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21 results on '"Gan, Sushrima"'

1. Proteome-Wide Genetic Investigation of Large Artery Stiffness

Author

Dib, Marie-Joe, Azzo, Joe David, Zhao, Lei, Salman, Oday, Gan, Sushrima, De Buyzere, Marc L., De Meyer, Tim, Ebert, Christina, Gunawardhana, Kushan, Liu, Laura, Gordon, David, Seiffert, Dietmar, Ching-Pin, Chang, Zamani, Payman, Cohen, Jordana B., Pourmussa, Bianca, Kun, Seavmeiyin, Gill, Dipender, Burgess, Stephen, van Empel, Vanessa, Richards, A. Mark, Dennis, Jaclyn, Javaheri, Ali, Mann, Douglas L., Cappola, Thomas P., Rietzschel, Ernst, and Chirinos, Julio A.

Published
2024
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2. Phenotypic and genotypic determinants of drug response to anti-hyperglycaemic drugs in white Europeans and Asian Indians

Author

Gan, Sushrima, Pearson, Ewan, and Doney, Alexander

Abstract

Type 2 diabetes (T2D) is a complex disease characterized by insulin deficiency, due to pancreatic beta cell dysfunction, and insulin resistance (IR) leading to hyperglycemia. The management of hyperglycemia in T2D has become extraordinarily complex with a large number of medicine regimes being available which creates a major challenge in determining the best approach to achieve and maintain the appropriate level of glycaemic control. Response to anti-hyperglycaemic agents is conditional on phenotypic and pharmacogenetic effects. It is important to determine the contributing factors affecting response to carry out treatment. In this thesis, we have focused on two ethnics groups- white Europeans and Asian Indians to study the phenotypic and genotypic determinants of response to oral anti-hyperglycemic agents. This thesis focuses on the anthropometric and clinical determinants of glycaemic response to treatment with DPP-4I, SU and TZD in T2D individuals from Tayside and Fife, Scotland, Madras Diabetes Research Foundation (MDRF), India and UKBB populations. We assessed whether anthropometric, clinical and biochemical factors including markers of insulin resistance and insulin secretion are associated with 6-month glycaemic response to DPP-4i, SU and TZD in White Europeans and Asian Indians. In the first half we conducted a meta-analysis on three newer anti-hyperglycaemic agents and showed that Asians responded better to the drugs compared to whites. It is interesting to note that with our data in the combined analyses Asian Indians responded better to all three drugs studied in this thesis. In my study, c-peptide and triglycerides were not associated with response for DPP-4I and HDL-c was not associated with glycaemic response for both the cohorts in our study. The sub-group analysis in the Asian Indian population showed that higher HOMA B is associated with better response. Also, clinical markers of lower beta cell response like longer duration of diabetes were associated with reduced response in the Asian Indian population. I have demonstrated obese women respond very well to TZD whereas slim men respond well to SUs in both Tayside and Fife population (White European) and MDRF population (Asian Indian). Most diabetes intervention trials are undertaken in the West and very few are focused on India. The pronounced difference in response between the two populations mandates ethnicity specific trials to be undertaken in order to move a step forward in the targeted therapy approach.

Published
2022

3. Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction

Author

Azzo, Joe David, Dib, Marie-Joe, Zagkos, Loukas, Zhao, Lei, Wang, Zhaoqing, Chang, Ching-Pin, Ebert, Christina, Salman, Oday, Gan, Sushrima, Zamani, Payman, Cohen, Jordana B., van Empel, Vanessa, Richards, A. Mark, Javaheri, Ali, Mann, Douglas L., Rietzschel, Ernst R., Schafer, Peter H., Seiffert, Dietmar A., Gill, Dipender, Burgess, Stephen, Ramirez-Valle, Francisco, Gordon, David A., Cappola, Thomas P., and Chirinos, Julio A.

Published
2024
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4. Proteomic Correlates of the Urinary Protein/Creatinine Ratio in Heart Failure With Preserved Ejection Fraction

Author

Gan, Sushrima, Zhao, Lei, Salman, Oday, Wang, Zhaoqing, Ebert, Christina, Azzo, Joe David, Dib, Marie Joe, Zamani, Payman, Cohen, Jordana B., Kammerhoff, Karl, Schafer, Peter, Seiffert, Dietmar A., Ramirez-Valle, Francisco, Gordon, David A., Cvijic, Mary Ellen, Gunawardhana, Kushan, Liu, Laura, Chang, Ching-Pin, Cappola, Thomas P., and Chirinos, Julio A.

Published
2023
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6. Prognostic Significance and Biologic Associations of Senescence-Associated Secretory Phenotype Biomarkers in Heart Failure.

Author

Salman, Oday, Zamani, Payman, Lei Zhao, Dib, Marie Joe, Gan, Sushrima, Azzo, Joe David, Pourmussa, Bianca, Richards, Arthur Mark, Javaheri, Ali, Mann, Douglas L., Rietzschel, Ernst, Manyun Zhao, Zhaoqing Wang, Ebert, Christina, Liu, Laura, Gunawardhana, Kushan L., Greenawalt, Danielle, Carayannopoulos, Leon, Ching-Pin Chang, and van Empel, Vanessa

Published
2024
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7. Proteomic Correlates and Prognostic Significance of Kidney Injury in Heart Failure With Preserved Ejection Fraction.

Author

Salman, Oday, Lei Zhao, Cohen, Jordana B., Dib, Marie Joe, Azzo, Joe David, Gan, Sushrima, Richards, A. Mark, Pourmussa, Bianca, Doughty, Rob, Javaheri, Ali, Mann, Douglas L., Rietzschel, Ernst, Manyun Zhao, Zhaoqing Wang, Ebert, Christina, van Empel, Vanessa, Kammerhoff, Karl, Maranville, Joseph, Gogain, Joseph, and Dennis, Jaclyn

Published
2024
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8. ASSOCIATIONS BETWEEN GENETICALLY PREDICTED PULSE PRESSURE AND TARGET ORGAN DAMAGE: A MENDELIAN RANDOMIZATION STUDY

Author

Dib, Marie -JOE, primary, Zagkos, Loukas, additional, Meena, Devendra, additional, Azzo, Joe David, additional, Salman, Oday, additional, Gan, Sushrima, additional, Pourmussa, Bianca, additional, Kun, Seavmeiyin, additional, Tzoulaki, Ioanna, additional, Gill, Dipender, additional, Burgess, Stephen, additional, and Chirinos, Julio, additional

Published
2024
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9. Proteomic Associations of Adverse Outcomes in Human Heart Failure

Author

Dib, Marie‐Joe, primary, Levin, Michael G., additional, Zhao, Lei, additional, Diab, Ahmed, additional, Wang, Zhaoqing, additional, Ebert, Christina, additional, Salman, Oday, additional, Azzo, Joe David, additional, Gan, Sushrima, additional, Zamani, Payman, additional, Cohen, Jordana B., additional, Gill, Dipender, additional, Burgess, Stephen, additional, Zagkos, Loukas, additional, van Empel, Vanessa, additional, Richards, A. Mark, additional, Doughty, Rob, additional, Rietzschel, Ernst R., additional, Kammerhoff, Karl, additional, Kvikstad, Erika, additional, Maranville, Joseph, additional, Schafer, Peter, additional, Seiffert, Dietmar A., additional, Ramirez‐Valle, Francisco, additional, Gordon, David A., additional, Chang, Ching‐Pin, additional, Javaheri, Ali, additional, Mann, Douglas L., additional, Cappola, Thomas P., additional, and Chirinos, Julio A., additional

Published
2024
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10. Proteomic Correlates And Prognostic Significance Of Kidney Injury In Heart Failure With Preserved Ejection Fraction

Author

Salman, Oday, primary, Zhao, Lei, additional, Cohen, Jordana B., additional, Dib, Marie Joe, additional, Azzo, Joe David, additional, Gan, Sushrima, additional, Richards, A. Mark, additional, Pourmussa, Bianca, additional, Doughty, Robert, additional, Javaheri, Ali, additional, Mann, Douglas L., additional, Rietzschel, Ernst, additional, Wang, Zhaoqing, additional, Ebert, Christina, additional, van Empel, Vanessa, additional, Kammerhoff, Karl, additional, Maranville, Joseph, additional, Gogain, Joseph, additional, Schafer, Peter H., additional, Seiffert, Dietmar, additional, Gordon, David A., additional, Ramirez-Valle, Francisco, additional, Cappola, Thomas P., additional, and Chirinos, Julio, additional

Published
2024
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11. Proteomic Associations Of N-terminal-pro Hormone Bnp In Heart Failure With Preserved Ejection Fraction In Two Cohorts

Author

Azzo, Joe David, primary, Dib, Marie-Joe, additional, Zhao, Lei, additional, Wang, Zhaoqing, additional, Ebert, Christina, additional, Salman, Oday, additional, Gan, Sushrima, additional, Zamani, Payman, additional, Cohen, Jordana (Jordy), additional, van Empel, Vanessa, additional, Richards, Mark, additional, Doughty, Robert, additional, Javaheri, Ali, additional, Schafer, Peter, additional, Seiffert, Dietmar, additional, Ramirez-Valle, Francisco, additional, Gordon, David, additional, Cappola, Thomas, additional, and Chirinos, Julio, additional

Published
2024
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12. Proteomic Correlates Of Urinary Protein Creatinine Ratio In Heart Failure With Preserved Ejection Fraction

Author

Gan, Sushrima, primary, Zhao, Lei, additional, Salman, Oday, additional, Wang, Zhaoqing, additional, Ebert, Christina, additional, Azzo, Joe David, additional, Dib, Marie Joe, additional, Zamani, Payman, additional, Cohen, Jordana (Jordy), additional, Kammerhoff, Karl, additional, Schafer, Peter, additional, Seiffert, Dietmar, additional, Gordon, David, additional, Cappola, Thomas, additional, and Chirinos, Julio, additional

Published
2024
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14. [Untitled]

Author

Gan, Sushrima

Abstract

Type 2 diabetes (T2D) is a complex disease characterized by insulin deficiency, due to pancreatic beta cell dysfunction, and insulin resistance (IR) leading to hyperglycemia. The management of hyperglycemia in T2D has become extraordinarily complex with a large number of medicine regimes being available which creates a major challenge in determining the best approach to achieve and maintain the appropriate level of glycaemic control. Response to anti-hyperglycaemic agents is conditional on phenotypic and pharmacogenetic effects. It is important to determine the contributing factors affecting response to carry out treatment. In this thesis, we have focused on two ethnics groups- white Europeans and Asian Indians to study the phenotypic and genotypic determinants of response to oral anti-hyperglycemic agents. This thesis focuses on the anthropometric and clinical determinants of glycaemic response to treatment with DPP-4I, SU and TZD in T2D individuals from Tayside and Fife, Scotland, Madras Diabetes Research Foundation (MDRF), India and UKBB populations. We assessed whether anthropometric, clinical and biochemical factors including markers of insulin resistance and insulin secretion are associated with 6-month glycaemic response to DPP-4i, SU and TZD in White Europeans and Asian Indians. In the first half we conducted a meta-analysis on three newer anti-hyperglycaemic agents and showed that Asians responded better to the drugs compared to whites. It is interesting to note that with our data in the combined analyses Asian Indians responded better to all three drugs studied in this thesis. In my study, c-peptide and triglycerides were not associated with response for DPP-4I and HDL-c was not associated with glycaemic response for both the cohorts in our study. The sub-group analysis in the Asian Indian population showed that higher HOMA B is associated with better response. Also, clinical markers of lower beta cell response like longer duration of diabetes were associated with reduced response in the Asian Indian population. I have demonstrated obese women respond very well to TZD whereas slim men respond well to SUs in both Tayside and Fife population (White European) and MDRF population (Asian Indian). Most diabetes intervention trials are undertaken in the West and very few are focused on India. The pronounced difference in response between the two populations mandates ethnicity specific trials to be undertaken in order to move a step forward in the targeted therapy approach.

Published
2022
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16. Response to Comment on Gan et al. Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diabetes Care 2020;43:1948–1957

Author

Gan, Sushrima, primary, Dawed, Adem Y., additional, Donnelly, Louise A., additional, Nair, Anand T.N., additional, Palmer, Colin N.A., additional, Mohan, Viswanathan, additional, and Pearson, Ewan R., additional

Published
2020
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20. PheGWAS: a new dimension to visualize GWAS across multiple phenotypes.

Author

George, Gittu, Gan, Sushrima, Huang, Yu, Appleby, Philip, Nar, A S, Venkatesan, Radha, Mohan, Viswanathan, Palmer, Colin N A, and Doney, Alex S F

Abstract

Motivation PheGWAS was developed to enhance exploration of phenome-wide pleiotropy at the genome-wide level through the efficient generation of a dynamic visualization combining Manhattan plots from GWAS with PheWAS to create a 3D 'landscape'. Pleiotropy in sub-surface GWAS significance strata can be explored in a sectional view plotted within user defined levels. Further complexity reduction is achieved by confining to a single chromosomal section. Comprehensive genomic and phenomic coordinates can be displayed. Results PheGWAS is demonstrated using summary data from Global Lipids Genetics Consortium GWAS across multiple lipid traits. For single and multiple traits PheGWAS highlighted all 88 and 69 loci, respectively. Further, the genes and SNPs reported in Global Lipids Genetics Consortium were identified using additional functions implemented within PheGWAS. Not only is PheGWAS capable of identifying independent signals but also provides insights to local genetic correlation (verified using HESS) and in identifying the potential regions that share causal variants across phenotypes (verified using colocalization tests). Availability and implementation The PheGWAS software and code are freely available at (https://github.com/georgeg0/PheGWAS). Supplementary information Supplementary data are available at Bioinformatics online. [ABSTRACT FROM AUTHOR]

Published
2020
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