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Your search keyword '"Gan, C.T."' showing total 14 results
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14 results on '"Gan, C.T."'

1. Transatlantic veno-venous ECMO bridge for lung transplantation

Author

van Gemert, J.P., primary, Droogh, J.M., additional, Finkenzeller, I., additional, Botero Bahamon, J.D., additional, Gan, C.T., additional, Heise, D., additional, van Steenwijk, R.P., additional, Uribe Molano, J.D., additional, Zapata Gonzalez, R.A., additional, Kock, S.M., additional, Verschuuren, E.A.M., additional, and Veldman, A., additional

Published
2024
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2. Broad Decline in Viral Infections During COVID-19 Lockdown: Association with Lung Function in Lung Transplant Recipients

Author

de Zwart, A.E., Riezebos-Brilman, A., Lunter, G., Neerken, E., Van Leer, C., Alffenaar, J.C., Van Gemert, J.P., Erasmus, M.E., Gan, C.T., Kerstjens, H.A., Vonk, J.M., Verschuuren, E.A., Life Course Epidemiology (LCE), Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
Coronavirus, Pulmonary and Respiratory Medicine, Transplantation, COVID-19, Surgery, Cardiology and Cardiovascular Medicine
Abstract

Purpose In April 2020 COVID-19 lockdown measures were instigated leading to a dramatic drop in non-COVID respiratory virus infections (RVI). This provided a unique situation to assess the impact of RVI on annual FEV1 decline, episodes of temporary drop in lung function suggestive of infection (TDLF) and CLAD in lung transplant recipients (LTR). Methods All lung function tests (LFT) of LTR transplanted between 2009-April 2020 were used from post-transplant baseline onward. LFT were censored after COVID-19 infection. Weekly RVI counts from the virology department defined RVI pressure over time. TDLF was defined as sudden, reversible FEV1 drop compared to previous 4 values (any TDLF ≥10% and ≥200ml, severe TDLF ≥20% and ≥500ml). Annual FEV1 decline was estimated using linear mixed effects models with separate estimates for 2009/20 and 2020/21. Effect modification by TDLF frequency of individual LTR (two subgroups, split at median) and RVI pressure was tested. Rates of CLAD and TDLF were analyzed over time. Results 479 LTR (12,775 LFT) were included. Annual FEV1 change in 2009/20 was -114ml [95%CI -133; -94], while in 2020/21 this was significantly less: 5ml [-38; 48] (p

Published
2022

5. Muscle mass, muscle strength and mortality in kidney transplant recipients: results of the TransplantLines Biobank and Cohort Study.

Author

van Vliet, Iris M.Y., Post, Adrian, Kremer, Daan, Boslooper‐Meulenbelt, Karin, van der Veen, Yvonne, de Jong, Margriet F.C., Pol, Robert A., Dijkstra, G., de Meijer, V.E., Leuvenink, H.G.D., Bakker, S.J.L., Gan, C.T., Sanders, J.S.F., Verschuuren, E.A.M., Damman, K., Lexmond, W.S., Blokzijl, J., de Borst, M.H., Erasmus, M.E., and Porte, R.J.

Published
2022
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6. Histological Analysis of Donor Lung Derived Thrombi

Author

Bergtop, J., primary, Zhang, K.L., additional, Timens, W., additional, Venema, L.H., additional, van de Wauwer, C., additional, Erasmus, M.E., additional, Gan, C.T., additional, Lisman, T., additional, and Verschuuren, E.A., additional

Published
2021
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8. Evaluation of Ten Years Of Parainfluenza virus, human Metapneumovirus And Respiratory Syncytial Virus Infections In Lung Transplant Recipients

Author

de Zwart, Auke E.S., Riezebos‐Brilman, Annelies, Alffenaar, Jan?Willem C., van den Heuvel, Edwin R., Gan, C.T., van der Bij, Wim, Kerstjens, Huib A.M., and Verschuuren, Erik A.M.

Subjects
Coronavirus, COVID-19
Abstract

Respiratory tract infection with Pneumoviruses (PV) and Paramyxoviruses (PMV) are increasingly associated with chronic lung allograft dysfunction (CLAD) in lung transplant recipients (LTR). Ribavirin may be a treatment option but its effectiveness is unclear, especially with respect to infection severity. We retrospectively analyzed ten years of PV/PMV infections in LTR. Main endpoints were FEV1 at three and six months post‐infection, expressed as a percentage of pre‐infection FEV1 and incidence of new or progressed CLAD six months post‐infection. A total of 139 infections were included; 88 (63%) severe infections (defined as >10% FEV1 loss at infection), 51 (37%) mild infections (≤10% FEV1 loss). Overall post‐infection CLAD incidence was 20%. Associations were estimated on post‐infection FEV1 for ribavirin vs. no ribavirin (+13.2% [7.79;18.67]) and severe vs. mild infection (‐11.1% [‐14.76; ‐7.37). Factors associated with CLAD incidence at six months were ribavirin treatment (OR 0.24 [0.10–0.59]), severe infection (OR 4.63 [1.66;12.88]) and mycophenolate mofetil use (OR 0.38 [0.14;0.97]). This data provides valuable information about the outcomes of lung transplant recipients with these infections and suggests possible associations of ribavirin use and infection severity with long‐term outcomes. Well‐designed prospective trials are needed to confirm these findings.

Published
2020

9. Muscle mass, muscle strength and mortality in kidney transplant recipients: results of the TransplantLines Biobank and Cohort Study

Author

Vliet, Iris M.Y., Post, Adrian, Kremer, Daan, Boslooper‐Meulenbelt, Karin, Veen, Yvonne, Jong, Margriet F.C., Pol, Robert A., Dijkstra, G., Meijer, V.E., Leuvenink, H.G.D., Bakker, S.J.L., Gan, C.T., Sanders, J.S.F., Verschuuren, E.A.M., Damman, K., Lexmond, W.S., Blokzijl, J., Borst, M.H., Erasmus, M.E., Porte, R.J., Boer, M.T., Pol, R.A., Berger, S.P., Eisenga, M.F., Neto, A.W. Gomes, Kremer, D., Londen, M., Jong, J.H. Annema‐de, Siebelink, M.J., Pelt, L.J., Niesters, H.G.M., Bodewes, F.A.J.A., Hepkema, B.G., Ranchor, A.V., Douwes, R.M., Jager‐Wittenaar, Harriët, Navis, Gerjan J., and Bakker, Stephan J.L.

Abstract

Survival of kidney transplant recipients (KTR) is low compared with the general population. Low muscle mass and muscle strength may contribute to lower survival, but practical measures of muscle status suitable for routine care have not been evaluated for their association with long‐term survival and their relation with each other in a large cohort of KTR. Data of outpatient KTR ≥ 1 year post‐transplantation, included in the TransplantLines Biobank and Cohort Study (ClinicalTrials.govIdentifier: NCT03272841), were used. Muscle mass was determined as appendicular skeletal muscle mass indexed for height2(ASMI) through bio‐electrical impedance analysis (BIA), and by 24‐h urinary creatinine excretion rate indexed for height2(CERI). Muscle strength was determined by hand grip strength indexed for height2(HGSI). Secondary analyses were performed using parameters not indexed for height2. Cox proportional hazards models were used to investigate the associations between muscle mass and muscle strength and all‐cause mortality, both in univariable and multivariable models with adjustment for potential confounders, including age, sex, body mass index (BMI), estimated glomerular filtration rate (eGFR) and proteinuria. We included 741 KTR (62% male, age 55 ± 13 years, BMI 27.3 ± 4.6 kg/m2), of which 62 (8%) died during a median [interquartile range] follow‐up of 3.0 [2.3–5.7] years. Compared with patients who survived, patients who died had similar ASMI (7.0 ± 1.0 vs. 7.0 ± 1.0 kg/m2; P= 0.57), lower CERI (4.2 ± 1.1 vs. 3.5 ± 0.9 mmol/24 h/m2; P< 0.001) and lower HGSI (12.6 ± 3.3 vs. 10.4 ± 2.8 kg/m2; P< 0.001). We observed no association between ASMI and all‐cause mortality (HR 0.93 per SD increase; 95% confidence interval [CI] [0.72, 1.19]; P= 0.54), whereas CERI and HGSI were significantly associated with mortality, independent of potential confounders (HR 0.57 per SD increase; 95% CI [0.44, 0.81]; P= 0.002 and HR 0.47 per SD increase; 95% CI [0.33, 0.68]; P< 0.001, respectively), and associations of CERI and HGSI with mortality remained independent of each other (HR 0.68 per SD increase; 95% CI [0.47, 0.98]; P= 0.04 and HR 0.53 per SD increase; 95% CI [0.36, 0.76]; P= 0.001, respectively). Similar associations were found for unindexed parameters. Higher muscle mass assessed by creatinine excretion rate and higher muscle strength assessed by hand grip strength are complementary in their association with lower risk of all‐cause mortality in KTR. Muscle mass assessed by BIA is not associated with mortality. Routine assessment using both 24‐h urine samples and hand grip strength is recommended, to potentially target interdisciplinary interventions for KTR at risk for poor survival to improve muscle status.

Published
2022
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10. Employment Status and Work Functioning among Kidney Transplant Recipients

Author

Knobbe, Tim J., Kremer, Daan, Abma, Femke I., Annema, Coby, Berger, Stefan P., Navis, Gerjan J., van der Mei, Sijrike F., B?ltmann, Ute, Visser, Annemieke, Bakker, Stephan J.L., Annema-de Jong, C., Bakker, S.J.L., Berger, S.P., Blokzijl, H., Bodewes, F.A.J.A., de Boer, M.T., Damman, K., de Borst, M.H., Diepstra, A., Dijkstra, G., Douwes, R.M., Eisenga, M.F., Erasmus, M.E., Gan, C.T., Gomes Neto, A.W., Hak, E., Hepkema, B.G., Klont, F., Knobbe, T.J., Kremer, D., Leuvenink, H.G.D., Lexmond, W.S., de Meijer, V.E., Niesters, H.G.M., van Pelt, L.J., Pol, R.A., Porte, R.J., Ranchor, A.V., Sanders, J.S.F., Siebelink, M.J., Slart, R.J.H.J.A., Swarte, J.C., Touw, D.J., van den Heuvel, M.C., van Leer-Buter, C., van Londen, M., Verschuuren, E.A.M., Vos, M.J., and Weersma, R.K.

Published
2022
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