additional

Published
2022
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5. High dose oral rifampicin to improve survival from adult tuberculous meningitis: A randomised placebo-controlled double-blinded phase III trial (the HARVEST study)

Author

Marais, Suzaan, primary, Cresswell, Fiona V, additional, Hamers, Raph L., additional, te Brake, Lindsey H.M., additional, Ganiem, Ahmad R., additional, Imran, Darma, additional, Bangdiwala, Ananta, additional, Martyn, Emily, additional, Kasibante, John, additional, Kagimu, Enock, additional, Musubire, Abdu, additional, Maharani, Kartika, additional, Estiasari, Riwanti, additional, Kusumaningrum, Ardiana, additional, Kusumadjayanti, Nadytia, additional, Yunivita, Vycke, additional, Naidoo, Kogieleum, additional, Lessells, Richard, additional, Moosa, Yunus, additional, Svensson, Elin M., additional, Huppler Hullsiek, Katherine, additional, Aarnoutse, Rob E., additional, Boulware, David R., additional, van Crevel, Reinout, additional, Ruslami, Rovina, additional, and Meya, David B., additional

Published
2020
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6. Pharmacokinetics and safety/tolerability of isoniazid, rifampicin and pyrazinamide in children and adolescents treated for tuberculous meningitis.

Author

Ruslami, Rovina, Gafar, Fajri, Yunivita, Vycke, Parwati, Ida, Ganiem, Ahmad R., Aarnoutse, Rob E., Wilffert, Bob, Alffenaar, Jan-Willem C., and Nataprawira, Heda M.

Subjects
TUBERCULOUS meningitis, ISONIAZID, ANTITUBERCULAR agents, RIFAMPIN, PYRAZINAMIDE
Abstract

Objective To assess the pharmacokinetics and safety/tolerability of isoniazid, rifampicin and pyrazinamide in children and adolescents with tuberculous meningitis (TBM). Design Prospective observational pharmacokinetic study with an exploratory pharmacokinetic/pharmacodynamic analysis. Setting Hasan Sadikin Hospital, Bandung, Indonesia. Patients Individuals aged 0-18 years clinically diagnosed with TBM and receiving first-line anti-tuberculosis drug dosages according to revised WHO-recommended treatment guidelines. Interventions Plasma and cerebrospinal fluid (CSF) concentrations of isoniazid, rifampicin and pyrazinamide were assessed on days 2 and 10 of treatment. Main outcome measures Plasma exposures during the daily dosing interval (AUC0-24), peak plasma concentrations (Cmax) and CSF concentrations. Results Among 20 eligible patients, geometric mean AUC0-24 of isoniazid, rifampicin and pyrazinamide was 18.5, 66.9 and 315.5 hour·mg/L on day 2; and 14.5, 71.8 and 328.4 hour·mg/L on day 10, respectively. Large interindividual variabilities were observed in AUC0-24 and Cmax of all drugs. All patients had suboptimal rifampicin AUC0-24 for TBM treatment indication and very low rifampicin CSF concentrations. Four patients developed grade 2-3 drug-induced liver injury (DILI) within the first 4 weeks of treatment, in whom anti-tuberculosis drugs were temporarily stopped, and no DILI recurred after reintroduction of rifampicin and isoniazid. AUC0-24 of isoniazid, rifampicin and pyrazinamide along with Cmax of isoniazid and pyrazinamide on day 10 were higher in patients who developed DILI than those without DILI (p<0.05). Conclusion Higher rifampicin doses are strongly warranted in treatment of children and adolescents with TBM. The association between higher plasma concentrations of isoniazid, rifampicin and pyrazinamide and the development of DILI needs confirmatory studies. [ABSTRACT FROM AUTHOR]

Published
2022
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7. High dose oral rifampicin to improve survival from adult tuberculous meningitis: A randomised placebo-controlled double-blinded phase III trial (the HARVEST study)

Author

Marais, Suzaan, primary, Cresswell, Fiona V, additional, Hamers, Raph L., additional, te Brake, Lindsey H.M., additional, Ganiem, Ahmad R., additional, Imran, Darma, additional, Bangdiwala, Ananta, additional, Martyn, Emily, additional, Kasibante, John, additional, Kagimu, Enock, additional, Musubire, Abdu, additional, Maharani, Kartika, additional, Estiasari, Riwanti, additional, Kusumaningrum, Ardiana, additional, Kusumadjayanti, Nadytia, additional, Yunivita, Vycke, additional, Naidoo, Kogieleum, additional, Lessells, Richard, additional, Moosa, Yunus, additional, Svensson, Elin M., additional, Huppler Hullsiek, Katherine, additional, Aarnoutse, Rob E., additional, Boulware, David R., additional, van Crevel, Reinout, additional, Ruslami, Rovina, additional, and Meya, David B., additional

Published
2019
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8. Use of whole genome sequencing to predict Mycobacterium tuberculosis drug resistance in Indonesia

Author

Sub Bioinformatics, Theoretical Biology and Bioinformatics, Chaidir, Lidya, Ruesen, Carolien, Dutilh, Bas E, Ganiem, Ahmad R, Andryani, Anggriani, Apriani, Lika, Huynen, Martijn A, Ruslami, Rovina, Hill, Philip C, Crevel, Reinout van, Alisjahbana, Bachti, Sub Bioinformatics, Theoretical Biology and Bioinformatics, Chaidir, Lidya, Ruesen, Carolien, Dutilh, Bas E, Ganiem, Ahmad R, Andryani, Anggriani, Apriani, Lika, Huynen, Martijn A, Ruslami, Rovina, Hill, Philip C, Crevel, Reinout van, and Alisjahbana, Bachti

Published
2019

9. Use of whole-genome sequencing to predict Mycobacterium tuberculosisdrug resistance in Indonesia

Author

Chaidir, Lidya, Ruesen, Carolien, Dutilh, Bas E., Ganiem, Ahmad R., Andryani, Anggriani, Apriani, Lika, Huynen, Martijn A., Ruslami, Rovina, Hill, Philip C., van Crevel, Reinout, and Alisjahbana, Bachti

Abstract

•Whole-genome sequencing (WGS) has the potential for comprehensive prediction of drug-resistant TB in Indonesia.•High agreement of WGS and phenotypic resistance for rifampicin and isoniazid, but lower for ethambutol and streptomycin.•Reported prior TB treatment poorly corresponded with genotypic drug resistance.•Primary drug resistance was common in this population of Indonesian patients.

Published
2019
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