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748 results on '"Gallo, Michele"'

7. Fast CP Model Fitting with Integrated ASD-ALS Procedure

Author

Todorov, Valentin, Simonacci, Violetta, Gallo, Michele, Trendafilov, Nickolay, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, García-Escudero, Luis A., editor, Gordaliza, Alfonso, editor, Mayo, Agustín, editor, Lubiano Gomez, María Asunción, editor, Gil, Maria Angeles, editor, Grzegorzewski, Przemyslaw, editor, and Hryniewicz, Olgierd, editor

Published
2023
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10. Lysosome purinergic receptor P2X4 regulates neoangiogenesis induced by microvesicles from sarcoma patients.

Author

Palinski, Wulf, Monti, Maria, Camerlingo, Rosa, Iacobucci, Ilaria, Bocella, Serena, Pinto, Federica, Iannuzzi, Clara, Mansueto, Gelsomina, Pignatiello, Sara, Fazioli, Flavio, Gallo, Michele, Marra, Laura, Cozzolino, Flora, De Chiara, Annarosaria, Pucci, Piero, Bilancio, Antonio, and de Nigris, Filomena

Subjects
Biochemistry and Cell Biology, Oncology and Carcinogenesis
Abstract

The tumor microenvironment modulates cancer growth. Extracellular vesicles (EVs) have been identified as key mediators of intercellular communication, but their role in tumor growth is largely unexplored. Here, we demonstrate that EVs from sarcoma patients promote neoangiogenesis via a purinergic X receptor 4 (P2XR4) -dependent mechanism in vitro and in vivo. Using a proteomic approach, we analyzed the protein content of plasma EVs and identified critical activated pathways in human umbilical vein endothelial cells (HUVECs) and human progenitor hematopoietic cells (CD34+). We then showed that vessel formation was due to rapid mitochondrial activation, intracellular Ca2+ mobilization, increased extracellular ATP, and trafficking of the lysosomal P2XR4 to the cell membrane, which is required for cell motility and formation of stable branching vascular networks. Cell membrane translocation of P2XR4 was induced by proteins and chemokines contained in EVs (e.g. Del-1 and SDF-1). Del-1 was found expressed in many EVs from sarcoma tumors and several tumor types. P2XR4 blockade reduced EVs-induced vessels in angioreactors, as well as intratumor vascularization in mouse xenografts. Together, these findings identify P2XR4 as a key mediator of EVs-induced tumor angiogenesis via a signaling mediated by mitochondria-lysosome-sensing response in endothelial cells, and indicate a novel target for therapeutic interventions.

Published
2021

18. Linear discriminant analysis (LDA)

Author

Trendafilov, Nickolay, Gallo, Michele, Banks, David, Series Editor, Fan, Jianqing, Series Editor, Jordan, Michael, Series Editor, Kannan, Ravi, Series Editor, Nesterov, Yurii, Series Editor, Ré, Christopher, Series Editor, Tibshirani, Ryan J., Series Editor, Wasserman, Larry, Series Editor, Trendafilov, Nickolay, and Gallo, Michele

Published
2021
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19. Procrustes analysis (PA)

Author

Trendafilov, Nickolay, Gallo, Michele, Banks, David, Series Editor, Fan, Jianqing, Series Editor, Jordan, Michael, Series Editor, Kannan, Ravi, Series Editor, Nesterov, Yurii, Series Editor, Ré, Christopher, Series Editor, Tibshirani, Ryan J., Series Editor, Wasserman, Larry, Series Editor, Trendafilov, Nickolay, and Gallo, Michele

Published
2021
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20. Cannonical correlation analysis (CCA)

Author

Trendafilov, Nickolay, Gallo, Michele, Banks, David, Series Editor, Fan, Jianqing, Series Editor, Jordan, Michael, Series Editor, Kannan, Ravi, Series Editor, Nesterov, Yurii, Series Editor, Ré, Christopher, Series Editor, Tibshirani, Ryan J., Series Editor, Wasserman, Larry, Series Editor, Trendafilov, Nickolay, and Gallo, Michele

Published
2021
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21. Common principal components (CPC)

Author

Trendafilov, Nickolay, Gallo, Michele, Banks, David, Series Editor, Fan, Jianqing, Series Editor, Jordan, Michael, Series Editor, Kannan, Ravi, Series Editor, Nesterov, Yurii, Series Editor, Ré, Christopher, Series Editor, Tibshirani, Ryan J., Series Editor, Wasserman, Larry, Series Editor, Trendafilov, Nickolay, and Gallo, Michele

Published
2021
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22. Factor analysis (FA)

Author

Trendafilov, Nickolay, Gallo, Michele, Banks, David, Series Editor, Fan, Jianqing, Series Editor, Jordan, Michael, Series Editor, Kannan, Ravi, Series Editor, Nesterov, Yurii, Series Editor, Ré, Christopher, Series Editor, Tibshirani, Ryan J., Series Editor, Wasserman, Larry, Series Editor, Trendafilov, Nickolay, and Gallo, Michele

Published
2021
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23. Principal component analysis (PCA)

Author

Trendafilov, Nickolay, Gallo, Michele, Banks, David, Series Editor, Fan, Jianqing, Series Editor, Jordan, Michael, Series Editor, Kannan, Ravi, Series Editor, Nesterov, Yurii, Series Editor, Ré, Christopher, Series Editor, Tibshirani, Ryan J., Series Editor, Wasserman, Larry, Series Editor, Trendafilov, Nickolay, and Gallo, Michele

Published
2021
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24. Matrix manifolds in MDA

Author

Trendafilov, Nickolay, Gallo, Michele, Banks, David, Series Editor, Fan, Jianqing, Series Editor, Jordan, Michael, Series Editor, Kannan, Ravi, Series Editor, Nesterov, Yurii, Series Editor, Ré, Christopher, Series Editor, Tibshirani, Ryan J., Series Editor, Wasserman, Larry, Series Editor, Trendafilov, Nickolay, and Gallo, Michele

Published
2021
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25. Introduction

Author

Trendafilov, Nickolay, Gallo, Michele, Banks, David, Series Editor, Fan, Jianqing, Series Editor, Jordan, Michael, Series Editor, Kannan, Ravi, Series Editor, Nesterov, Yurii, Series Editor, Ré, Christopher, Series Editor, Tibshirani, Ryan J., Series Editor, Wasserman, Larry, Series Editor, Trendafilov, Nickolay, and Gallo, Michele

Published
2021
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26. Matrix analysis and differentiation

Author

Trendafilov, Nickolay, Gallo, Michele, Banks, David, Series Editor, Fan, Jianqing, Series Editor, Jordan, Michael, Series Editor, Kannan, Ravi, Series Editor, Nesterov, Yurii, Series Editor, Ré, Christopher, Series Editor, Tibshirani, Ryan J., Series Editor, Wasserman, Larry, Series Editor, Trendafilov, Nickolay, and Gallo, Michele

Published
2021
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27. Metric multidimensional scaling (MDS) and related methods

Author

Trendafilov, Nickolay, Gallo, Michele, Banks, David, Series Editor, Fan, Jianqing, Series Editor, Jordan, Michael, Series Editor, Kannan, Ravi, Series Editor, Nesterov, Yurii, Series Editor, Ré, Christopher, Series Editor, Tibshirani, Ryan J., Series Editor, Wasserman, Larry, Series Editor, Trendafilov, Nickolay, and Gallo, Michele

Published
2021
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28. Data analysis on simplexes

Author

Trendafilov, Nickolay, Gallo, Michele, Banks, David, Series Editor, Fan, Jianqing, Series Editor, Jordan, Michael, Series Editor, Kannan, Ravi, Series Editor, Nesterov, Yurii, Series Editor, Ré, Christopher, Series Editor, Tibshirani, Ryan J., Series Editor, Wasserman, Larry, Series Editor, Trendafilov, Nickolay, and Gallo, Michele

Published
2021
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35. Modelling Human Intelligence Using Mixed Model Approach

Author

Gokul, Thanigaivasan, Srinivasan, Mamandur Rangaswamy, Gallo, Michele, Gaul, Wolfgang, Managing Editor, Vichi, Maurizio, Managing Editor, Weihs, Claus, Managing Editor, Baier, Daniel, Editorial Board Member, Critchley, Frank, Editorial Board Member, Decker, Reinhold, Editorial Board Member, Diday, Edwin, Editorial Board Member, Greenacre, Michael, Editorial Board Member, Lauro, Carlo Natale, Editorial Board Member, Meulman, Jacqueline, Editorial Board Member, Monari, Paola, Editorial Board Member, Nishisato, Shizuhiko, Editorial Board Member, Ohsumi, Noboru, Editorial Board Member, Opitz, Otto, Editorial Board Member, Ritter, Gunter, Editorial Board Member, Schader, Martin, Editorial Board Member, Mariani, Paolo, editor, and Zenga, Mariangela, editor

Published
2021
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