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3. Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?

Author

Rebollo-Mesa, I., Nova-Lamperti, E., Mobillo, P., Runglall, M., Christakoudi, S., Norris, S., Smallcombe, N., Kamra, Y., Hilton, R., Bhandari, S., Baker, R., Berglund, D., Carr, S., Game, D., Griffin, S., Kalra, P.A., Lewis, R., Mark, P.B., Marks, S., Macphee, I., McKane, W., Mohaupt, M.G., Pararajasingam, R., Kon, S.P., Serón, D., Sinha, M.D., Tucker, B., Viklický, O., Lechler, R.I., Lord, G.M., and Hernandez-Fuentes, M.P. more...

Published
2016
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14. Xanthomatous Cells in Cutaneous Graft-Versus-Host Disease Biopsies: A Clue for the Diagnosis of Hepatic Graft-Versus-Host Disease.

Author

Gamé D, López L, Román C, and Santos-Briz Á

Subjects
Adult, Biopsy, Child, Graft vs Host Disease etiology, Humans, Hypercholesterolemia diagnosis, Hypercholesterolemia etiology, Hypertriglyceridemia diagnosis, Hypertriglyceridemia etiology, Immunohistochemistry, Liver Diseases etiology, Male, Middle Aged, Predictive Value of Tests, Skin Diseases etiology, Graft vs Host Disease pathology, Hematopoietic Stem Cell Transplantation adverse effects, Histiocytes pathology, Liver pathology, Liver Diseases pathology, Skin pathology, Skin Diseases pathology, Xanthomatosis pathology
Abstract

Graft-versus-host disease (GVHD) is one of the most common and serious complications of hematopoietic stem-cell transplantation that mainly affects the skin, gastrointestinal tract, and liver. Hepatic GVHD is associated with high morbidity and mortality, and its diagnosis can be especially challenging because of nonspecific clinical signs and symptoms. It must be suspected in patients with elevated liver enzymes and cholestasis, especially in those with a history of preceding skin rash and diarrhea. We describe 3 patients with cutaneous and hepatic GVHD that presented with severe hypercholesterolemia and hypertriglyceridemia, and no xanthomatous macular lesions, in which cutaneous biopsies revealed the presence of xanthomatous dermal histiocytes. We propose that the presence of these xanthomatous cells in skin biopsies from patients with cutaneous GVHD could be a dermatopathological clue for the diagnosis of hepatic GVHD. more...

Published
2018
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