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539 results on '"Gallimore, Awen"'

1. Lower Humoral and Cellular Immunity Following Asymptomatic SARS-CoV-2 Infection Compared to Symptomatic Infection in Education (The ACE Cohort)

Author

Hopkins, Georgina, Gomez, Nancy, Tucis, Davis, Bartlett, Laura, Steers, Graham, Burns, Ellie, Brown, Michaela, Harvey-Cowlishaw, Tyler, Santos, Rute, Lauder, Sarah N, Scurr, Martin, Capitani, Lorenzo, Burnell, Stephanie, Rees, Tara, Smart, Kathryn, Somerville, Michelle, Gallimore, Awen, Perera, Marianne, Potts, Martin, Metaxaki, Marina, Krishna, Benjamin, Jackson, Hannah, Tighe, Paddy, Onion, David, Godkin, Andrew, Wills, Mark, and Fairclough, Lucy

Published
2024
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3. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation

Author

Hulin-Curtis, Sarah, Geary, James K., MacLachlan, Bruce J., Altmann, Danny M., Baillon, Laury, Cole, David K., Greenshields-Watson, Alex, Hesketh, Sophie J., Humphreys, Ian R., Jones, Ian M., Lauder, Sarah N., Mason, Georgina H., Smart, Kathryn, Scourfield, D. Oliver, Scott, Jake, Sukhova, Ksenia, Stanton, Richard J., Wall, Aaron, Rizkallah, Pierre J., Barclay, Wendy S., Gallimore, Awen, and Godkin, Andrew

Published
2024
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6. PI3K Isoform Immunotherapy for Solid Tumours

Author

Scott, Jake, Rees, Lauren, Gallimore, Awen, Lauder, Sarah N., Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Casadevall, Arturo, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Malissen, Bernard, Series Editor, Rappuoli, Rino, Series Editor, and Dominguez-Villar, Margarita, editor

Published
2022
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10. CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

Author

Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L., Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J., Gallimore, Awen M., Sewell, Andrew K., Godkin, Andrew J., and Cole, David K.

Published
2020
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14. Lower Humoral and Cellular Immunity following Asymptomatic SARS-CoV-2 Infection in Education (The ACE Cohort)

Author

Hopkins, Georgina, primary, Gomez, Nancy, additional, Tucis, Davis, additional, Bartlett, Laura, additional, Steers, Graham, additional, Burns, Ellie, additional, Brown, Michaela, additional, Harvey-Cowlishaw, Tyler, additional, Santos, Rute, additional, Lauder, Sarah N, additional, Scurr, Martin, additional, Capitani, Lorenzo, additional, Burnell, Stephanie, additional, Rees, Tara, additional, Smart, Kathryn, additional, Somerville, Michelle, additional, Gallimore, Awen, additional, Perera, Marianne, additional, Potts, Martin, additional, Metaxaki, Marina, additional, Krishna, Benjamin, additional, Jackson, Hannah, additional, Tighe, Paddy, additional, Onion, David, additional, Godkin, Andrew, additional, Wills, Mark, additional, and Fairclough, Lucy, additional

Published
2024
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17. TIM3 is a context-dependent co-regulator of cytotoxic T cell function

Author

Alamir, Hanin, primary, Wong, Carissa C.W., additional, Alsubaiti, Amal, additional, Edmunds, Grace L., additional, Grant, Tressan, additional, Alsulaimani, Safaa, additional, Boyd, James, additional, Holland, Christopher J., additional, Morgan, David J., additional, Gallimore, Awen M., additional, and Wülfing, Christoph, additional

Published
2023
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18. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry

Author

Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S.J., Galloway, Sarah A.E., Laugel, Bruno, Clement, Mathew, Makinde, Julia, Ladell, Kristin, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann, Gallimore, Awen, Rizkallah, Pierre J., Gras, Stephanie, Rossjohn, Jamie, Burrows, Scott R., Cole, David K., Price, David A., and Sewell, Andrew K.

Subjects
Combinatorial chemistry -- Health aspects -- Methods, Synthetic biology -- Research, Influenza vaccines -- Research, Biomimetics -- Health aspects -- Usage, Polypeptides -- Health aspects -- Chemical properties, Pharmacological research, Health care industry
Abstract

Polypeptide vaccines effectively activate human T cells but suffer from poor biological stability, which confines both transport logistics and in vivo therapeutic activity. Synthetic biology has the potential to address these limitations through the generation of highly stable antigenic 'mimics' using subunits that do not exist in the natural world. We developed a platform based on D-amino acid combinatorial chemistry and used this platform to reverse engineer a fully artificial [CD8.sup.+] T cell agonist that mirrored the immunogenicity profile of a native epitope blueprint from influenza virus. This nonnatural peptide was highly stable in human serum and gastric acid, reflecting an intrinsic resistance to physical and enzymatic degradation. In vitro, the synthetic agonist stimulated and expanded an archetypal repertoire of polyfunctional human influenza virus-specific [CD8.sup.+] T cells. In vivo, specific responses were elicited in naive humanized mice by subcutaneous vaccination, conferring protection from subsequent lethal influenza challenge. Moreover, the synthetic agonist was immunogenic after oral administration. This proof-of-concept study highlights the power of synthetic biology to expand the horizons of vaccine design and therapeutic delivery., Introduction [CD8.sup.+] T cells recognize short peptide fragments presented by MHC class I (MHC-I) molecules on the surface of nucleated cells (1-3). These peptide-MHC-I (pMHC-I) molecular arrays are scanned by [...]

Published
2018
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21. Figure S5 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, primary, Jones, Emma, primary, Kelch, Inken, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Ware, Carl, primary, Godkin, Andrew, primary, Stein, Jens V., primary, Bogle, Gib, primary, and Gallimore, Awen, primary

Published
2023
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22. Supplementary Figures from Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection

Author

Pires, Ana, primary, Greenshields-Watson, Alexander, primary, Jones, Emma, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Milutinovic, Stefan, primary, Kendrick, Howard, primary, Hindley, James P., primary, French, Rhiannon, primary, Smalley, Matthew J., primary, Watkins, William J., primary, Andrews, Robert, primary, Godkin, Andrew, primary, and Gallimore, Awen, primary

Published
2023
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23. Data from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, primary, Jones, Emma, primary, Kelch, Inken, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Ware, Carl, primary, Godkin, Andrew, primary, Stein, Jens V., primary, Bogle, Gib, primary, and Gallimore, Awen, primary

Published
2023
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24. Supplementary Movie 2 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, primary, Jones, Emma, primary, Kelch, Inken, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Ware, Carl, primary, Godkin, Andrew, primary, Stein, Jens V., primary, Bogle, Gib, primary, and Gallimore, Awen, primary

Published
2023
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25. Supplementary Movie 1 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, primary, Jones, Emma, primary, Kelch, Inken, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Ware, Carl, primary, Godkin, Andrew, primary, Stein, Jens V., primary, Bogle, Gib, primary, and Gallimore, Awen, primary

Published
2023
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26. Data from Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection

Author

Pires, Ana, primary, Greenshields-Watson, Alexander, primary, Jones, Emma, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Milutinovic, Stefan, primary, Kendrick, Howard, primary, Hindley, James P., primary, French, Rhiannon, primary, Smalley, Matthew J., primary, Watkins, William J., primary, Andrews, Robert, primary, Godkin, Andrew, primary, and Gallimore, Awen, primary

Published
2023
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27. Supplementary Movie 3 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, primary, Jones, Emma, primary, Kelch, Inken, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Ware, Carl, primary, Godkin, Andrew, primary, Stein, Jens V., primary, Bogle, Gib, primary, and Gallimore, Awen, primary

Published
2023
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29. Data from Escalating Regulation of 5T4-Specific IFN-γ+ CD4+ T Cells Distinguishes Colorectal Cancer Patients from Healthy Controls and Provides a Target for In Vivo Therapy

Author

Scurr, Martin, primary, Bloom, Anja, primary, Pembroke, Tom, primary, Srinivasan, Rohit, primary, Brown, Clare, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Davies, Mike, primary, Hargest, Rachel, primary, Phillips, Simon, primary, Christian, Adam, primary, Hockey, Tom, primary, Gallimore, Awen, primary, and Godkin, Andrew, primary

Published
2023
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31. Supplementary Figure Legend from Escalating Regulation of 5T4-Specific IFN-γ+ CD4+ T Cells Distinguishes Colorectal Cancer Patients from Healthy Controls and Provides a Target for In Vivo Therapy

Author

Scurr, Martin, primary, Bloom, Anja, primary, Pembroke, Tom, primary, Srinivasan, Rohit, primary, Brown, Clare, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Davies, Mike, primary, Hargest, Rachel, primary, Phillips, Simon, primary, Christian, Adam, primary, Hockey, Tom, primary, Gallimore, Awen, primary, and Godkin, Andrew, primary

Published
2023
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33. Supplementary Figures 1 - 4 from Escalating Regulation of 5T4-Specific IFN-γ+ CD4+ T Cells Distinguishes Colorectal Cancer Patients from Healthy Controls and Provides a Target for In Vivo Therapy

Author

Scurr, Martin, primary, Bloom, Anja, primary, Pembroke, Tom, primary, Srinivasan, Rohit, primary, Brown, Clare, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Davies, Mike, primary, Hargest, Rachel, primary, Phillips, Simon, primary, Christian, Adam, primary, Hockey, Tom, primary, Gallimore, Awen, primary, and Godkin, Andrew, primary

Published
2023
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34. Supplementary Data from Low-Dose Cyclophosphamide Induces Antitumor T-Cell Responses, which Associate with Survival in Metastatic Colorectal Cancer

Author

Scurr, Martin, primary, Pembroke, Tom, primary, Bloom, Anja, primary, Roberts, David, primary, Thomson, Amanda, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Adams, Richard, primary, Brewster, Alison, primary, Jones, Robert, primary, Gwynne, Sarah, primary, Blount, Daniel, primary, Harrop, Richard, primary, Hills, Robert, primary, Gallimore, Awen, primary, and Godkin, Andrew, primary

Published
2023
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35. Supplementary Tables from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells

Author

Scurr, Martin J., primary, Greenshields-Watson, Alex, primary, Campbell, Emma, primary, Somerville, Michelle S., primary, Chen, Yuan, primary, Hulin-Curtis, Sarah L., primary, Burnell, Stephanie E.A., primary, Davies, James A., primary, Davies, Michael M., primary, Hargest, Rachel, primary, Phillips, Simon, primary, Christian, Adam D., primary, Ashelford, Kevin E., primary, Andrews, Robert, primary, Parker, Alan L., primary, Stanton, Richard J., primary, Gallimore, Awen, primary, and Godkin, Andrew, primary

Published
2023
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36. Data from T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion

Author

Hindley, James P., primary, Jones, Emma, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Lauder, Sarah N., primary, Ondondo, Beatrice, primary, Cutting, Scott, primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Withers, David, primary, Price, David A., primary, Ager, Ann, primary, Godkin, Andrew J., primary, and Gallimore, Awen M., primary

Published
2023
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37. Supplementary Figures 1-3 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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38. Data from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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39. Supplementary Figure 6 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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40. Supplementary Figure 4 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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41. Supplementary Figure Legends 1-7 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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42. Supplementary Figure 5 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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43. Supplementary Figure 7 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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44. Supplementary Figures 1-6 from T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion

Author

Hindley, James P., primary, Jones, Emma, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Lauder, Sarah N., primary, Ondondo, Beatrice, primary, Cutting, Scott, primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Withers, David, primary, Price, David A., primary, Ager, Ann, primary, Godkin, Andrew J., primary, and Gallimore, Awen M., primary

Published
2023
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45. Oncogenic Properties of Apoptotic Tumor Cells in Aggressive B Cell Lymphoma

Author

Ford, Catriona A., Petrova, Sofia, Pound, John D., Voss, Jorine J.L.P., Melville, Lynsey, Paterson, Margaret, Farnworth, Sarah L., Gallimore, Awen M., Cuff, Simone, Wheadon, Helen, Dobbin, Edwina, Ogden, Carol Anne, Dumitriu, Ingrid E., Dunbar, Donald R., Murray, Paul G., Ruckerl, Dominik, Allen, Judith E., Hume, David A., van Rooijen, Nico, Goodlad, John R., Freeman, Tom C., and Gregory, Christopher D.

Published
2015
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46. A Targeted Amino Acid Mutation in Influenza a Virus Universal Epitope Transforms Immunogenicity and Protective Immunity via CD4 T Cell Activation

Author

Hulin-Curtis, Sarah Louise, primary, Geary, James, additional, MacLachlan, Bruce, additional, Altmann, Daniel, additional, Baillon, Laury, additional, Cole, David, additional, Greenshields-Watson, Alexander, additional, Hesketh, Sophie, additional, Humphreys, Ian R., additional, Jones, Ian, additional, Lauder, Sarah, additional, Mason, Georgina, additional, Smart, Kathryn, additional, Scourfield, Oliver, additional, Scott, Jake, additional, Sukhova, Ksenia, additional, Stanton, Richard J., additional, Wall, Aaron, additional, Rizkallah, Pierre, additional, Barclay, Wendy S., additional, Gallimore, Awen, additional, and Godkin, Andrew, additional

Published
2023
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48. Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, additional, Jones, Emma, additional, Kelch, Inken, additional, Smart, Kathryn, additional, Lauder, Sarah N., additional, Somerville, Michelle, additional, Ware, Carl, additional, Godkin, Andrew, additional, Stein, Jens V., additional, Bogle, Gib, additional, and Gallimore, Awen, additional

Published
2022
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