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3. Characteristics, Physiopathology and Management of Dyslipidemias in Pregnancy: A Narrative Review.

Author

Formisano, Elena, Proietti, Elisa, Perrone, Giuseppina, Demarco, Valentina, Galoppi, Paola, Stefanutti, Claudia, and Pisciotta, Livia

Abstract

Dyslipidemia is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD). During pregnancy, physiological changes elevate cholesterol and triglyceride levels to support fetal development, which can exacerbate pre-existing conditions and lead to complications such as pre-eclampsia, gestational diabetes, and increased ASCVD risk for both mother and child. Effective management strategies are necessary, especially for pregnant women with inherited forms of dyslipidemia (i.e., familial hypertriglyceridemia, hyperchylomicronemia), where personalized dietary adjustments are crucial for successful pregnancy outcomes. Pharmacological interventions and lipoprotein apheresis may be necessary for severe cases, though their use is often limited by factors such as cost, availability, and potential fetal risks. Despite the promise of advanced therapies, their widespread application remains constrained by limited studies and high costs. Thus, a personalized, multidisciplinary approach is essential for optimizing outcomes. This review provides a comprehensive overview of current strategies and evidence-based practices for managing dyslipidemia during pregnancy, emphasizing the balance of maternal and fetal health. Additionally, it discusses the physiological changes in lipid metabolism during pregnancy and their implications, particularly for women with inherited forms of dyslipidemia. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Removal Versus Retention of Cervical Cerclage With Preterm Prelabor Rupture of Membranes: Systematic Review and Meta-analysis

Author

Zullo, Fabrizio, primary, Di Mascio, Daniele, additional, Chauhan, Suneet P., additional, Chrysostomou, Spyridakis, additional, Suff, Natalie, additional, Pecorini, Francesco, additional, D'Ambrosio, Valentina, additional, Sorrenti, Sara, additional, D'Alberti, Elena, additional, Galoppi, Paola, additional, Muzii, Ludovico, additional, Giancotti, Antonella, additional, and Brunelli, Roberto, additional

Published
2024
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8. Severe maternal thrombocytopenia and prenatal invasive procedures: still a grey zone.

Author

D'Alberti, Elena, Brunelli, Roberto, D'Ambrosio, Valentina, Galoppi, Paola, Santoro, Cristina, and Giancotti, Antonella

Subjects
THROMBOCYTOPENIA treatment, ADRENOCORTICAL hormones, AMNIOCENTESIS, OPERATIVE surgery, SEVERITY of illness index, INTRAVENOUS immunoglobulins, CHORIONIC villus sampling, PLATELET count, THROMBOCYTOPENIA, PRENATAL care, ADVERSE health care events, PREGNANCY
Abstract

Management of severe thrombocytopenia, particularly of ITP, in pregnancy is mainly based on expert consensus and clinical experience while there are no clear indications about the minimum platelet count requested for prenatal diagnosis invasive procedures. Since the lack of specific recommendations we reported our clinical management of a patient suffering from severe thrombocytopenia, undergoing amniocentesis. Due to the anecdotic possibility of maternal and fetal bleeding in case of severe thrombocytopenia, prophylaxis with IVIG or even corticosteroids could be considered as a safer strategy to prevent post-procedural adverse outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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9. SARS-CoV-2 vertical transmission in a twin-pregnant woman: a case report

Author

Sessa, Rosa, primary, Masciullo, Luisa, additional, Filardo, Simone, additional, Di Pietro, Marisa, additional, Brandolino, Gabriella, additional, Brunelli, Roberto, additional, Galoppi, Paola, additional, Terrin, Gianluca, additional, Viscardi, Maria Federica, additional, Anastasi, Emanuela, additional, and Porpora, Maria Grazia, additional

Published
2022
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11. Prevention of Fetal Anemia with Plasma Exchange and Intravenous Immunoglobulin in a Pregnancy with a Complex Anti-K and Anti-C Alloimmunization.

Author

Galoppi, Paola, Rocca, Ursula La, Giovannetti, Gianluca, Perrone, Giuseppina, Gozzer, Maria, Bafti, Mahnaz Shafii, Biondino, Giovanna, Equitani, Francesco, Neri, Alessia, Savastano, Giovanna, Pompeo, Damiana, Lobozzo, Benedetta, Santilio, Isabella, Falco, Federica, Paoli, Adele Delli, Brunelli, Roberto, and Coluzzi, Serelina

Published
2023
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14. Stillbirth and fetal capillary infection by SARS-CoV-2

Author

di Gioia, Cira, Zullo, Fabrizio, Bruno Vecchio, Roberta Costanza, Pajno, Cristina, Perrone, Giuseppina, Galoppi, Paola, Pecorini, Francesco, Di Mascio, Daniele, Carletti, Raffaella, Prezioso, Carla, Pietropaolo, Valeria, Masuelli, Laura, Bei, Roberto, Ciallella, Costantino, Della Rocca, Carlo, Giancotti, Antonella, and Brunelli, Roberto

Published
2022
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15. Immune Response of Neonates Born to Mothers Infected With SARS-CoV-2

Author

Conti, Maria Giulia, primary, Terreri, Sara, additional, Piano Mortari, Eva, additional, Albano, Christian, additional, Natale, Fabio, additional, Boscarino, Giovanni, additional, Zacco, Giulia, additional, Palomba, Patrizia, additional, Cascioli, Simona, additional, Corrente, Francesco, additional, Capponi, Claudia, additional, Mirabella, Mattia, additional, Salinas, Ane Fernandez, additional, Marciano, Alessandra, additional, De Luca, Francesca, additional, Pangallo, Ida, additional, Quaranta, Cecilia, additional, Alteri, Claudia, additional, Russo, Cristina, additional, Galoppi, Paola, additional, Brunelli, Roberto, additional, Perno, Carlo Federico, additional, Terrin, Gianluca, additional, and Carsetti, Rita, additional

Published
2021
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16. Immigration and Adverse Pregnancy Outcomes in an Italian Free Care Hospital

Author

Caruso, Giuseppe, primary, Marcoccia, Eleonora, additional, Brunelli, Roberto, additional, Candelieri, Miriam, additional, Schiavi, Michele Carlo, additional, Zannini, Ilaria, additional, Perrone, Seila, additional, Capri, Oriana, additional, Muzii, Ludovico, additional, Perrone, Giuseppina, additional, and Galoppi, Paola, additional

Published
2021
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17. sj-pdf-1-lup-10.1177_0961203321995263 - Supplemental material for Breastfeeding in women affected by systemic lupus erythematosus: Rate, duration and associated factors

Author

Orefice, Valeria, Ceccarelli, Fulvia, Pirone, Carmelo, Galoppi, Paola, Spinelli, Francesca Romana, Alessandri, Cristiano, Brunelli, Roberto, Perrone, Giuseppina, and Conti, Fabrizio

Subjects
111702 Aged Health Care, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-1-lup-10.1177_0961203321995263 for Breastfeeding in women affected by systemic lupus erythematosus: Rate, duration and associated factors by Valeria Orefice, Fulvia Ceccarelli, Carmelo Pirone, Paola Galoppi, Francesca Romana Spinelli, Cristiano Alessandri, Roberto Brunelli, Giuseppina Perrone and Fabrizio Conti in Lupus

Published
2021
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18. Clinical management of hypertensive disorders in postpartum women. A narrative review

Author

Scudo, Maria, Petruzziello, Luciano, Carbone, Fabiana, Logoteta, Alessandra, Paoni Saccone, Giulia, D'Oria, Ottavia, Galoppi, Paola, Brunelli, Roberto, and Monti, Marco

Subjects
preclampsia, preclampsia, hypertensive disease of pregnancy, puerperal hypertesion, hypertensive disease of pregnancy, puerperal hypertesion
Published
2021

19. Immigration and Adverse Pregnancy Outcomes in an Italian Free Care Hospital

Author

Caruso,Giuseppe, Marcoccia,Eleonora, Brunelli,Roberto, Candelieri,Miriam, Schiavi,Michele Carlo, Zannini,Ilaria, Perrone,Seila, Capri,Oriana, Muzii,Ludovico, Perrone,Giuseppina, Galoppi,Paola, Caruso,Giuseppe, Marcoccia,Eleonora, Brunelli,Roberto, Candelieri,Miriam, Schiavi,Michele Carlo, Zannini,Ilaria, Perrone,Seila, Capri,Oriana, Muzii,Ludovico, Perrone,Giuseppina, and Galoppi,Paola

Abstract

Giuseppe Caruso,1 Eleonora Marcoccia,1,2 Roberto Brunelli,1 Miriam Candelieri,1 Michele Carlo Schiavi,1 Ilaria Zannini,1 Seila Perrone,1 Oriana Capri,1 Ludovico Muzii,1 Giuseppina Perrone,1 Paola Galoppi1 1Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Umberto I Hospital, Rome, Italy; 2Department of Experimental Medicine, Sapienza University of Rome, Umberto I Hospital, Rome, ItalyCorrespondence: Giuseppe CarusoDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Umberto I Hospital, Viale del Policlinico, 155, Rome, 00161, ItalyTel +39064463069; +390649972568Email g.caruso@uniroma1.itIntroduction: The ever-increasing wave of immigration in Italy has posed demanding challenges in the management of the new multiethnic obstetric population. The aim of this study was to compare pregnancy and perinatal outcomes between immigrants and the native population in an Italian public hospital.Materials and Methods: Singleton pregnant women (≥ 24 weeks of gestation) who delivered during a 3-year period in an Italian free care hospital were included. Long-term (≥ 2 years of residence) immigrant patients were divided into 4 groups according to their ethnic origin: Europeans, Asians, Latin Americans, and Africans. Perinatal indicators of obstetric outcomes were collected and compared between immigrants and Italians.Results: Of the 3556 patients included, 1092 were immigrants and 2464 Italians. The immigrant cohort experienced a higher rate of macrosomia (1.8% vs 0.6%; p = 0.001), very low birth weight (1.3% vs 0.6%; p = 0.048), very early preterm delivery (1.4% vs 0.4%; p = 0.048), and gestational diabetes mellitus (1.8% vs 0.5%; p = 003) compared with the native population. The overall rate of cesarean sections was greater among Italians (56% vs 45.8%; p < 0.001). Among ethnic groups, Europeans and Latin Americans reported a higher rate of preterm delivery (20.2% and 19%, respectively; p

Published
2021

23. Pregnancy outcome in systemic lupus erythematosus patients: a monocentric cohort analysis

Author

Ceccarelli, Fulvia, primary, Pirone, Carmelo, additional, Perricone, Carlo, additional, Selntigia, Aikaterina, additional, Orefice, Valeria, additional, Pacucci, Viviana Antonella, additional, Truglia, Simona, additional, Spinelli, Francesca Romana, additional, Galoppi, Paola, additional, Alessandri, Cristiano, additional, Valesini, Guido, additional, Brunelli, Roberto, additional, Perrone, Giuseppina, additional, and Conti, Fabrizio, additional

Published
2020
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27. Non-compaction cardiomyopathy in pregnancy: a case report of spongy myocardium in both mother and foetus and systematic review of literature.

Author

Bardhi, Erlisa, Faralli, Ida, Deroma, Marianna, Galoppi, Paola, Ventriglia, Flavia, Giancotti, Antonella, Perrone, Giuseppina, and Brunelli, Roberto

Subjects
PERIPARTUM cardiomyopathy, MYOCARDIUM, MYOCARDIAL infarction, CARDIOVASCULAR diseases, PREGNANCY, CARDIOMYOPATHIES
Abstract

Cardiovascular disease is the main nonobstetric cause of maternal death during pregnancy and is present in 0.5–4% of pregnancies in the western world. While hypertensive disorders remain the most frequent events, occurring in 6–8% of all pregnancies, cardiomyopathies are rare but encompass high complication rates. The aim of this systematic review is to report all data available up to date regarding pregnancies in patients with left ventricular noncompaction (LVNC) cardiomyopathy. PubMed, Medline, Cochrane, Scopus and Embase were searched, up to January 2019, using combinations of these terms: left ventricular noncompaction, hypertrabeculation cardiomyopathy, spongy myocardium, spongiform cardiomyopathy and delivery, gestation, pregnancy, cesarean section (CS). After careful selection, 22 articles, reporting a total of 30 cases, including our own were included in the review. Fifteen out of 26 women (58%) were diagnosed with LVNC before pregnancy. Around 56% of women presented with symptoms during pregnancy while 44% were asymptomatic. Heart failure is by far the most common symptom occurring in almost half the cases. Uncommon clinical presentations included a heart attack, a stroke, and pulmonary hypertension. Timing of delivery was reported preterm in 58% of cases and at term in 42%. Eleven women gave birth through vaginal delivery, while 15 (58%) underwent a CS. Our reported case is the first case of a pregnancy where both mother and fetus are affected by LVNC and the fetus is diagnosed prenatally. LVNC is not a contraindication for pregnancy, but clearly increases the risk of preterm birth and the rate of cesarean section. On the other hand, pregnancy in a LVNC patient exposes her to increased risk of clinical deterioration. Further studies are needed to better characterize the management of pregnancies in women with cardiomyopathies. [ABSTRACT FROM AUTHOR]

Published
2021
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29. OP0130 PREMATURE OVARIAN FAILURE IN PATIENTS AFFECTED BY SYSTEMIC LUPUS ERYTHEMATOSUS: A CROSS-SECTIONAL CASE CONTROL STUDY

Author

Orefice, Valeria, primary, Ceccarelli, Fulvia, additional, Perrone, Giuseppina, additional, Pirone, Carmelo, additional, Perricone, Carlo, additional, Truglia, Simona, additional, Miranda, Francesca, additional, Pacucci, Viviana Antonella, additional, Spinelli, Francesca, additional, Galoppi, Paola, additional, Alessandri, Cristiano, additional, Valesini, Guido, additional, and Conti, Fabrizio, additional

Published
2019
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30. New‐onset ulcerative colitis in pregnancy associated to toxic megacolon and sudden fetal decompensation: Case report and literature review

Author

Brunelli, Roberto, primary, Perrone, Seila, additional, Perrone, Giuseppina, additional, Galoppi, Paola, additional, De Stefano, Maria G., additional, Maragno, Anna M., additional, Cesarini, Monica, additional, De Carolis, Aurora, additional, Masselli, Gabriele, additional, and Vernia, Piero, additional

Published
2019
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31. Pregnancy outcome in systemic lupus erythematosus patients: a monocentric cohort analysis.

Author

Ceccarelli, Fulvia, Pirone, Carmelo, Perricone, Carlo, Selntigia, Aikaterina, Orefice, Valeria, Pacucci, Viviana Antonella, Truglia, Simona, Spinelli, Francesca Romana, Galoppi, Paola, Alessandri, Cristiano, Valesini, Guido, Brunelli, Roberto, Perrone, Giuseppina, and Conti, Fabrizio

Subjects
STATISTICS, DNA, COUNSELING, RHEUMATOLOGY, GYNECOLOGY, AUTOIMMUNE diseases, REGRESSION analysis, FISHER exact test, PREGNANCY outcomes, T-test (Statistics), HEALTH care teams, DESCRIPTIVE statistics, INTERPROFESSIONAL relations, CHI-squared test, SYSTEMIC lupus erythematosus, DATA analysis software, DISEASE complications, PREGNANCY
Abstract

Objective SLE is an autoimmune disease, mainly affecting women of childbearing age, with possible impact on pregnancy. In this study, we evaluated pregnancy outcomes in all pregnant patients affected by SLE, followed in the context of a rheumatology/gynaecology multi-disciplinary team. Methods Since 2008, we evaluated 70 consecutive pregnancies occurring in 50 SLE patients referring to the Lupus Clinic of Sapienza University of Rome; as controls we evaluated 100 consecutive pregnancies in 100 women without autoimmune diseases. Results By comparing SLE patients and controls, we did not find differences in terms of pregnancy outcomes, except for the occurrence of small for gestational age, which was significantly higher in the SLE group (22.8% vs 11%, P  =0.003). Small for gestational age was associated with the positivity for anti-dsDNA, anti-Sm and anti-RNP (P  =0.009, P  =0.02, P  =0.002, respectively). A disease flare was reported in 28 pregnancies (40%) and in 31 puerperium periods (44.3%). Flare during pregnancy was associated with anti-SSA (P  =0.02), while puerperium relapse with previous MMF treatment (P  =0.01) and haematological flare during pregnancy (P  =0.03). Conclusion The present study confirms how pre-gestational counselling and a multi-disciplinary approach could result in positive pregnancy outcomes for SLE patients. The high percentage of disease relapse justifies even more the need for multi-disciplinary management. [ABSTRACT FROM AUTHOR]

Published
2021
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34. Magnetic Resonance Imaging and H-proton Spectroscopy assessment of maternal and foetal brains in a case of pregnancy-associated Wernicke encephalopathy

Author

Masselli, Gabriele, primary, Bernieri, Maria Giulia, additional, De Stefano, Maria Grazia, additional, Maragno, Anna Maria, additional, Patti, Simona, additional, Galoppi, Paola, additional, Laghi, Francesca, additional, Cardinale, Vincenzo, additional, Gualdi, Gianfranco, additional, and Brunelli, Roberto, additional

Published
2016
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35. Epirubicin: a new entry in the list of fetal cardiotoxic drugs? Intrauterine death of one fetus in a twin pregnancy. Case report and review of literature

Author

Framarino-dei-Malatesta, Marialuisa, primary, Perrone, Giuseppina, additional, Giancotti, Antonella, additional, Ventriglia, Flavia, additional, Derme, Martina, additional, Iannini, Isabella, additional, Tibaldi, Valentina, additional, Galoppi, Paola, additional, Sammartino, Paolo, additional, Cascialli, Gianluca, additional, and Brunelli, Roberto, additional

Published
2015
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37. Anticorpi agonisti del recettore dell’angiotensina II nell’ipertensione in gravidanza

Author

Perrone, Giuseppina, DE STEFANO, MARIA GRAZIA, Bevilacqua, Elisa, Davide, Nicoli, Galoppi, Paola, Stefanutti, Claudia, Porpora, Maria Grazia, Capri, Oriana, and Brunelli, Roberto

Subjects
autoanticorpi antirecettore ati, gravidanza, anticorpi agonisti recettore angiotensina ii, ipertensione in gravidanza, autoanticorpi antirecettore ati - angiotensina ii - gravidanza - ipertensione.autoantibodies anti ati receptor - angiotensin ii - pregnancy - hypertension, angiotensina ii, ipertensione
Published
2012

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