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10. Prospects

Author

Gallon, J. R., Masepohl, B., Klipp, Werner, editor, Masepohl, Bernd, editor, Gallon, John R., editor, and Newton, William E., editor

Published
2005
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11. Science Goals and Mission Architecture of the Europa Lander Mission Concept

Author

Hand, K. P., primary, Phillips, C. B., additional, Murray, A., additional, Garvin, J. B., additional, Maize, E. H., additional, Gibbs, R. G., additional, Reeves, G., additional, Martin, A. M. San, additional, Tan-Wang, G. H., additional, Krajewski, J., additional, Hurst, K., additional, Crum, R., additional, Kennedy, B. A., additional, McElrath, T. P., additional, Gallon, J. C., additional, Sabahi, D., additional, Thurman, S. W., additional, Goldstein, B., additional, Estabrook, P., additional, Lee, S. W., additional, Dooley, J. A., additional, Brinckerhoff, W. B., additional, Edgett, K. S., additional, German, C. R., additional, Hoehler, T. M., additional, Hörst, S. M., additional, Lunine, J. I., additional, Paranicas, C., additional, Nealson, K., additional, Smith, D. E., additional, Templeton, A. S., additional, Russell, M. J., additional, Schmidt, B., additional, Christner, B., additional, Ehlmann, B., additional, Hayes, A., additional, Rhoden, A., additional, Willis, P., additional, Yingst, R. A., additional, Craft, K., additional, Cameron, M. E., additional, Nordheim, T., additional, Pitesky, J., additional, Scully, J., additional, Hofgartner, J., additional, Sell, S. W., additional, Barltrop, K. J., additional, Izraelevitz, J., additional, Brandon, E. J., additional, Seong, J., additional, Jones, J.-P., additional, Pasalic, J., additional, Billings, K. J., additional, Ruiz, J. P., additional, Bugga, R. V., additional, Graham, D., additional, Arenas, L. A., additional, Takeyama, D., additional, Drummond, M., additional, Aghazarian, H., additional, Andersen, A. J., additional, Andersen, K. B., additional, Anderson, E. W., additional, Babuscia, A., additional, Backes, P. G., additional, Bailey, E. S., additional, Balentine, D., additional, Ballard, C. G., additional, Berisford, D. F., additional, Bhandari, P., additional, Blackwood, K., additional, Bolotin, G. S., additional, Bovre, E. A., additional, Bowkett, J., additional, Boykins, K. T., additional, Bramble, M. S., additional, Brice, T. M., additional, Briggs, P., additional, Brinkman, A. P., additional, Brooks, S. M., additional, Buffington, B. B., additional, Burns, B., additional, Cable, M. L., additional, Campagnola, S., additional, Cangahuala, L. A., additional, Carr, G. A, additional, Casani, J. R., additional, Chahat, N. E., additional, Chamberlain-Simon, B. K., additional, Cheng, Y., additional, Chien, S. A., additional, Cook, B. T., additional, Cooper, M., additional, DiNicola, M., additional, Clement, B., additional, Dean, Z., additional, Cullimore, E. A., additional, Curtis, A. G., additional, Croix, J-P. de la, additional, Pasquale, P. Di, additional, Dodd, E. M., additional, Dubord, L. A., additional, Edlund, J. A., additional, Ellyin, R., additional, Emanuel, B., additional, Foster, J. T., additional, Ganino, A. J., additional, Garner, G. J., additional, Gibson, M. T., additional, Gildner, M., additional, Glazebrook, K. J., additional, Greco, M. E., additional, Green, W. M., additional, Hatch, S. J., additional, Hetzel, M. M., additional, Hoey, W. A., additional, Hofmann, A. E., additional, Ionasescu, R., additional, Jain, A., additional, Jasper, J. D., additional, Johannesen, J. R., additional, Johnson, G. K., additional, Jun, I., additional, Katake, A. B., additional, Kim-Castet, S. Y., additional, Kim, D. I., additional, Kim, W., additional, Klonicki, E. F., additional, Kobeissi, B., additional, Kobie, B. D., additional, Kochocki, J., additional, Kokorowski, M., additional, Kosberg, J. A., additional, Kriechbaum, K., additional, Kulkarni, T. P., additional, Lam, R. L., additional, Landau, D. F., additional, Lattimore, M. A., additional, Laubach, S. L., additional, Lawler, C. R., additional, Lim, G., additional, Lin, J. Y, additional, Litwin, T. E., additional, Lo, M. W., additional, Logan, C. A., additional, Maghasoudi, E., additional, Mandrake, L., additional, Marchetti, Y., additional, Marteau, E., additional, Maxwell, K. A., additional, Namee, J. B. Mc, additional, Mcintyre, O., additional, Meacham, M., additional, Melko, J. P., additional, Mueller, J., additional, Muliere, D. A., additional, Mysore, A., additional, Nash, J., additional, Ono, H., additional, Parker, J. M., additional, Perkins, R. C., additional, Petropoulos, A. E, additional, Gaut, A., additional, Gomez, M. Y. Piette, additional, Casillas, R. P., additional, Preudhomme, M., additional, Pyrzak, G., additional, Rapinchuk, J., additional, Ratliff, J. M., additional, Ray, T. L., additional, Roberts, E. T., additional, Roffo, K., additional, Roth, D. C., additional, Russino, J. A., additional, Schmidt, T. M., additional, Schoppers, M. J., additional, Senent, J. S., additional, Serricchio, F., additional, Sheldon, D. J., additional, Shiraishi, L. R., additional, Shirvanian, J., additional, Siegel, K. J., additional, Singh, G., additional, Sirota, A. R., additional, Skulsky, E. D., additional, Stehly, J. S., additional, Strange, N. J., additional, Stevens, S. U., additional, Sunada, E. T., additional, Tepsuporn, S. P., additional, Tosi, L. P. C., additional, Trawny, N., additional, Uchenik, I., additional, Verma, V., additional, Volpe, R. A., additional, Wagner, C. T., additional, Wang, D., additional, Willson, R. G., additional, Wolff, J. L., additional, Wong, A. T., additional, Zimmer, A. K., additional, Sukhatme, K. G., additional, Bago, K. A., additional, Chen, Y., additional, Deardorff, A. M., additional, Kuch, R. S., additional, Lim, C., additional, Syvertson, M. L., additional, Arakaki, G. A., additional, Avila, A., additional, DeBruin, K. J., additional, Frick, A., additional, Harris, J. R., additional, Heverly, M. C., additional, Kawata, J. M., additional, Kim, S.-K., additional, Kipp, D. M., additional, Murphy, J., additional, Smith, M. W., additional, Spaulding, M. D., additional, Thakker, R., additional, Warner, N. Z., additional, Yahnker, C. R., additional, Young, M. E., additional, Magner, T., additional, Adams, D., additional, Bedini, P., additional, Mehr, L., additional, Sheldon, C., additional, Vernon, S., additional, Bailey, V., additional, Briere, M., additional, Butler, M., additional, Davis, A., additional, Ensor, S., additional, Gannon, M., additional, Haapala-Chalk, A., additional, Hartka, T., additional, Holdridge, M., additional, Hong, A., additional, Hunt, J., additional, Iskow, J., additional, Kahler, F., additional, Murray, K., additional, Napolillo, D., additional, Norkus, M., additional, Pfisterer, R., additional, Porter, J., additional, Roth, D., additional, Schwartz, P., additional, Wolfarth, L., additional, Cardiff, E. H., additional, Grob, E. W., additional, Adam, J. R., additional, Betts, E., additional, Norwood, J., additional, Heller, M. M., additional, Voskuilen, T., additional, Sakievich, P., additional, Gray, L., additional, Hansen, D. J., additional, Irick, K. W., additional, Hewson, J. C., additional, Lamb, J., additional, Stacy, S. C., additional, Brotherton, C. M., additional, Tappan, A. S, additional, Benally, D., additional, Thigpen, H., additional, Ortiz, E., additional, Sandoval, D., additional, Ison, A. M., additional, Warren, M., additional, Stromberg, P. G., additional, Thelen, P. M., additional, Blasy, B., additional, Nandy, P., additional, Haddad, A. W., additional, Trujillo, L. B., additional, Wiseley, T. H., additional, Bell, S. A., additional, Teske, N. P., additional, Post, C., additional, Torres-Castro, L., additional, Grosso, C., additional, and Wasiolek, M., additional

Published
2022
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18. Incidence et morbi-mortalité des tumeurs de la voie excrétrice du transplant après transplantation rénale : étude multicentrique française

Author

Hutin, M., primary, Thezenas, S., additional, Timsit, M.O., additional, Pettenati, C., additional, Gallon, J., additional, Karam, G., additional, Branchereau, J., additional, Heldhli, O., additional, Badet, L., additional, Matillon, X., additional, Salomon, L., additional, Cholley, I., additional, Bessede, T., additional, Neuzillet, Y., additional, Robert, G., additional, Bensadoun, H., additional, Allenet, C., additional, Cormier, L., additional, Schneider, A., additional, Leclercq, V., additional, Sallusto, F., additional, Descazeaud, A., additional, Peyronnet, B., additional, Hascoet, J., additional, Bouye, S., additional, Lechevallier, E., additional, Delaporte, V., additional, Lannes, F., additional, Boutin, J.M., additional, Berthelot, L.P., additional, Iborra, F., additional, and Thuret, R., additional

Published
2019
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27. Platinum-based chemotherapy induces methylation changes in blood DNA associated with overall survival in ovarian cancer patients

Author

Flanagan, JM, Wilson, A, Koo, C, Masrour, N, Gallon, J, Loomis, E, Flower, K, Wilhelm-Benartzi, C, Hergovich, A, Cunnea, P, Gabra, H, Braicu, EI, Sehouli, J, Darb-Esfahani, S, Vanderstichele, A, Vergote, I, Kreuzinger, C, Cacsire Castillo-Tong, D, Wisman, GB, Berns, EM, Siddiqui, N, Paul, J, Brown, R, Ovarian Cancer Action, Imperial College Healthcare NHS Trust- BRC Funding, Cancer Research UK, and National Institute for Health Research

Subjects
GENES, DNA Repair, DISEASE, DNA Adducts, Cell Line, Tumor, Humans, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, Promoter Regions, Genetic, Aged, Platinum, Ovarian Neoplasms, CARBOPLATIN, Science & Technology, COMBINATIONS, DNA, Neoplasm, 1ST-LINE CHEMOTHERAPY, DNA Methylation, Middle Aged, R1, Gene Expression Regulation, Neoplastic, Oncology, Drug Resistance, Neoplasm, Female, Neoplasm Recurrence, Local, Life Sciences & Biomedicine, DNA Damage
Abstract

PURPOSE: DNA damage repair can lead to epigenetic changes. DNA mismatch repair proteins bind to platinum DNA adducts and at sites of DNA damage can recruit the DNA methylating enzyme DNMT1, resulting in aberrant methylation. We hypothesised that DNA damage repair during platinum-based chemotherapy may cause aberrant DNA methylation in normal tissues of patients such as blood. EXPERIMENTAL DESIGN: We used Illumina 450k methylation arrays and bisulphite pyrosequencing to investigate methylation at presentation and relapse in blood DNA from ovarian cancer patients enrolled in the SCOTROC1 trial (n=247) and in a cohort of ovarian tumour DNA samples collected at first relapse (n=46). We used an ovarian cancer cell line model to investigate the role of the DNA mismatch repair gene MLH1 in platinum induced methylation changes. RESULTS: Specific CpG methylation changes in blood at relapse are observed following platinum-based chemotherapy and are associated with patient survival, independent of other clinical factors (HR=3.7; 95%CI 1.8-7.6, p=2.8x10-4). Similar changes occur in ovarian tumours at relapse, also associate with patient survival (HR=2.6; 95%CI 1.0-6.8, p=0.048). Using an ovarian cancer cell line model, we demonstrate that functional mismatch repair (MMR) increases the frequency of platinum-induced methylation. CONCLUSION: DNA methylation in blood at relapse following chemotherapy, and not at presentation, is informative about ovarian cancer patient survival. Functional DNA mismatch repair increases the frequency of DNA methylation changes induced by platinum. DNA methylation in blood following chemotherapy could provide a non-invasive means of monitoring patients' epigenetic responses to treatment without requiring a tumour biopsy.

Published
2017

31. MEMBERS' CORNER

Author

MARTIN, J. W., WATLING, D. E., GALLON, J. E., MOTTRAM, ROY, and Farrance, J. P.

Published
1962

32. Maximum rates of N2 fixation and primary production are out of phase in a developing cyanobacterial bloom in the Baltic Sea

Author

Gallon, J. R., Evans, A. M., Jones, D. A., Albertano, P., Canini, A., Congresti, R., Bergmann, B., Gundersen, K., Orcutt, K. M., von Bröckel, Klaus, Fritsche, Peter, Meyerhöfer, Michael, Nachtigall, Kerstin, Ohlendieck, U, Lintel Hekkert, S., Sivonen, K., Repka, S., Stal, L. J., Staal, M., and Marine Microbiology

Subjects
0106 biological sciences, Cyanobacteria, Biogeochemical cycle, education.field_of_study, 010504 meteorology & atmospheric sciences, biology, Ecology, 010604 marine biology & hydrobiology, Carbon fixation, Population, chemistry.chemical_element, Aquatic Science, Oceanography, biology.organism_classification, 01 natural sciences, Nitrogen, Baltic sea, chemistry, Nitrogen fixation, 14. Life underwater, Bloom, education, 0105 earth and related environmental sciences
Abstract

Although N2-fixing cyanobacteria contribute significantly to oceanic sequestration of atmospheric CO2, little is known about how N2 fixation and carbon fixation (primary production) interact in natural populations of marine cyanobacteria. In a developing cyanobacterial bloom in the Baltic Sea, rates of N2 fixation (acetylene reduction) showed both diurnal and longer-term fluctuations. The latter reflected fluctuations in the nitrogen status of the cyanobacterial population and could be correlated with variations in the ratio of acetylene reduced to 15N2 assimilated. The value of this ratio may provide useful information about the release of newly fixed nitrogen by a cyanobacterial population. However, although the diurnal fluctuations in N2 fixation broadly paralleled diurnal fluctuations in carbon fixation, the longer-term fluctuations in these two processes were out of phase.

Published
2002

36. Cyanobacteria attack rocks (CATS):Control and preventive strategies to avoid damage caused by cyanobacteria and associated microorganisms in Roman hypogean monuments

Author

Albertano, P., Moscone, D., Palleschi, G., Hermosin, B., Saiz-Jimenez, C., Sanchez-Moral, S., Hernandez-Marine, M., Urzi, C., Groth, I., Schroeckh, V., Saarela, Maria, Mattila-Sandholm, Tiina, Gallon, J. R., Graziottin, F., Bisconti, F., Giuliani, R., and Saiz-Jimenez, C.

Abstract

The CATS project focuses on the control, prevention and monitoring of cyanobacteria-dominated biofilms that cause damage to rock surfaces in Roman hypogea. It develops and integrates physical and biotechnological methods intended to limit the growth of microorganisms on valuable archaeological surfaces, and applies analytical methods to monitor the presence and the extent of the microbial damage. As in other hypogea, the development of biofilms is favoured by the limited air circulation, the even temperature throughout the year, and the high level of humidity. Biofilms composed of sciaphilous chroococcal and filamentous cyanobacteria associated with other microorganisms develop thanks to the light gradients that occur in the proximity of entrances and artificial lamps. Terrestrial cyanobacteria and associated microorganisms are the first colonisers of exposed lithic faces and their extensive development is supported by the mineral composition of the substrata and facilitated by the porous nature of the, mostly calcareous, surfaces.

Published
2003

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