118 results on '"Galloway, Sheila M."'
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2. Genotoxicity Tests for Novel Oligonucleotide-Based Therapeutics
3. Potentially mutagenic impurities: Analysis of structural classes and carcinogenic potencies of chemical intermediates in pharmaceutical syntheses supports alternative methods to the default TTC for calculating safe levels of impurities
4. Cytochrome P-450 Metabolic Activity in Embryonic and Extraembryonic Tissue Lineages of Mouse Embryos
5. Cultured Mouse Embryos Metabolize Benzo[a]pyrene during Early Gestation: Genetic Differences Detectable by Sister Chromatid Exchange
6. A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards
7. Predictions of Genotoxic Potential, Mode of Action, Molecular Targets, and Potency via a Tiered MultiFlow® Assay Data Analysis Strategy
8. Proceedings of a workshop on DNA adducts: Biological significance and applications to risk assessment Washington, DC, April 13–14, 2004
9. In Vivo Mutagenicity Testing of Arylboronic Acids and Esters
10. Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy
11. Induction of chromosome aberrations in vitro by phenolphthalein: mechanistic studies
12. The genetic toxicity of the peroxisome proliferator class of rodent hepatocarcinogen
13. Rapid method for improving slide quality in the bone marrow micronucleus assay; an adapted cellulose column procedure
14. Cytogenetic Monitoring of Human Populations
15. International regulatory requirements for genotoxicity testing for pharmaceuticals used in human medicine, and their impurities and metabolites
16. OSWG Recommendations for Genotoxicity Testing of Novel Oligonucleotide-Based Therapeutics
17. Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β 3 adrenergic receptor agonists
18. Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β3 adrenergic receptor agonists
19. Chromosome aberrations in Chinese hamster and human cells: A comparison using compounds with various genotoxicity profiles
20. Synthesis and Evaluation of S-Acyl-2-thioethyl Esters of Modified Nucleoside 5‘-Monophosphates as Inhibitors of Hepatitis C Virus RNA Replication
21. Population doubling: A simple and more accurate estimation of cell growth suppression in the in vitro assay for chromosomal aberrations that reduces irrelevant positive results
22. Genotoxicity of naturally occurring indole compounds: correlation between covalent DNA binding and other genotoxicity tests
23. Cytotoxicity and chromosome aberrations in vitro: Experience in industry and the case for an upper limit on toxicity in the aberration assay
24. Fewer chromosome aberrations and earlier apoptosis induced by DNA synthesis inhibitors, a topoisomerase II inhibitor or alkylating agents in human cells with normal compared with mutant p53
25. DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens
26. Chromosome aberrations in vitro related to cytotoxicity of nonmutagenic chemicals and metabolic poisons
27. Multilaboratory comparison of in vitro tests for chromosome aberrations in CHO and CHL cells tested under the same protocols
28. The micronucleus test and NTP rodent carcinogens: not so many false negatives
29. Human liver S-9 metabolic activation: proficiency in cytogenetic assays and comparison with phenobarbital/β-naphthoflavone or Aroclor 1254 induced ratS-9
30. A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells
31. Report from working group on in vitro tests for chromosomal aberrations
32. Chromosome aberrations induced in vitro: Mechanisms, delayed expression, and intriguing questions
33. 2,4,6-Trichlorophenol (TCP) induces chromosome breakage and aneuploidy in vitro
34. Evaluation of the need for a late harvest time in the assay for chromosome aberrations in Chinese hamster ovary cells
35. Micronuclei induced in peripheral blood of Eμ-PIM-1-transgenic mice by chronic oral treatment with 2-acetylaminofluorene or benzene but not with diethyl-nitrosamine or 1,2-dichloroethane
36. Activation of immediate‐early gene expression by peroxisome proliferators in vitro
37. Comments on the report of ‘association’ of omeprazole with DNA by Phillips et al
38. A quantitative assessment of the cytotoxicity associated with chromosomal aberration detection in Chinese hamster ovary cells
39. Effect of sampling time on chromosome aberration yield for 7 chemicals in Chinese hamster ovary cells
40. Genotoxicity under extreme culture conditions
41. Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains
42. Relationships among cytotoxicity, lysosomal breakdown, chromosome aberrations, and DNA double-strand breaks
43. Chemically induced aneuploidy in mammalian cells in culture
44. Chromosome aberrations in individuals occupationally exposed to ethylene oxide, and in a large control population
45. A text on cytogenetic tests for mutagens and carcinogens. “Cytogenetic Assays of Environmental Mutagens,” T.C. Hsu (ed). Totowa, New Jersey: Allanheld, Osmun & Co., Publishers, 1982, 430 pp, $45.00
46. Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and DNA strand breaks, and the relation to toxicity
47. Repair of sister-chromatid exchange-inducing lesions in mutagen-treated cultures of human whole blood and purified fresh or frozen lymphocytes
48. Ataxia telangiectasia: The effects of chemical mutagens and x-rays on sister chromatid exchanges in blood lymphocytes
49. The relation between chemically induced sister-chromatid exchanges and chromatid breakage
50. Sister-chromatid exchanges in association with occupational exposure to ethylene oxide
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