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High-quality academic publishing is built on a rigorous peer review process, and Games is no exception, upholding its high standards for published papers due to the outstanding efforts of our reviewers [...]

Rigorous peer-reviews are the basis of high-quality academic publishing [...]

Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Games maintains its standards for the high quality of its published papers [...]

The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process over the past 12 months, regardless of whether the papers are finally published or not [...]

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]

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The editors of Games would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. [...]

The editors of Games would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2013.

The editors of Games would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2014:[...]

Games has received help from many individuals since its inaugural issue in 2009. We are especially grateful to the following 146 referees for their great support of Games during the past two years.

Background: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and inflammation. Natural products, such as monoterpenes, displayed anti-inflammatory and anti-oxidant activities and can be used as a source of new compounds to COPD treatment. Our aim was to evaluate, in an elastase-induced pulmonary emphysema in mice, the effects of and underlying mechanisms of three related natural monoterpenes ( p -cymene, carvacrol and thymol) isolated from essential oil from leaves Lippia sidoides Cham. (Verbenaceae)., Methods: Mices received porcine pancreatic elastase (PPE) and were treated with p -cymene, carvacrol, thymol or vehicle 30 min later and again on 7th, 14th and 28th days. Lung inflammatory profile and histological sections were evaluated., Results: In the elastase-instilled animals, the tested monoterpenes reduced alveolar enlargement, macrophages and the levels of IL-1β, IL-6, IL-8 and IL-17 in bronchoalveolar lavage fluid (BALF), and collagen fibers, MMP-9 and p-65-NF-κB-positive cells in lung parenchyma ( p < 0.05). All treatments attenuated levels of 8-iso-PGF2α but only thymol was able to reduced exhaled nitric oxide ( p < 0.05)., Conclusion: Monoterpenes p -cymene, carvacrol and thymol reduced lung emphysema and inflammation in mice. No significant differences among the three monoterpenes treatments were found, suggesting that the presence of hydroxyl group in the molecular structure of thymol and carvacrol do not play a central role in the anti-inflammatory effects.