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145 results on '"Gambaccini, D."'

3. T.02.6 EFFECTIVENESS OF VERY LOW-VOLUME PREPARATION FOR COLONOSCOPY IN HOSPITALIZED OLDER PATIENTS: SINGLE CENTER OBSERVATIONAL TRIAL

Author

Ovidi, F., primary, Solinas, I., additional, Bolognesi, V., additional, Visaggi, P., additional, Tapete, G., additional, Adamo, G., additional, Bellini, M., additional, Gambaccini, D., additional, Natali, V., additional, Tarducci, L., additional, Marciano, E., additional, Fuccio, L., additional, Savarino, E.V., additional, and De Bortoli, N., additional

Published
2023
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8. Fecal Clostridiales distribution and short-chain fatty acids reflect bowel habits in irritable bowel syndrome

Author

Gargari, G, Taverniti, V, Gardana, C, Cremon, C, Canducci, F, Pagano, I, Barbaro, M, Bellacosa, L, Castellazzi, A, Valsecchi, C, Tagliacarne, S, Bellini, M, Bertani, L, Gambaccini, D, Marchi, S, Cicala, M, Germana, B, Dal Pont, E, Vecchi, M, Ogliari, C, Fiore, W, Stanghellini, V, Barbara, G, Guglielmetti, S, Gargari G., Taverniti V., Gardana C., Cremon C., Canducci F., Pagano I., Barbaro M. R., Bellacosa L., Castellazzi A. M., Valsecchi C., Tagliacarne S. C., Bellini M., Bertani L., Gambaccini D., Marchi S., Cicala M., Germana B., Dal Pont E., Vecchi M., Ogliari C., Fiore W., Stanghellini V., Barbara G., Guglielmetti S., Gargari, G, Taverniti, V, Gardana, C, Cremon, C, Canducci, F, Pagano, I, Barbaro, M, Bellacosa, L, Castellazzi, A, Valsecchi, C, Tagliacarne, S, Bellini, M, Bertani, L, Gambaccini, D, Marchi, S, Cicala, M, Germana, B, Dal Pont, E, Vecchi, M, Ogliari, C, Fiore, W, Stanghellini, V, Barbara, G, Guglielmetti, S, Gargari G., Taverniti V., Gardana C., Cremon C., Canducci F., Pagano I., Barbaro M. R., Bellacosa L., Castellazzi A. M., Valsecchi C., Tagliacarne S. C., Bellini M., Bertani L., Gambaccini D., Marchi S., Cicala M., Germana B., Dal Pont E., Vecchi M., Ogliari C., Fiore W., Stanghellini V., Barbara G., and Guglielmetti S.

Abstract

Irritable bowel syndrome (IBS), a common functional gastrointestinal disorder, is classified according to bowel habits as IBS with constipation (IBS-C), with diarrhea (IBS-D), with alternating constipation and diarrhea (IBS-M), and unsubtyped (IBS-U). The mechanisms leading to the different IBS forms are mostly unknown. This study aims to evaluate whether specific fecal bacterial taxa and/or short-chain fatty acids (SCFAs) can be used to distinguish IBS subtypes and are relevant for explaining the clinical differences between IBS subcategories. We characterized five fecal samples collected at 4-weeks intervals from 40 IBS patients by 16S rRNA gene profiling and SCFA quantification. Finally, we investigated the potential correlations in IBS subtypes between the fecal microbial signatures and host physiological and clinical parameters. We found significant differences in the distribution of Clostridiales OTUs among IBS subtypes and reduced levels of SCFAs in IBS-C compared to IBS-U and IBS-D patients. Correlation analyses showed that the diverse representation of Clostridiales OTUs between IBS subtypes was associated with altered levels of SCFAs; furthermore, the same OTUs and SCFAs were associated with the fecal cytokine levels and stool consistency. Our results suggest that intestinal Clostridiales and SCFAs might serve as potential mechanistic biomarkers of IBS subtypes and represent therapeutic targets.

Published
2018

9. Effect of Lactobacillus paracasei CNCM I-1572 on symptoms, gut microbiota, short chain fatty acids, and immune activation in patients with irritable bowel syndrome: A pilot randomized clinical trial

Author

Cremon, C, Guglielmetti, S, Gargari, G, Taverniti, V, Castellazzi, A, Valsecchi, C, Tagliacarne, C, Fiore, W, Bellini, M, Bertani, L, Gambaccini, D, Cicala, M, Germana, B, Vecchi, M, Pagano, I, Barbaro, M, Bellacosa, L, Stanghellini, V, Barbara, G, Cremon C., Guglielmetti S., Gargari G., Taverniti V., Castellazzi A. M., Valsecchi C., Tagliacarne C., Fiore W., Bellini M., Bertani L., Gambaccini D., Cicala M., Germana B., Vecchi M., Pagano I., Barbaro M. R., Bellacosa L., Stanghellini V., Barbara G., Cremon, C, Guglielmetti, S, Gargari, G, Taverniti, V, Castellazzi, A, Valsecchi, C, Tagliacarne, C, Fiore, W, Bellini, M, Bertani, L, Gambaccini, D, Cicala, M, Germana, B, Vecchi, M, Pagano, I, Barbaro, M, Bellacosa, L, Stanghellini, V, Barbara, G, Cremon C., Guglielmetti S., Gargari G., Taverniti V., Castellazzi A. M., Valsecchi C., Tagliacarne C., Fiore W., Bellini M., Bertani L., Gambaccini D., Cicala M., Germana B., Vecchi M., Pagano I., Barbaro M. R., Bellacosa L., Stanghellini V., and Barbara G.

Abstract

Background: Evidence suggests a role of intestinal microbiota-host interactions in the pathophysiology and symptoms of irritable bowel syndrome (IBS). Objective: The objective of this article is to assess the effects of Lactobacillus paracasei CNCM I-1572 on clinical and gut microbiota-related factors in IBS. Methods: We conducted a multicenter, randomized, double-blind, cross-over, 18-week, placebo-controlled, pilot trial assessing the effect of Lactobacillus paracasei CNCM I-1572 on symptoms, gut microbiota composition, fecal short chain fatty acid (SCFA), immunoglobulin A, and cytokines in IBS. The intestinal microbial ecosystem was characterized by 16S rRNA gene profiling. Results: Forty IBS patients were enrolled from five Italian centers. Lactobacillus paracasei CNCM I-1572 did not significantly improve IBS symptoms, including primary efficacy variables worst abdominal pain/discomfort and IBS degree of relief. Interestingly, Lactobacillus paracasei CNCM I-1572 induced a significant reduction in genus Ruminococcus, dominated by taxa related to Ruminococcus bromii and Ruminococcus callidus, a significant increase in the SCFAs acetate and butyrate, and a significant reduction in the pro-inflammatory cytokine interleukin-15. Conclusions: This pilot study shows that Lactobacillus paracasei CNCM I-1572 is able to modulate gut microbiota structure/function and reduce immune activation in IBS. As no statistically significant effect on IBS-symptoms was found, further studies are necessary to determine the role of this probiotic in IBS. The study was registered at ClinicalTrials.gov registry under identifier NCT02371499.

Published
2018

15. P.02.6 LOW FODMAP DIET IN THE LONG TERM: EFFICACY, ACCEPTABILITY AND INDIVIDUAL PERCEPTION OF TRIGGER FOODS. A PILOT STUDY

Author

Rossi, A., primary, Nagy, A.G., additional, Gambaccini, D., additional, Bertani, L., additional, Pancetti, A., additional, Zari, M., additional, Costa, F., additional, Bazzichi, L., additional, De Bortoli, N., additional, Morganti, R., additional, Mosca, M., additional, Marchi, S., additional, and Bellini, M., additional

Published
2019
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16. OC.05.3 HISTOMORPHOLOGICAL AND MOLECULAR CHARACTERIZATION OF PARKINSON'S DISEASE PATIENTS WITH CONSTIPATION: A PILOT STUDY

Author

Fani, B., primary, Bellini, G., additional, Fornai, M., additional, Ippolito, C., additional, Segnani, C., additional, Frosini, D., additional, Pellegrini, C., additional, Benvenuti, L., additional, Gambaccini, D., additional, Bernardini, N., additional, Ceravolo, R., additional, Blandizzi, C., additional, Marchi, S., additional, and Bellini, M., additional

Published
2019
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19. P.08.24 EUS-FNA WET-TECHNIQUE IN 31 SOLID PANCREATIC LESIONS: PISA EXPERIENCE

Author

Gambaccini, D., primary, Fabbri, C., additional, Russo, S., additional, Campani, D., additional, Fani, B., additional, Giannotti, S., additional, Natali, V., additional, Luglio, G., additional, Grilli, M., additional, Sansotta, L., additional, Giovanelli, S., additional, Bellini, M., additional, Marchi, S., additional, Bresci, G., additional, and Marciano, E., additional

Published
2018
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23. Exploring the genetics of irritable bowel syndrome: A GWA study in the general population and replication in multinational case-control cohorts

Author

Ek, W.E. Reznichenko, A. Ripke, S. Niesler, B. Zucchelli, M. Rivera, N.V. Schmidt, P.T. Pedersen, N.L. Magnusson, P. Talley, N.J. Holliday, E.G. Houghton, L. Gazouli, M. Karamanolis, G. Rappold, G. Burwinkel, B. Surowy, H. Rafter, J. Assadi, G. Li, L. Papadaki, E. Gambaccini, D. Marchi, S. Colucci, R. Blandizzi, C. Barbaro, R. Karling, P. Walter, S. Ohlsson, B. Tornblom, H. Bresso, F. Andreasson, A. Dlugosz, A. Simren, M. Agreus, L. Lindberg, G. Boeckxstaens, G. Bellini, M. Stanghellini, V. Barbara, G. Daly, M.J. Camilleri, M. Wouters, M.M. D'Amato, M.

Abstract

Objective: IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies. Design: We conducted a GWA study (GWAS) of IBS in a general population sample of 11 326 Swedish twins. IBS cases (N=534) and asymptomatic controls (N=4932) were identified based on questionnaire data. Suggestive association signals were followed-up in 3511 individuals from six case-control cohorts. We sought genotype-gene expression correlations through single nucleotide polymorphism (SNP)-expression quantitative trait loci interactions testing, and performed in silico prediction of gene function. We compared candidate gene expression by real-time qPCR in rectal mucosal biopsies of patients with IBS and controls. Results: One locus at 7p22.1, which includes the genes KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2) and GRID2IP (glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein), showed consistent IBS risk effects in the index GWAS and all replication cohorts and reached p=9.31×10-6 in a meta-analysis of all datasets. Several SNPs in this region are associated with cis effects on KDELR2 expression, and a trend for increased mucosal KDLER2 mRNA expression was observed in IBS cases compared with controls. Conclusions: Our results demonstrate that general population-based studies combined with analyses of patient cohorts provide good opportunities for gene discovery in IBS. The 7p22.1 and other risk signals detected in this study constitute a good starting platform for hypothesis testing in future functional investigations. © 2015, BMJ Publishing Group. All rights reserved.

Published
2015

24. Diagnosis and treatment of Chronic Constipation and Obstructed Defecation (part II: treatment)

Author

Bove, A, Pucciani, F, Bellini, M, Battaglia, E, Bocchini, R, Altomare, Fd, Dodi, G, Sciaudone, Guido, Faletto, E, Piloni, V, Gambaccini, D, Bove, V., Bove, A, Pucciani, F, Bellini, M, Battaglia, E, Bocchini, R, Altomare, Fd, Dodi, G, Sciaudone, Guido, Faletto, E, Piloni, V, Gambaccini, D, and Bove, V.

Subjects
STARR, OBSTRUITE DEFAECATION SYNDROME, OUTLET OBSTRUCTION, RECTOCELE
Abstract

The second part of the Consensus Statement of the Italian Association of Hospital Gastroenterologists and Italian Society of Colo-Rectal Surgery reports on the treatment of chronic constipation and obstructed defecation. There is no evidence that increasing fluid intake and physical activity can relieve the symptoms of chronic constipation. Patients with normal-transit constipation should increase their fibre intake through their diet or with commercial fibre. Osmotic laxatives may be effective in patients who do not respond to fibre supplements. Stimulant laxatives should be reserved for patients who do not respond to osmotic laxatives. Controlled trials have shown that serotoninergic enterokinetic agents, such as prucalopride, and prosecretory agents, such as lubiprostone, are effective in the treatment of patients with chronic constipation. Surgery is sometimes necessary. Total colectomy with ileorectostomy may be considered in patients with slow-transit constipation and inertia coli who are resistant to medical therapy and who do not have defecatory disorders, generalised motility disorders or psychological disorders. Randomised controlled trials have established the efficacy of rehabilitative treatment in dys-synergic defecation. Many surgical procedures may be used to treat obstructed defecation in patients with acquired anatomical defects, but none is considered to be the gold standard. Surgery should be reserved for selected patients with an impaired quality of life. Obstructed defecation is often associated with pelvic organ prolapse. Surgery with the placement of prostheses is replacing fascial surgery in the treatment of pelvic organ prolapse, but the efficacy and safety of such procedures have not yet been established.

Published
2012

25. P.09.4 THREE-DIMENSIONAL HIGH-RESOLUTION ANORECTAL MANOMETRY AND RECTOANAL DELTA CONTRACTILE INTEGRAL FOR THE ASSESSMENT OF FUNCTIONAL DEFECATORY DISORDERS: TOY OR TOOL?

Author

Gambaccini, D., primary, Bellini, M., additional, De Bortoli, N., additional, Russo, S., additional, Zari, M., additional, Martinucci, I., additional, Ricchiuti, A., additional, Surace, L., additional, Costa, F., additional, Mumolo, M.G., additional, and Marchi, S., additional

Published
2016
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26. OC.06.9 IRRITABLE BOWEL SYNDROME: RESULTS OF AIGO SURVEY 2014–2015

Author

Soncini, M., primary, Milazzo, G., additional, Leandro, G., additional, Bellini, M., additional, Carrara, M., additional, Montalbano, L., additional, Muscatiello, N., additional, Monica, F., additional, Usai Satta, P., additional, Cabras, F., additional, Camilleri, S., additional, Gambaccini, D., additional, Tammaro, L., additional, D'Alba, L., additional, Turco, L., additional, Gasparini, P., additional, Galeazzi, F., additional, Solinas, A., additional, Russo, G., additional, Salvioli, B., additional, Anderloni, A., additional, Bassotti, G., additional, Lai, M., additional, Antonino, M., additional, De Bona, M., additional, Boschetto, S., additional, Rentini, S., additional, Rossitti, P., additional, Limido, E., additional, and Balzano, A., additional

Published
2016
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27. P.02.11 EXOCRINE PANCREATIC INSUFFICIENCY IN INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM (IPMN) WITH WIDESPREAD GLANDULAR INVOLVEMENT

Author

Gambaccini, D., primary, Bellini, M., additional, Luglio, G., additional, Russo, S., additional, Maltinti, S., additional, Battaglia, V., additional, Giannotti, S., additional, Albano, E., additional, Pianadei, S., additional, Ricchiuti, A., additional, Mumolo, M.G., additional, Costa, F., additional, and Marchi, S., additional

Published
2016
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29. P.13.4 A LOW FODMAP DIET IN IRRITABLE BOWEL SYNDROME IMPROVES SYMPTOMS WITHOUT AFFECTING BODY COMPOSITION AND EXTRACELLULAR BODY WATER

Author

Rossi, A., primary, Bellini, M., additional, Saviozzi, A., additional, Gambaccini, D., additional, Bertani, L., additional, Ricchiuti, A., additional, Urbano, M.T., additional, Mumolo, M.G., additional, Costa, F., additional, De Bortoli, N., additional, Bazzichi, L., additional, Mosca, M., additional, and Marchi, S., additional

Published
2016
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30. Are IBS patients alexithymic?

Author

Tongiorgi, A., Bellini, M., Vaselli, E., Meo, C., Gambaccini, D., DE BORTOLI, Nicola, Ceccarelli, L., Di Fluri, G., Mismas, V., and Marchi, Santino

Published
2012

32. Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation (Part Ⅱ: Treatment)

Author

Bove, A., Bellini, M., Battaglia, E., Bocchini, R., Gambaccini, D., Bove, V., Pucciani, Filippo, Altomare, D. F., Dodi, G., Sciaudone, G., Falletto, E., and Piloni, V.

Subjects
Laxatives, Prokinetics, Biofeedback, Pelvic floor rehabilitation, Outlet obstruction, Stapled transanal rectal resection, Delorme operation, Colectomy, Pelvic organ prolapse, Mesh
Published
2012

36. Management of chronic constipation in general practice

Author

Bellini, M., primary, Gambaccini, D., additional, Salvadori, S., additional, Tosetti, C., additional, Urbano, M. T., additional, Costa, F., additional, Monicelli, P., additional, Mumolo, M. G., additional, Ricchiuti, A., additional, De Bortoli, N., additional, and Marchi, S., additional

Published
2013
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40. P.07.6 MANAGEMENT OF CHRONIC CONSTIPATION IN GENERAL PRACTICE

Author

Gambaccini, D., primary, Bellini, M., additional, Salvadori, S., additional, Tosetti, S., additional, De Bortoli, N., additional, Costa, F., additional, Ricchiuti, A., additional, Mumolo, M.G., additional, Urbano, M.T., additional, Racale, C., additional, and Marchi, S., additional

Published
2012
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41. P.07.19 ARE IBS PATIENTS ALEXITHYMIC?

Author

Tongiorgi, A., primary, Bellini, M., additional, Vaselli, E., additional, Meo, C., additional, Gambaccini, D., additional, De Bortoli, N., additional, Ceccarelli, L., additional, Di Fluri, G., additional, Mismas, V., additional, and Marchi, S., additional

Published
2012
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