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389 results on '"Ganguly, Nirmal K."'

1. Current Concepts and Advances in Oncobiology

Author

Gosipatala, Sunil Babu, Reddy, Pushpa, Khalko, Raj Kumar, Bisht, Nivedita, Kuril, Shruti R., Madhuri, Kaja, Kasaudhan, Rishabh, Yadav, Saurabh, Chand, Gyan, Kaur, Tejinder, Thakur, Manish, Sobti, R. C., Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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2. Technological Advancements in Cancer Diagnosis and Prognosis

Author

Reddy, Pushpa, Singh, Pradyumn, Kuril, Shruti R., Priyadarshini, Arti, Gosipatala, Sunil Babu, Chand, Gyan, R., Venkatesh Kumar, Kaur, Tejinder, Thakur, Manish, Sobti, R. C., Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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3. Mechanisms of Oncogenesis

Author

Guleria, Kamlesh, Sambyal, Vasudha, Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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4. Advanced Therapeutic Approaches in Cancer Therapy

Author

Sobti, R. C., Gosipatala, Sunil Babu, Reddy, Pushpa, Bisht, Nivedita, Kuril, Shruti R., Madhuri, Kaja, Chand, Gyan, Kaur, Tejinder, Thakur, Manish, Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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5. Genetics of Cancer: Past, Present, and Future

Author

Guleria, Kamlesh, Sambyal, Vasudha, Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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7. Point of Care Molecular Diagnostics in Cancer

Author

Gill, Sikander S., Gill, Rajwant K., Sobti, R. C., Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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10. Strategies of Early Diagnosis of Cancers

Author

Singh, Ashutosh, Handa, Vrishbhanu, Kaur, Harminder, Likhitkar, Shailesh, Singh, Rahul Soloman, Medhi, Bikash, Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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13. Molecular Pathways in Breast Cancer Chemoresistance

Author

Das, Subhayan, Kundu, Moumita, Dey, Ankita, Bharadwaj, Deblina, Roy, Pritam Kumar, Banerjee, Shreya, Mandal, Mahitosh, Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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19. Types of Cancers, Epidemiology, and Molecular Insights

Author

Sobti, R. C., Gosipatala, Sunil Babu, Sharma, Monica, Reddy, Pushpa, Khalko, Raj Kumar, Kaur, Tejinder, Thakur, Manish, Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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23. Skin Cancer: An Overview

Author

Kaur, Harjot, Bhardwaj, Alka, Sehgal, Amit, Mohi, Gursimran Kaur, Kumar, Ravinder, Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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25. Recent Developments in Cancer Detection and Treatment

Author

Bairmani, Zinah Aqeel, Alfroukh, Khadeejeh M. A., Bairmani, Fatimah Aqeel, Singh, Jagmohan, Gandhi, Vishwa V., Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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27. Advances in Cancer Pain Management

Author

Sharma, Gautam, Lynn, Rachael Rzasa, Sharma, Tushar, Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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30. Tumor Heterogeneity in Breast Cancer Progression

Author

Mishra, Yasaswi Gayatri, Kalali, Sruchytha, Kizhuvedath, Ajnas, Indumathi, A., Adhikari, Arkaprabha, Tanisha, Manavathi, Bramanandam, Sobti, Ranbir Chander, Section editor, Kumar, Rakesh, Section editor, Ganguly, Nirmal K., Section editor, Sobti, R. C., editor, Ganguly, Nirmal K., editor, and Kumar, Rakesh, editor

Published
2024
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33. Chandipura Virus Forms Cytoplasmic Inclusion Bodies through Phase Separation and Proviral Association of Cellular Protein Kinase R and Stress Granule Protein TIA-1.

Author

Sarkar, Sharmistha, Ganguly, Surajit, Ganguly, Nirmal K., Sarkar, Debi P., and Sharma, Nishi Raj

Subjects
RNA-binding proteins, HEAT shock proteins, STRESS granules, INITIATION factors (Biochemistry), CELLULAR inclusions
Abstract

Negative-strand RNA viruses form cytoplasmic inclusion bodies (IBs) representing virus replication foci through phase separation or biomolecular condensation of viral and cellular proteins, as a hallmark of their infection. Alternatively, mammalian cells form stalled mRNA containing antiviral stress granules (SGs), as a consequence of phosphorylation of eukaryotic initiation factor 2α (eIF2α) through condensation of several RNA-binding proteins including TIA-1. Whether and how Chandipura virus (CHPV), an emerging human pathogen causing influenza-like illness, coma and death, forms IBs and evades antiviral SGs remain unknown. By confocal imaging on CHPV-infected Vero-E6 cells, we found that CHPV infection does not induce formation of distinct canonical SGs. Instead, CHPV proteins condense and co-localize together with SG proteins to form heterogeneous IBs, which ensued independent of the activation of eIF2α and eIF2α kinase, protein kinase R (PKR). Interestingly, siRNA-mediated depletion of PKR or TIA-1 significantly decreased viral transcription and virion production. Moreover, CHPV infection also caused condensation and recruitment of PKR to IBs. Compared to SGs, IBs exhibited significant rapidity in disassembly dynamics. Altogether, our study demonstrating that CHPV replication co-optimizes with SG proteins and revealing an unprecedented proviral role of TIA-1/PKR may have implications in understanding the mechanisms regulating CHPV-IB formation and designing antiviral therapeutics. Importance: CHPV is an emerging tropical pathogen reported to cause acute influenza-like illness and encephalitis in children with a very high mortality rate of ~70%. Lack of vaccines and an effective therapy against CHPV makes it a potent pathogen for causing an epidemic in tropical parts of globe. Given these forewarnings, it is of paramount importance that CHPV biology must be understood comprehensively. Targeting of host factors offers several advantages over targeting the viral components due to the generally higher mutation rate in the viral genome. In this study, we aimed at understanding the role of SGs forming cellular RNA-binding proteins in CHPV replication. Our study helps understand participation of cellular factors in CHPV replication and could help develop effective therapeutics against the virus. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Oxidative Stress in Tuberculosis

Author

Verma, Indu, Jindal, Surinder K., Ganguly, Nirmal K., Armstrong, Donald, Editor-in-chief, Ganguly, Nirmal K., editor, Jindal, Surinder K., editor, Biswal, Shyam, editor, Barnes, Peter J., editor, and Pawankar, Ruby, editor

Published
2014
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39. Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial

Author

Sur, Dipika, Lopez, Anna Lena, Kanungo, Suman, Paisley, Allison, Manna, Byomkesh, Ali, Mohammad, Niyogi, Swapan K, Park, Jin Kyung, Sarkar, Banawarilal, Puri, Mahesh K, Kim, Deok Ryun, Deen, Jacqueline L, Holmgren, Jan, Carbis, Rodney, Rao, Raman, Van, Nguyen Thu, Donner, Allan, Ganguly, Nirmal K, Nair, G Balakrish, Bhattacharya, Sujit K, and Clemens, John D

Published
2009
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40. Group A streptococcal sore throat in a periurban population of northern India: a one-year prospective study

Author

Nandi Sobhan, Kumar Rajesh, Ray Pallab, Vohra Harpreet, and Ganguly Nirmal K.

Subjects
Pharyngitis/microbiology, Streptococcus pyogenes/pathogenicity, Child, Smoke/adverse effects, Poverty areas, Socioeconomic factors, Cohort studies, India, Public aspects of medicine, RA1-1270
Abstract

OBJECTIVE: To estimate the incidence and risk factors of group A streptococcus (GAS) sore throat among school-aged children living in a periurban slum area of Chandigarh, North India. METHODS: A total of 536 children aged 5-15 years from 261 families identified by a systematic random selection method were enrolled in the study. Episodes of sore throat were recorded through fortnightly home visits over a one-year period. The local vernacular (Hindi) terms gala kharab (bad throat) and khansi jukam (cough and cold) were used to identify symptoms of sore throat, and throat swab specimens were collected from children who had these symptoms on the day of the home visit. Bacterial culture was carried out and the isolation of GAS was confirmed using group-A-specific antiserum. FINDINGS: The incidences of sore throat and GAS sore throat were, respectively, 7.05 and 0.95 episodes per child-year. The incidence was higher in the following situations: among 11-year-olds, during the winter (November to January) and rainy (August) months (a bimodal peak), among children living in houses where there was no separate room for the kitchen, and in homes that included a tobacco smoker. CONCLUSION: The results show that the incidence of GAS sore throat was related to age, season, and indoor air pollution.

Published
2001

41. A cluster-randomized effectiveness trial of Vi-typhoid vaccine in India

Author

Sur, Dipika, Ochiai, Leon, Bhattacharya, Sujit K., Ganguly, Nirmal K., Ali, Mohammad, Manna, Byomkesh, Dutta, Shanta, Donner, Allan, Kanungo, Suman, Park, Jin Kung, Puri, Mahesh K., Kim, Deok Ryun, Dutta, Dharitri, Clemens, John D., Acosta, Camilo J., and Bhaduri, Barnali

Subjects
Polysaccharides -- Usage, Typhoid fever -- Control, Typhoid vaccine -- Dosage and administration, Typhoid vaccine -- Evaluation
Abstract

A study was conducted to ascertain the efficacy of the Vi polysaccharide typhoid vaccine when administered to children less than 5 years of age. Results revealed that the vaccine was effective in young children as well as protected the unvaccinated neighbors of vaccinees and should be used in areas where typhoid is endemic.

Published
2009

47. Acknowledgements

Author

Ganguly, Nirmal K., primary, Takeda, Yoshifumi, additional, Nair, G.B, additional, David Clemens, John, additional, and Qadri, Firdausi, additional

Published
2020
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48. Topical Sisomycin In The Management Of Atopic Dermatitis

Author

Dhar Sandipan, Kanwar Amrinder J, Kohil Manjula, and Ganguly Nirmal K

Subjects
Dermatology, RL1-803
Abstract

Thirty-four children (up to 12 years) with atopic dermatitis (AD) having few localized lesions of eczema were treated with topical sisomicin sulphate (0.1%). After 2 weeks of twice daily application of sisomicin, there was neither any clinical nor any bacteriological improvement. Topical sisomicin was not found to be useful in the management of AD.

Published
1996

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