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3. Health innovation networks to help developing countries address neglected diseases

Author

Morel, Carlos M., Acharya, Tara, Broun, Denis, Dangi, Ajit, Elias, Christopher, Ganguly, N.K., Gardner, Charles A., Gupta, R.K., Haycock, Jane, Heher, Anthony D., Hotez, Peter J., Kettler, Hannah E., Keusch, Gerald T., Krattiger, Anatole F., Kreutz, Fernando T., Lall, Sanjaya, Lee, Keun, Mahoney, Richard, Martinez-Palomo, Adolfo, Mashelkar, R.A., Matlin, Stephen A., Mzimba, Mandi, Oehler, Joachim, Ridley, Robert G., Senanayake, Pramilla, Singer, Peter, and Yun, Mikyung

Subjects
Diseases -- Care and treatment -- Prevention -- International aspects, Developing countries -- Health aspects -- Diseases, Public health -- International aspects -- Finance -- Quality management -- Health aspects, Company financing, Science and technology
Abstract

Gross inequities in disease burden between developed and developing countries are now the subject of intense global attention. Public and private donors have marshaled resources and created organizational structures to accelerate the development of new health products and to procure and distribute drugs and vaccines for the poor. Despite these encouraging efforts directed primarily from and funded by industrialized countries, sufficiency and sustainability remain enormous challenges because of the sheer magnitude of the problem. Here we highlight a complementary and increasingly important means to improve health equity: the growing ability of some developing countries to undertake health innovation., Improving the health of the poorest people in the developing world depends on the development and deployment of many varieties of health innovations, including new drugs, vaccines, devices, and diagnostics, [...]

Published
2005

5. The need for a global HIV vaccine enterprise. (Medicine)

Author

Klausner, Richard D., Fauci, Anthony S., Corey, Lawrence, Nabel, Gary J., Gayle, Helene, Berkley, Seth, Haynes, Barton F., Baltimore, David, Collins, Chris, Douglas, R. Gordon, Esparza, Jose, Francis, Donald P., Ganguly, N.K., Gerberding, Julie Louise, Johnston, Margaret I., Kazatchkine, Michael D., McMichael, Andrew J., Makgoba, Malegapuru W., Pantaleo, Giuseppe, Piot, Peter, Shao, Yiming, Tramont, Edmund, Varmus, Harold E., and Wasserheit, Judith N.

Subjects
International aspects, Research, Product development, AIDS vaccines -- Research -- International aspects -- Product development
Abstract

Since the discovery of HIV 20 years ago and the demonstration that HIV is the cause of AIDS, the world has awaited the development of an effective preventive vaccine. Recent [...]

Published
2003

14. Epidemiology of rheumatic fever and rheumatic heart disease in a rural community in northern India

Author

Grover, A., Dhawan, A., Iyengar, S.D., Anand, I.S., Wahi, P.L., and Ganguly, N.K.

Subjects
Rheumatic fever -- Demographic aspects, Rheumatic heart disease -- Demographic aspects, India -- Health aspects
Abstract

The epidemiology of rheumatic fever and rheumatic heart disease in a rural community (total population 114 610) in northern India was studied by setting up a registry based on primary health care centres. Health workers and schoolteachers were trained to identify suspected patients in school and village surveys (121 villages). Medical specialists screened 5-15-year-olds (n = 31 200). The population was followed up for 3 years (from March 1988 to March 1991). All suspected and registered cases were investigated by serial echocardiography and Doppler ultrasonography at a tertiary care centre. A total of 102 cases were confirmed to have rheumatic fever/rheumatic heart disease (prevalence, 0.09%); 66 were aged 5-15 years (prevalence, 0.21%). A total of 48 patients (24 males, 24 females; mean age, 12.11 +/- 3.7 years) were diagnosed to have a possible first attack of rheumatic fever (incidence, 0.54 per 1000 per year). Arthritis was observed in 36 (75%) and carditis in 18 (37.5%) of cases. Prolapse of the anterior mitral leaflet into the left atrium occurred in 5 (22%) cases with carditis. Mitral regurgitation was observed in all 18 cases of carditis; over the period of observation it disappeared in three cases and progressed to mitral stenosis in a further three. A total of 22 patients (11 males, 11 females; mean age, 19.41 +/- 8.1 years) were registered as rheumatic fever recurrences, and 32 patients (1 8 females, 14 males; mean age, 22. 1 +/- 10.1 years) had chronic rheumatic heart disease. Of those with recurrences, 9 (41%) had carditis and 11 (50%) had arthritis. No recurrences were observed among patients who complied with secondary prophylaxis with benzathine penicillin at 4-week intervals. Four patients with chronic rheumatic heart disease required mitral valvotomy and three required valve replacements. Eight patients (5 males, 3 females; mean age, 21.8 +/- 8.8 years) died over the duration of the study period (3 with acute rheumatic fever, 3 from progressive heart failure, 1 from an adverse penicillin reaction, and 1 from a non-cardiac cause)., Introduction In developed countries acute rheumatic fever and rheumatic heart disease were considered to be of decreasing significance until reports of recent outbreaks.[1-8] In developing countries most studies of these [...]

Published
1993

26. India's response to the HIV epidemic

Author

Rao, J.V.R. Prasada, Ganguly, N.K., Mehendale, Sanjay M., and Bollinger, Robert C.

Subjects
Tuberculosis -- Care and treatment, HIV infection -- Care and treatment, Patients -- Care and treatment
Published
2004

27. Volatile Organic Compounds as Exhaled Biomarkers of Inflammation and Oxidative Stress in Respiratory Diseases

Author

van Schooten, F.J., Boots, A.W., Smolinska, A.M., Dallinga, J.W., Ganguly, N.K., Jindal, S.K., Biswal, S., Barnes, P.J., Pawankar, R., Farmacologie en Toxicologie, and RS: NUTRIM - R4 - Gene-environment interaction

Subjects
Electronic nose, business.industry, Inflammation, Disease monitoring, medicine.disease, medicine.disease_cause, Liver disease, Clinical diagnosis, Immunology, Medicine, Respiratory system, medicine.symptom, business, Relevant information, Oxidative stress
Abstract

In ancient times, physicians already valued human breath as a window of diseased and healthy organs. For instance, advanced liver disease was indicated by the fishy smell of a patient’s breath. Hundreds of volatile organic compounds (vocs) are produced in different organs and are transported by blood to the lungs where they are released. Inflammatory and deviant metabolic processes change the composition of the vocs and therefore they can be used for clinical diagnosis and disease monitoring. The total amount of vocs (volatome) in exhaled breath can be detected based on gas chromatography–mass spectrometry-based methods and combined with chemometric analysis in selecting those compounds containing the relevant information about the disease state. The profiles of excreted vocs from healthy and diseased persons are numerically very complex and the biological and environmental variations are usually very large. The challenge is to extract the relevant information from the large amount of data and to relate subsets or profiles of vocs to the disease with predictive and diagnostic power.in this overview, applications are focussed on using vocs analysis in monitoring inflammatory conditions concerning the pulmonary tract. Available methodologies regarding sampling, sample analysis, and data processing as well as their advantages and potential drawbacks are discussed.keywordschronic obstructive pulmonary diseaseidiopathic pulmonary fibrosisdynamic time warpingpartial little square discriminant analysiselectronic nosethese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Published
2014
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29. VII International Conference on “Few Body Problems in Nuclear and Particle Physics” December 29, 1975 – January 3, 1976

Author

Afnan, I.R., primary, Afzal, S.A., additional, Ahmad, M., additional, Aitchison, I.J.R., additional, Akaishi, Y., additional, Ali, S., additional, Allas, R.G., additional, Alt, E.O., additional, Auluck, F.C., additional, Bakker, B.L.G., additional, Banerjee, D.K., additional, Banerjee, M., additional, Bansal, R.K., additional, Bencze, G., additional, Bhamathi, G., additional, Bhasin, V.S., additional, Bhatia, R.P., additional, Bhowmik, B., additional, Bleszynski, M., additional, Bleuler, K., additional, Bondelid, R.O., additional, Bosco, B., additional, Bouchez, B., additional, Brayshaw, D.D., additional, Cameron, J.M., additional, Chandler, C., additional, Chatterji, D., additional, Chavda, L.K., additional, Conzett, H.E., additional, Dalitz, R., additional, Deka, A.K., additional, Divatia, A.S., additional, Doornbos, J., additional, Englefield, M.J., additional, Fabre de la Ripelle, M., additional, Fang, K.K., additional, Ganguly, N.K., additional, Gautam, V., additional, Gerjuoy, E., additional, Glantz, L., additional, Gross, F., additional, Gruebler, W., additional, Gupta, V.K., additional, Hackenbroich, H.H., additional, Haftel, M.I., additional, Hanna, S.S., additional, Hans, H.S., additional, Heiss, P., additional, Henley, E.M., additional, Holinde, K., additional, Horgan, R., additional, Igo, G., additional, Iyengar, P.K., additional, Jacob, H., additional, Jain, A.K., additional, Jain, B.K., additional, Jain, M., additional, Kabir, P.K., additional, Karlsson, B.R., additional, Katyal, D.L., additional, Kaushal, R.S., additional, Kim, Y.E., additional, Kok, L.P., additional, Komarov, V., additional, Kothari, D.S., additional, Kothari, L.S., additional, Kouri, D., additional, Kuhn, B., additional, Kumpf, H., additional, Kundu, D.N., additional, Lagu, A.V., additional, Lambert, J.M., additional, Levin, F.S., additional, Lim, T.K., additional, Lodhi, M.A.K., additional, Lovas, I., additional, Maheshwari, C., additional, Majumdar, C.K., additional, Mantri, A.N., additional, Mathur, V.S., additional, McCarthy, I.E., additional, McKellar, B.H.J., additional, Mehdi, S.S., additional, Mehta, G.K., additional, Mehta, M.K., additional, Menon, M.G.K., additional, Mitra, A.N., additional, Monga, S.K., additional, Moravcsik, M., additional, Morioka, S., additional, Mosconi, B., additional, Mukherjee, Saila, additional, Mukherjee, Shankar, additional, Mukherjee, Suprokash, additional, Nagchaudhuri, B.D., additional, Namyslowski, J., additional, Narsimhan, V.L., additional, Northcliffe, L., additional, Noyes, H.P., additional, Oryu, S., additional, Pancholi, S.C., additional, Pandya, S.P., additional, Parashar, D.N., additional, Petersen, E.L., additional, Piragino, G., additional, Pisent, G., additional, Prakash, Y., additional, Pugh, H.G., additional, Rajaraman, R., additional, Rajasekaran, G., additional, Ramachandran, R., additional, Ramanna, R., additional, Rao, Y.S.T., additional, Redish, E., additional, Richardson, J.R., additional, Rodney, W., additional, Saha, A., additional, Sandhas, W., additional, Sarma, N., additional, Sasakawa, T., additional, Sauer, P.U., additional, Scadron, M., additional, Schmid, E., additional, Schwager, J., additional, Shah, M.S., additional, Sharma, J.S., additional, Sharma, V.K., additional, Shaw, G., additional, Singh, P.P., additional, Singh, V., additional, Slaus, I., additional, Sloan, I.H., additional, Slobodrian, R.J., additional, Sood, P.C., additional, Spruch, L., additional, Srinivasa Rao, K., additional, Srivastava, B.K., additional, Srivastava, M.K., additional, Sundaresan, M.K., additional, Tamagaki, R., additional, Tandy, P., additional, Tjon, J.A., additional, Tubis, A., additional, van Haeringen, H., additional, van Oers, W.T.H., additional, van Wageningen, R., additional, Vanzani, V., additional, Verma, A.R., additional, Vinh Mau, R., additional, Warke, C.S., additional, Weber, H.J., additional, Wolfe, D.M., additional, Yuasa, T., additional, Zankel, H., additional, Zingl, H., additional, Anand, J.D., additional, Ansari, A., additional, Bondopadhyay, D., additional, Garg, V.P., additional, Govil, I.M., additional, Goyal, D.P., additional, Goyal, R.K., additional, Jayaraman, J., additional, Nair, S.C.K., additional, Naqvi, J., additional, Praharaj, C.R., additional, Rizvi, S.H., additional, Sharma, D.K., additional, Sharma, M.L., additional, Sharma, S.D., additional, Shivpuri, R.K., additional, Sirohi, A.P.S., additional, Thakur, J.N., additional, and Zahid, M., additional

Published
1976
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31. Rheumatic fever

Author

Ganguly, N.K. and Kaur, S.

Subjects
Rheumatic fever -- India, India -- Health aspects
Published
1998

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