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195 results on '"Gallo, Elisa"'

1. The Core & Periphery Hypothesis: A Conceptual Basis for Generality in Cell and Developmental Biology

Author

Gallo, Elisa, De Renzis, Stefano, Sharpe, James, Mayor, Roberto, and Hartmann, Jonas

Subjects
Quantitative Biology - Cell Behavior, Quantitative Biology - Populations and Evolution, Quantitative Biology - Subcellular Processes
Abstract

The discovery of general principles underlying the complexity and diversity of cellular and developmental systems is a central and long-standing aim of biology. Whilst new technologies collect data at an ever-accelerating rate, there is growing concern that conceptual progress is not keeping pace. We contend that this is due to a paucity of appropriate conceptual frameworks to serve as a basis for general theories of mesoscale biological phenomena. In exploring this issue, we have developed a foundation for one such framework, termed the Core and Periphery (C&P) hypothesis, which reveals hidden generality across the diverse and complex behaviors exhibited by cells and tissues. Here, we present the C&P concept, provide examples of its applicability across multiple scales, argue its consistency with evolution, and discuss key implications and open questions. We propose that the C&P hypothesis could unlock new avenues of conceptual progress in cell and developmental biology., Comment: 35 pages, 5 figures

Published
2023
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2. Application of the Weighted-Incidence Syndromic Combination Antibiogram (WISCA) to guide the empiric antibiotic treatment of febrile neutropenia in oncological paediatric patients: experience from two paediatric hospitals in Northern Italy

Author

Liberati, Cecilia, Donà, Daniele, Maestri, Linda, Petris, Maria Grazia, Barbieri, Elisa, Gallo, Elisa, Gallocchio, Jacopo, Pierobon, Marta, Calore, Elisabetta, Zin, Annachiara, Brigadoi, Giulia, Mariani, Marcello, Mesini, Alessio, Saffioti, Carolina, Ugolotti, Elisabetta, Gregori, Dario, Giaquinto, Carlo, Castagnola, Elio, and Biffi, Alessandra

Published
2024
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4. The 2024 Europe report of the Lancet Countdown on health and climate change: unprecedented warming demands unprecedented action

Author

van Daalen, Kim R, Tonne, Cathryn, Semenza, Jan C, Rocklöv, Joacim, Markandya, Anil, Dasandi, Niheer, Jankin, Slava, Achebak, Hicham, Ballester, Joan, Bechara, Hannah, Beck, Thessa M, Callaghan, Max W, Carvalho, Bruno M, Chambers, Jonathan, Pradas, Marta Cirah, Courtenay, Orin, Dasgupta, Shouro, Eckelman, Matthew J, Farooq, Zia, Fransson, Peter, Gallo, Elisa, Gasparyan, Olga, Gonzalez-Reviriego, Nube, Hamilton, Ian, Hänninen, Risto, Hatfield, Charles, He, Kehan, Kazmierczak, Aleksandra, Kendrovski, Vladimir, Kennard, Harry, Kiesewetter, Gregor, Kouznetsov, Rostislav, Kriit, Hedi Katre, Llabrés-Brustenga, Alba, Lloyd, Simon J, Batista, Martín Lotto, Maia, Carla, Martinez-Urtaza, Jaime, Mi, Zhifu, Milà, Carles, Minx, Jan C, Nieuwenhuijsen, Mark, Palamarchuk, Julia, Pantera, Dafni Kalatzi, Quijal-Zamorano, Marcos, Rafaj, Peter, Robinson, Elizabeth J Z, Sánchez-Valdivia, Nacho, Scamman, Daniel, Schmoll, Oliver, Sewe, Maquins Odhiambo, Sherman, Jodi D, Singh, Pratik, Sirotkina, Elena, Sjödin, Henrik, Sofiev, Mikhail, Solaraju-Murali, Balakrishnan, Springmann, Marco, Treskova, Marina, Triñanes, Joaquin, Vanuytrecht, Eline, Wagner, Fabian, Walawender, Maria, Warnecke, Laura, Zhang, Ran, Romanello, Marina, Antó, Josep M, Nilsson, Maria, and Lowe, Rachel

Published
2024
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20. Heat-related mortality in Europe during 2023 and the role of adaptation in protecting health

Author

Gallo, Elisa, Quijal-Zamorano, Marcos, Méndez Turrubiates, Raúl Fernando, Tonne, Cathryn, Basagaña, Xavier, Achebak, Hicham, and Ballester, Joan

Abstract

The year of 2023 was the warmest on record globally and the second warmest in Europe. Here we applied epidemiological models to temperature and mortality records in 823 contiguous regions from 35 countries to estimate sex- and age-specific heat-related mortality in Europe during 2023 and to quantify the mortality burden avoided by societal adaptation to rising temperatures since the year 2000. We estimated 47,690 (95% confidence interval 28,853 to 66,525) heat-related deaths in 2023, the second highest mortality burden during the study period 2015–2023, only surpassed by 2022. We also estimated that the heat-related mortality burden would have been +80.0% higher in absence of present-century adaptation, especially in the elderly (+100.7% in people aged 80+ years). Our results highlight the importance of historical and ongoing adaptations in saving lives during recent summers and the urgency for more effective strategies to further reduce the mortality burden of forthcoming hotter summers.

Published
2024
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21. Infantile anogenital digitate keratoses: A case series of a novel entity

Author

Bar-Ilan, Efrat, primary, Mashiah, Jacob, additional, Molho-Pessach, Vered, additional, Horev, Liran, additional, Confino, Yizhak, additional, Gál, Andrea I., additional, Szalai, Zsuzsanna, additional, Gallo, Elisa S., additional, Barzilai, Aviv, additional, Greenberger, Shoshana, additional, and Ollech, Ayelet, additional

Published
2023
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29. Increased risk of emergency department presentations for bronchiolitis in infants exposed to air pollution.

Author

Gallo, Elisa, Bressan, Silvia, Baraldo, Simonetta, Bottigliengo, Daniele, Geremia, Sara, Acar, Aslihan Senturk, Zagolin, Luca, Marson, Giovanna, Da Dalt, Liviana, and Gregori, Dario

Subjects
AIR pollution, PEDIATRIC respiratory diseases, BRONCHIOLITIS, HOSPITAL emergency services, INFANTS, HOSPITAL care of children, FOOD advertising
Abstract

Air pollution has been linked to an increased risk of several respiratory diseases in children, especially respiratory tract infections. The present study aims to evaluate the association between pediatric emergency department (PED) presentations for bronchiolitis and air pollution. PED presentations due to bronchiolitis in children aged less than 1 year were retrospectively collected from 2007 to 2018 in Padova, Italy, together with daily environmental data. A conditional logistic regression based on a time‐stratified case‐crossover design was performed to evaluate the association between PED presentations and exposure to NO2, PM2.5, and PM10. Models were adjusted for temperature, relative humidity, atmospheric pressure, and public holidays. Delayed effects in time were evaluated using distributed lag non‐linear models. Odds ratio for lagged exposure from 0 to 14 days were obtained. Overall, 2251 children presented to the PED for bronchiolitis. Infants' exposure to higher concentrations of PM10 and PM2.5 in the 5 days before the presentation to the PED increased the risk of accessing the PED by more than 10%, whereas high concentrations of NO2 between 2 and 12 days before the PED presentation were associated with an increased risk of up to 30%. The association between pollutants and infants who required hospitalization was even greater. A cumulative effect of NO2 among the 2 weeks preceding the presentation was also observed. In summary, PM and NO2 concentrations are associated with PED presentations and hospitalizations for bronchiolitis. Exposure of infants to air pollution could damage the respiratory tract mucosa, facilitating viral infections and exacerbating symptoms. [ABSTRACT FROM AUTHOR]

Published
2023
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32. A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo

Author

Möller, Katrin; https://orcid.org/0000-0002-4720-8568, Brambach, Max; https://orcid.org/0000-0001-6194-9568, Villani, Ambra; https://orcid.org/0000-0002-4468-6353, Gallo, Elisa; https://orcid.org/0000-0003-2203-6787, Gilmour, Darren; https://orcid.org/0000-0001-7613-090X, Peri, Francesca; https://orcid.org/0000-0001-7068-4952, Möller, Katrin; https://orcid.org/0000-0002-4720-8568, Brambach, Max; https://orcid.org/0000-0001-6194-9568, Villani, Ambra; https://orcid.org/0000-0002-4468-6353, Gallo, Elisa; https://orcid.org/0000-0003-2203-6787, Gilmour, Darren; https://orcid.org/0000-0001-7613-090X, and Peri, Francesca; https://orcid.org/0000-0001-7068-4952

Abstract

During brain development, many newborn neurons undergo apoptosis and are engulfed by microglia, the tissue-resident phagocytes of the brain, in a process known as efferocytosis. A hallmark of microglia is their highly branched morphology characterized by the presence of numerous dynamic extensions that these cells use for scanning the brain parenchyma and engulfing unwanted material. The mechanisms driving branch formation and apoptotic cell engulfment in microglia are unclear. By taking a live-imaging approach in zebrafish, we show that while microglia generate multiple microtubule-based branches, they only successfully engulf one apoptotic neuron at a time. Further investigation into the mechanism underlying this sequential engulfment revealed that targeted migration of the centrosome into one branch is predictive of phagosome formation and polarized vesicular trafficking. Moreover, experimentally doubling centrosomal numbers in microglia increases the rate of engulfment and even allows microglia to remove two neurons simultaneously, providing direct supporting evidence for a model where centrosomal migration is a rate-limiting step in branch-mediated efferocytosis. Conversely, light-mediated depolymerization of microtubules causes microglia to lose their typical branched morphology and switch to an alternative mode of engulfment, characterized by directed migration towards target neurons, revealing unexpected plasticity in their phagocytic ability. Finally, building on work focusing on the establishment of the immunological synapse, we identified a conserved signalling pathway underlying centrosomal movement in engulfing microglia.

Published
2022

33. A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo

Author

Möller, Katrin, Brambach, Max, Villani, Ambra, Gallo, Elisa, Gilmour, Darren, Peri, Francesca, and University of Zurich

Subjects
Neurons, Centrosome, General Immunology and Microbiology, General Neuroscience, Genetics and Molecular Biology, General Medicine, 10124 Institute of Molecular Life Sciences, General Biochemistry, Genetics and Molecular Biology, Phagocytosis, General Biochemistry, Animals, 570 Life sciences, biology, Microglia, Zebrafish
Abstract

During brain development, many newborn neurons undergo apoptosis and are engulfed by microglia, the tissue-resident phagocytes of the brain, in a process known as efferocytosis. A hallmark of microglia is their highly branched morphology characterized by the presence of numerous dynamic extensions that these cells use for scanning the brain parenchyma and engulfing unwanted material. The mechanisms driving branch formation and apoptotic cell engulfment in microglia are unclear. By taking a live-imaging approach in zebrafish, we show that while microglia generate multiple microtubule-based branches, they only successfully engulf one apoptotic neuron at a time. Further investigation into the mechanism underlying this sequential engulfment revealed that targeted migration of the centrosome into one branch is predictive of phagosome formation and polarized vesicular trafficking. Moreover, experimentally doubling centrosomal numbers in microglia increases the rate of engulfment and even allows microglia to remove two neurons simultaneously, providing direct supporting evidence for a model where centrosomal migration is a rate-limiting step in branch-mediated efferocytosis. Conversely, light-mediated depolymerization of microtubules causes microglia to lose their typical branched morphology and switch to an alternative mode of engulfment, characterized by directed migration towards target neurons, revealing unexpected plasticity in their phagocytic ability. Finally, building on work focusing on the establishment of the immunological synapse, we identified a conserved signalling pathway underlying centrosomal movement in engulfing microglia.

Published
2022
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36. Perfluoroalkyl substances and thyroid stimulating hormone levels in a highly exposed population in the Veneto Region

Author

Gallo, Elisa, primary, Barbiellini Amidei, Claudio, additional, Barbieri, Giulia, additional, Fabricio, Aline S.C., additional, Gion, Massimo, additional, Pitter, Gisella, additional, Daprà, Francesca, additional, Russo, Francesca, additional, Gregori, Dario, additional, Fletcher, Tony, additional, and Canova, Cristina, additional

Published
2022
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44. [Gender and age factors affecting the mortality during the COVID-19 epidemic in Italy]

Author

Azzolina, Daniela, Magnani, Corrado, Gallo, Elisa, Ferrante, Daniela, and Gregori, Dario

Subjects
Adult, Male, COVID-19, mortality, age, gender, Aged, Cause of Death, Comorbidity, Female, Humans, Italy, Middle Aged, Time Factors, Age Factors, Mortality, Pandemics, SARS-CoV-2, Sex Factors
Abstract

the COVID-19 epidemic severely affected Italy among European countries causing a considerable number of deaths across the country, especially in Northern Italy, leading also to serious problems to the Italian healthcare system, in particular the overcrowding of Intensive Care Units (ICU). In literature, the debate on the overall mortality during the COVID-19 epidemic, directly and indirectly, associated with the disease, is still open.to describe the time trend of the mortality in Italy during the COVID-19 pandemic accounting for age, gender, and geographical areas.analysis of mortality trend, by region, age, and gender.the Italian mortality data, released by the Italian National Institute of Statistics (Istat), have been considered for the analyses. The data refer to the first four months of 2015-2019 and 2020, involving 7,270 municipalities, corresponding to 93% of the Italian population.the mortality rates in the first four months of 2015-2019 and 2020, age-adjusted, have been calculated together with the percent variation. The data were analysed by gender, age class (65;=65 years), Region, and geographical areas (Northern versus Central-Southern Italy). The overall daily mortality series have been represented as rates over 100,000 resident population.in addition to the geographical location, the age component was a major determinant of the mortality pattern. The greater increase in the overall mortality was evidenced among elderly subjects in the Northern Italian Regions most affected by the epidemic. In these areas, also gender component played an important role in determining the mortality excess: higher mortality rates in the first four months of 2020 are observed for males in comparison to female populations.this research reveals that the population components are an important issue in determining the COVID-19 mortality excess. For this reason, it is of primary importance to monitor mortality (overall and by COVID-19) by age and gender and to consider these components and the related factors (comorbidity, exposures affecting the lung) in the public prevention policies towards the protection of the most fragile population groups.

Published
2021

45. Air Pollution Relates to Airway Pathology in Wheezing Children

Author

Bonato, Matteo, Gallo, Elisa, Bazzan, Erica, Marson, Giovanna, Zagolin, Luca, Cosio, Manuel G, Barbato, Angelo, Saetta, Marina, Gregori, Dario, and Baraldo, Simonetta

Subjects
particulate matter, wheezing, air pollution, asthma
Published
2021

46. Perioperative management of children with neuromuscular disorders based on a common protocol: A prospective, national study in Italy

Author

Racca, Fabrizio, primary, Longhitano, Yaroslava, additional, Wolfler, Andrea, additional, Carfagna, Fabio, additional, Grattarola, Claudia, additional, Serio, Paola, additional, Sbaraglia, Fabio, additional, Amigoni, Angela, additional, Savron, Fabio, additional, Caramelli, Fabio, additional, Montagnini, Luigi, additional, Astuto, Marinella, additional, Gallo, Elisa, additional, Zanza, Christian, additional, Vaschetto, Rosanna, additional, and Conti, Giorgio, additional

Published
2021
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48. An image-based data-driven analysis of cellular architecture in a developing tissue

Author

Hartmann, Jonas; https://orcid.org/0000-0002-5600-8285, Wong, Mie, Gallo, Elisa; https://orcid.org/0000-0003-2203-6787, Gilmour, Darren; https://orcid.org/0000-0001-7613-090X, Hartmann, Jonas; https://orcid.org/0000-0002-5600-8285, Wong, Mie, Gallo, Elisa; https://orcid.org/0000-0003-2203-6787, and Gilmour, Darren; https://orcid.org/0000-0001-7613-090X

Abstract

Quantitative microscopy is becoming increasingly crucial in efforts to disentangle the complexity of organogenesis, yet adoption of the potent new toolbox provided by modern data science has been slow, primarily because it is often not directly applicable to developmental imaging data. We tackle this issue with a newly developed algorithm that uses point cloud-based morphometry to unpack the rich information encoded in 3D image data into a straightforward numerical representation. This enabled us to employ data science tools, including machine learning, to analyze and integrate cell morphology, intracellular organization, gene expression and annotated contextual knowledge. We apply these techniques to construct and explore a quantitative atlas of cellular architecture for the zebrafish posterior lateral line primordium, an experimentally tractable model of complex self-organized organogenesis. In doing so, we are able to retrieve both previously established and novel biologically relevant patterns, demonstrating the potential of our data-driven approach.

Published
2020

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